JPS5661369A - Inclusion compound of thialamide or its acid addition salt - Google Patents
Inclusion compound of thialamide or its acid addition saltInfo
- Publication number
- JPS5661369A JPS5661369A JP13770279A JP13770279A JPS5661369A JP S5661369 A JPS5661369 A JP S5661369A JP 13770279 A JP13770279 A JP 13770279A JP 13770279 A JP13770279 A JP 13770279A JP S5661369 A JPS5661369 A JP S5661369A
- Authority
- JP
- Japan
- Prior art keywords
- thialamide
- cyclodextrin
- acid addition
- addition salt
- inclusion compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain an inclusion compound wherein the bitterness of a thialamide or an acid addition salt thereof useful as an anti-inflammatory agent or an analgesic agent is suppressed, by including the thialamide or the acid addition salt thereof in cyclodextrin.
CONSTITUTION: A thialamide of the formula or an acid addition salt thereof is included in cyclodextrin to give an inclusion compound. The cyclodextrin may be any of the α-, β- and γ-isomers, and the inclusion compound can be prepared by kneading or the saturated aqueous solution method. In the kneading method, water in an amount of 0.1W5 times that of the cyclodextrin is added to the cyclodextrin, and an equimolar amount of the thialamide is added thereto. The mixture is then kneaded fully and dried to give the aimed substance. In the saturated aqueous solution method, the thialamide is added to a saturated aqueous solution of cyclodextrin to collect the formed precipitate or the solution is concentrated and dried to afford the aimed substance.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13770279A JPS5661369A (en) | 1979-10-26 | 1979-10-26 | Inclusion compound of thialamide or its acid addition salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13770279A JPS5661369A (en) | 1979-10-26 | 1979-10-26 | Inclusion compound of thialamide or its acid addition salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5661369A true JPS5661369A (en) | 1981-05-26 |
Family
ID=15204812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13770279A Pending JPS5661369A (en) | 1979-10-26 | 1979-10-26 | Inclusion compound of thialamide or its acid addition salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5661369A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5821620A (en) * | 1981-07-30 | 1983-02-08 | Riken Kagaku Kogyo Kk | Clathrate of garlic constituents |
JPS58203915A (en) * | 1982-05-20 | 1983-11-28 | Riken Kagaku Kogyo Kk | Cardiac of purified oil of garlic |
JPS6478447A (en) * | 1987-04-16 | 1989-03-23 | Canon Kk | Production of optical recording medium |
US5126333A (en) * | 1989-09-06 | 1992-06-30 | Farmitalia Carlo Erba S.R.L. | Pharmaceutical compositions having improved dissolution properties |
-
1979
- 1979-10-26 JP JP13770279A patent/JPS5661369A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5821620A (en) * | 1981-07-30 | 1983-02-08 | Riken Kagaku Kogyo Kk | Clathrate of garlic constituents |
JPH0366289B2 (en) * | 1981-07-30 | 1991-10-16 | Riken Chemical Ind | |
JPS58203915A (en) * | 1982-05-20 | 1983-11-28 | Riken Kagaku Kogyo Kk | Cardiac of purified oil of garlic |
JPH0366288B2 (en) * | 1982-05-20 | 1991-10-16 | Riken Chemical Ind | |
JPS6478447A (en) * | 1987-04-16 | 1989-03-23 | Canon Kk | Production of optical recording medium |
US5126333A (en) * | 1989-09-06 | 1992-06-30 | Farmitalia Carlo Erba S.R.L. | Pharmaceutical compositions having improved dissolution properties |
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