JPS5661369A - Inclusion compound of thialamide or its acid addition salt - Google Patents

Inclusion compound of thialamide or its acid addition salt

Info

Publication number
JPS5661369A
JPS5661369A JP13770279A JP13770279A JPS5661369A JP S5661369 A JPS5661369 A JP S5661369A JP 13770279 A JP13770279 A JP 13770279A JP 13770279 A JP13770279 A JP 13770279A JP S5661369 A JPS5661369 A JP S5661369A
Authority
JP
Japan
Prior art keywords
thialamide
cyclodextrin
acid addition
addition salt
inclusion compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13770279A
Other languages
Japanese (ja)
Inventor
Tsugio Okada
Toshio Kikuchi
Takashi Sano
Koki Horikoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IWAKI SEIYAKU KK
Original Assignee
IWAKI SEIYAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IWAKI SEIYAKU KK filed Critical IWAKI SEIYAKU KK
Priority to JP13770279A priority Critical patent/JPS5661369A/en
Publication of JPS5661369A publication Critical patent/JPS5661369A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain an inclusion compound wherein the bitterness of a thialamide or an acid addition salt thereof useful as an anti-inflammatory agent or an analgesic agent is suppressed, by including the thialamide or the acid addition salt thereof in cyclodextrin.
CONSTITUTION: A thialamide of the formula or an acid addition salt thereof is included in cyclodextrin to give an inclusion compound. The cyclodextrin may be any of the α-, β- and γ-isomers, and the inclusion compound can be prepared by kneading or the saturated aqueous solution method. In the kneading method, water in an amount of 0.1W5 times that of the cyclodextrin is added to the cyclodextrin, and an equimolar amount of the thialamide is added thereto. The mixture is then kneaded fully and dried to give the aimed substance. In the saturated aqueous solution method, the thialamide is added to a saturated aqueous solution of cyclodextrin to collect the formed precipitate or the solution is concentrated and dried to afford the aimed substance.
COPYRIGHT: (C)1981,JPO&Japio
JP13770279A 1979-10-26 1979-10-26 Inclusion compound of thialamide or its acid addition salt Pending JPS5661369A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13770279A JPS5661369A (en) 1979-10-26 1979-10-26 Inclusion compound of thialamide or its acid addition salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13770279A JPS5661369A (en) 1979-10-26 1979-10-26 Inclusion compound of thialamide or its acid addition salt

Publications (1)

Publication Number Publication Date
JPS5661369A true JPS5661369A (en) 1981-05-26

Family

ID=15204812

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13770279A Pending JPS5661369A (en) 1979-10-26 1979-10-26 Inclusion compound of thialamide or its acid addition salt

Country Status (1)

Country Link
JP (1) JPS5661369A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5821620A (en) * 1981-07-30 1983-02-08 Riken Kagaku Kogyo Kk Clathrate of garlic constituents
JPS58203915A (en) * 1982-05-20 1983-11-28 Riken Kagaku Kogyo Kk Cardiac of purified oil of garlic
JPS6478447A (en) * 1987-04-16 1989-03-23 Canon Kk Production of optical recording medium
US5126333A (en) * 1989-09-06 1992-06-30 Farmitalia Carlo Erba S.R.L. Pharmaceutical compositions having improved dissolution properties

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5821620A (en) * 1981-07-30 1983-02-08 Riken Kagaku Kogyo Kk Clathrate of garlic constituents
JPH0366289B2 (en) * 1981-07-30 1991-10-16 Riken Chemical Ind
JPS58203915A (en) * 1982-05-20 1983-11-28 Riken Kagaku Kogyo Kk Cardiac of purified oil of garlic
JPH0366288B2 (en) * 1982-05-20 1991-10-16 Riken Chemical Ind
JPS6478447A (en) * 1987-04-16 1989-03-23 Canon Kk Production of optical recording medium
US5126333A (en) * 1989-09-06 1992-06-30 Farmitalia Carlo Erba S.R.L. Pharmaceutical compositions having improved dissolution properties

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