JPS579719A - Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent - Google Patents

Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent

Info

Publication number
JPS579719A
JPS579719A JP8353980A JP8353980A JPS579719A JP S579719 A JPS579719 A JP S579719A JP 8353980 A JP8353980 A JP 8353980A JP 8353980 A JP8353980 A JP 8353980A JP S579719 A JPS579719 A JP S579719A
Authority
JP
Japan
Prior art keywords
water
extract
reaction
plant
genus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8353980A
Other languages
Japanese (ja)
Inventor
Susumu Mihashi
Muneaki Takase
Sousuke Yasui
Ichiro Washisawa
Kimitomo Yoshioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Priority to JP8353980A priority Critical patent/JPS579719A/en
Priority to DE3116695A priority patent/DE3116695C2/en
Priority to NL8102073A priority patent/NL8102073A/en
Priority to CA000376500A priority patent/CA1153696A/en
Priority to GB8113312A priority patent/GB2076002B/en
Priority to CH2842/81A priority patent/CH652028A5/en
Priority to FR8108748A priority patent/FR2481704A1/en
Priority to KR1019810001493A priority patent/KR840001510B1/en
Priority to IT21484/81A priority patent/IT1136593B/en
Publication of JPS579719A publication Critical patent/JPS579719A/en
Priority to US06/520,760 priority patent/US4501736A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

NEW MATERIAL:An extract, obtained by extracting a plant of the genus Epimedium with either one of a mixed solvent of a water-miscible organic solvent, e.g. a lower alcohol, ketone or ether, with water or water, defatting the resultant aqueous extract, and dialyzing the defatted extract. Positive to any one of the anthrone- sulfuric acid reaction, ferric chloride reaction, Molisch reaction, skatole reaction and Bial reaction, and having a ultraviolet absorption spectrum λmax(nm)=270.
USE: An immunological enhancer capable of enhancing the phagocytosis of mobile and fixed marcophages in tests on mice and also the cellular immunity against BC-47 cells (derived from the cancer of the bladder in ACI-strain rats).
PROCESS: The whole herb of the genus Epidemium is extracted with a mixed solvent of a water-miscible organic solvent with water or water, defatted and dialyzed to give the aimed extract.
COPYRIGHT: (C)1982,JPO&Japio
JP8353980A 1980-04-30 1980-06-20 Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent Pending JPS579719A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP8353980A JPS579719A (en) 1980-06-20 1980-06-20 Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent
DE3116695A DE3116695C2 (en) 1980-04-30 1981-04-28 New plant extract, process for its preparation and a medicinal product containing it
NL8102073A NL8102073A (en) 1980-04-30 1981-04-28 NEW EXTRACT FROM A PLANT OF THE GENDER EPIMEDIUM SP., PROCESS FOR PREPARING THE EXTRACT, IMMUNITY STIMULATOR, INCLUDING THE EXTRACT AS AN EFFECTIVE COMPONENT AND IMMUNOTHERAPY USING THE EXTRACT.
CA000376500A CA1153696A (en) 1980-04-30 1981-04-29 Extract from plant of genus epimedium sp., process for preparation of said extract, immunostimulating agent comprising said extract as effective component and immunotherapy by using said extract
CH2842/81A CH652028A5 (en) 1980-04-30 1981-04-30 EXTRACT FROM PLANTS OF THE GENUS EPIMEDIUM SP., METHOD FOR THE PRODUCTION OF THIS EXTRACT AND USE OF THE EXTRACT AS AN EFFECTIVE COMPONENT IN AN IMMUNTIMULATING AGENT.
GB8113312A GB2076002B (en) 1980-04-30 1981-04-30 Extract and process for extraction from plant of genus epimedium sp immunostimulating agent comprising said extract and extract for use in immunotherapy
FR8108748A FR2481704A1 (en) 1980-04-30 1981-04-30 PLANT EXTRACT OF THE GENUS EPIMADIUM SP PROCESS FOR PREPARING THE EXTRACT, IMMUNOSTIMULATING AGENT COMPRISING THE EXTRACT AS AN ACTIVE COMPONENT AND IMMUNOTHERAPY OBTAINED USING THE EXTRACT
KR1019810001493A KR840001510B1 (en) 1980-06-20 1981-04-30 Process for preparing extract from plant of genus epimedium s.p.
IT21484/81A IT1136593B (en) 1980-04-30 1981-04-30 EXTRACT FROM PLANTS OF THE GENRE EPIMEDIUM, PROCEDURE FOR THE PREPARATION OF THAT EXTRACT, IMMUNOSTIMULATING AGENT THAT INCLUDES THE EXTRACT AS AN EFFECTIVE COMPONENT AND IMMUNOTHERAPY THROUGH THE USE OF THE EXTRACT
US06/520,760 US4501736A (en) 1980-04-30 1983-08-08 Extract from barrenwort

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8353980A JPS579719A (en) 1980-06-20 1980-06-20 Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent

Publications (1)

Publication Number Publication Date
JPS579719A true JPS579719A (en) 1982-01-19

Family

ID=13805303

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8353980A Pending JPS579719A (en) 1980-04-30 1980-06-20 Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent

Country Status (2)

Country Link
JP (1) JPS579719A (en)
KR (1) KR840001510B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013541625A (en) * 2010-11-05 2013-11-14 インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ Epimedium polysaccharide, its fractions, and its use as a vaccine adjuvant

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013541625A (en) * 2010-11-05 2013-11-14 インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ Epimedium polysaccharide, its fractions, and its use as a vaccine adjuvant

Also Published As

Publication number Publication date
KR840001510B1 (en) 1984-09-29
KR830004854A (en) 1983-07-20

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