JPS5629519A - Preparation of active antitumor agent - Google Patents
Preparation of active antitumor agentInfo
- Publication number
- JPS5629519A JPS5629519A JP10468379A JP10468379A JPS5629519A JP S5629519 A JPS5629519 A JP S5629519A JP 10468379 A JP10468379 A JP 10468379A JP 10468379 A JP10468379 A JP 10468379A JP S5629519 A JPS5629519 A JP S5629519A
- Authority
- JP
- Japan
- Prior art keywords
- solution
- water
- organic solvent
- added
- rice bran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain the titled agent having preventing action on a solid cancer without troublesome purification through dialysis, by treating an extracted solution of rice bran through an alkaline aqueous solution with a water-soluble organic solvent so that harmful impurities are precipitated and removed, followed by neutralization.
CONSTITUTION: For example, rice bran is boiled in 5W20wt. times water to remove hot water-soluble ingredients, e.g., polysaccharides. A basic aqueous solution, e.g., 5wt% aqueous solution of caustic soda is added to the rice bran, which is preferably extracted at 50°C for 10W20hr. An organic solvent miscible with water, e.g., ethanol, etc., is added to the prepared extracted solution in such a way that the solution has 40wt% ethanol concentration so that harmful impurities are precipitated and removed. An acid, e.g., hydrochloric acid, etc. is added to the solution and neutralized to form the desired agent as a precipitate. The prepared product consists of a polar organic solvent-soluble ingredient and an insoluble ingredient, and the former had extremely controlling effect against mouce ascites tumor and the latter has one against mouce solid cancer respectively.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54104683A JPS591690B2 (en) | 1979-08-17 | 1979-08-17 | Method for producing antitumor active substances |
KR1019800003223A KR840001511B1 (en) | 1979-08-17 | 1980-08-14 | Process for preparing antitumor substance |
EP80104847A EP0027514B1 (en) | 1979-08-17 | 1980-08-14 | Antitumor substance and its production |
DE8080104847T DE3064701D1 (en) | 1979-08-17 | 1980-08-14 | Antitumor substance and its production |
US06/377,490 US4457863A (en) | 1979-08-17 | 1982-05-12 | Antitumor substance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54104683A JPS591690B2 (en) | 1979-08-17 | 1979-08-17 | Method for producing antitumor active substances |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5629519A true JPS5629519A (en) | 1981-03-24 |
JPS591690B2 JPS591690B2 (en) | 1984-01-13 |
Family
ID=14387261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54104683A Expired JPS591690B2 (en) | 1979-08-17 | 1979-08-17 | Method for producing antitumor active substances |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS591690B2 (en) |
KR (1) | KR840001511B1 (en) |
-
1979
- 1979-08-17 JP JP54104683A patent/JPS591690B2/en not_active Expired
-
1980
- 1980-08-14 KR KR1019800003223A patent/KR840001511B1/en active
Also Published As
Publication number | Publication date |
---|---|
KR830003211A (en) | 1983-06-18 |
KR840001511B1 (en) | 1984-09-29 |
JPS591690B2 (en) | 1984-01-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS55120770A (en) | Purification of stevioside solution | |
JOP20180046B1 (en) | Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes | |
JPS5628202A (en) | Polysaccharide rbs substance, its preparation, and antitumor agent containing it as effective component | |
CN103054775B (en) | A kind of sterilization moisture retention hand cleanser of environmental protection | |
JPS536412A (en) | Preparation of n-containing polysaccharides | |
JPS5390368A (en) | Preparation of cation-modified cellulose derivative | |
WO2002002645A8 (en) | COLD WATER SOLUBLE β-GLUCAN PRODUCT AND PROCESS FOR PREPARING THE SAME | |
CN101270323A (en) | Degerming soap of natural plant | |
CN107669547B (en) | Bacteriostatic hand sanitizer containing purslane and preparation method thereof | |
JPS5629519A (en) | Preparation of active antitumor agent | |
US3395223A (en) | Fern extract for treating gastric ulcers | |
JPS5347479A (en) | Water-soluble, partially deacetylated chitin and its preparation | |
JPS5571701A (en) | Hydrolyzate polysaccharide, its preparation, and immunoregulator containing hydrolyzate polysaccharide as active ingredient | |
CN109646325A (en) | The preparation method of amphipathic carboxymethyl chitosan and its nursing washing lotion application | |
CN113876629A (en) | Wash-free hand sanitizer and preparation method thereof | |
JPS57102160A (en) | Preparation of dried young sardines | |
CN110151781A (en) | A kind of medical fluid and preparation method thereof for treating hemorrhoid | |
KR950005844A (en) | Method for preparing water-soluble derivatives of chitin and chitosan | |
JP2003047495A5 (en) | ||
CH639279A5 (en) | Process for the production of a preparation acting against neoplasms and preparation prepared according to this process | |
JPS5572101A (en) | Control agent for viral disease of plant | |
JPH11279050A (en) | Bathing agent | |
CN112618412A (en) | Antibacterial composition and preparation method thereof | |
US1517002A (en) | Pharmaceutical compound containing the sodium-silver compound of thiodiglycolic acid | |
DE900378C (en) | Process for the production of therapeutically highly effective, easily absorbable substances with little irritation |