CN110151781A - A kind of medical fluid and preparation method thereof for treating hemorrhoid - Google Patents
A kind of medical fluid and preparation method thereof for treating hemorrhoid Download PDFInfo
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- CN110151781A CN110151781A CN201910367128.4A CN201910367128A CN110151781A CN 110151781 A CN110151781 A CN 110151781A CN 201910367128 A CN201910367128 A CN 201910367128A CN 110151781 A CN110151781 A CN 110151781A
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- China
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- medical fluid
- alumen
- glycerol
- treating hemorrhoid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Abstract
The present invention relates to hemorrhoid, in particular to a kind of medical fluid and preparation method thereof for treating hemorrhoid, formula includes the ingredient of following weight parts: 1~1.2 part of tannic acid, 58~65 parts of alumen, 50~53 parts of glycerol, 14.5~16 parts of sodium citrate；Its method includes preparation mixing alumen melt, prepares glycerol tan-liquor, Hybrid Heating and packing；Finished product medical fluid use process made of the present invention is simple, no pain, and cure rate is high, recurrence rate is low, no sequel and complication, effect stability.
Description
Technical field
The present invention relates to hemorrhoid, in particular to a kind of medical fluid and preparation method thereof for treating hemorrhoid.
Background technique
On domestic market, most widely used is XIAOZHILING ZHUSHEYE, and the effect of XIAOZHILING ZHUSHEYE is good, but is used
It measures larger, easily makes troubles to clinical manipulation, and medicine high price is expensive, high recurrence rate after 2 years.Dosage is inferior to XIAOZHILING ZHUSHEYE
For Sodium Humate, but the medicine is downright bad agent, very painful after injection treatment, easily causes local necrosis, falls off, after there will be severe
Lose disease such as rectum cicatricial contracture, narrow, big bleeding etc..
Xiaozhiling injection in clinical application, though cure rate is satisfactory, the high recurrence rate after 2 years；Sodium Humate clinical cure
Rate is also very high, but sequelae, and complication incidence is very high, and all there is some hidden danger.
Summary of the invention
For above-mentioned deficiency in the prior art, the present invention provides a kind of medical fluid for treating hemorrhoid, environmental protection, stablize and
Efficiently.
In order to achieve the above object of the invention, the technical solution adopted by the present invention are as follows:
A kind of medical fluid for treating hemorrhoid, the ingredient including following weight parts: 1~1.2 part of tannic acid, 58~65 parts of alumen, sweet
50~53 parts, 14.5~16 parts of sodium citrate of oil.
Preferably, the tannic acid mass fraction is 0.1%, the alumen mass fraction is 6%, described sweet
Oil quality score is 5%, the sodium citrate mass fraction is 1.5%.
Preferably, a kind of medical fluid for treating hemorrhoid, further includes the ingredient of following weight parts: 1000 parts of water.
Preferably, a kind of medical fluid for treating hemorrhoid, the ingredient including following weight parts: 1 part of tannic acid, alumen
60 parts, 50 parts of glycerol, 15 parts of sodium citrate, 1000 parts of water.
A kind of preparation method of medical fluid that treating hemorrhoid, includes the following steps:
(1) preparation mixing alumen melt: taking distilled water 1000ml, alumen, sodium citrate is added in distilled water, heating is stirred
It mixes and dissolves, alumen melt must be mixed；
(2) it prepares glycerol tan-liquor: glycerol being taken to be heated in beaker, and tannic acid is added in glycerol, stir molten
Solution.
(3) Hybrid Heating: the glycerol tan-liquor dissolved is added in mixing alumen solution and is stirred evenly, is heated
To boiling, stop heating, filtering, and make its natural cooling；
(4) it dispenses: coolant liquid is divided in ampoule bottle, sealing, is packed to get finished product medical fluid at disinfection.
Preferably, the capacity of the ampoule bottle is 5ml.
The invention has the benefit that use process is simple, no pain, cure rate is high, recurrence rate is low, no sequel and simultaneously
Send out disease, effect stability.
Specific embodiment
In order that the present invention can be more clearly and readily understood, below by technical solution in the embodiment of the present invention
It is clearly and completely described.
Tannic acid: a kind of tannic acid tannin as obtained in Chinese gall is yellow or light brown lightweight without crystalline substance powder or squama
Piece；Odorless, micro- to have special odor, taste is extremely puckery.It is dissolved in water and ethyl alcohol, is soluble in glycerol, is practically insoluble in ether, chloroform or benzene.
Tannic acid is astringent, can precipitating proteins, can form insoluble compound with alkaloid, glucoside and heavy metal etc..Pharmaceutical procedures
For external application, it is mainly used for part, 11%~20% ointment is used for exudative ulcer, scald, bedsore, hemorrhoid, eczema etc.,
15%~20% glycerite is for stomatitis, tonsillitis and sphagitis etc., also for detoxifying, to year of Apomorphinum, scholar,
When digitalis, lead, silver, copper, zinc etc. are poisoned, its solution gastric lavage can be used, existing oneself is replaced with other antidote；For colon radiography
When, 0.25~0.5% bowel lavage of this product is added in barium sulfate enema, to clean colon, convenient for development.Tannic acid can inhibit snake
The activity of toxalbumin, cleaning wound when having very strong detoxication to toxin such as cobras, can be used for venomous snake bite.Tannic acid is also
Enteric bacteria infectious disease can be treated, inhibit mutation, be such as used as the RG tannic acid (Rheum or other plant) of ADP enzyme inhibitor
It is used in combination with other antimicrobials, is effective to the cutaneum carcinoma and skin aging that prevent UV from inducing.
Alumen: also known as alum is forged, it is colourless, transparent or semitransparent not of uniform size, irregular crystalline solid, surface is slightly flat
It is sliding or uneven, have fine and closely woven vertical rib, there is hyaloid gloss.Matter is hard and crisp, easily smashes, and gas is micro-, slightly sweet and puckery, white with color,
It is transparent, matter is hard and crisp, free from admixture person is preferred, soluble easily in water or glycerol, do not dissolve in alcohol, aqueous solution shows aluminium salt, sylvite and sulfuric acid
The various reactions of salt.It is antipruritic that alumen plays the role of convergence, anti-inflammatory, anti-corrosion, hemostasis, desinsection, is mainly used for eczema wet sore, ear pavilion ear
Flow the symptoms such as dense, pruritus vulvae leukorrhagia, chronic diarrhea, hematochezia, metrorrhagia and metrostaxis, nosebleed epistaxis bleeding from the gum, nasal polyp.Alumen is made into powder, can treat gruel
Dermatoses, all sores are itched, and are enhanced the rotten effect of inducing astrigency sore, myogenic, hemostasisization, are imitated in terms for the treatment of skin disease, gynaecological disease
Fruit is most significant.
Glycerol: colourless, odorless, sweet, it is a kind of organic matter that appearance, which is in clear and bright viscous liquid state,.In papermaking, cosmetics, system
Extensive purposes is suffered from the industry such as leather, photograph, printing, intermetallic composite coating, electrical material and rubber, is mainly used in terms of medicine
To produce various preparations, solvent, hygroscopic agent, antifreezing agent and sweetener, ingredients externally-applied ointment or suppository etc..
Sodium citrate: also known as sodium citrate, it is odorless, have refrigerant salty pungent.Stablize in room temperature and air, it is soluble easily in water, can
It is dissolved in glycerol, is insoluble in alcohols and other organic solvents, cross and thermally decompose, it is micro- in a humid environment to have deliquescence, in hot-air
Micro- to have weathering, solution ph is about 8.Sodium citrate is used as acidity regulator, flavouring agent, stabilization in food, beverage industry
Agent；It is used as anticoagulant, apophlegmatisant and diuretics in medical industry；In detergent industry, alternative sodium tripolyphosphate is made
For the auxiliary agent of non-toxic detergent；It is also used to brewing, injection, photographic chemical and plating etc..
In terms of medicine, having many uses too for sodium citrate is general, can form soluble network using citrate and calcium ion
The characteristic for closing object can be used as anticoagulant and blood transfusion agent, save and process blood product；For protecting when sodium citrate is as preservative
Deposit the drugs such as syrup.When sodium citrate is injected as sylvite, for correcting blood, body fluid and the acidity of urine, as diuresis
Agent, resolving sputum agent etc..Sodium citrate and other reagent compatibility can be used for extracting, purify animal's liver ribonucleic acid.
A kind of medical fluid for treating hemorrhoid, the ingredient including following weight parts: 1~1.2 part of tannic acid, 58~65 parts of alumen, sweet
50~53 parts, 14.5~16 parts of sodium citrate of oil.
Preferably, the tannic acid mass fraction is 0.1%, the alumen mass fraction is 6%, described sweet
Oil quality score is 5%, the sodium citrate mass fraction is 1.5%.
Preferably, a kind of medical fluid for treating hemorrhoid, further includes the ingredient of following weight parts: 1000 parts of water.
(1) preparation mixing alumen melt: taking distilled water 1000ml, alumen, sodium citrate is added in distilled water, heating is stirred
It mixes and dissolves, alumen melt must be mixed；
(2) it prepares glycerol tan-liquor: glycerol being taken to be heated in beaker, and tannic acid is added in glycerol, stir molten
Solution.
(3) Hybrid Heating: the glycerol tan-liquor dissolved is added in mixing alumen solution and is stirred evenly, is heated
To boiling, stop heating, filtering, and make its natural cooling；
(4) it dispenses: coolant liquid is divided in ampoule bottle, sealing, is packed to get finished product medical fluid at disinfection.
Preferably, the capacity of the ampoule bottle is 5ml.
The invention has the benefit that use process is simple, no pain, cure rate is high, recurrence rate is low, no sequel and simultaneously
Send out disease, effect stability.
Embodiment one:
A kind of medical fluid for treating hemorrhoid, the ingredient including following weight parts: 1 part of tannic acid, 60 parts of alumen, 50 parts of glycerol, lemon
15 parts of lemon acid sodium, 1000 parts of water.
A kind of preparation method of medical fluid that treating hemorrhoid, includes the following steps:
(1) distilled water 1000ml is taken, 6%, alumen, 1.5% sodium citrate are added in distilled water, heating stirring is dissolved,
Alumen melt must be mixed；
(2) it takes glycerol to be heated in beaker, and 0.1% tannic acid, stirring and dissolving is added in 5% glycerol.
(3) the glycerol tan-liquor dissolved is added in mixing alumen solution and is stirred evenly, after being heated to boiling,
Stop heating, filtering, and makes its natural cooling；
(4) coolant liquid is divided in 5ml ampoule bottle, sealing, is packed to get finished product medical fluid at disinfection.
Embodiment two:
A kind of medical fluid for treating hemorrhoid, the ingredient including following weight parts: 1 part of tannic acid, 60 parts of alumen, 52 parts of glycerol, lemon
14.5 parts of lemon acid sodium, 1000 parts of water.
A kind of preparation method of medical fluid that treating hemorrhoid, includes the following steps:
(1) distilled water 1000ml is taken, 6%, alumen, 1.5% sodium citrate are added in distilled water, heating stirring is dissolved,
Alumen melt must be mixed；
(2) it takes glycerol to be heated in beaker, and 0.1% tannic acid, stirring and dissolving is added in 5% glycerol.
(3) the glycerol tan-liquor dissolved is added in mixing alumen solution and is stirred evenly, after being heated to boiling,
Stop heating, filtering, and makes its natural cooling；
(4) coolant liquid is divided in 5ml ampoule bottle, sealing, is packed to get finished product medical fluid at disinfection.
The present invention is suitable for a variety of piles, and there are many application methods:
(1) application method one: the present invention is suitable for each phase internal piles, high-order external piles；
Finished product medical fluid 1.5ml made from Example one matches Bupivacaine 4.5ml (ratio 1:3), right under proctoscope
Each haemorrhoids carries out submucosal injections 0.5ml, injects 1.0ml in haemorrhoids；After injection, put in rectum gentamicin and
Dexamethasone cotton balls each one, exiting proctoscope terminates；General seance can cure.
(2) application method two: the present invention is suitable for 1,2 phase rectal prolapses；
It takes the hemorrhoid spirit injection 1.5ml that withers with Bupivacaine 4.5ml (1:3), under proctoscope, abjection mucous membrane of rectum is carried out
Injection, each point injection 1.5ml；After injection, gentamicin and dexamethasone cotton balls each one are put into rectum；Generally
Children's rectal prolapse can once cure, and adult rectal prolapse needs 1~3 injection treatment, can cure according to state of an illness weight.
(3) application method three: the present invention is suitable for adapting to intussusception, encysted rectum in rectum；
Take the hemorrhoid spirit injection 1.5ml that withers with Bupivacaine 4.5ml, under proctoscope, to each mucous membrane of rectum pleat point
Injection treatment is not carried out, 0.5~1.5ml of each injection point medication；After injection, gentamicin and ground plug are put in rectum
Loose each one of the cotton balls of rice；The general seance of intussusception can cure in rectum；Encysted rectum need to be injected treatment 1~3 time, when interval
Between 15 days, can cure.
Case one: Li little Jie, 25 years old, office staff was sedentary when because of work, suffered from internal piles before 2 years, maintenance of taking medicine,
It recurs repeatedly frequently, in May, 2017 is used cooperatively method one using medical fluid made of the embodiment of the present invention one, treats primary rear anus
No longer pain at door, internal piles symptom is substantially reduced, is almost recovered after a week；To in March, 2019, internal piles symptom is without recurrence.
Case two: Mr. Zhang, 19 years old, student, on ordinary days in lack movement, suffer from high-order external piles, it is frequently in great pain, 2016
September uses medical fluid made of the embodiment of the present invention one to be used cooperatively method one, and it is sick to treat no longer pain, external piles at primary rear anus
Shape is substantially reduced, is almost recovered after two weeks；To in March, 2019, external piles symptom is without recurrence.
Case three: Mr. Chen, 68 years old, there is rectal prolapse symptom in retired employees, long-term diarrhea before 3 years, used in June, 2016
Medical fluid made of the embodiment of the present invention one is used cooperatively method two, treats pain relief at primary rear anus, continues partner treatment 2
After secondary, rectal prolapse symptom is substantially reduced, and last time is almost recovered after treating；To in March, 2019, rectal prolapse symptom is without recurrence.
Case four: Wang Baobao, 3 years old, preschool child, body was weaker after birth, rectal prolapse symptom occurred, made in July, 2017
The medical fluid made of the embodiment of the present invention two is used cooperatively method two, and it is bright to treat no longer pain, rectal prolapse symptom at primary rear anus
It is aobvious to mitigate, it is almost recovered after five days；To in March, 2019, rectal prolapse symptom is without recurrence.
Case five: Zhao Nvshi, 48 years old, enterprise staff, appearance defecation was not clean before 2 years, bowel frequency increases, feces volume is few and anus
Gate resistance plug sense, intussusception in rectum is suffered from discovery after inspection, is used cooperatively using medical fluid made of the embodiment of the present invention one within 2 months 2017
Method three treats primary rear symptom and is eased, is almost recovered after a week；To in March, 2019, intussusception symptom is without multiple in rectum
Hair.
Case six: Xu Nvshi, 63 years old, retired employees did not paid attention to not treated with the constipation more than ten years, after retirement just
Secret situation is further serious, and hospital is diagnosed as encysted rectum after checking, uses medicine made of the embodiment of the present invention two in December, 2015
Liquid is used cooperatively method three, treats primary rear constipation situation and is eased, interval carried out Retreatment after 15 days, and defecation is substantially just
It often, is progress last time treatment after after treatment effect 15 days, until in March, 2019, then without the serious constipation situation of appearance.
The above description is only a preferred embodiment of the patent of the present invention, is not intended to limit the invention patent, all at this
Made any modifications, equivalent replacements, and improvements etc., should be included in the invention patent within the spirit and principle of patent of invention
Protection scope within.
Claims (6)
1. a kind of medical fluid for treating hemorrhoid, which is characterized in that the ingredient including following weight parts: 1~1.2 part of tannic acid, alumen 58
~65 parts, 50~53 parts of glycerol, 14.5~16 parts of sodium citrate.
2. a kind of medical fluid for treating hemorrhoid according to claim 1, it is characterised in that: the tannic acid mass fraction is
0.1%, the alumen mass fraction is 6%, the qualities of glycerin score is 5%, the sodium citrate mass fraction is
1.5%.
3. a kind of medical fluid for treating hemorrhoid according to claim 1, it is characterised in that: further include following weight parts at
Point: 1000 parts of water.
4. a kind of medical fluid for treating hemorrhoid according to claim 1, it is characterised in that: the ingredient including following weight parts:
1 part of tannic acid, 60 parts of alumen, 50 parts of glycerol, 15 parts of sodium citrate, 1000 parts of water.
5. a kind of preparation method of medical fluid for treating hemorrhoid according to claim 1, it is characterised in that: including walking as follows
It is rapid:
(1) preparation mixing alumen melt: taking distilled water 1000ml, alumen, sodium citrate is added in distilled water, heating stirring is molten
Change, alumen melt must be mixed；
(2) it prepares glycerol tan-liquor: glycerol being taken to be heated in beaker, and tannic acid is added in glycerol, stirring and dissolving.
(3) Hybrid Heating: the glycerol tan-liquor dissolved is added in mixing alumen solution and is stirred evenly, is heated to boiling
After rising, stop heating, filtering, and make its natural cooling；
(4) it dispenses: coolant liquid is divided in ampoule bottle, sealing, is packed to get finished product medical fluid at disinfection.
6. a kind of preparation method of medical fluid for treating hemorrhoid according to claim 5, it is characterised in that: the ampoule bottle
Capacity is 5ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910367128.4A CN110151781A (en) | 2019-05-05 | 2019-05-05 | A kind of medical fluid and preparation method thereof for treating hemorrhoid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910367128.4A CN110151781A (en) | 2019-05-05 | 2019-05-05 | A kind of medical fluid and preparation method thereof for treating hemorrhoid |
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| CN110151781A true CN110151781A (en) | 2019-08-23 |
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| CN201910367128.4A Pending CN110151781A (en) | 2019-05-05 | 2019-05-05 | A kind of medical fluid and preparation method thereof for treating hemorrhoid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115227736A (en) * | 2022-08-10 | 2022-10-25 | 李先俊 | Hemorrhoid radical treatment liquid and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081880A (en) * | 1993-05-18 | 1994-02-16 | 苏宁芳 | The injection of treatment internal hemorrhoid |
-
2019
- 2019-05-05 CN CN201910367128.4A patent/CN110151781A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081880A (en) * | 1993-05-18 | 1994-02-16 | 苏宁芳 | The injection of treatment internal hemorrhoid |
Non-Patent Citations (5)
| Title |
|---|
| "复方紫珠草注射液治疗内痔、混合痔 ", 《广州医药》 * |
| 刘恒均: "《肛肠科病最新中医治疗》", 30 June 1999, 中医古籍出版社 * |
| 王平: "《常见病家庭疗法 外科》", 31 January 2001, 天津科学技术出版社 * |
| 翁维良: "《临床中药学》", 31 May 1998, 河南科学技术出版社 * |
| 芮洪顺: "《肛肠脱出性疾病诊疗精要》", 31 January 2011, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115227736A (en) * | 2022-08-10 | 2022-10-25 | 李先俊 | Hemorrhoid radical treatment liquid and preparation method thereof |
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Application publication date: 20190823 |
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