CN107213242A - A kind of paste for being used to treat eczema - Google Patents
A kind of paste for being used to treat eczema Download PDFInfo
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- CN107213242A CN107213242A CN201710525060.9A CN201710525060A CN107213242A CN 107213242 A CN107213242 A CN 107213242A CN 201710525060 A CN201710525060 A CN 201710525060A CN 107213242 A CN107213242 A CN 107213242A
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- parts
- eczema
- paste
- coptis
- borneol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
A kind of paste for being used to treat eczema of the present invention, belong to Chinese herbal medicine and its preparation technique field, the present invention overcomes the deficiencies in the prior art, technical problem to be solved is to provide a kind of paste for being used to treat eczema particularly eczema diabrosis, in order to solve the above technical problems, the technical solution adopted in the present invention is:A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:1 20 parts of indigo naturalis, 1 40 parts of calcined gypsum, 1 40 parts of talcum powder, 1 20 parts of golden cypress, 1 30 parts of the coptis, 1 10 parts of borneol, 1 10 parts of alumen, in the paste of the present invention, the coptis and golden cypress can carry out sterilizing and hygroscopic to eczema surface, and indigo naturalis has preferable permeability, work the wound depths that the efficacy of a drug of carrying calcined gypsum borneol and alumen penetrates into ulceration, two aspects are combined, and are contributed to the tissue Fast Convergent of ulceration flowing water to heal, are reached the purpose of fast treating eczema ulceration flowing water.
Description
Technical field
A kind of paste for being used to treat eczema of the present invention, belongs to Chinese herbal medicine and its preparation technique field.
Background technology
The pathogenic factor of dermatitis and eczema is extremely complex, is simply divided into internal factor and external factor, difficult point therebetween
Primary and secondary, is typically to interknit, synergy.External cause such as chemicals, cosmetics, zootoxin, fishes and shrimps, pollen, dust, day
Shine, scratch.Internal cause includes inherent cause, mental element, the immune factor of body, metabolic factor etc..Psychological factor is to dermatitis
The dermopathic influence of eczema is increasingly taken seriously, and dermatitis and eczema is also possible to have with diet, rule of life, environment etc.
Certain relation.
With being deepened continuously to disease research, it is found that microorganism plays the part of important angle in dermatitis and eczema develops
Color --- they participate in, have aggravated disease.Research shows, in patient's dermatitis and eczema site of pathological change, and the quantity of fungi and bacterium is remote
Far above the quantity of carrying disease germs at the same position of normal population.Bad life habits, such as:The water face-washing of conventional overheat, or overfrequency make
With skin cleaning articles such as perfumed soap, mildy wash, do not note protection to ultraviolet etc. usually, these factors stimulate can all change or
Damage the protective barrier and regulation of blood vessels function of skin.
In current eczema treatment, suppurated for eczema ulceration flowing water, effective medicine and method are seldom, in
Medicine Opsonizing method then typically using include Chinese ephedra, windproof, imperial halberd grass, schizonepeta, zaocys dhumnade, full worm, centipede, the root of Dahurain angelica, peppermint, carefully
The Chinese medicine of pungent, frutus cnidii, Korean ginseng, agalloch eaglewood, aurin grass etc. carries out partner treatment, and these traditional Chinese medicines are used cooperatively can be thorough
Alkaline abnormal phlegm is removed, immunity is improved, recovers skin vitality, so as to reach the purpose of thoroughly radical cure eczema.
The content of the invention
The present invention overcomes the deficiencies in the prior art, and technical problem to be solved is to provide a kind of special for treating eczema
It is the paste of eczema diabrosis.
In order to solve the above technical problems, the technical solution adopted in the present invention is:
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:
1-20 parts of indigo naturalis, 1-40 parts of calcined gypsum, 1-40 parts of talcum powder, 1-20 parts of golden cypress, 1-30 parts of the coptis, 1-10 parts of borneol is withered
1-10 parts of alum.
As a kind of preferred paste for being used to treat eczema, raw materials used medicine is according to following weight:
3-8 parts of indigo naturalis, 15-25 parts of calcined gypsum, 10-20 parts of talcum powder, 5-10 parts of golden cypress, 3-7 parts of the coptis, 3-7 parts of borneol, alumen
2-5 parts.
Further, currently preferred drug regimen is, a kind of paste for being used to treat eczema diabrosis, raw materials used medicine
Thing is according to following weight:
11-15 parts of indigo naturalis, 5-10 parts of calcined gypsum, 25-35 parts of talcum powder, 12-18 parts of golden cypress, 20-30 parts of the coptis, borneol 5-10
Part, 5-10 parts of alumen.
Efficacy of drugs used is as follows in side:
Indigo naturalis:Taste is salty;It is cold in nature, Return liver, lung, stomach, major function:It is clearing heat and detoxicating, cooling blood and hemostasis, clearing liver-fire.Main warm disease heat
Malicious macula.
Calcined gypsum:Nature and flavor are sweet, pungent, puckery, tremble with fear.Attach to the lung and stomach meridians.Hygroscopic, myogenic, sore, hemostasis.Unhealing ulcer is controlled outside, it is wet
Rash itch, scald, traumatism and bleeding.
Talcum powder:It is sweet, light, tremble with fear;Return bladder, lung, stomach.Major function:Inducing diuresis for treating strangurtia, clearing away summerheat, clearing damp sore.With
In heat gonorrhea, urolithiasis urinates hot puckery pain, summer-heat and damp polydipsia, damp and hot watery diarrhea;Control eczema, wet sore, prickly heat outside.
Golden cypress:It is bitter in taste, tremble with fear.Return kidney;Bladder warp.Major function:Heat-clearing and damp-drying drug;Purging intense heat and detonicating.Main red eye, swell pain;Ulcer
Sore;Skin eczema.
The coptis;It is bitter in taste, tremble with fear.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating.Eczema is controlled outside, it is wet
Sore.
Borneol:Also known as piece brain, tangerine piece, kapur, it is pungent bitter, cool in nature, enter the heart, lung channel.With clearing away heat to and alleviating pain, remove necrosis and promote granulation
Effect, eliminate the more not caused inflammation of the edge of a knife simultaneously promote granulation tissue generation, preferably treat the edge of a knife be not cured.
Alumen:It is sour and astringent, tremble with fear.It is poisonous.Enter lung, spleen, stomach, large intestine channel, dissolving phlegm, eliminating dampness, antidiarrheal is stopped blooding, removing toxic substances, desinsection.
In the paste of the present invention, the coptis and golden cypress can carry out sterilizing and hygroscopic to eczema surface, indigo naturalis have compared with
The wound depths that the efficacy of a drug of good permeability, carrying calcined gypsum borneol and alumen penetrates into ulceration is worked, and two aspects are combined, and are had
Help the tissue Fast Convergent healing of ulceration flowing water, reach the purpose of fast treating eczema ulceration flowing water.
Compared with prior art the invention has the advantages that:The Chinese medicine of the present invention has hygroscopic antipruritic, heat-clearing solution
Effect of poison, can be used in skin itch, redness, water outlet etc., available for treating eczema, acute and chronic eczema, neurodermatitis, day
Photosensitiveness dermatitis etc..Particularly the present invention is used to treat ulceration eczema.
Embodiment
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of paste for being used to treat eczema diabrosis, raw materials used medicine is according to following weight:11 parts of indigo naturalis, forges stone
5 parts of cream, 26 parts of talcum powder, 13 parts of golden cypress, 20 parts of the coptis, 8 parts of borneol, 10 parts of alumen.
Embodiment 2
A kind of paste for being used to treat eczema diabrosis, raw materials used medicine is according to following weight:12 parts of indigo naturalis, forges stone
10 parts of cream, 35 parts of talcum powder, 12 parts of golden cypress, the coptis 24,7 parts of borneol, alumen 9.
Embodiment 3
A kind of paste for being used to treat eczema diabrosis, raw materials used medicine is according to following weight:14 parts of indigo naturalis, forges stone
7 parts of cream, 30 parts of talcum powder, 18 parts of golden cypress, the coptis 28,10 parts of borneol, alumen 7.
Embodiment 4
A kind of paste for being used to treat eczema diabrosis, raw materials used medicine is according to following weight:15 parts of indigo naturalis, forges stone
6 parts of cream, 33 parts of talcum powder, 15 parts of golden cypress, the coptis 30,5 parts of borneol, 5 parts of alumen.
Embodiment 5
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:3 parts of indigo naturalis, 25 parts of calcined gypsum,
14 parts of talcum powder, 8 parts of golden cypress, 5 parts of the coptis, 6 parts of borneol, 2 parts of alumen.
Embodiment 6
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:5 parts of indigo naturalis, calcined gypsum 22 is slided
20 parts of stone flour, 7 parts of golden cypress, 3 parts of the coptis, 5 parts of borneol, 5 parts of alumen.
Embodiment 7
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:6 parts of indigo naturalis, calcined gypsum 17 is sliding
18 parts of stone flour, 5 parts of golden cypress, 7 parts of the coptis, 3 parts of borneol, 4 parts of alumen.
Embodiment 8
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:Indigo naturalis 4, calcined gypsum 18, talcum
13 parts of powder, 10 parts of golden cypress, the coptis 6,4 parts of borneol, 3 parts of alumen.
Embodiment 9
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:Indigo naturalis 8,15 parts of calcined gypsum is sliding
10 parts of stone flour, 8 parts of golden cypress, 5 parts of the coptis, borneol 7,4 parts of alumen.
Embodiment 10
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:1 part of indigo naturalis, 5 parts of calcined gypsum,
15 parts of talcum powder, 7 parts of golden cypress, 10 parts of the coptis, 1 part of borneol, 2 parts of alumen.
Embodiment 11
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:3 parts of indigo naturalis, 11 parts of calcined gypsum,
30 parts of talcum powder, 20 parts of golden cypress, 30 parts of the coptis, 6 parts of borneol, 3 parts of alumen.
Embodiment 12
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:20 parts of indigo naturalis, calcined gypsum 24
Part, 1 part of talcum powder, 13 parts of golden cypress, 28 parts of the coptis, 3 parts of borneol, 1 part of alumen.
Embodiment 13
A kind of paste for being used to treat eczema, raw materials used medicine is according to following weight:14 parts of indigo naturalis, calcined gypsum 30
Part, 40 parts of talcum powder, 12 parts of golden cypress, 7 parts of the coptis, 7 parts of borneol, 10 parts of alumen.
Model case 1, patient Shanxi people from Xiangfen, Zhang, man, for many years, blood is followed for right leg varix of lower limb in 65 years old
Ring is bad, causes the black purple of skin to fester, itch, flowing water formation eczema.After iodophor disinfection, external application Chinese medicine eczema of the present invention is applied
Cream, after twice daily applying five days, symptom substantially mitigates, no flowing water phenomenon, and skin is in white powder shape.Fully recover within 15 days.
Model case 2, Shanxi people from Xiangning County, it is ancient so-and-so, man, 52 years old because of Post operation, immunity degradation, skin many places itch,
And having bubble, rotten position, flowing water is more than.Coating external application Chinese medicine eczema ointment of the present invention, daily two to three times, oral anti-allergy increases
Strong immunity medicine.Symptom substantially mitigates after five days, fully recovers within ten days.
Model case 3, patient Shanxi people from Xiangfen Jia XX female 35 years old, because of working haircut row for many years, long-term contact stimulus product,
Cause two, fester, red and swollen, itch flowing water is more than a year, invalid through many places treatment, and external application Chinese medicine eczema ointment of the present invention, mouth are used afterwards
Antiallergy is taken, anti-infectious agent, more than ten days are clearly better, and continue to take, fully recovered within 15 days.
The present invention can be summarized with others without prejudice to the concrete form of the spirit or essential characteristics of the present invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and can not limit invention,
Claims indicate the scope of the present invention, and above-mentioned explanation does not point out the scope of the present invention, therefore, with the present invention
The suitable implication and scope of claims in any change, be all considered as being included within the scope of the claims.
Claims (3)
1. a kind of paste for being used to treat eczema, it is characterised in that raw materials used medicine is according to following weight:
1-20 parts of indigo naturalis, 1-40 parts of calcined gypsum, 1-40 parts of talcum powder, 1-20 parts of golden cypress, 1-30 parts of the coptis, 1-10 parts of borneol is withered
1-10 parts of alum.
A kind of be used to treat the paste of eczema 2. according to claim 1, it is characterised in that raw materials used medicine according to
Lower weight:
3-8 parts of indigo naturalis, 15-25 parts of calcined gypsum, 10-20 parts of talcum powder, 5-10 parts of golden cypress, 3-7 parts of the coptis, 3-7 parts of borneol, alumen
2-5 parts.
A kind of be used to treat the paste of eczema 3. according to claim 1, it is characterised in that raw materials used medicine according to
Lower weight:
11-15 parts of indigo naturalis, 5-10 parts of calcined gypsum, 25-35 parts of talcum powder, 12-18 parts of golden cypress, 20-30 parts of the coptis, borneol 5-10
Part, 5-10 parts of alumen.
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CN201710525060.9A CN107213242A (en) | 2017-06-30 | 2017-06-30 | A kind of paste for being used to treat eczema |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108938852A (en) * | 2018-09-30 | 2018-12-07 | 仇琮艳 | A kind of Chinese medicine preparation that treating eczema and preparation method |
CN113041296A (en) * | 2021-05-07 | 2021-06-29 | 河南宏业保健科技有限公司 | Traditional Chinese medicine composition for treating atopic dermatitis |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104706751A (en) * | 2013-12-12 | 2015-06-17 | 罗启东 | External preparation for treating acute eczema |
-
2017
- 2017-06-30 CN CN201710525060.9A patent/CN107213242A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104706751A (en) * | 2013-12-12 | 2015-06-17 | 罗启东 | External preparation for treating acute eczema |
Non-Patent Citations (3)
Title |
---|
ELKE RODRÍGUEZ: "Meta-analysis of filaggrin polymorphisms in eczema and asthma:Robust risk factors in atopic disease", 《ALLERGY CLIN IMMUNOL》 * |
刘清池: "《临证常用中药速查便览》", 30 November 2015, 中国医药科技出版社 * |
周祯祥: "《中药学》", 31 August 2016, 中国中医药出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108938852A (en) * | 2018-09-30 | 2018-12-07 | 仇琮艳 | A kind of Chinese medicine preparation that treating eczema and preparation method |
CN113041296A (en) * | 2021-05-07 | 2021-06-29 | 河南宏业保健科技有限公司 | Traditional Chinese medicine composition for treating atopic dermatitis |
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