RU2039566C1 - Method for treating inflammatory and dystrophic diseases of mucous membranes of digestive organs - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: essence of this method resides in taking in "Rotokan" medicine three times a day during 10 to 25 days 30 minutes before food intake at dose of 1/2 tea spoonfuls of prescribed drug per glass of warm boiled water. In specific case, disclosed method prescribes administering enema, that is, one tea spoonful of drug per 50 to 100 ml of warm boiled water. EFFECT: higher efficiency. 4 tbl

Description

 The invention relates to medicine, namely to methods for treating inflammatory and dystrophic diseases of the mucous membranes of the digestive system.

 There is a method of treating inflammatory diseases of the mucous membranes of the digestive system using the drug Romazulan, manufactured by the Romanian company Biofarm. Romazulan is a liquid extract of chamomile flowers pharmacy (96 ml), azulene (0.036 g) and tween (4.0 g). Romazulan is used as an anti-inflammatory and deodorizing agent for diseases of the oral cavity, as well as inside for gastritis, colitis.

 The disadvantage of this drug is the presence in it of synthetic azulene, as well as tween, which are difficult to clean from toxic by-products. In addition, even pure tween is not an indifferent substance.

 The aim of the invention is the creation of a domestic drug based on an extract of chamomile flowers without tween and synthetic azulene, which has a more effective effect for the treatment of inflammatory and dystrophic diseases of the mucous membranes of the gastrointestinal tract.

 For this, liquid extracts of calendula flowers (25 ml) and yarrow (25 ml) were added to the liquid extract of chamomile flowers (50 ml), and tween and synthetic azulene were excluded. The composition was called rotokan. Calendula and yarrow extracts increased the anti-inflammatory and regenerative activity of the drug due to the content of flavonoids and triterpenoids in them, as well as natural azulene present in the yarrow.

 Experimental animal studies show that rotokan stimulates preparative processes in the gastric mucosa at a dose of 0.1 ml / kg. The drug delays or completely prevents the development of ulcerative destruction in the stomach under the influence of ulcerogenic agents of the caffeine-arsenic mixture, butadione, pyloric dressings, and this effect is observed in doses at which the effect of romazulan is less distinct (see Table 1).

 A study of the effect of rotokan on the healing strength of linear wounds of rat skin showed that it exceeds Romazulan by 22% in efficiency (see Table 2).

 In experiments to study the effect of rotokan on blood coagulation indices, it was found that, unlike romazulan, it has a distinct hemostatic effect.

 In addition, the rotokan established a distinct antispasmodic effect, not inferior to romazulan, and a sedative effect.

Rotokan is slightly toxic. When injected into mice with a dealcoholized rotokan inside at doses of 0.2 to 1.2 ml / mouse (11.6-66.77 ml / kg), no signs of toxic effects were observed. The general condition and behavior of mice after the introduction of a diluted rotokan (1: 1) did not differ significantly from those in mice treated with 20% alcohol in the same doses. The LD ₅₀ was 57 ml / kg. The LD ₅₀ for 20% alcohol, established in parallel experiments, was 49.7 ml / kg. Determination of LD _{50 of} romazulan showed greater toxicity of 35.4 ml / kg than that of rotokan.

 Based on the described properties, rotokan was recommended for clinical radiation as an anti-inflammatory, enhancing regeneration, hemostatic and antispasmodic agent in therapeutic practice for the treatment of diseases of the gastrointestinal tract (gastritis, gastroduodenitis, gastric ulcer, colitis, spastic colitis).

 Rotokan treatment was carried out in 5 gastroenterological clinics for 600 patients with erosive and ulcerative lesions of the gastrointestinal tract.

 A comparative assessment of the therapeutic efficacy of rotokan was performed with romazulan.

 To assess the effectiveness of treatment used biochemical, endoscopic, radiological, ultrasound methods.

 In medical institutions, various methods of introducing rotokan were used: inside, by duodenal irrigation, in the form of microclysters, as well as in combination.

 In the first group of patients with esophagitis, chronic gastritis, gastroduodenitis, gastric ulcer and duodenal ulcer, rotokan was used orally. Depending on the severity of the clinical symptoms, the dose was individual from a few drops to 3 teaspoons per dose with warm boiled water, both before meals for 20-30 minutes, and 40-60 minutes after meals (see table 3) .

 PRI me R 1. Patient Silverstov I.I. 31 years old, sick for 5 years. During the examination, a 0.4 cm ulcer was diagnosed in the bottom of the stomach. Complaints of pain in the epigastric region, dyspeptic disorders. Rotokan was administered orally by 1 teaspoon per glass of warm boiled water an hour before meals. As a result of treatment with rotokan, the pain syndrome decreased, scarring was observed after 2 weeks, and appetite improved.

 In the second group of patients with chronic enterocolitis, chronic spastic colitis, ulcerative colitis, proctosigmoiditis, rotokan was used as microclysters or combined: inside in microclysters. For microclysters, 1 teaspoon per 50-100 ml of warm boiled water (after a cleansing enema) was used. The course of treatment consisted of 10-15 microclysters (see table 4).

 PRI me R 2. Patient Sushko V.E. 49 years old, diagnosed with chronic enterocolitis. The main complaints of abdominal pain, rumbling, bloating, loose stools, mucus in the bowel movements. The drug Rotokan was administered orally by 1/2 teaspoon per glass of hot water 3 times a day 30 minutes before meals in microclysters daily or every other day (for a course of 10-15). The course of treatment is 20-25 days. As a result of treatment, a decrease in abdominal pain, flatulence, rumbling was noted on the 7-10th day of treatment. A control endoscopic examination at the end of the course of treatment noted a decrease in swelling, hyperemia, and healing of erosion.

 In the third group of patients with chronic cholecystitis, with cholesterol syndromes, gastroduodenitis, postcholecystectomy syndromes according to the hypokinetic type, rotokans were used as duodenal irrigation with a warm solution of rotokan through a probe and an additional rotokan was taken orally in the same dosage: 1/2 teaspoon per glass of warm water 3 times a day 30 minutes before meals. The course of treatment is 20-25 days. After a course of treatment, the rotokan improves the functional state of the colon, reduces inflammation in the sigmoid and rectum, has a beneficial effect on the flora of the colon.

 PRI me R 3. Patient Kuzovlev A.I. 28 years old, sick since 19 years. Complaints of pain in the right hypochondrium, belching, bitterness in the mouth, dyspeptic disorders.

 The diagnosis of gastroduodenitis, chronic cholecystitis. A course of combined treatment with rotokan was carried out: both inside and by duodenal irrigation. After a week-long course of treatment with Rotokan, an improvement in the general condition of the patient was noted, pain decreased, the stool somewhat normalized, and bitterness in the mouth disappeared.

 As a result of the course of treatment, the patient returned to normal stools and the pain disappeared. During the control examination, the inflammatory phenomena in the gastroduodenal zone significantly decreased, the functional-motor activity of the gallbladder normalized.

 When treating patients with this group with romazulan, a slight therapeutic effect was noted. This is probably why the instructions for use of romazulan have no recommendations for diseases of the biliary tract.

 All gastroenterological clinics gave a positive conclusion about the therapeutic efficacy of rotokan.

 Thus, in comparison with romazulan, rotokan more effectively reduces pain in case of erosive and ulcerative diseases of the upper gastrointestinal tract (gastritis, peptic ulcer, etc.), as well as when used as microclysters, significantly reduces inflammatory manifestations and contributes to the epithelization of erosion and ulcers of these departments.

 It has an effect on the dynamics of dyspeptic disorders, either completely stopping the latter with erosive and ulcerative lesions, or significantly reducing them with cholecystitis, colitis with hypomotor dyskinesia.

 Positive effect on the "lower" dyspepsia, regulating the stool, reduces bloating, rumbling.

 After a course of treatment, the rotokan improves the functional state of the colon, reduces inflammation in the sigmoid and rectum, has a beneficial effect on the flora of the colon.

 Rotokan tolerance was good during treatment.

 Marked good taste and smell of the drug. No allergic reactions were detected. Clinical blood tests and biochemical liver tests remained unchanged.

Claims (1)

 METHOD FOR TREATMENT OF INFLAMMATORY AND DYSTROPHIC DISEASES OF Mucous membranes of the digestive system through the use of alcoholic extracts of plant materials, characterized in that they take Rotokan 1/2 teaspoon per glass of warm boiled water three times a day 30 minutes before meals 30 minutes before meals , in case of indications, they make an enema with one teaspoon of Rotokan per 50 100 ml of warm boiled water.

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