CN103520492B - A kind of liniment of prevention and therapy gout and preparation method - Google Patents
A kind of liniment of prevention and therapy gout and preparation method Download PDFInfo
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- CN103520492B CN103520492B CN201210231495.XA CN201210231495A CN103520492B CN 103520492 B CN103520492 B CN 103520492B CN 201210231495 A CN201210231495 A CN 201210231495A CN 103520492 B CN103520492 B CN 103520492B
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Abstract
The invention belongs to the field of Chinese medicines, relate to a kind of liniment for prevention and therapy gout and preparation method thereof.This liniment is by Chinese medicine: Fructus Liquidambaris 30-150 part: Radix et Caulis Opuntiae Dillenii 50-100 part: Cortex Fraxini 10-80 part: Pseudobulbus Cremastrae Seu Pleiones 10-80 part: extract and Borneolum Syntheticum 5-20 part and forming.These application compress 1, prevention gout: Fructus Liquidambaris ointment is slightly embrocated in gout affected part by symptom, gently soft wiping about ten minutes, until ointment be cannot see.Very there is tall and erect effect every day for 3-4 time.2, gout serious symptom is treated: ointment is applied to affected part gauze dressing wrapping, immobilization with adhesive tape.Once a day, six days courses for the treatment of.In the past few years, treat gout more than 200 example altogether, reach more than 94% through clinical trial total effective rate.Prevention and therapy gout of the present invention has following features: control combines, and easy to use, low cost, treating both the principal and secondary aspects of a disease, instant effect, does not recur, non-stimulated, has no side effect.
Description
Technical field:
The invention belongs to the field of Chinese medicines, relate to a kind of liniment for prevention and therapy gout and preparation method thereof.
Background technology:
Along with the change of expanding economy and people life style, the sickness rate of gout is in rising trend in China at present.
Gout a kind of to increase due to purine thing anabolism, uric acid produce too much or because of urate excretion bad, and in hyperamization, uric acid raises, and urate crystal is deposited on the repeated relapsing disease caused in joint, synovial bursa, cartilage and other tissue.This sick onset is hurried, mostly is side simple joint at first, especially common with the first nurse toe joint.Clinical manifestation be red, swollen, hot, pain and the dyskinesia, arthralgia splits bone as torn muscle.Current treatment still lacks radical cure measure, the outbreak of western medicine acute stage gout to control inflammation outbreak with the NSAID (non-steroidal anti-inflammatory drug) such as " colchicine ", " probenecid ", " other purine " or hormone, but it is comparatively serious to stomach, intestinal untoward reaction, and toxic and side effects will affect Liver and kidney function simultaneously.
Gout belongs to categories such as the traditional Chinese medical science " arthromyodynia " " severe and migratory arthralgia " " pyretic arthralgia ", and " numbness person " closes also, with QI and blood by heresy closed, must not pass through and disease also.Trace it to its cause, Chinese and western medicine theory has identical part more.The traditional Chinese medical science is thought: gout is many because of eating and drinking without temperance, the thick greasy product of surfeit delicious food, and impairing the spleen and stomach or ferritic are not good for, so that transporting imbalance, and make and wet into expectorant, accumulate warm heat-transformation, wet hot phlegm is turbid, and stasis of blood heresy is cementing, and retardance joint, meridians form." stagnation of QI and blood may bring about pain ".For the cause of disease and the pathogenesis of primary disease, Zhi Qiben is worked as in prevention, and " Qinghua damp and hot, turbidity discharging paralysis relaxing " is main.Treatment should: " mass dissipating and swelling eliminating, removing obstruction in the collateral to relieve pain " thus reach the object of " general rule is not bitterly ".
Summary of the invention:
Object of the present invention aims to provide a kind of Traditional Chinese Medicine for external application of prevention and therapy gout and the preparation of medicine thereof, for prevention and the needs of clinical treatment.
Detailed description of the invention:
(1) a kind of liniment of prevention and therapy gout is made up of the raw material of following weight parts:
Fructus Liquidambaris 30-150 part, Radix et Caulis Opuntiae Dillenii 50-100 part, Cortex Fraxini 10-80 part, Pseudobulbus Cremastrae Seu Pleiones 10-80 part.
Borneolum Syntheticum 5-20 part vaseline is appropriate
(2) meridian distribution of property and flavor in liniment combination of the present invention and function cure mainly:
1, Fructus Liquidambaris: nature and flavor hardship is flat.Return Liver and kidney warp.Effect: dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.Kind current 12 warps of this product, the diuretic that can stimulate the menstrual flow, except damp-heat arthralgia pain, again can dredging blood vessel, promoting flow of QI and blood.
2, Radix et Caulis Opuntiae Dillenii: nature and flavor are bitter, cold.GUIXIN, lung, kidney three warp.Effect: heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral, dissipating blood stasis for subsidence of swelling, intestinal detoxication, cooling blood and relieving pain.For duodenal ulcer, hemorrhoid, acute dysentery.Mumps, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald are controlled in external.Good detumescence, analgesic effect is had to the gout of damp-heat arthralgia resistance type.
3, Cortex Fraxini: nature and flavor are bitter, puckery, cold.Return liver, gallbladder, large intestine channel.Effect: heat clearing and damp drying, removing toxic substances, astringent therapy, improving eyesight.Pharmacological action: the Main Ingredients and Appearance of Cortex Fraxini is containing aesculetin: 1. have analgesic activity, its analgesic activity is stronger than aspirin, more weak than codeine.2. antiinflammatory action: aesculetin has obvious antiinflammatory action, shows as the swelling that can alleviate ankle joint and acceleration is disappeared.Act on comparatively Alysine (Marion Merrell Dow) strong.3. the urate excretion of rheumatisant can be promoted.
4, Pseudobulbus Cremastrae Seu Pleiones: nature and flavor are sweet, pungent, cool.Return liver, spleen channel.Function: heat-clearing and toxic substances removing, dissipating phlegm and resolving masses.For the swollen furunculosis of pain, scrofula sucutaneous nodule, lymphoid tuberculosis, worm venom.Modern pharmacology research confirms: Pseudobulbus Cremastrae Seu Pleiones contains colchicine, to gout antiinflammatory targetedly, and analgesic activity.And the inflammatory reaction of urate microcrystal can be disturbed.
5, Borneolum Syntheticum, nature and flavor: pungent, bitter, be slightly cold.GUIXIN, spleen, lung meridian.Effect: have clearing away heat to alleviate pain, detumescence effect.And there is good Cutaneous permeation function.
More than combine, make a distinction between the important and the lesser one, formula is rigorous, and all medicines share, and can play clearing away heat-damp and promoting diuresis, let out the effect of turbid eliminating impediment, mass dissipating and swelling eliminating, removing obstruction in the collateral to relieve pain.Thus can prevent, treat red, swollen, the burning pain symptom of gout and promote to have no side effect metabolism and the excretion of blood uric acid.
(3) preparation method
1, added by the Borneolum Syntheticum of proportional quantity in the ethanol of a small amount of 95%, it is for subsequent use that continuous stirring makes it dissolve.
2, new fresh Radix et Caulis Opuntiae Dillenii is scraped off burr, cleans, squeezes the juice.
3, by Fructus Liquidambaris, Cortex Fraxini, Pseudobulbus Cremastrae Seu Pleiones, three taste tcm and herbal slices, clean, decoct with water three times, first time decocts 2 hours, gets filtrate; Filtering residue decocts with water 1 and a half hours, gets filtrate; Filtering residue third time decocts with water 1 hour.Get the filtrate decocted for three times to filter, be concentrated into the clear paste that relative density is 1.19-1.21 (60 DEG C).
4, by the clear paste of above three taste Chinese crude drugs and the mixing of squeezing the juice of Radix et Caulis Opuntiae Dillenii, then add appropriate vaseline and stir, to be cooled to less than 30 DEG C, add Borneolum Syntheticum alcoholic solution, stir, to obtain final product.
Application compress of the present invention have following features:
Control combine, easy to use, expense is low, treating both the principal and secondary aspects of a disease, instant effect, non-stimulated, have no side effect.
(4) using method:
1, prevent gout (symptom is slight): embrocated by ointment in gout affected part, gently soft wiping about ten minutes, until ointment be cannot see, every day 3-4 time, very have tall and erect effect.
2, gout (serious symptom) is treated: ointment is applied to affected part, with gauze, absorbent cotton dressing wrapping, immobilization with adhesive tape, once a day, six days courses for the treatment of.
(5) below, the invention will be further described for several embodiment:
Embodiment 1: Fructus Liquidambaris 80; Radix et Caulis Opuntiae Dillenii 90, Cortex Fraxini 30, Pseudobulbus Cremastrae Seu Pleiones 30;
Borneolum Syntheticum 10; Vaseline is appropriate;
Above medicine, by the preparation of " preparation method " technique, is studied.
Embodiment 2: Fructus Liquidambaris 150; Radix et Caulis Opuntiae Dillenii 100; Cortex Fraxini 80; Pseudobulbus Cremastrae Seu Pleiones 80;
Borneolum Syntheticum 20; Vaseline is appropriate;
Above medicine, by the preparation of " preparation method " technique, is studied.
Embodiment 3: Fructus Liquidambaris 30; Radix et Caulis Opuntiae Dillenii 50; Cortex Fraxini 10; Pseudobulbus Cremastrae Seu Pleiones 10;
Borneolum Syntheticum 5; Vaseline is appropriate;
Above medicine, by the preparation of " preparation method " technique, is studied.
(6) therapeutic effect: "
Criterion of therapeutical effect: treatment gout Outcome measure Main Basis:
1, complete incidence graph: through to apply medicinal lotion or ointment or after the drug of topical application one course for the treatment of, joint clinical symptoms is red, swollen, hot, pain all disappears, automatically movable, blood uric acid recovers normal.
2, take a turn for the better: through to apply medicinal lotion or ointment or after the drug of topical application one course for the treatment of, joint clinical symptoms is red, swollen, hot, pain improvement, activity still can, serum uric acid level decline.
3, invalid, through to apply medicinal lotion or ointment or after the drug of topical application one course for the treatment of, Clinical symptom and sign is not improved, without significant change before blood uric acid and treatment.
Use liniment prevention and therapy gout case summary sheet
(7) model case:
Case one: wear certain, man 53 years old, having the beer because accompanying friend, eating beef, in the late into the night in the evening right sufficient nurse toe red, swollen, hot, bitterly, in hospital one week, occur together heat.Hospital assay blood uric acid, is diagnosed as " acute gouty arthritis " up to (600umol/L).Take " colchicines tablets " and " probenecid sheet " two days, occur tormina, suffer from diarrhoea, be difficult to adhere to, require to leave hospital.Through tcm diagnosis: card belongs to " damp-heat arthralgia ".Take Chinese medicine two days, lose and be clearly better, introduce this traditional Chinese herb medicine of application through relative.The drug of topical application is after one day, heat is moved back, swollenly disappear, pain only.Advise its polydipsia boiled water more than 2000ml every day, symptom alleviates gradually.After the drug of topical application one week, red, swollen, hot, bitterly, symptom disappears completely, activity freely.To examination in hospital, serum uric acid level recovers normal.
Case two: Liu, man 47 years old, main cause is insobriety before 4 days, affection of exogenous wind-cold, and midnight, unexpected left foot first nurse toe joint acutely swelled and ache, and joint motion is limited, is held up, say that friend introduces Traditional Chinese Medicine for external application very effective by household.I advises it to use Fructus Liquidambaris ointment, embrocate in gout affected part, rub more than ten minute gently, at that time patient feel some take a turn for the better and comfortable, after going home, it oneself is embrocated several times again, second day red, swollen, hot, pain symptom alleviate, activity not employment is held up, and within the 3rd day, symptom disappears completely, activity freely, continues preventatively to embrocate three days.Follow up a case by regular visits to and within 2 years, have no gout outbreak.
Case three: model, man 58 years old, biped toe is red, swollen, hot, bitterly near two weeks, frequent night sudden onset.Like seafood, yellow wine at ordinary times.Be " gouty arthritis " through Western medicine diagnose.Take Western medicine 3-4 days, ineffective.After please tcm diagnosis be " damp-heat arthralgia " through this ointment of application three days, symptom alleviates greatly, can freely walk.I advise its slightly pain just can embrocate ointment, polydipsia boiled water.About five days, symptom disappeared completely.Model introduces function and the effect of this ointment everywhere to friend, and oneself is often carried at body, slightly uncomfortable, just embrocates and rubs.Follow up a case by regular visits to 2-3 and have no gout recurrence.
Case four: Zhang, man 62 years old, has an intense pain in the burst of upper right crus of diaphragm 2 year evening before yesterday large nurse toe, red and swollen, second day difficulty in walking.Through examination in hospital, be diagnosed as " gouty arthritis ", once took " colchicine ", " indometacin ", send out during state of an illness fashion, controlled always, introduce by friend, external-applied ointment is brought into use to embrocate, four times a day, one the course for the treatment of pain subtract greatly, redness disappears, activity freely, through arriving examination in hospital, blood uric acid also returns to normal level.Henceforth, he notes drinking water more, drink less, eat meat less, eat fresh vegetables more, fruit, this ointment standing, having pain just to wipe, over nearly 3 years, not recurring gout always.
Case five: thank certain, man 73 years old, the large nurse toe of two feet in evening on June 20th, 2012 is red and swollen, have an intense pain, and cannot walk, be " gouty arthritis " through examination in hospital.Because this Mr. suffered from apoplectic hemiplegia originally.Therefore, very pessimistic, misery is shed tears.Suitable touch me and go to visit him, after I sees his patient's condition, just know that he eats recently and friedly decoct stir-fry and drunk yellow wine.This disease is " damp invasion of lower energizer, stasis of blood heresy retardance joint ".I fetches Fructus Liquidambaris gout application compress immediately, helps him to smear in affected part.After four hours, he has called not bitterly.I advises him to continue to embrocate affected part, and within second day, I goes again to visit him, and he can stand up walking, and can greet guest, and company is had a meal, and plays the conversation in a gay manner.I advises him up to ten million it should be noted that eat deep fried foodstuff less at diet from now on, definitely can not have the beer, yellow wine, eats the light foods such as veterinary antibiotics more.
Claims (1)
1. a liniment for prevention and therapy gout, is characterized in that: it is made up of the raw material of following weight portion: Fructus Liquidambaris 30-150 part, Radix et Caulis Opuntiae Dillenii 50-100 part, Cortex Fraxini 10-80 part, Pseudobulbus Cremastrae Seu Pleiones 10-80 part, Borneolum Syntheticum 5-20 part, vaseline is appropriate, processes described raw material according to following steps:
1) 5-20 part Borneolum Syntheticum is added in 95% ethanol, stir and described Borneolum Syntheticum is dissolved, obtain Borneolum Syntheticum alcoholic solution;
2) get 50-100 part Radix et Caulis Opuntiae Dillenii, deburring, clean, squeeze the juice, obtain Radix et Caulis Opuntiae Dillenii juice;
3) get Fructus Liquidambaris 30-150 part, Cortex Fraxini 10-80 part, Pseudobulbus Cremastrae Seu Pleiones 10-80 part, after cleaning, decoct with water 2 hours, filter, obtain first time filtrate, filtering residue; Get the first filtering residue, decoct with water 1 hour 30 minutes, filter, obtain second time filtrate, filtering residue; Get second time filtering residue, decoct 1 hour after adding water, obtain third time filtrate, filtering residue;
4) get the filtrate decocted for three times to filter, being concentrated into 60 DEG C of relative densities is the clear paste of 1.19-1.21;
5) in described clear paste, add described Radix et Caulis Opuntiae Dillenii juice, vaseline is appropriate, stir; To be cooled to less than 30 DEG C, add Borneolum Syntheticum alcoholic solution, stir, to obtain final product.
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| CN105056039A (en) * | 2015-09-21 | 2015-11-18 | 南京正亮医药科技有限公司 | Traditional Chinese medicine ointment for treating gout |
| CN110354222A (en) * | 2019-08-20 | 2019-10-22 | 江苏博润医疗集团有限公司 | It is a kind of for treating the external drug of gout |
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| 痛风发作的虚寒特征及中药治疗的初步临床观察研究;郑刚;《中国优秀博硕士学位论文全文数据库 (硕士) 医药卫生科技辑》;20061115(第11期);20-21 * |
| 通黄膏外敷辅助治疗痛风性关节炎病人的护理;姚小珠 等;《护理学报》;20080630;第15卷(第6期);13 * |
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