CN104547079A - Pharmaceutical composition for treating liver diseases - Google Patents
Pharmaceutical composition for treating liver diseases Download PDFInfo
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- CN104547079A CN104547079A CN201510034668.2A CN201510034668A CN104547079A CN 104547079 A CN104547079 A CN 104547079A CN 201510034668 A CN201510034668 A CN 201510034668A CN 104547079 A CN104547079 A CN 104547079A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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Abstract
The invention provides a pharmaceutical composition for treating liver diseases. The pharmaceutical composition comprises buttercups products and external creams, and is used for treating hepatic ascites, cirrhosis, fast repairing wound surfaces, treating skin ulcer, scars and burns, and relieving pain and itching. The preparation method of the pharmaceutical composition is simple, the cost is low, and the side effects caused by oral administration of patients and injections can be avoided. The external cream is prepared from the following traditional Chinese medicines by weight: 500-10000g of edible vegetable oil, 5-500g of polygonaceae plants, 10-500g of beewax, 10-500g of borneolum syntheticum and 10-500g of propolis. When the external cream is used for treating wound surfaces, the effects of relieving pain and itching and diminishing inflammation are strong. The wound surfaces are easily banded up after being applied with the cream, and no scars are left after recovery.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine, be specifically related to a kind of drug regimen for the treatment of hepatopathy.
Background technology
Hepatopathy, as the stronger disease of a kind of infectiousness, causes great harm to the health of the mankind.The paathogenic factor of hepatopathy mainly contains stagnated blood of liver, fatty degeneration of liver and hepatic necrosis three kinds, the hepatopathy caused mainly comprise hepatitis A, hepatitis B, hepatitis C, fatty liver, alcoholic liver, liver cirrhosis, hepatocarcinoma, etc.
Chronic hepatitis refers to that causing liver generation chronic inflammatory disease by the various cause of disease changes, and the course of disease is at least more than half a year.Visible jaundice, the side of body costalgia, tympanites, the performance such as to gather.The diseases such as the traditional Chinese medical science shows as deficiency of liver-QI more, cloudy blood two loses, hyperactive liver-QI attacking the spleen, stagnation of QI due to depression of the liver, residual poison are unclear.The chronic hepatitis course of disease is delayed, several years even repeatedly, more than ten years, the developed into liver cirrhosis had.
Non-alcohol fatty liver is a hereditary environment one metabolic stress related liver diseases, comprise simple fatty liver and by its develop fat hepatitis and liver cirrhosis.It is reported, at present, the prevalence of simple fatty liver is 30% at western developed country; In China, due to the change of living habit and dietary structure, sickness rate is in rising trend in recent years.
Liver cirrhosis is the major fate of the hepatic disease development such as chronic hepatitis B, current China chronic hepatitis B patient about 3,000 ten thousand, through this pathological process of hepatic fibrosis, 20% ~ 40% chb patient finally develops into liver cirrhosis, and liver cirrhosis due to hbv is one of disease of China's main vital, effectively treatment hbv-liver cirrhosis is the important channel reducing hepatitis B mortality rate.
Clinical research shows that effective antiviral therapy partly can reverse hepatic fibrosis, but (overall efficiency in week is only 45% to treat 48.Current anti-hepatitis virus treatment is all difficult to reach the object thoroughly removing virus, and hepatitis B virus causes the reasons such as body's immunity exception, the etiological treatment of hbv-liver cirrhosis can not substitute the treatment of hepatic fibrosis completely, and hepatic fibrosis also affects the effect of antiviral drugs.Therefore, for hbv-liver cirrhosis patient, antiviral therapy is necessary, and anti-hepatic fibrosis is also very important.Domestic and international many scholars are trying to explore cirrhosis treatment method, the medicines such as report colchicine, D mono-penicillamine, Malotilate are had to have the effect of anti-hepatic fibrosis, wherein colchicine had once once been considered to have the effect suppressing substrate to generate, but due to unsatisfactory curative effect, toxic and side effects is comparatively large, and clinical practice is subject to great restriction.
Cirrhotic ascites is commonly encountered diseases, mostly be cardiac cirrhosis, morphologically in micronodular cirrhosis, this kind of liver cirrhosis all in hepatosplenomegaly and serum albumin amount reduce, cause albumin and globulin imbalance, impel hepatocyte distortion widely and necrosis gradually, fibrous tissue diffusivity hypertrophy, though liver function injury is still not serious, causes abdominal cavity to gather and stayed hydrops, and involved other system in body, as treated not in time, the long-term stagnant knot of abdominal cavity ascites, liver function goes down further, is out of shape gradually and the more multisystem multiple performance of getting involved by causing liver.
In recent years, Chinese medicine has become state's internal therapy liver cirrhosis, and especially Decompensated cirrhosis, improves liver function, and contract one of nodular Main Means.Actually rare to all medicable Chinese medicine of above-mentioned hepatopathy, great majority are used for the treatment of the Chinese medicine of hepatopathy can only be oral, and for the hepatopath having gastroenteropathy simultaneously, oral medication then can increase the misery of patient.Therefore, the drug regimen developing a kind of efficient treatment hepatopathy is unusual meaning.
Summary of the invention
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, be made up of the machining object of ranunculus, external plaster.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, the suit of pharmaceutical composition, pharmaceutical composition can be prepared into.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, external plaster composition is: vegetable oil 500-10000 gram, Cera Flava 10-500 gram, polygonaceae plant 5-500 gram, Borneolum Syntheticum 10-500 gram, propolis 10-500 gram.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, external plaster is for the preparation for the treatment of tuberosity, and treatment hepatic ascites, hepatitis, wound surface is repaired fast, treat skin ulcer, treat cicatrix, treat burn, pain relieving, antipruritic pharmaceutical composition.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, ranunculus be in Herba Ranunculi Japonici, Radix Ranunculi Ternati, Herba Ranunculi Scelerati (Radix Anemones rupicolae) any one or multiple.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, ranunculus is for the preparation of one-tenth external preparation; The medical material position of ranunculus is: fresh or the fresh root hair of ranunculus.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed with stone mortar.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed, vacuum freeze-drying, obtains powder with stone mortar;
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, squeezes Fresh sap;
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed, squeezes Fresh sap, obtain powder with stone mortar;
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, external plaster is for the preparation of one-tenth external preparation.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, the preparation method of external plaster is:
Select medical material: get vegetable oil 500-10000 gram, Cera Flava 10-500 gram, polygonaceae plant 5-500 gram, Borneolum Syntheticum 10-500 gram, propolis 10-500 gram;
Boil: poured into by vegetable oil in rustless steel pan and endure with slow fire, by ready Cera Flava, polygonaceae plant is put into pot slow fire simultaneously and is endured, and boils 0.5-4 hour;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, polygonaceae plant is any one or multiple combination of Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, oxtail seven.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, vegetable oil is any one or multiple combination in soybean oil, Oleum sesami, Oleum sesami, Oleum Arachidis hypogaeae semen, olive oil, Semen Maydis oil, Oleum Helianthi.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the Herba Ranunculi Japonici come are cleaned, control is dry, is pounded pureed with stone mortar.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh of the Herba Ranunculi Japonici come collection or fresh root hair are cleaned, and control is dry, is pounded pureed, vacuum freeze-drying, obtains powder with stone mortar;
The present invention relates to a kind of external plaster,
External plaster composition is: Oleum sesami 500-10000 gram, Cera Flava 10-500 gram, Radix Et Rhizoma Rhei 5-500 gram, Borneolum Syntheticum 10-500 gram, propolis 10-500 gram.
The preferred composition of external plaster is: Oleum sesami 2500 grams, 135 grams, Cera Flava, 100 grams, Radix Et Rhizoma Rhei, Borneolum Syntheticum 25 grams, propolis 15 grams.
External plaster is for the preparation for the treatment of tuberosity, and treatment hepatic ascites, liver cirrhosis, hepatitis, wound surface is repaired fast, treat skin ulcer, treat cicatrix, treat burn, pain relieving, antipruritic pharmaceutical composition.
Select medical material: get Oleum sesami 500-10000 gram, Cera Flava 10-500 gram, Radix Et Rhizoma Rhei 5-500 gram, Borneolum Syntheticum 10-500 gram, propolis 10-500 gram;
Boil: poured into by Oleum sesami in rustless steel pan and endure with slow fire, by ready Cera Flava, polygonaceae plant is put into pot slow fire simultaneously and is endured, and boils 0.5-4 hour;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.
External plaster of the present invention is easily preserved, and easyization after heating up, easily absorbs, and makes patient can reach pain relieving, antipruritic effect within 15 minutes.
The present invention relates to a kind of external plaster, external plaster name of the present invention is called sweet source of students burn cream.
Treat a drug regimen for liver cirrhosis, be made up of Herba Ranunculi Japonici, external plaster.
Treat a drug regimen for liver cirrhosis, Herba Ranunculi Japonici is for the preparation of one-tenth external preparation.
Treat a drug regimen for liver cirrhosis, the medical material position of Herba Ranunculi Japonici is: fresh or the fresh root hair of Herba Ranunculi Japonici.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed with stone mortar.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed, vacuum freeze-drying, obtains powder with stone mortar; When using, with water dissolution;
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, squeezes Fresh sap,
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed, squeezes Fresh sap, vacuum freeze-drying, obtain powder with stone mortar; When using, with water dissolution;
Treat a drug regimen for liver cirrhosis, external plaster is for the preparation of one-tenth external preparation.
The present invention relates to a kind of drug regimen for the treatment of hepatopathy, hepatopathy is any one or multiple combination in hepatitis A, hepatitis B, icterohepatitis, fatty liver, liver cirrhosis, hepatic ascites.
Buttercup is the herb of plant Ranunculaceae buttercup Ranunculus japonicus Thunb..Pulsatilla fennel Fructus Foeniculi, for herbaceos perennial is high by 30---60cm, Herb has white hair, and fibrous root is flourishing, yellow-white, stem leaf, blade palmate, nearly five-pointed star, three drastic cracks, and leaf is avette, and dredge raw sawtooth, petal yellow is bright-coloured, and aggregate fruit is spherical.The florescence 4--6 month, the fruit phase 6--9 month.Use mountain range, Changbai Mountain, the whole nation all has.
Tiger claw grass belongs to this plant of (Herba Ranunculi Japonici) section.Just on the books in CHEN Zang-Qi supplement to the Herbal: the merit that Herba Ranunculi Japonici has " jaundice eliminating Dingchuan malaria, analgesia ".Ancients have cured the disease its fresh and have been used as medicine, and mash, are affixed on the area on the wrist over the radial artery where the pulse is felt for diagnosis or Neiguan acupoint, namely remove with scorching hot foaming.According to modern medicine study, Herba Ranunculi Japonici main component contains Anemonin, and Anemonin is to staphylococcus aureus, and gram negative bacteria and mycete have very strong inhibitory action.Have antagonism to histamine, energy vasodilator, removes smooth muscle spasm effect.Therefore be improved liver microcirculation, favourable hepatitis, liver cirrhosis, the recovery of tuberosity and ascites.
The traditional Chinese medical science thinks that blood stasis profit heat in blood is the Basic disease cause pathogenesis of chronic hepatitis: eliminating damp-heat, blood circulation promoting and blood stasis dispelling is its base therapy rule, tiger claw grass (Herba Ranunculi Japonici) can make vasodilation that skin is bubbled, and the thing (bubble liquid) of discharging turbid damp in body illustrates that it has clearing away heat-damp and promoting diuresis effect so can treat chronic hepatitis.
Herba Ranunculi Japonici is containing protoanemonin; Protoanemonin can make the condensing destruction of cancerous cell, has cytotoxicity.Fresh juice and protoanemonin have intense stimulus, skin can be made to foam, mucous hyperemia; To guinea pig in vitro or the spasm that causes at bronchus and the ileum antihistaminic of body all in antagonism.Preserved material or decoct all have stronger killing action to gram-positive and negative bacteria, leptospira, protozoon etc.
The Herba Ranunculi Japonici property of medicine: pungent, micro-hardship, temperature.Poisonous.Return lung, spleen, Liver Channel.Herba Ranunculi Japonici drug effect: relieve internal heat anticancer, pain relieving nebula removing, diminishing inflammation and resolving masses, parasite killing preventing the attack (or recurrence) of malaria.
Effect of Radix Et Rhizoma Rhei and effect, nature and flavor: bitter, cold.Gui Jing: stomach warp; Large intestine channel; Liver Channel; Spleen channel, effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Cure mainly: excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lumps in the chest and abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.
Borneolum Syntheticum acrid in the mouth, hardship, be slightly cold; GUIXIN, liver, lung meridian; Delicate fragrance a surname is loose, has refreshment of having one's ideas straightened out, and the loose poison of heat clearing away, effect of improving acuity of vision and removing nebula, cures mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, and heat-damp in summer hoodwinks key clearly, and sore throat is deaf, and aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, and nebula film hides fine.
Propolis has antibiotic effect: the sterilizing of propolis energy, sterilization, sterilization, antibacterial, mildew-resistant, anticorrosion, solves the defect that antibiotic only works to single microorganism, and is free from side effects.Good therapeutic effect is had in daily life to dermatosis.Propolis can promote that histiocyte regenerates, and is have good repair to various oral disease, can be used for treating gastric ulcer.Prophylaxis of tumours.Containing abundant cancer-resisting substance in propolis, research proves, cancer patient after taking propolis, can cancerous cell be reduced and chemotherapy can be alleviated, side effect that radiotherapy causes.Propolis can strengthen body immunity, strengthens the ability of human body opposing virus infraction.。Propolis also has good effect in analgesia.
Oleum sesami have moisturize, fluid infusion, endogenous wind stopping, removing toxic substances parasite killing and the swollen effect of all skin ulcers that disappears, meridian distribution of property and flavor: sweet, tepor.Effect: astringent therapy, sore, granulation promoting, pain relieving.Cure mainly: outer for ulcer being unable to heal, ecthyma is rotten to the corn, wound, burn
Cera Flava sweet in the mouth; Light; Property is put down, and returns spleen; Stomach; Large intestine channel can detoxify; Granulation promoting; Dysentery relieving; Hemostasis; Analgesic therapy.Cure mainly carbuncle carbuncle on the back, ulcer is for holding back; Anxious pained; Dysentery pus and blood; Incessant chronic diarrhea; Vaginal bleeding due to excessive movement of fetus; Seminal emission; Leukorrhagia.
The medical value of Cera Flava is also very high.Chinese medicine beeswax has effect of removing toxic substances, granulation promoting, analgesic therapy, and for oral administration and external application can cure mainly has to go to the toilet pained, and dysentery pus and blood, incessant chronic diarrhea, vaginal bleeding due to excessive movement of fetus, carbuncle sore inside fire attack, bursts for a long time and do not hold back, burn due to hot liquid or fire etc.Doctor trained in Western medicine aspect is the ester that higher fatty acids and high alcohol are formed due to the Main Ingredients and Appearance of Cera Flava, is made into various ointment, Emulsion, suppository, can be used to the various diseases such as treatment ulcer, furuncle, burn and wound.Cera Flava is chewed in oral cavity can treat angina and maxillary sinusitis.Chew capping wax and can strengthen respiratory immunity power and treatment rhinitis, mucous membrane of accessory sinus inflammation and Radix Glycyrrhizae calentura.Cera Flava is made refrigerant compress ointment to apply ointment or plaster affected part, endarteritis obliterans, periodontitis and spastic colitis can be treated.The compound that Cera Flava and calcium carbonate, mineral oil and pure Colophonium mix can treat chronic mastitis, eczema, burn, wound, tinea, dermatitis, abscess, papilloma.
Drug of topical application method:
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed with stone mortar.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed, vacuum freeze-drying, obtains powder with stone mortar; When using, with water dissolution;
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, squeezes Fresh sap,
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed, squeezes Fresh sap, vacuum freeze-drying, obtain powder with stone mortar; When using, with water dissolution;
Be layered on the liver of patient with sterile absorbent gauze, get purees, medicine is evenly tiled on gauze, drug of topical application area hepatic region is approximately 15*20 centimetre (determining hepatic region because of patient body weight size, spleen district);
Be layered on the liver of patient with sterile absorbent gauze, get the vacuum freeze-drying product of purees, with water furnishing pasty state, medicine is evenly tiled on gauze, drug of topical application area hepatic region is approximately 15*20 centimetre (determining hepatic region because of patient body weight size, spleen district);
Be layered on the liver of patient with sterile absorbent gauze, get Fresh sap, medicine is evenly tiled on gauze, drug of topical application area hepatic region is approximately 15*20 centimetre (determining hepatic region because of patient body weight size, spleen district);
Be layered on the liver of patient with sterile absorbent gauze, get the vacuum freeze-drying product of Fresh sap, with water furnishing pasty state, medicine is evenly tiled on gauze, drug of topical application area hepatic region is approximately 15*20 centimetre (determining hepatic region because of patient body weight size, spleen district).
Carry out external application according to 10-20 gram of Herba Ranunculi Japonici fresh each adult (70 kilograms), the consumption that Herba Ranunculi Japonici is fresh adjusts according to body weight and the state of an illness.
Again with in north material film cover, prevent the moisture in medicine from evaporating.With medico paper adhesive tape, the plastic sheeting surrounding covered on medicine is sealed, do not allow ventilative, allow the efficacy of a drug toward subcutaneous motion.Patient's drug of topical application time 8--10 hour.
Patient's drug of topical application two hours, skin has terribly hot sensation, and belly rumble, rumble is sound directly.Have slight pain, four hours, patient can feel abdominal distention, a large amount of aerofluxuss.Under skin, red and swollen fine hair hole increases thick, and medicine oozes from fine hair hole, reaches the effect of administration.After the drug of topical application, patient skin is just as pinprick, occurs that ant row is felt.
Medicine was taken off in 8-10 hour, can bubble.(if also do not bubble, stir yourself of can getting up, will bubble).Some patients treat that blister plays can with the thing (bubble liquid) of sterilization medical needle dazzling releasing turbid damp, as long as have will be dazzling for blister, until bubble liquid has not had.Start dazzling releasing bubble liquid, patient will feel light, and hepatopath optical fundus and face all can turn to be yellow, as long as bubble is after liquid releases 24 hours, the face of patient all can blush, and recover the face of normal person, mental restoration, urinates and increase, and hepatalgia sense alleviates.Color weight when the drug of topical application is urinated, twice or thrice will recover normal.
Control in the place of the drug of topical application, bubble liquid to be blotted to the dazzling bubble liquid of putting of patient as far as possible, avoid bubble liquid stream local to other.Because the place that bubble liquid stream is crossed, can flow down red seal if dried not in time, red seal also can bubble.Because the bubble liquid flowed out also has the composition of medicine residual flow.Here it is saidly flows to which, the reason which bubbles.Because when curing the disease to patient certain it should be noted that be not ascites patient's cleaning in general a hour once, must special messenger's nursing, handle well steeping liquid.Allow well more bubble liquid out, bubble liquid more multiple-effect fruit is out better.When going out if any careless bubble liquid stream, in time with the vestige that normal saline flushing flows through.
Red seal on cleaned vestige coats external plaster of the present invention.Within every 12 hours, be coated with once, two days all right, can not bubble, and more can not ache.Patients with ascites duty will put bubble liquid, and liquid measure is large.Within the general 1-3 of bubble liquid days of patient, just do not flow.
External application is carried out according to each red seal 10-20 gram external plaster.Preferred each red seal 15 grams of external plasters carry out external application.The consumption of external plaster adjusts according to body weight and the state of an illness.
This time, patient had pain, and burning is itched, and skin is tight, with povidone iodine, wound surface surrounding was cleaned out sterilization.At this moment smooth with sterile absorbent cotton cloth and coat external plaster of the present invention, smear evenly.
Gauze will go out greatly wound surface two centimeters, solves wound surface contact position pain.By the gauze of unction in the face of wound surface covers, smooth gently, allow each wound surface be to touch external plaster of the present invention, then be layered on above ground floor with the cotton cloth of one deck good water absorption, size is the same, plays drainage.Consider how many wound surface also has the bubble liquid of residual flow, with medical weight reducing Elastic bandage, suitable pressure dressing (patient feels that extruding is not ached just).After Elastic bandage wrapping, the bubble liquid of subcutaneous for wound surface residual flow can be squeezed out, the bubble liquid squeezed out can absorb on second layer gauze by the gauze gap of ground floor, the dry and comfortable healing of such wound surface fast.
External application is carried out according to each wound surface 10-20 gram external plaster.Preferred each wound surface 15 grams of external plasters carry out external application.The consumption of external plaster adjusts according to body weight and the state of an illness.
This external plaster can keep the moisturizing of wound surface, and absorbs pus from the wound surface of humidity, bubble liquid, control the antibacterial on wound and microorganism, there is putrefaction removing, decrustation effect, make dead corrupt tissue's dry crusts fast-falling, promote the incarnant speed of balance, can function of promoting blood circulation to disperse blood clots.The circulation of wound surface peripheral blood can be improved, promote wound surface nutrition supply, effectively reduce cicatrization.It is gentle by force to the putrefaction removing ability of ulcer that this external plaster of more than ten years experience improves wound surface, and granulation promoting is rapid, can balance the speed of growth of granulation, reduces cicatrization (vestige of general wound surface is having disappeared to two courses for the treatment of).
7 days courses for the treatment of of product of the present invention.
Medicine of the present invention is directly entered by external application and acts on human body, can remove toxin contained in human body, damaged hepatocyte is brought back to life again, makes liver again recover hemopoietic function.For the patient suffering from gastrointestinal disease simultaneously, use external application for curing can alleviate the misery of its Long-term Oral medicine.Medicine of the present invention all has good curative effect to hepatopathys such as hepatitis, liver cirrhosis, hepatitis A, hepatitis B, hepatitis C, fatty liver, alcoholic liver.
External plaster of the present invention (sweet source of students burn cream) relates to skin wound burn, skin ulcer, cicatrix, pain relieving, antipruritic, antiinflammatory, especially liver cirrhosis treated by tiger claw grass (Herba Ranunculi Japonici), tuberosity, the ointment of hepatic ascites Chinese herbs, filled up in the past tiger claw grass at treatment liver cirrhosis, tuberosity, hepatic ascites, easily inflammation after bubbling, ulcer, bitterly, the inflammation of itching.Thus solve hepatopath's misery.
Clinical case
Honest and clean ××, man, 48 years old, in July, 2011 color ultrasound examination severe fatty liver, liver cirrhosis, after using 12 courses for the treatment of of product of the embodiment of the present invention 1, in April, 2013 color ultrasound examination, liver size is normal, and liver surface is smooth, and essence echo is fine and closely woven, be evenly distributed, have no occupying lesion, liver portal vein no abnormality seen blood returned signal, liver pain obviously alleviates, liver function is also recovered gradually, and sb.'s illness took a favorable turn.
Poplar ×, man, 46 years old, multiple low-density shade in December, 2009 color ultrasound examination livers, cirrhotic nodule, early hepatocarcinoma, after using 14 courses for the treatment of of product of the embodiment of the present invention 2, in February, 2013 color ultrasound examination, liver is full, and profile is clear, liver surface is smooth, essence Echoenhance, have no pathological changes occupy-place stove in liver, liver pain obviously alleviates, liver function is also recovered gradually, and sb.'s illness took a favorable turn.
Bent ×, man, 49 years old, in August, 2014, hepatitis B virus (HBV) DNA identified, 3.250E+06IU/ml (reference range 5.000E+02), after using 2 courses for the treatment of of product of the embodiment of the present invention 2, in December, 2014 hepatitis B virus (HBV) DNA identifies, <5.000E+02IU/ml (reference range 5.000E+02)
Within 2010 to 2013, meet patients with cirrhosis ascites 10 example of diagnostic criteria.Man 3 example, female 7 example, wherein hepatitis A 3 example, hepatitis B 4 example, icterohepatitis 3 example; Age 59-74 year, average 66.7 years old ,-7 years Mays of the course of disease;
Choice criteria
Diagnose the diagnostic criteria all met about liver cirrhosis in " viral hepatitis control prece ", and accompany ascites person.
Tcm diagnosis addresses the medicine typing of tympanites in " Chinese Internal Medicine " with reference to the theory of correlation of liver cirrhosis clinical diagnosis, differential diagnosis in tcm and criterion of therapeutical effect.
Therapeutic Method
Patient all adopts at viewing duration and takes a good rest, reasonable diet, protects the liver, limits the measures such as the absorption of water sodium, etiological treatment.
Treatment group is treated by following scheme:
Purees coated patient's hepatic portion skin of embodiment 1, with the external plaster external application skin injury place of embodiment 1, exchanges once a day, 7 days course for the treatment of, totally 8 courses for the treatment of
(1) main symptom improves situation, the improvement situation of two groups of symptoms before and after comparison therapy; (2) biochemical: TBIL, ALB, ALT, PT change; (3) B ultrasonic: portal vein, the splenic vein change, ascites disappears situation; (4) safety detects: observe experimenter emerging sings and symptoms (heating, feel sick, erythra etc.); Blood, routine urinalysis, renal function (Cr, BUN), electrocardiogram (ECG) checks, detects 1 time respectively before and after above index treatment.
Curative effect determinate standard
" cirrhotic ascites Efficacy of Traditional Chinese Medicine standard " (the tentative draft) formulated with reference to hepatopathy Professional Committee of Chinese Chinese medicine association is drafted:
Effective: main subjective symptoms disappears, and ordinary circumstance is good, ascites reduces situation (abdominal circumference reduction more than 8cm, ultrasound diagnosis ascites do not find opaque dark area of fluid).Liver function (ALT, AST, TBIL, ALB), PT recover normal, detect twenty-four-hour urine sodium excretion amount and are greater than 90mmol/L, and urine sodium is greater than 2 with urine potassium ratio, and above 4 indexs keep stablizing 3 months.
Effective: cardinal symptom disappears or is clearly better, ascites reduces situation (a small amount of ascites is pointed out in abdominal circumference reduction 3-8cm, ultrasound diagnosis).Liver function index fall is completely abnormal more than 50%, and detect between twenty-four-hour urine sodium excretion amount 50-90 mmol/L, urine sodium is greater than 2 with urine potassium ratio.
Invalid: clinical symptoms is without change or increase the weight of, indices is without improvement or worsen.
Result
Effective 8 examples for the treatment of group, effective 1 example, total effective rate 90.0%,
After treatment, abdominal circumference, the twenty-four-hour urine amount for the treatment of group are obviously improved:
After treatment, Abdominal B type ultrasonography, the portal vein for the treatment of group is wide, the splenic vein is wide, the ascites degree of depth is obviously improved:
After treatment, the indexs such as ALB, TBIL, ALT, PT for the treatment of group are obviously improved:
Heating, erythra, the untoward reaction such as hemorrhage is there is not: general physical examination, blood routine, routine urine examination,urine for routine, renal function, electrocardiogram Non Apparent Abnormality, illustrate that compositions of the present invention is safe and reliable and have no side effect in treatment group.
The following stated is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Detailed description of the invention
Embodiment 1.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Japonici, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :clean fresh that gathers the Herba Ranunculi Japonici come, control is dry, is pounded pureed with stone mortar.Put into vial for subsequent use;
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: Oleum sesami 2500 grams, 100 grams, Radix Et Rhizoma Rhei, 135 grams, Cera Flava, Borneolum Syntheticum 25 grams, propolis 15 grams;
Boil: poured into by Oleum sesami in rustless steel pan and endure with slow fire, by ready Cera Flava, Radix Et Rhizoma Rhei put into pot slow fire simultaneously and endure, and boil 1 hour;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 2.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Japonici, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :cleaned by the fresh root hair gathering the Herba Ranunculi Japonici come, control is dry, is pounded pureed with stone mortar.Put into vial for subsequent use.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: Oleum sesami 2500 grams, Radix Et Rhizoma Rhei 100 grams, 135 grams, Cera Flava, Borneolum Syntheticum 25 grams, propolis 15 grams;
Boil: poured into by Oleum sesami in rustless steel pan and endure with slow fire, by ready Cera Flava, Radix Et Rhizoma Rhei is put into pot slow fire simultaneously and is endured, and boils 1 hour;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 3.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Japonici, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :clean fresh that gathers the Herba Ranunculi Japonici come, control is dry, squeezes Fresh sap.Put into vial for subsequent use.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: Oleum sesami 2500 grams, 100 grams, Radix Et Rhizoma Rhei, 135 grams, Cera Flava, Borneolum Syntheticum 25 grams, propolis 15 grams;
Boil: poured into by Oleum sesami in rustless steel pan and endure with slow fire, by ready Cera Flava, Radix Et Rhizoma Rhei put into pot slow fire simultaneously and endure, and boil 1 hour;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 4.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Japonici, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :cleaned by the fresh root hair gathering the Herba Ranunculi Japonici come, control is dry, squeezes Fresh sap.Put into vial for subsequent use.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: Oleum sesami 2500 grams, 100 grams, Radix Et Rhizoma Rhei, 135 grams, Cera Flava, Borneolum Syntheticum 25 grams, propolis 15 grams;
Boil: poured into by Oleum sesami in rustless steel pan and endure with slow fire, by ready Cera Flava, Radix Et Rhizoma Rhei put into pot slow fire simultaneously and endure, and boil 2 hours;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 5.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Japonici, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :clean fresh that gathers the Herba Ranunculi Japonici come, control is dry, is pounded pureed, vacuum freeze-drying, puts into vial for subsequent use with stone mortar.Add water when using furnishing pasty state.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: Oleum sesami 2500 grams, Radix Et Rhizoma Rhei 100 grams, 135 grams, Cera Flava, Borneolum Syntheticum 25 grams, propolis 15 grams;
Boil: poured into by Oleum sesami in rustless steel pan and endure with slow fire, by ready Cera Flava, Radix Et Rhizoma Rhei is put into pot slow fire simultaneously and is endured, and boils 2 hours;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 6.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Japonici, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :cleaned by the fresh root hair gathering the Herba Ranunculi Japonici come, control is dry, is pounded pureed, vacuum freeze-drying, puts into vial for subsequent use with stone mortar.Add water when using furnishing pasty state.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: soybean oil 5000 grams, Rhizoma Polygoni Cuspidati 500 grams, 300 grams, Cera Flava, Borneolum Syntheticum 50 grams, propolis 15 grams;
Boil: poured into by soybean oil in rustless steel pan and endure with slow fire, by ready Cera Flava, Rhizoma Polygoni Cuspidati is put into pot slow fire simultaneously and is endured, and boils 3 hours;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 7.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Japonici, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :cleaned by the fresh root hair gathering the Herba Ranunculi Japonici come, control is dry, squeezes Fresh sap, puts into vial for subsequent use.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: soybean oil 5000 grams, Rhizoma Polygoni Cuspidati 500 grams, 300 grams, Cera Flava, Borneolum Syntheticum 50 grams, propolis 15 grams;
Boil: poured into by soybean oil in rustless steel pan and endure with slow fire, by ready Cera Flava, Rhizoma Polygoni Cuspidati is put into pot slow fire simultaneously and is endured, and boils 3 hours;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 8.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Japonici, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :cleaned by the fresh root hair gathering the Herba Ranunculi Japonici come, control is dry, squeezes Fresh sap, vacuum freeze-drying, puts into vial for subsequent use.Add water when using furnishing pasty state.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: soybean oil 5000 grams, Radix Et Rhizoma Rhei 500 grams, 300 grams, Cera Flava, Borneolum Syntheticum 50 grams, propolis 15 grams;
Boil: poured into by soybean oil in rustless steel pan and endure with slow fire, by ready Cera Flava, Radix Et Rhizoma Rhei is put into pot slow fire simultaneously and is endured, and boils 3 hours;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 9.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Herba Ranunculi Scelerati (Radix Anemones rupicolae), and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :clean fresh that gathers the Herba Ranunculi Scelerati (Radix Anemones rupicolae) come, control is dry, squeezes Fresh sap, vacuum freeze-drying, puts into vial for subsequent use.Add water when using furnishing pasty state.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: Oleum sesami 1000 grams, oxtail 7 100 grams, 50 grams, Cera Flava, Borneolum Syntheticum 10 grams, propolis 15 grams;
Boil: poured into by Oleum sesami in rustless steel pan and endure with slow fire, by ready Cera Flava, oxtail seven is put into pot slow fire simultaneously and is endured, and boils 1 hour;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Embodiment 10.
The present invention relates to a kind of drug regimen for the treatment of liver cirrhosis, is by the machining object of fresh of Radix Ranunculi Ternati, and external plaster forms;
The drug regimen for the treatment of liver cirrhosis of the present invention, adopts the form of suit.
The machining object of fresh of Herba Ranunculi Japonici
be :cleaned by the fresh root hair gathering the Radix Ranunculi Ternati come, control is dry, squeezes Fresh sap, vacuum freeze-drying, puts into vial for subsequent use.Add water when using furnishing pasty state.
The present invention relates to a kind of external plaster, the preferred medical material of external plaster: Oleum Arachidis hypogaeae semen 2500 grams, Rhizoma Polygoni Cuspidati 100 grams, 135 grams, Cera Flava, Borneolum Syntheticum 25 grams, propolis 15 grams;
Boil: poured into by Oleum Arachidis hypogaeae semen in rustless steel pan and endure with slow fire, by ready Cera Flava, Rhizoma Polygoni Cuspidati is put into pot slow fire simultaneously and is endured, and boils 2 hours;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.Put into vial for subsequent use.
Claims (10)
1. treat a drug regimen for hepatopathy, be characterised in that: be made up of the machining object of ranunculus, external plaster.
2. a kind of drug regimen for the treatment of hepatopathy according to claim 1, is characterised in that: external plaster Chinese medicinal ingredients is:
Vegetable oil 500-10000 gram, polygonaceae plant 5-500 gram, Cera Flava 10-500 gram, Borneolum Syntheticum 10-500 gram, propolis 10-500 gram.
3. a kind of drug regimen for the treatment of hepatopathy according to claim 1, be characterised in that: the machining object of ranunculus, external plaster are for the preparation for the treatment of tuberosity, treatment hepatic ascites, liver cirrhosis, wound surface are repaired fast, treat skin ulcer, treat cicatrix, treat burn, pain relieving, antipruritic pharmaceutical composition.
4. a kind of drug regimen for the treatment of hepatopathy according to claim 1, is characterised in that: ranunculus be in Herba Ranunculi Japonici, Radix Ranunculi Ternati, Herba Ranunculi Scelerati (Radix Anemones rupicolae) any one or multiple.
5. a kind of drug regimen for the treatment of hepatopathy according to claim 1, is characterised in that: ranunculus is for the preparation of one-tenth external preparation; The medical material position of ranunculus is: fresh or the fresh root hair of ranunculus.
6. a kind of drug regimen for the treatment of hepatopathy according to claim 1, is characterised in that: the processing method of ranunculus is
Fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed with stone mortar;
Or fresh or fresh root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed, vacuum freeze-drying, obtains powder with stone mortar;
Or fresh or root hair gathering the ranunculus come are cleaned, control is dry, squeezes Fresh sap;
Or fresh or root hair gathering the ranunculus come are cleaned, control is dry, is pounded pureed, squeezes Fresh sap, obtain powder with stone mortar.
7. a kind of drug regimen for the treatment of hepatopathy according to claim 1, is characterised in that: the preparation method of external plaster is:
Select medical material: get vegetable oil 500-10000 gram, Cera Flava 10-500 gram, polygonaceae plant 5-500 gram, Borneolum Syntheticum 10-500 gram, propolis 10-500 gram;
Boil: poured into by vegetable oil in rustless steel pan and endure with slow fire, by ready Cera Flava, polygonaceae plant is put into pot slow fire simultaneously and is endured, and boils 0.5-4 hour;
Cease fire 10 minutes, oil stops boiling, medicinal residues in pot is pulled out and controls dry, outwell, propolis is put into pot after dissolving completely;
Receive cream: with the back of the hand examination pot temperature micro-boiling hot time, Borneolum Syntheticum is put into pot and melts away and stir, obtain external plaster.
8. according to a kind of drug regimen for the treatment of hepatopathy of claim 1-10, be characterised in that: polygonaceae plant is Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, oxtail seven.
9. according to a kind of drug regimen for the treatment of hepatopathy of claim 1-10, be characterised in that: vegetable oil is any one or multiple combination in soybean oil, Oleum sesami, Oleum sesami, Oleum Arachidis hypogaeae semen, olive oil, Semen Maydis oil, Oleum Helianthi.
10. according to a kind of drug regimen for the treatment of hepatopathy of claim 1-10, be characterised in that: hepatopathy is any one or multiple combination in hepatitis A, hepatitis B, icterohepatitis, fatty liver, liver cirrhosis, hepatic ascites.
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| CN111420012A (en) * | 2019-11-19 | 2020-07-17 | 房纳生 | Traditional Chinese medicine composition for treating liver diseases and preparation method and application thereof |
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| CN1626171A (en) * | 2003-12-12 | 2005-06-15 | 胡本华 | Chinese traditional medicine for external application for treating primary liver cancer and cirrhosis of liver |
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| CN1626171A (en) * | 2003-12-12 | 2005-06-15 | 胡本华 | Chinese traditional medicine for external application for treating primary liver cancer and cirrhosis of liver |
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