GB393319A - Medicinal preparation and process of producing same - Google Patents
Medicinal preparation and process of producing sameInfo
- Publication number
- GB393319A GB393319A GB1495031A GB1495031A GB393319A GB 393319 A GB393319 A GB 393319A GB 1495031 A GB1495031 A GB 1495031A GB 1495031 A GB1495031 A GB 1495031A GB 393319 A GB393319 A GB 393319A
- Authority
- GB
- United Kingdom
- Prior art keywords
- copper
- nucleinate
- iron
- alcohol
- caseinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Solutions of iron-copper protein compounds such as iron nucleinate or peptonate and and copper nucleinate or caseinate are stabilized by the addition of water-soluble fruit acid salts such as sodium citrate. Copper nucleinate is prepared from yeast by treatment with dilute sodium hydroxide, partial neutralization with hydrochloric acid followed by acidification with acetic acid. The solid matter is allowed to settle and the liquid filtered, copper sulphate is added and stirred till dissolved and the flocculent precipitate allowed to settle, filtered and washed till free from sulphates. The precipitate is then washed with alcohol and ether and dried. In preparing iron nucleinate from yeast a similar procedure is followed, ferric chloride being the source of iron, while the precipitation is effected in 60 per cent alcohol. A copper nucleinate is obtained from nucleic acid by a similar process in which the percentage of copper is considerably less than that in that obtained from yeast. Copper caseinate is obtained by the addition of a solution of copper sulphate to a solution of casein in dilute sodium hydroxide, filtration and washing with alcohol and ether. Alcohol, glycerine, sugar and flavouring substances (oil of orange, ethyl acetate, vanillin) are added to the mixture for therapeutic use.ALSO:Solutions of iron-copper protein compounds such as iron nucleinate or peptonate and copper nucleinate or caseinate are stabilized by the addition of water soluble fruit acid salts such as sodium citrate. Alcohol, glycerine, sugar and flavouring substances (oil of orange, ethyl acetate, vanillin) are also added. The Specification describes methods of preparing the metal protein compounds which are employed in such proportions that the mixture contains about twice as much iron as copper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1495031A GB393319A (en) | 1932-05-24 | 1932-05-24 | Medicinal preparation and process of producing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1495031A GB393319A (en) | 1932-05-24 | 1932-05-24 | Medicinal preparation and process of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB393319A true GB393319A (en) | 1933-06-08 |
Family
ID=10050399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1495031A Expired GB393319A (en) | 1932-05-24 | 1932-05-24 | Medicinal preparation and process of producing same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB393319A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3002519A1 (en) * | 1979-02-09 | 1980-08-21 | Nestle Sa | CASEINATES OF OLIGOELEMENTS AND THEIR PRODUCTION AND USE |
| EP1213013A2 (en) * | 2000-11-29 | 2002-06-12 | Basf Aktiengesellschaft | Process for preparing solid compositions of water-soluble, hardly water-soluble or water-insoluble active agents |
| US7105176B2 (en) | 2000-11-29 | 2006-09-12 | Basf Aktiengesellschaft | Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds |
-
1932
- 1932-05-24 GB GB1495031A patent/GB393319A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3002519A1 (en) * | 1979-02-09 | 1980-08-21 | Nestle Sa | CASEINATES OF OLIGOELEMENTS AND THEIR PRODUCTION AND USE |
| EP1213013A2 (en) * | 2000-11-29 | 2002-06-12 | Basf Aktiengesellschaft | Process for preparing solid compositions of water-soluble, hardly water-soluble or water-insoluble active agents |
| EP1213013A3 (en) * | 2000-11-29 | 2004-01-02 | Basf Aktiengesellschaft | Process for preparing solid compositions of water-soluble, hardly water-soluble or water-insoluble active agents |
| US7105176B2 (en) | 2000-11-29 | 2006-09-12 | Basf Aktiengesellschaft | Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds |
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