DE720937C - Process for the production of therapeutically valuable gold compounds from keratin breakdown products - Google Patents
Process for the production of therapeutically valuable gold compounds from keratin breakdown productsInfo
- Publication number
- DE720937C DE720937C DESCH112875D DESC112875D DE720937C DE 720937 C DE720937 C DE 720937C DE SCH112875 D DESCH112875 D DE SCH112875D DE SC112875 D DESC112875 D DE SC112875D DE 720937 C DE720937 C DE 720937C
- Authority
- DE
- Germany
- Prior art keywords
- breakdown products
- gold compounds
- gold
- keratin
- therapeutically valuable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000011782 Keratins Human genes 0.000 title claims description 9
- 108010076876 Keratins Proteins 0.000 title claims description 9
- 230000015556 catabolic process Effects 0.000 title claims description 6
- 150000002344 gold compounds Chemical class 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 5
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 239000002253 acid Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 150000007513 acids Chemical class 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 3
- 150000004679 hydroxides Chemical class 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- GEHJBWKLJVFKPS-UHFFFAOYSA-N bromochloroacetic acid Chemical compound OC(=O)C(Cl)Br GEHJBWKLJVFKPS-UHFFFAOYSA-N 0.000 claims description 2
- 230000006862 enzymatic digestion Effects 0.000 claims description 2
- LQHZJYFIRFRDKF-UHFFFAOYSA-N gold magnesium Chemical compound [Mg].[Au] LQHZJYFIRFRDKF-UHFFFAOYSA-N 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 238000001226 reprecipitation Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 7
- 239000010931 gold Substances 0.000 description 6
- 229910052737 gold Inorganic materials 0.000 description 4
- -1 gold chloride hydrochloric acid Chemical compound 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000002343 gold Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 150000002681 magnesium compounds Chemical class 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
- A61K38/015—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen from keratin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung therapeutisch wertvoller Goldverbindungen von Keratinabbauprodukten Zusatz zum Patent 663 380 In weiterer Ausbildung des Verfahrens des Patents 663 380, bei dem therapeutisch wertvolle Goldverbindungen von Keratinabbauprodukten erhalten werden, indem man auf die in bekannter Weise durch saure Hydrolyse bzw. gelinde saure Hydrolyse in Verbindung mit enzymatischer Verdauung von Keratinen mit oder ohne gleichzeitige oder nachfolgende Reduktion und Umsetzung mit Goldsalzen erhaltenen Goldkeratinate, Oxyde, Hydroxyde oder Carbonate der Erdalkalien bzw. des Magnesiums einwirken läßt und die so erhaltenen wasserlöslichen Erdalkali- oder Magnesiumgoldkeratinate mittels Alkohol oder anderer mit Wasser mischbaren organischen Lösungsmittel aus der wäßrigen Lösung ausfällt, hat es sich gezeigt, daß man zu den gewünschten Verbindungen auch gelangen kann, wenn man von den Keratinabbauprodukten bzw. den Keratinsäuren selbst ausgeht und gleichzeitig Goldverbindungen und die Oxyde, Hydroxyde oder Carbonate der Erdalkalien bzw. des Magnesiums auf diese Verbindungen einwirken läßt. Das Verfahren hat den besonderen Vorteil, daß hierbei das Umsetzungsgemisch nicht sauer wird und daher die Goldkeratinsäuren nicht ausfallen. Auf diese Weise wird ihre vollständige Umsetzung mit den Erdalkali-bzw. Magnesiumverbindungen sicher erreicht.Process for the production of therapeutically valuable gold compounds of keratin degradation products Addition to patent 663 380 In further development of the process of the patent 663 380, in which therapeutically valuable gold compounds of keratin breakdown products be obtained by in a known manner by acid hydrolysis or mild acid hydrolysis combined with enzymatic digestion of keratins with or without simultaneous or subsequent reduction and conversion with gold salts obtained gold keratinates, oxides, hydroxides or carbonates of the alkaline earths or of magnesium can act and the resulting water-soluble alkaline earth or Magnesium gold keratinates using alcohol or other water-miscible organic compounds Solvent precipitates from the aqueous solution, it has been shown that one too The desired compounds can also be obtained if one of the keratin breakdown products or the keratinic acids themselves run out and at the same time gold compounds and the Oxides, hydroxides or carbonates of alkaline earths or magnesium on these compounds can act. The process has the particular advantage that this reaction mixture does not become acidic and therefore the gold keratinic acids do not precipitate. In this way their full implementation with the alkaline earth or. Magnesium compounds safe achieved.
BeispielI Zu einer Lösung von 40 g einer nach der Patentschrift 578 828 hergestellten Sulfhydrylkeratinsäure in 200 ccm Wasser werden 40 ccm einer 200/eigen Goldchloridchlorwasserstoffsäure allmählich unter Rühren zugegeben und gleichzeitig so viel Magnesiumcarbonat eingetragen, daß die Reaktion der Lösung neutral bleibt, nach Beendigung des Zugebens der Goldchloridchlorwasserstoffsäurelösung jedoch ein Pur = 7,4 zeigt. Es wird von geringen Ausscheidungen abfiltriert, das Filtrat in die zehnfache Menge Alkohol eingerührt, das hierbei ausgefällte Magnesiumsalz der Goldsulfhydrylkeratinsäure abgesaugt, mit Alkohol und Äther gewaschen und im Vakuum getrocknet. Es wird als ein in Wasser leicht lösliches schwach graugelb gefärbtes Pulver erhalten, das 2,40/0 Mg und IQ6O,o Au enthält. Example I To a solution of 40 g of one according to patent specification 578 828 sulfhydryl keratinic acid in 200 cc of water 40 ccm of 200 / proper gold chloride hydrochloric acid was gradually added with stirring and at the same time entered so much magnesium carbonate that the reaction of the solution remains neutral after the addition of the hydrochloric acid gold chloride solution is complete however shows a Pur = 7.4. It is filtered off from small excretions that The filtrate was stirred into ten times the amount of alcohol, the magnesium salt precipitated in this way suctioned off the gold sulfhydryl keratinic acid, washed with alcohol and ether and im Vacuum dried. It appears as a slightly gray-yellow colored slightly soluble in water Obtained powder containing 2.40 / 0 Mg and IQ6O, o Au.
Beispiel 2 100 g eines Keratinabbauproduktes, das durch Hydrolyse von Haaren mit 30 Obiger Schwefelsäure auf dem Wasserbad bis zur Lösung, Dialyse des Hydrolysats und Eindampfen des erhaltenen Dialysats bis zur Trockene gewonnen worden ist, werden in 1 1 Wasser gelöst und zu dieser Lösung I30 ccm einer 20 obigen wäßrigen Goldchloridchlorwasserstoffsäure allmählich unter Rühren zugegeben und gleichzeitig so viel Calciumhydroxyd eingetragen, daß die Reaktion nach Zugabe der Goldchloridchlorwasserstoffsäure schwach alkalisch ist. Nach Filtrieren der Lösung wird durch Ausfällung mit Alkohol das Calciumsalz der Goldkeratinsäure isoliert und zur Abtrennung von geringen Mengen schwer löslicher Verunreinigungen aus wäßobiger Lösung noch einmal umgefällt. Das so gewonnene fast weiße Calciumsalz enthält etwa 5,5% Ca und 1 50/0 Au. Example 2 100 g of a keratin breakdown product obtained by hydrolysis of hair with 30 above sulfuric acid on the water bath to the solution, dialysis of the hydrolyzate and evaporation of the dialysate obtained to dryness is dissolved in 1 l of water and added to this solution I30 ccm of a 20 above aqueous gold chloride hydrochloric acid gradually added with stirring and at the same time so much calcium hydroxide entered that the reaction after the addition of the Gold chloride hydrochloric acid is weakly alkaline. After filtering the solution the calcium salt of gold keratinic acid is isolated by precipitation with alcohol and for the separation of small amounts of sparingly soluble impurities from the above Solution fell over again. The almost white calcium salt obtained in this way contains about 5.5% Ca and 1 50/0 Au.
Claims (1)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESCH112875D DE720937C (en) | 1936-12-24 | 1936-12-24 | Process for the production of therapeutically valuable gold compounds from keratin breakdown products |
| DK59701D DK59701C (en) | 1936-12-24 | 1937-12-22 | Process for the preparation of alkaline earth metal keratinates from keratinic acids or their salts. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESCH112875D DE720937C (en) | 1936-12-24 | 1936-12-24 | Process for the production of therapeutically valuable gold compounds from keratin breakdown products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE720937C true DE720937C (en) | 1942-05-20 |
Family
ID=7449726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DESCH112875D Expired DE720937C (en) | 1936-12-24 | 1936-12-24 | Process for the production of therapeutically valuable gold compounds from keratin breakdown products |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE720937C (en) |
| DK (1) | DK59701C (en) |
-
1936
- 1936-12-24 DE DESCH112875D patent/DE720937C/en not_active Expired
-
1937
- 1937-12-22 DK DK59701D patent/DK59701C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DK59701C (en) | 1942-04-27 |
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