CH204379A - Process for the production of the azo protein from mercury dianiline and serum protein. - Google Patents

Process for the production of the azo protein from mercury dianiline and serum protein.

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Publication number
CH204379A
CH204379A CH204379DA CH204379A CH 204379 A CH204379 A CH 204379A CH 204379D A CH204379D A CH 204379DA CH 204379 A CH204379 A CH 204379A
Authority
CH
Switzerland
Prior art keywords
protein
azo
dianiline
mercury
production
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH204379A publication Critical patent/CH204379A/en

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Description

  

      Verfahren    zur Herstellung des     Azoproteins    aus     Queeksilberdianilin    und Serumprotein.    Man hat bereits     Azoproteine    hergestellt,  jedoch sind Verbindungen von     Azoproteinen     mit Schwermetallen bisher nicht bekannt ge  wesen.  



  Es wurde nun gefunden, dass man diese  neuartigen Verbindungen erhalten kann, wenn  man     Schwermetallverbindungen    aromatischer  Amine     diazotiert    und dann mit Eiweiss kup  pelt, oder wenn man das Schwermetall nach  träglich in ein     Azoprotein    einführt.

   Das vor  liegende Patent betrifft ein Verfahren zur  Herstellung des     Azoproteins    aus     Quecksilber-          dianilin    und Serumprotein, welches dadurch  gekennzeichnet ist, dass man das     Quecksilber-          dianilin        diazotiert,    die     Diazoverbindung    mit  Serum kuppelt und das     Azoprotein    durch  Säurefällung abscheidet.  



  Die so erhaltene Verbindung ist eine braun  gefärbte Substanz mit Eiweisscharakter, die  in Wasser löslich, in Säuren und organischen  Lösungsmitteln unlöslich ist; sie soll für  chemotherapeutische Zwecke verwendet wer  den.    <I>Beispiel:</I>  <B>19</B>     Quecksilberdianilin    wird in salzsaurer  Lösung mit 52 cm' 0,1     rr-Natriumnitritlösung          diazotiert    und die     Diazoverbindung    mit 125 cm-'  Pferdeserum in     sodaalkalischer    Lösung ge  kuppelt. Das Produkt wird mit Säure um  gefällt und durch Dialyse gereinigt.

   Die dialy  sierte Lösung enthält bei einem Trockengehalt       von        3,8        %,        0,1        %        Quecksilber.  



      Process for the production of the azo protein from queek silver dianiline and serum protein. Azo proteins have already been made, but compounds of azo proteins with heavy metals have not been known to date.



  It has now been found that these novel compounds can be obtained if heavy metal compounds of aromatic amines are diazotized and then coupled with protein, or if the heavy metal is subsequently introduced into an azo protein.

   The present patent relates to a process for the production of the azo protein from mercury dianiline and serum protein, which is characterized in that the mercury dianiline is diazotized, the diazo compound is coupled with serum and the azo protein is deposited by acid precipitation.



  The compound thus obtained is a brown-colored substance with a protein character, which is soluble in water, insoluble in acids and organic solvents; it is intended to be used for chemotherapeutic purposes. <I> Example: </I> <B> 19 </B> Mercury dianiline is diazotized in a hydrochloric acid solution with 52 cm 0.1 rr sodium nitrite solution and the diazo compound is coupled with 125 cm horse serum in a soda-alkaline solution. The product is precipitated with acid and purified by dialysis.

   The dialy-based solution contains at a dry content of 3.8%, 0.1% mercury.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung des Azoproteins aus Quecksilberdianilin und Serumprotein, da durch gekennzeichnet, dass man das Queck- silberdianilin diazotiert, an Serum kuppelt und das Azoprotein durch Säurefällung ab scheidet. Die so erhaltene Verbindung ist eine braun gefärbte Substanz mit Eiweisscharakter, die in Wasser löslich, in Säuren und organischen Lösungsmitteln unlöslich ist; sie soll für chemotherapeutische Zwecke verwendet wer den. PATENT CLAIM: Process for the production of the azo protein from mercury dianiline and serum protein, characterized in that the mercury dianiline is diazotized, coupled to serum and the azo protein separated by acid precipitation. The compound thus obtained is a brown-colored substance with a protein character, which is soluble in water, insoluble in acids and organic solvents; it is intended to be used for chemotherapeutic purposes.
CH204379D 1936-08-13 1936-08-13 Process for the production of the azo protein from mercury dianiline and serum protein. CH204379A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH204379T 1936-08-13

Publications (1)

Publication Number Publication Date
CH204379A true CH204379A (en) 1939-04-30

Family

ID=4444137

Family Applications (1)

Application Number Title Priority Date Filing Date
CH204379D CH204379A (en) 1936-08-13 1936-08-13 Process for the production of the azo protein from mercury dianiline and serum protein.

Country Status (1)

Country Link
CH (1) CH204379A (en)

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