JPS5618999A

JPS5618999A - Preparation of 25-hydroxy-24-oxocholestane derivative

Preparation of 25-hydroxy-24-oxocholestane derivative

Info

Publication number: JPS5618999A
Authority: JP; Japan
Prior art keywords: oxocholestane; derivative; hydroxy; preparation; hydroperoxy
Prior art date: 1979-07-26
Legal status : Granted

Application number

JP9418379A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6220997B2 (enrdf_load_stackoverflow

Inventor

Osamu Nishikawa

Kenji Ishimaru

Toru Takeshita

Hideki Tsuruta

Current Assignee

Teijin Ltd

Original Assignee

Teijin Ltd

Priority date

1979-07-26

Filing date

1979-07-26

Publication date

1981-02-23

1979-07-26 Application filed by Teijin Ltd filed Critical Teijin Ltd

1979-07-26 Priority to JP9418379A priority Critical patent/JPS5618999A/ja

1980-02-14 Priority to CA000345624A priority patent/CA1138859A/en

1980-02-14 Priority to DE8080300426T priority patent/DE3064789D1/de

1980-02-14 Priority to DK063080A priority patent/DK162648C/da

1980-02-14 Priority to EP82200223A priority patent/EP0055999B1/en

1980-02-14 Priority to DE8282200223T priority patent/DE3069391D1/de

1980-02-14 Priority to EP80300426A priority patent/EP0015122B1/en

1980-02-15 Priority to US06/121,857 priority patent/US4292249A/en

1981-02-23 Publication of JPS5618999A publication Critical patent/JPS5618999A/ja

1985-05-24 Priority to DK233585A priority patent/DK233585D0/da

1987-05-11 Publication of JPS6220997B2 publication Critical patent/JPS6220997B2/ja

Status Granted legal-status Critical Current

Links

BLSMMOLVDURDEB-BMXWGISTSA-N (6r)-6-[(8r,9s,10s,13r,14s,17r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-hydroxy-2-methylheptan-3-one Chemical class C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC(=O)C(C)(C)O)C)[C@@]1(C)CC2 BLSMMOLVDURDEB-BMXWGISTSA-N 0.000 title 1
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 abstract 3
WSMIHAXRUXBPHY-BMXWGISTSA-N (6r)-6-[(8r,9s,10s,13r,14s,17r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-hydroperoxy-2-methylheptan-3-one Chemical class C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC(=O)C(C)(C)OO)C)[C@@]1(C)CC2 WSMIHAXRUXBPHY-BMXWGISTSA-N 0.000 abstract 2
229910052751 metal Inorganic materials 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
239000012434 nucleophilic reagent Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
239000011647 vitamin D3 Substances 0.000 abstract 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1