JPS57188542A - Preparation of tetrahydronaphthacene derivative - Google Patents
Preparation of tetrahydronaphthacene derivativeInfo
- Publication number
- JPS57188542A JPS57188542A JP7394681A JP7394681A JPS57188542A JP S57188542 A JPS57188542 A JP S57188542A JP 7394681 A JP7394681 A JP 7394681A JP 7394681 A JP7394681 A JP 7394681A JP S57188542 A JPS57188542 A JP S57188542A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reacting
- tetrahydronaphthacene
- hydrolyzing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as a drug, without protecting the side chain ketone group, by using a compound such as 9-acetyl-6,9,11-trihydroxy-7,8,9,10-tetrahydronaphthacene-5,12-dione, as a raw material.
CONSTITUTION: The objective compound of formula VII (R' is H or alkanoyl) can be prepared by (1) reacting the compound of formulaIwith a halogenation reagent such as N-bromosuccinimide to obtain the compound of formula II (X is halogen), (2) reacting the product with a carboxylic acid metal salt of formula III (R is lower in a solvent such as diethyl ether in the presence of a halogenation reagent such as chlorine to obtain the compound of formula V, (4) reacting the comound with sodium salt or potassium salt of trifluoroacetic acid and hydrolyzing the resultant compound of formula VI, and (5) if necessary further hydrolyzing the produced compound.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7394681A JPS57188542A (en) | 1981-05-15 | 1981-05-15 | Preparation of tetrahydronaphthacene derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7394681A JPS57188542A (en) | 1981-05-15 | 1981-05-15 | Preparation of tetrahydronaphthacene derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57188542A true JPS57188542A (en) | 1982-11-19 |
Family
ID=13532769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7394681A Pending JPS57188542A (en) | 1981-05-15 | 1981-05-15 | Preparation of tetrahydronaphthacene derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57188542A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020117468A (en) * | 2019-01-25 | 2020-08-06 | 日本マイクロバイオファーマ株式会社 | Production method of 14-bromo anthracycline |
-
1981
- 1981-05-15 JP JP7394681A patent/JPS57188542A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020117468A (en) * | 2019-01-25 | 2020-08-06 | 日本マイクロバイオファーマ株式会社 | Production method of 14-bromo anthracycline |
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