JPS56138180A - Di-n6',o3-demethylistamycin a and its preparation - Google Patents
Di-n6',o3-demethylistamycin a and its preparationInfo
- Publication number
- JPS56138180A JPS56138180A JP3888980A JP3888980A JPS56138180A JP S56138180 A JPS56138180 A JP S56138180A JP 3888980 A JP3888980 A JP 3888980A JP 3888980 A JP3888980 A JP 3888980A JP S56138180 A JPS56138180 A JP S56138180A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- demethylistamycin
- protected
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003277 amino group Chemical group 0.000 abstract 4
- 125000006239 protecting group Chemical group 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical group C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- NEFDRWXEVITQMN-JWYRXTSNSA-N Sannamycin A Chemical compound O1[C@H](CNC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@H](N(C)C(=O)CN)[C@@H](OC)C[C@@H]1N NEFDRWXEVITQMN-JWYRXTSNSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 229940126575 aminoglycoside Drugs 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- NEFDRWXEVITQMN-UHFFFAOYSA-N istamycin B Natural products O1C(CNC)CCC(N)C1OC1C(O)C(N(C)C(=O)CN)C(OC)CC1N NEFDRWXEVITQMN-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3888980A JPS56138180A (en) | 1980-03-28 | 1980-03-28 | Di-n6',o3-demethylistamycin a and its preparation |
| GB8108886A GB2073182B (en) | 1980-03-28 | 1981-03-20 | Di-n6',o3-demethylistamycin a and preparation thereof |
| DE3111859A DE3111859C2 (de) | 1980-03-28 | 1981-03-26 | Di-N↑6↑↑'↑,O↑3↑-desmethylistamycin A Verfahren zu dessen Herstellung und diese Verbindung enthaltende pharmazeutische Zubereitungen |
| IT09369/81A IT1167854B (it) | 1980-03-28 | 1981-03-27 | Di-n6'-,03-demetilistamicina a avente attivita' antibatterica,e sua preparazione |
| CA000374047A CA1175817A (en) | 1980-03-28 | 1981-03-27 | Di-n su6' xx, o.sup.3-demethylistamycin a and preparation thereof |
| IT1981A09369A IT8109369A1 (it) | 1980-03-28 | 1981-03-27 | Di-n6', 03-demetilistamicina a avente attivita' antibatterica, e sua preparazione |
| FR8106816A FR2482107A1 (fr) | 1980-03-28 | 1981-03-27 | Nouvel antibiotique aminoglycosidique derive de l'istamycine a, procede de preparation et compositions pharmaceutiques le renfermant |
| US06/530,006 US4474946A (en) | 1980-03-28 | 1983-09-07 | Di-N6', O3 -Demethylistamycin A preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3888980A JPS56138180A (en) | 1980-03-28 | 1980-03-28 | Di-n6',o3-demethylistamycin a and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56138180A true JPS56138180A (en) | 1981-10-28 |
| JPS6362513B2 JPS6362513B2 (ja) | 1988-12-02 |
Family
ID=12537765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3888980A Granted JPS56138180A (en) | 1980-03-28 | 1980-03-28 | Di-n6',o3-demethylistamycin a and its preparation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4474946A (ja) |
| JP (1) | JPS56138180A (ja) |
| CA (1) | CA1175817A (ja) |
| DE (1) | DE3111859C2 (ja) |
| FR (1) | FR2482107A1 (ja) |
| GB (1) | GB2073182B (ja) |
| IT (2) | IT8109369A1 (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS617284A (ja) * | 1984-06-22 | 1986-01-13 | Daicel Chem Ind Ltd | 糖類アセチル誘導体の選択的脱アセチル化方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231924A (en) * | 1976-09-23 | 1980-11-04 | Abbott Laboratories | 4-N-Acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A |
| US4312858A (en) * | 1978-07-13 | 1982-01-26 | Kowa Company, Ltd. | Antibiotic KA-7038 and compositions containing same |
| SE447386B (sv) * | 1978-10-18 | 1986-11-10 | Kowa Co | Aminoglykosider, komposition innehallande dem samt forfarande for framstellning av dem |
| US4330673A (en) * | 1979-03-29 | 1982-05-18 | Abbott Laboratories | Process for producing 3-O-demethylaminoglycoside and novel 3-O-demethylfortimicin derivatives |
| US4282211A (en) * | 1979-09-26 | 1981-08-04 | Abbott Laboratories | 1-Epi-2-deoxyfortimicin B and derivatives |
| US4251516A (en) * | 1979-09-26 | 1981-02-17 | Abbott Laboratories | 2-Deoxy-3-O-Demethylfortimicins |
| US4382926A (en) * | 1980-04-01 | 1983-05-10 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics |
| JPS5740496A (en) * | 1980-08-22 | 1982-03-06 | Microbial Chem Res Found | Low toxic derivative of istamycin antibiotic |
| JPS5772998A (en) * | 1980-10-24 | 1982-05-07 | Shionogi & Co Ltd | Novel appamycin derivative |
| JPS5775994A (en) * | 1980-10-27 | 1982-05-12 | Shionogi & Co Ltd | Novel aprosamine derivative |
-
1980
- 1980-03-28 JP JP3888980A patent/JPS56138180A/ja active Granted
-
1981
- 1981-03-20 GB GB8108886A patent/GB2073182B/en not_active Expired
- 1981-03-26 DE DE3111859A patent/DE3111859C2/de not_active Expired
- 1981-03-27 IT IT1981A09369A patent/IT8109369A1/it unknown
- 1981-03-27 CA CA000374047A patent/CA1175817A/en not_active Expired
- 1981-03-27 FR FR8106816A patent/FR2482107A1/fr active Granted
- 1981-03-27 IT IT09369/81A patent/IT1167854B/it active
-
1983
- 1983-09-07 US US06/530,006 patent/US4474946A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT8109369A1 (it) | 1982-09-27 |
| GB2073182B (en) | 1983-09-21 |
| US4474946A (en) | 1984-10-02 |
| DE3111859A1 (de) | 1982-02-11 |
| CA1175817A (en) | 1984-10-09 |
| DE3111859C2 (de) | 1983-03-03 |
| GB2073182A (en) | 1981-10-14 |
| IT1167854B (it) | 1987-05-20 |
| FR2482107A1 (fr) | 1981-11-13 |
| IT8109369A0 (it) | 1981-03-27 |
| JPS6362513B2 (ja) | 1988-12-02 |
| FR2482107B1 (ja) | 1984-02-10 |
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