JPS56122366A - Tetrazole derivative - Google Patents
Tetrazole derivativeInfo
- Publication number
- JPS56122366A JPS56122366A JP2708480A JP2708480A JPS56122366A JP S56122366 A JPS56122366 A JP S56122366A JP 2708480 A JP2708480 A JP 2708480A JP 2708480 A JP2708480 A JP 2708480A JP S56122366 A JPS56122366 A JP S56122366A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- agent
- cycloalkyl
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound of formula I (R1 is H, lower alkyl, phenyl, or cycloalkyl; A is lower alkylene; R2 is lower alkyl, phenyl or cycloalkyl).
EXAMPLE: 3-(1-Methyl-1,2,3,4-tetrazol-5-yl)thiopropyl ethyl ketone.
USE: Antiulcer agent and antiphlogistic agent.
PROCESS: The compound of formula I is prepared, e.g. by reacting the compound of formula II with the compound of formula III(X is halogen) in the presence of sodium iodide, etc. using a dehydrohalogenating agent (e.g. NaOH) at 50W150°C. As an alternative method, it can be obtained by reacting the compound of formula II with a compound of formula X-A-CN to obtain the compound of formula IV, which is made to react with a Grignard reagent of formula R2MgX in an inert solvent at -30°CW room temp. for 1W6hr.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2708480A JPS56122366A (en) | 1980-03-03 | 1980-03-03 | Tetrazole derivative |
FI810571A FI73423C (en) | 1980-02-29 | 1981-02-24 | FRAMEWORK FOR THE FRAMEWORK OF PHARMACOLOGICAL VEHICLES TETRAZOLDERIVAT. |
EP81101352A EP0035228B1 (en) | 1980-02-29 | 1981-02-25 | Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same |
PT72569A PT72569B (en) | 1980-02-29 | 1981-02-25 | Tetrazole derivatives process for the preparation thereof and anti-ulcer composition |
AU67638/81A AU537266B2 (en) | 1980-02-29 | 1981-02-25 | Tetrazole derivatives |
DE8181101352T DE3167997D1 (en) | 1980-02-29 | 1981-02-25 | Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same |
AT81101352T ATE11047T1 (en) | 1980-02-29 | 1981-02-25 | TETRAZOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND ANTI-ULCER COMPOSITION CONTAINING THEM. |
DK088081A DK162524C (en) | 1980-02-29 | 1981-02-26 | ANALOGY PROCEDURE FOR THE PREPARATION OF 5-ALKYLTHIO-TETRAZOLD DERIVATIVES |
MX815964A MX157430A (en) | 1980-02-29 | 1981-02-27 | PROCEDURE FOR THE PREPARATION OF TETRAZOLE DERIVATIVES |
ES499930A ES499930A0 (en) | 1980-02-29 | 1981-02-27 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
US06/239,044 US4372953A (en) | 1980-02-29 | 1981-02-27 | Tetrazole derivatives, and anti-ulcer composition containing the same |
PH25282A PH17406A (en) | 1980-02-29 | 1981-02-27 | Tetrazole derivatives and anti-ulcer composition containing the same |
NO810675A NO166320C (en) | 1980-02-29 | 1981-02-27 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE TETRAZOLD DERIVATIVES. |
CA000372021A CA1162196A (en) | 1980-02-29 | 1981-02-27 | Tetrazole derivatives having prophylactic and therapeutic activities against peptic and duodenal ulcers |
ES510404A ES510404A0 (en) | 1980-02-29 | 1982-03-12 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES510403A ES8307228A1 (en) | 1980-02-29 | 1982-03-12 | 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents |
ES510405A ES510405A0 (en) | 1980-02-29 | 1982-03-12 | "A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE". |
ES511822A ES8303367A1 (en) | 1980-02-29 | 1982-04-29 | A procedure for the preparation of a tetrazol derivative. (Machine-translation by Google Translate, not legally binding) |
ES520699A ES8404336A1 (en) | 1980-02-29 | 1983-03-16 | 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents |
ES83520900A ES8404997A1 (en) | 1980-02-29 | 1983-03-23 | 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents |
ES520898A ES520898A0 (en) | 1980-02-29 | 1983-03-23 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES520899A ES520899A0 (en) | 1980-02-29 | 1983-03-23 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2708480A JPS56122366A (en) | 1980-03-03 | 1980-03-03 | Tetrazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56122366A true JPS56122366A (en) | 1981-09-25 |
JPH0122271B2 JPH0122271B2 (en) | 1989-04-25 |
Family
ID=12211203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2708480A Granted JPS56122366A (en) | 1980-02-29 | 1980-03-03 | Tetrazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56122366A (en) |
-
1980
- 1980-03-03 JP JP2708480A patent/JPS56122366A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH0122271B2 (en) | 1989-04-25 |
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