JPS56122366A - Tetrazole derivative - Google Patents

Tetrazole derivative

Info

Publication number
JPS56122366A
JPS56122366A JP2708480A JP2708480A JPS56122366A JP S56122366 A JPS56122366 A JP S56122366A JP 2708480 A JP2708480 A JP 2708480A JP 2708480 A JP2708480 A JP 2708480A JP S56122366 A JPS56122366 A JP S56122366A
Authority
JP
Japan
Prior art keywords
formula
compound
agent
cycloalkyl
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2708480A
Other languages
Japanese (ja)
Other versions
JPH0122271B2 (en
Inventor
Minoru Uchida
Takao Nishi
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP2708480A priority Critical patent/JPS56122366A/en
Priority to FI810571A priority patent/FI73423C/en
Priority to EP81101352A priority patent/EP0035228B1/en
Priority to PT72569A priority patent/PT72569B/en
Priority to AU67638/81A priority patent/AU537266B2/en
Priority to DE8181101352T priority patent/DE3167997D1/en
Priority to AT81101352T priority patent/ATE11047T1/en
Priority to DK088081A priority patent/DK162524C/en
Priority to PH25282A priority patent/PH17406A/en
Priority to US06/239,044 priority patent/US4372953A/en
Priority to MX815964A priority patent/MX157430A/en
Priority to NO810675A priority patent/NO166320C/en
Priority to CA000372021A priority patent/CA1162196A/en
Priority to ES499930A priority patent/ES499930A0/en
Publication of JPS56122366A publication Critical patent/JPS56122366A/en
Priority to ES510404A priority patent/ES510404A0/en
Priority to ES510403A priority patent/ES8307228A1/en
Priority to ES510405A priority patent/ES510405A0/en
Priority to ES511822A priority patent/ES8303367A1/en
Priority to ES520699A priority patent/ES8404336A1/en
Priority to ES83520900A priority patent/ES8404997A1/en
Priority to ES520898A priority patent/ES520898A0/en
Priority to ES520899A priority patent/ES520899A0/en
Publication of JPH0122271B2 publication Critical patent/JPH0122271B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formula I (R1 is H, lower alkyl, phenyl, or cycloalkyl; A is lower alkylene; R2 is lower alkyl, phenyl or cycloalkyl).
EXAMPLE: 3-(1-Methyl-1,2,3,4-tetrazol-5-yl)thiopropyl ethyl ketone.
USE: Antiulcer agent and antiphlogistic agent.
PROCESS: The compound of formula I is prepared, e.g. by reacting the compound of formula II with the compound of formula III(X is halogen) in the presence of sodium iodide, etc. using a dehydrohalogenating agent (e.g. NaOH) at 50W150°C. As an alternative method, it can be obtained by reacting the compound of formula II with a compound of formula X-A-CN to obtain the compound of formula IV, which is made to react with a Grignard reagent of formula R2MgX in an inert solvent at -30°CW room temp. for 1W6hr.
COPYRIGHT: (C)1981,JPO&Japio
JP2708480A 1980-02-29 1980-03-03 Tetrazole derivative Granted JPS56122366A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
JP2708480A JPS56122366A (en) 1980-03-03 1980-03-03 Tetrazole derivative
FI810571A FI73423C (en) 1980-02-29 1981-02-24 FRAMEWORK FOR THE FRAMEWORK OF PHARMACOLOGICAL VEHICLES TETRAZOLDERIVAT.
EP81101352A EP0035228B1 (en) 1980-02-29 1981-02-25 Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same
PT72569A PT72569B (en) 1980-02-29 1981-02-25 Tetrazole derivatives process for the preparation thereof and anti-ulcer composition
AU67638/81A AU537266B2 (en) 1980-02-29 1981-02-25 Tetrazole derivatives
DE8181101352T DE3167997D1 (en) 1980-02-29 1981-02-25 Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same
AT81101352T ATE11047T1 (en) 1980-02-29 1981-02-25 TETRAZOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND ANTI-ULCER COMPOSITION CONTAINING THEM.
DK088081A DK162524C (en) 1980-02-29 1981-02-26 ANALOGY PROCEDURE FOR THE PREPARATION OF 5-ALKYLTHIO-TETRAZOLD DERIVATIVES
MX815964A MX157430A (en) 1980-02-29 1981-02-27 PROCEDURE FOR THE PREPARATION OF TETRAZOLE DERIVATIVES
ES499930A ES499930A0 (en) 1980-02-29 1981-02-27 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.
US06/239,044 US4372953A (en) 1980-02-29 1981-02-27 Tetrazole derivatives, and anti-ulcer composition containing the same
PH25282A PH17406A (en) 1980-02-29 1981-02-27 Tetrazole derivatives and anti-ulcer composition containing the same
NO810675A NO166320C (en) 1980-02-29 1981-02-27 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE TETRAZOLD DERIVATIVES.
CA000372021A CA1162196A (en) 1980-02-29 1981-02-27 Tetrazole derivatives having prophylactic and therapeutic activities against peptic and duodenal ulcers
ES510404A ES510404A0 (en) 1980-02-29 1982-03-12 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.
ES510403A ES8307228A1 (en) 1980-02-29 1982-03-12 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents
ES510405A ES510405A0 (en) 1980-02-29 1982-03-12 "A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE".
ES511822A ES8303367A1 (en) 1980-02-29 1982-04-29 A procedure for the preparation of a tetrazol derivative. (Machine-translation by Google Translate, not legally binding)
ES520699A ES8404336A1 (en) 1980-02-29 1983-03-16 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents
ES83520900A ES8404997A1 (en) 1980-02-29 1983-03-23 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents
ES520898A ES520898A0 (en) 1980-02-29 1983-03-23 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.
ES520899A ES520899A0 (en) 1980-02-29 1983-03-23 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2708480A JPS56122366A (en) 1980-03-03 1980-03-03 Tetrazole derivative

Publications (2)

Publication Number Publication Date
JPS56122366A true JPS56122366A (en) 1981-09-25
JPH0122271B2 JPH0122271B2 (en) 1989-04-25

Family

ID=12211203

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2708480A Granted JPS56122366A (en) 1980-02-29 1980-03-03 Tetrazole derivative

Country Status (1)

Country Link
JP (1) JPS56122366A (en)

Also Published As

Publication number Publication date
JPH0122271B2 (en) 1989-04-25

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