ATE11047T1 - TETRAZOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND ANTI-ULCER COMPOSITION CONTAINING THEM. - Google Patents
TETRAZOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND ANTI-ULCER COMPOSITION CONTAINING THEM.Info
- Publication number
- ATE11047T1 ATE11047T1 AT81101352T AT81101352T ATE11047T1 AT E11047 T1 ATE11047 T1 AT E11047T1 AT 81101352 T AT81101352 T AT 81101352T AT 81101352 T AT81101352 T AT 81101352T AT E11047 T1 ATE11047 T1 AT E11047T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- opt
- phenyl
- substd
- cycloalkyl
- Prior art date
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tetrazole derivs. of formula (I) and their salts are new: (where (a) R1 is lower alkyl or phenyl and R2 is BCOR4, or (b) R1 is S(O)n-A-(X)m-R3 and R2 is H, lower alkyl, phenyl or cycloalkyl. In case (a), B is lower alkylene and R4 is OH, lower alkoxy or NR1OR11, where R10 and R11 are (i) H, (ii) lower alkyl opt. substd. by OH, furyl, pyridyl, phenyl or mono- or dialkoxyphenyl, (iii) cycloalkyl opt. substd. by OH or alkoxy, (iv) phenyl opt. mono- or disubstd. by alkyl, alkoxy, halogen, NO2, COOH and/or alkylamino, or (v) thiazolyl, or NR1OR11 is a 5- or 6- membered satd. ring opt. contg. another heteroatom (N or O) and opt. substd. by alkyl. In case (b). X is CO or S(O)x; n and x are 0-2; m = 0 or 1; A is 1-8C alkylene; R3 is (i) lower alkyl, cycloalkyl or naphthyl, (ii) C(NH)NHR5, where R5 is alkyl, (iii) phenylalkyl opt. ring-substd. by halogen, (iv) phenyl opt. substd. by 1-3 gps. selected from halogen, alkyl, alkoxy, alkanoylamino, OH, COOH and NH2, (v) pyridyl-, furyl- or thiazolyalkyl opt. substd. by alkyl or NH2, (vi) a heterocyclic gp. with 1-4 heteroatoms selected from N, O and S and opt. 1 or 2 substituents selected from alkyl, halogen, COOH, oxo, NH2, alkoxycarbonyl, alkoxy, OH, NO2, Ph, cycloalkyl and alkylamino, or (vii) NR6R7, where R6 is H, alkyl or phenylalkyl and R7 is H, alkyl, C(Z)NHR8, tetrazolyl, alkyltetrazolyl or COR9, where Z is S, NH or N-alkyl, R8 is alkyl or NH2 and R9 is alkyl, phenyl, mono-, di- or trialkoxyphenyl, cycloalkyl or a 5- or 6- membered unsatd. heterocyclic gp. with a N or O heteroatom, or NR6R7 is phthalimido; with the proviso that m must be O when R3 is NR6R7, and that R3 cannot be unsubstd. phenylalkyl or phenyl when m=O). (I) have anti-ulcer activity, e.g. giving more than 50% redn. in gastric juice vol., total acidity and pepsin activity at doses of 100 mg/kg (s.c., rat) in the Shay pylorus ligation test.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2552180A JPS56122363A (en) | 1980-02-29 | 1980-02-29 | Tetrazole derivative |
JP2570780A JPS56122364A (en) | 1980-03-01 | 1980-03-01 | Tetrazole derivative |
JP2570880A JPS56122365A (en) | 1980-03-01 | 1980-03-01 | Tetrazole derivative |
JP2708480A JPS56122366A (en) | 1980-03-03 | 1980-03-03 | Tetrazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE11047T1 true ATE11047T1 (en) | 1985-01-15 |
Family
ID=27458331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT81101352T ATE11047T1 (en) | 1980-02-29 | 1981-02-25 | TETRAZOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND ANTI-ULCER COMPOSITION CONTAINING THEM. |
Country Status (2)
Country | Link |
---|---|
AT (1) | ATE11047T1 (en) |
ES (8) | ES8300723A1 (en) |
-
1981
- 1981-02-25 AT AT81101352T patent/ATE11047T1/en not_active IP Right Cessation
- 1981-02-27 ES ES499930A patent/ES8300723A1/en not_active Expired
-
1982
- 1982-03-12 ES ES510404A patent/ES510404A0/en active Granted
- 1982-03-12 ES ES510405A patent/ES510405A0/en active Granted
- 1982-03-12 ES ES510403A patent/ES510403A0/en active Granted
-
1983
- 1983-03-16 ES ES520699A patent/ES520699A0/en active Granted
- 1983-03-23 ES ES83520900A patent/ES8404997A1/en not_active Expired
- 1983-03-23 ES ES520898A patent/ES8405383A1/en not_active Expired
- 1983-03-23 ES ES520899A patent/ES520899A0/en active Granted
Also Published As
Publication number | Publication date |
---|---|
ES499930A0 (en) | 1982-11-16 |
ES520898A0 (en) | 1984-06-01 |
ES8307228A1 (en) | 1983-06-16 |
ES8303366A1 (en) | 1983-02-01 |
ES8404336A1 (en) | 1984-04-16 |
ES8405384A1 (en) | 1984-06-01 |
ES8307229A1 (en) | 1983-06-16 |
ES510405A0 (en) | 1983-06-16 |
ES520899A0 (en) | 1984-06-01 |
ES8405383A1 (en) | 1984-06-01 |
ES510403A0 (en) | 1983-06-16 |
ES520900A0 (en) | 1984-05-16 |
ES510404A0 (en) | 1983-02-01 |
ES520699A0 (en) | 1984-04-16 |
ES8300723A1 (en) | 1982-11-16 |
ES8404997A1 (en) | 1984-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |