JPS56122363A - Tetrazole derivative - Google Patents

Tetrazole derivative

Info

Publication number
JPS56122363A
JPS56122363A JP2552180A JP2552180A JPS56122363A JP S56122363 A JPS56122363 A JP S56122363A JP 2552180 A JP2552180 A JP 2552180A JP 2552180 A JP2552180 A JP 2552180A JP S56122363 A JPS56122363 A JP S56122363A
Authority
JP
Japan
Prior art keywords
formula
compound
react
agent
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2552180A
Other languages
Japanese (ja)
Other versions
JPH0123464B2 (en
Inventor
Minoru Uchida
Takao Nishi
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP2552180A priority Critical patent/JPS56122363A/en
Priority to ZA00811178A priority patent/ZA811178B/en
Priority to FI810571A priority patent/FI73423C/en
Priority to KR1019810000593A priority patent/KR840001570B1/en
Priority to EP81101352A priority patent/EP0035228B1/en
Priority to DE8181101352T priority patent/DE3167997D1/en
Priority to PT72569A priority patent/PT72569B/en
Priority to AT81101352T priority patent/ATE11047T1/en
Priority to AU67638/81A priority patent/AU537266B2/en
Priority to DK088081A priority patent/DK162524C/en
Priority to PH25282A priority patent/PH17406A/en
Priority to ES499930A priority patent/ES499930A0/en
Priority to CA000372021A priority patent/CA1162196A/en
Priority to US06/239,044 priority patent/US4372953A/en
Priority to MX815964A priority patent/MX157430A/en
Priority to NO810675A priority patent/NO166320C/en
Publication of JPS56122363A publication Critical patent/JPS56122363A/en
Priority to ES510405A priority patent/ES510405A0/en
Priority to ES510403A priority patent/ES8307228A1/en
Priority to ES510404A priority patent/ES8303366A1/en
Priority to ES511822A priority patent/ES511822A0/en
Priority to ES520699A priority patent/ES520699A0/en
Priority to ES520898A priority patent/ES520898A0/en
Priority to ES520899A priority patent/ES8405384A1/en
Priority to ES83520900A priority patent/ES520900A0/en
Priority to KR1019840004273A priority patent/KR840002343B1/en
Publication of JPH0123464B2 publication Critical patent/JPH0123464B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A tetrazole derivative of formula I [R1 is lower alkyl; A is lower alkylene; R2 is OH, lower alkoxy, or group formula -N(R3)R4 (R3 and R4 are H, lower alkyl, or cycloalkyl)] and its salt.
EXAMPLE: 4-(5-Methyl-1,2,3,4-tetrazol-1-yl)butyric acid.
USE: Antiulcer agent and antiphlogistic agent.
PROCESS: For example, reaction of an aminocarboxylic acid of formula (2) with a lower alcohol of formula (3) (R5 is alkyl) gives an aminocarboxylic acid ester of formula (4), which is made to react with a carboxylic acid halide of formula (5) (X is halogen) in the presence of a dehydrohalogenating agent to afford a compound of formula (6). The compound is made to react with PCl5, and the resulting imine derivative is made to react with HN3 without separating from the reaction system to obtain the compound of formula (10). Hydrolysis of the compound of formula (10) affords the compound of formula Ib, which can be converted to the compound of formula Ic by reacting with an amine of formula (7).
COPYRIGHT: (C)1981,JPO&Japio
JP2552180A 1980-02-29 1980-02-29 Tetrazole derivative Granted JPS56122363A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
JP2552180A JPS56122363A (en) 1980-02-29 1980-02-29 Tetrazole derivative
ZA00811178A ZA811178B (en) 1980-02-29 1981-02-23 Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same
FI810571A FI73423C (en) 1980-02-29 1981-02-24 FRAMEWORK FOR THE FRAMEWORK OF PHARMACOLOGICAL VEHICLES TETRAZOLDERIVAT.
KR1019810000593A KR840001570B1 (en) 1980-02-29 1981-02-24 Process for preparing tetrazole derivatives
EP81101352A EP0035228B1 (en) 1980-02-29 1981-02-25 Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same
DE8181101352T DE3167997D1 (en) 1980-02-29 1981-02-25 Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same
PT72569A PT72569B (en) 1980-02-29 1981-02-25 Tetrazole derivatives process for the preparation thereof and anti-ulcer composition
AT81101352T ATE11047T1 (en) 1980-02-29 1981-02-25 TETRAZOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND ANTI-ULCER COMPOSITION CONTAINING THEM.
AU67638/81A AU537266B2 (en) 1980-02-29 1981-02-25 Tetrazole derivatives
DK088081A DK162524C (en) 1980-02-29 1981-02-26 ANALOGY PROCEDURE FOR THE PREPARATION OF 5-ALKYLTHIO-TETRAZOLD DERIVATIVES
CA000372021A CA1162196A (en) 1980-02-29 1981-02-27 Tetrazole derivatives having prophylactic and therapeutic activities against peptic and duodenal ulcers
NO810675A NO166320C (en) 1980-02-29 1981-02-27 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE TETRAZOLD DERIVATIVES.
ES499930A ES499930A0 (en) 1980-02-29 1981-02-27 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.
PH25282A PH17406A (en) 1980-02-29 1981-02-27 Tetrazole derivatives and anti-ulcer composition containing the same
US06/239,044 US4372953A (en) 1980-02-29 1981-02-27 Tetrazole derivatives, and anti-ulcer composition containing the same
MX815964A MX157430A (en) 1980-02-29 1981-02-27 PROCEDURE FOR THE PREPARATION OF TETRAZOLE DERIVATIVES
ES510405A ES510405A0 (en) 1980-02-29 1982-03-12 "A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE".
ES510403A ES8307228A1 (en) 1980-02-29 1982-03-12 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents
ES510404A ES8303366A1 (en) 1980-02-29 1982-03-12 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents
ES511822A ES511822A0 (en) 1980-02-29 1982-04-29 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.
ES520699A ES520699A0 (en) 1980-02-29 1983-03-16 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.
ES520898A ES520898A0 (en) 1980-02-29 1983-03-23 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.
ES520899A ES8405384A1 (en) 1980-02-29 1983-03-23 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents
ES83520900A ES520900A0 (en) 1980-02-29 1983-03-23 A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE.
KR1019840004273A KR840002343B1 (en) 1980-02-29 1984-07-19 Process for preparing tetrazole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2552180A JPS56122363A (en) 1980-02-29 1980-02-29 Tetrazole derivative

Publications (2)

Publication Number Publication Date
JPS56122363A true JPS56122363A (en) 1981-09-25
JPH0123464B2 JPH0123464B2 (en) 1989-05-02

Family

ID=12168353

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2552180A Granted JPS56122363A (en) 1980-02-29 1980-02-29 Tetrazole derivative

Country Status (3)

Country Link
JP (1) JPS56122363A (en)
KR (2) KR840001570B1 (en)
ZA (1) ZA811178B (en)

Also Published As

Publication number Publication date
KR840002343B1 (en) 1984-12-20
KR840001570B1 (en) 1984-10-06
JPH0123464B2 (en) 1989-05-02
KR850001460A (en) 1985-03-18
KR830005169A (en) 1983-08-03
ZA811178B (en) 1982-03-31

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