ES8404997A1 - 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents - Google Patents
1,5-Di:substd. tetrazole derivs. - useful as antiulcer agentsInfo
- Publication number
- ES8404997A1 ES8404997A1 ES83520900A ES520900A ES8404997A1 ES 8404997 A1 ES8404997 A1 ES 8404997A1 ES 83520900 A ES83520900 A ES 83520900A ES 520900 A ES520900 A ES 520900A ES 8404997 A1 ES8404997 A1 ES 8404997A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- opt
- substd
- phenyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tetrazole derivs. of formula (I) and their salts are new: (where (a) R1 is lower alkyl or phenyl and R2 is BCOR4, or (b) R1 is S(O)n-A-(X)m-R3 and R2 is H, lower alkyl, phenyl or cycloalkyl. In case (a), B is lower alkylene and R4 is OH, lower alkoxy or NR1OR11, where R10 and R11 are (i) H, (ii) lower alkyl opt. substd. by OH, furyl, pyridyl, phenyl or mono- or dialkoxyphenyl, (iii) cycloalkyl opt. substd. by OH or alkoxy, (iv) phenyl opt. mono- or disubstd. by alkyl, alkoxy, halogen, NO2, COOH and/or alkylamino, or (v) thiazolyl, or NR1OR11 is a 5- or 6- membered satd. ring opt. contg. another heteroatom (N or O) and opt. substd. by alkyl. In case (b). X is CO or S(O)x; n and x are 0-2; m = 0 or 1; A is 1-8C alkylene; R3 is (i) lower alkyl, cycloalkyl or naphthyl, (ii) C(NH)NHR5, where R5 is alkyl, (iii) phenylalkyl opt. ring-substd. by halogen, (iv) phenyl opt. substd. by 1-3 gps. selected from halogen, alkyl, alkoxy, alkanoylamino, OH, COOH and NH2, (v) pyridyl-, furyl- or thiazolyalkyl opt. substd. by alkyl or NH2, (vi) a heterocyclic gp. with 1-4 heteroatoms selected from N, O and S and opt. 1 or 2 substituents selected from alkyl, halogen, COOH, oxo, NH2, alkoxycarbonyl, alkoxy, OH, NO2, Ph, cycloalkyl and alkylamino, or (vii) NR6R7, where R6 is H, alkyl or phenylalkyl and R7 is H, alkyl, C(Z)NHR8, tetrazolyl, alkyltetrazolyl or COR9, where Z is S, NH or N-alkyl, R8 is alkyl or NH2 and R9 is alkyl, phenyl, mono-, di- or trialkoxyphenyl, cycloalkyl or a 5- or 6- membered unsatd. heterocyclic gp. with a N or O heteroatom, or NR6R7 is phthalimido; with the proviso that m must be O when R3 is NR6R7, and that R3 cannot be unsubstd. phenylalkyl or phenyl when m=O). (I) have anti-ulcer activity, e.g. giving more than 50% redn. in gastric juice vol., total acidity and pepsin activity at doses of 100 mg/kg (s.c., rat) in the Shay pylorus ligation test.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2552180A JPS56122363A (en) | 1980-02-29 | 1980-02-29 | Tetrazole derivative |
JP2570880A JPS56122365A (en) | 1980-03-01 | 1980-03-01 | Tetrazole derivative |
JP2570780A JPS56122364A (en) | 1980-03-01 | 1980-03-01 | Tetrazole derivative |
JP2708480A JPS56122366A (en) | 1980-03-03 | 1980-03-03 | Tetrazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
ES520900A0 ES520900A0 (en) | 1984-05-16 |
ES8404997A1 true ES8404997A1 (en) | 1984-05-16 |
Family
ID=27458331
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES499930A Expired ES8300723A1 (en) | 1980-02-29 | 1981-02-27 | 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents |
ES510403A Granted ES510403A0 (en) | 1980-02-29 | 1982-03-12 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES510404A Granted ES510404A0 (en) | 1980-02-29 | 1982-03-12 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES510405A Expired ES8307229A1 (en) | 1980-02-29 | 1982-03-12 | 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents |
ES520699A Granted ES520699A0 (en) | 1980-02-29 | 1983-03-16 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES520899A Granted ES520899A0 (en) | 1980-02-29 | 1983-03-23 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES520898A Granted ES520898A0 (en) | 1980-02-29 | 1983-03-23 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES83520900A Expired ES8404997A1 (en) | 1980-02-29 | 1983-03-23 | 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents |
Family Applications Before (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES499930A Expired ES8300723A1 (en) | 1980-02-29 | 1981-02-27 | 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents |
ES510403A Granted ES510403A0 (en) | 1980-02-29 | 1982-03-12 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES510404A Granted ES510404A0 (en) | 1980-02-29 | 1982-03-12 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES510405A Expired ES8307229A1 (en) | 1980-02-29 | 1982-03-12 | 1,5-Di:substd. tetrazole derivs. - useful as antiulcer agents |
ES520699A Granted ES520699A0 (en) | 1980-02-29 | 1983-03-16 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES520899A Granted ES520899A0 (en) | 1980-02-29 | 1983-03-23 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
ES520898A Granted ES520898A0 (en) | 1980-02-29 | 1983-03-23 | A PROCEDURE FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE. |
Country Status (2)
Country | Link |
---|---|
AT (1) | ATE11047T1 (en) |
ES (8) | ES8300723A1 (en) |
-
1981
- 1981-02-25 AT AT81101352T patent/ATE11047T1/en not_active IP Right Cessation
- 1981-02-27 ES ES499930A patent/ES8300723A1/en not_active Expired
-
1982
- 1982-03-12 ES ES510403A patent/ES510403A0/en active Granted
- 1982-03-12 ES ES510404A patent/ES510404A0/en active Granted
- 1982-03-12 ES ES510405A patent/ES8307229A1/en not_active Expired
-
1983
- 1983-03-16 ES ES520699A patent/ES520699A0/en active Granted
- 1983-03-23 ES ES520899A patent/ES520899A0/en active Granted
- 1983-03-23 ES ES520898A patent/ES520898A0/en active Granted
- 1983-03-23 ES ES83520900A patent/ES8404997A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES8405384A1 (en) | 1984-06-01 |
ES8307228A1 (en) | 1983-06-16 |
ES8404336A1 (en) | 1984-04-16 |
ES510403A0 (en) | 1983-06-16 |
ES520900A0 (en) | 1984-05-16 |
ES510405A0 (en) | 1983-06-16 |
ES8405383A1 (en) | 1984-06-01 |
ES8307229A1 (en) | 1983-06-16 |
ES520899A0 (en) | 1984-06-01 |
ES499930A0 (en) | 1982-11-16 |
ES520699A0 (en) | 1984-04-16 |
ES520898A0 (en) | 1984-06-01 |
ATE11047T1 (en) | 1985-01-15 |
ES8300723A1 (en) | 1982-11-16 |
ES8303366A1 (en) | 1983-02-01 |
ES510404A0 (en) | 1983-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |