JPS56100757A - Novel sufonamide* its manfacture and blood platelet aggregation inhibiting and*or lipid lowering drug containing it - Google Patents
Novel sufonamide* its manfacture and blood platelet aggregation inhibiting and*or lipid lowering drug containing itInfo
- Publication number
- JPS56100757A JPS56100757A JP54081A JP54081A JPS56100757A JP S56100757 A JPS56100757 A JP S56100757A JP 54081 A JP54081 A JP 54081A JP 54081 A JP54081 A JP 54081A JP S56100757 A JPS56100757 A JP S56100757A
- Authority
- JP
- Japan
- Prior art keywords
- sufonamide
- manfacture
- novel
- platelet aggregation
- drug containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001772 blood platelet Anatomy 0.000 title abstract 2
- 239000003524 antilipemic agent Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000000881 depressing effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Devices That Are Associated With Refrigeration Equipment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803000377 DE3000377A1 (de) | 1980-01-07 | 1980-01-07 | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56100757A true JPS56100757A (en) | 1981-08-12 |
| JPS6352625B2 JPS6352625B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-10-19 |
Family
ID=6091629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54081A Granted JPS56100757A (en) | 1980-01-07 | 1981-01-07 | Novel sufonamide* its manfacture and blood platelet aggregation inhibiting and*or lipid lowering drug containing it |
Country Status (22)
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01175962A (ja) * | 1987-12-28 | 1989-07-12 | Tanabe Seiyaku Co Ltd | フェニル酢酸誘導体 |
| JPH0296537A (ja) * | 1988-04-11 | 1990-04-09 | E R Squibb & Sons Inc | プロタミンの使用における有害作用の予防または減少用組成物 |
| WO1993013057A1 (en) * | 1991-12-20 | 1993-07-08 | Hokuriku Pharmaceutical Co., Ltd. | Substituted benzenesulfonamide derivative |
| WO1994007848A1 (en) * | 1992-10-01 | 1994-04-14 | Hokuriku Seiyaku Co., Ltd. | Benzenesulfonamide derivative and use thereof |
| JP2010525029A (ja) * | 2007-04-27 | 2010-07-22 | テイボテク・フアーマシユーチカルズ・リミテツド | Ｎ−イソブチル−ｎ−（２−ヒドロキシ−３−アミノ−４−フェニルブチル）−ｐ−ニトロベンゼンスルホニルアミド誘導体の製造方法 |
| JP2011527345A (ja) * | 2008-07-07 | 2011-10-27 | ファスジェン， インコーポレイテッド | 新規な化合物、この化合物を含む医薬組成物、この化合物の使用方法、およびこの化合物の調製方法 |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4401663A (en) * | 1981-06-30 | 1983-08-30 | The Procter & Gamble Company | Novel sulfonamide derivatives |
| AU567140B2 (en) * | 1984-01-06 | 1987-11-12 | Shionogi & Co., Ltd. | Sulphonamido-benzamide derivatives |
| EP0194548A3 (de) * | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE3535167A1 (de) * | 1985-10-02 | 1987-04-09 | Boehringer Mannheim Gmbh | Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel |
| US4689182A (en) * | 1985-12-20 | 1987-08-25 | Warner-Lambert Company | Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity |
| FR2598412B1 (fr) * | 1986-03-12 | 1988-10-21 | Sanofi Sa | Nouveaux derives de diarylcetones et leurs procedes de preparation et les compositions pharmaceutiques les contenant |
| IL83230A (en) * | 1986-08-06 | 1992-06-21 | Tanabe Seiyaku Co | Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
| DE3629929A1 (de) * | 1986-09-03 | 1988-03-10 | Thomae Gmbh Dr K | Neue sulfonamido-aethylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| AU600992B2 (en) * | 1986-10-28 | 1990-08-30 | Smith Kline & French Laboratories Limited | Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids |
| GB8708233D0 (en) * | 1987-04-07 | 1987-05-13 | Smith Kline French Lab | Pharmaceutically active compounds |
| KR880012221A (ko) * | 1987-04-13 | 1988-11-26 | 사노 가즈오 | 에스테르 또는 아미드를 활성성분으로 함유하는 약제 조성물 |
| CA1294974C (en) * | 1987-05-08 | 1992-01-28 | Sanji Hagishita | Bicyclic sulfonamide derivatives and process therefor |
| US4752616A (en) * | 1987-06-29 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use |
| GB8717374D0 (en) * | 1987-07-22 | 1987-08-26 | Smith Kline French Lab | Pharmaceutically active compounds |
| US4752613A (en) * | 1987-08-03 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Sulphonamidothienylcarboxylic acid compounds |
| US4783473A (en) * | 1987-09-02 | 1988-11-08 | E. R. Squibb & Sons, Inc. | Geminally substituted cyclic ether carboxylic acids, derivatives thereof, compositions containing same and method of use |
| US4931460A (en) * | 1987-09-17 | 1990-06-05 | E. R. Squibb & Sons, Inc. | Post-ischemic myocardial dysfunction using thromboxane A2 antagonists |
| EP0325245B1 (en) * | 1988-01-19 | 1993-10-20 | Tanabe Seiyaku Co., Ltd. | Phenoxyacetic acid derivatives, preparation thereof, pharmaceutical compositions comprising them and use |
| DE3819052A1 (de) * | 1988-06-04 | 1989-12-07 | Basf Ag | Neue sulfonamid-derivate, ihre herstellung und verwendung |
| DE3829455A1 (de) * | 1988-08-31 | 1990-03-15 | Boehringer Mannheim Gmbh | Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel |
| US4925873A (en) * | 1988-09-01 | 1990-05-15 | E. R. Squibb & Sons, Inc. | Method of treating skin injuries using thromboxane A2 receptor antagonists |
| US5280043A (en) * | 1988-10-10 | 1994-01-18 | Smith Kline & French Laboratories Ltd. | Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists |
| GB8823731D0 (en) * | 1988-10-10 | 1988-11-16 | Smith Kline French Lab | Biologically active compounds |
| US5006542A (en) * | 1988-10-31 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use |
| US5070099A (en) * | 1988-10-31 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use |
| US4959383A (en) * | 1988-10-31 | 1990-09-25 | E. R. Squibb & Sons, Inc. | Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use |
| US5106991A (en) * | 1989-06-02 | 1992-04-21 | E. R. Squibb & Sons, Inc. | Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof |
| US4975452A (en) * | 1989-06-02 | 1990-12-04 | E. R. Squibb & Sons, Inc. | Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof |
| US5153214A (en) * | 1989-06-28 | 1992-10-06 | Ciba-Geigy Corporation | Certain (arylsulfonamido- and imidazolyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity |
| US5025025A (en) * | 1989-06-28 | 1991-06-18 | Ciba-Geigy Corporation | (Arylsulfonamido- and pyridyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity |
| DE4010536A1 (de) * | 1990-04-02 | 1991-10-10 | Boehringer Mannheim Gmbh | Pharmazeutische waessrige loesung von 4-(2-(benzolsulfonylamino)-ethyl)-phenoxyessigsaeure |
| FR2665440B1 (fr) * | 1990-07-31 | 1994-02-04 | Lipha | Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant. |
| US5189211A (en) * | 1990-08-01 | 1993-02-23 | Taisho Pharmaceutical Co., Ltd. | Sulfonamide derivatives |
| US5409959A (en) * | 1991-01-29 | 1995-04-25 | Genelabs Incorporated | Antithrombotic treatment with calix(n)arene compounds |
| DE4109735A1 (de) * | 1991-03-25 | 1992-10-01 | Boehringer Mannheim Gmbh | Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US5280034A (en) * | 1991-08-23 | 1994-01-18 | E. R. Squibb & Sons, Inc. | Bis-heterocyclic prostaglandin analogs |
| US5827868A (en) * | 1991-10-07 | 1998-10-27 | E. R. Squibb & Sons, Inc. | Prostaglandin analogs |
| GB9220137D0 (en) * | 1992-09-23 | 1992-11-04 | Pfizer Ltd | Therapeutic agents |
| AU711159B2 (en) * | 1996-02-22 | 1999-10-07 | Tularik Inc. | Pentafluorobenzenesulfonamides and analogs |
| ATE249214T1 (de) * | 1996-07-19 | 2003-09-15 | Tularik Inc | Pentafluorobenzensulfonamide und analoge |
| GB9702194D0 (en) * | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
| FR2760235B1 (fr) * | 1997-02-28 | 1999-04-09 | Adir | Nouveaux derives de benzenesulfonylamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| UA67754C2 (uk) * | 1997-10-10 | 2004-07-15 | Пфайзер, Інк. | Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти) |
| US6693137B1 (en) * | 1998-07-31 | 2004-02-17 | Eli Lilly And Company | Sulphonamide derivatives |
| AP2001002357A0 (en) | 1999-12-22 | 2001-12-31 | Pfizer Prod Inc | EP4 receptor selective agonists in the treatment of osteoporosis. |
| US20050250854A1 (en) * | 2000-11-03 | 2005-11-10 | Amgen Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| WO2002039958A2 (en) | 2000-11-03 | 2002-05-23 | Tularik Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| MX2007004862A (es) * | 2004-10-29 | 2007-05-09 | Astrazeneca Ab | Nuevos derivados de sulfonamida como moduladores del receptor de glucocorticoides para el tratamiento de enfermedades inflamatorias. |
| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| TWI445705B (zh) | 2008-05-20 | 2014-07-21 | Astrazeneca Ab | 經苯基及苯并二基取代之吲唑衍生物 |
| CN104812382A (zh) * | 2012-09-20 | 2015-07-29 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
| US12161632B2 (en) | 2014-05-16 | 2024-12-10 | Cumberland Pharmaceuticals Inc. | Compositions and methods of treating cardiac fibrosis with ifetroban |
| CN111728970A (zh) | 2014-05-16 | 2020-10-02 | 坎伯兰医药品股份有限公司 | 用伊非曲班治疗心脏纤维化的组合物和方法 |
| US20170000771A1 (en) | 2015-06-30 | 2017-01-05 | Cumberland Pharmaceuticals, Inc. | Thromboxane Receptor Antagonists in AERD/Asthma |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| KR102354243B1 (ko) | 2016-05-11 | 2022-01-20 | 큠버랜드 파마슈티컬즈 인코포레이티드 | 트롬복산-a2 수용체 길항제를 이용한 근위축증 치료 조성물 및 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE542184A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1954-10-21 | |||
| US3027405A (en) * | 1959-07-29 | 1962-03-27 | Geigy Chem Corp | Nu-(alkylarylsulfonyl)-amino acids and salts thereof |
| US3991106A (en) * | 1974-09-13 | 1976-11-09 | Merck & Co., Inc. | 16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins |
| DK148576A (da) * | 1975-04-18 | 1976-10-19 | Boehringer Mannheim Gmbh | Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling |
| US4112236A (en) * | 1977-04-04 | 1978-09-05 | Merck & Co., Inc. | Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins |
| GB1572201A (en) * | 1977-04-05 | 1980-07-23 | Bristol Myers Co | Cephalosporins |
| DE2809377A1 (de) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| DE3000519A1 (de) * | 1979-02-01 | 1980-08-14 | Byk Gulden Lomberg Chem Fab | Sulfonamido-alkansaeuren, ihre verwendung und herstellung sowie sie enthaltende arzneimittel |
-
1980
- 1980-01-07 DE DE19803000377 patent/DE3000377A1/de not_active Withdrawn
- 1980-12-17 CA CA000366994A patent/CA1241341A/en not_active Expired
- 1980-12-24 EP EP80108207A patent/EP0031954B1/de not_active Expired
- 1980-12-24 DE DE8080108207T patent/DE3067068D1/de not_active Expired
- 1980-12-24 AT AT80108207T patent/ATE6641T1/de not_active IP Right Cessation
- 1980-12-29 GR GR63765A patent/GR72486B/el unknown
- 1980-12-31 IL IL61834A patent/IL61834A/xx not_active IP Right Cessation
- 1980-12-31 CS CS809599A patent/CS238611B2/cs unknown
- 1980-12-31 FI FI804085A patent/FI73667C/fi not_active IP Right Cessation
-
1981
- 1981-01-02 PT PT72305A patent/PT72305B/pt not_active IP Right Cessation
- 1981-01-02 ZA ZA00810032A patent/ZA8132B/xx unknown
- 1981-01-03 ES ES498308A patent/ES498308A0/es active Granted
- 1981-01-04 SU SU813223600A patent/SU1088664A3/ru active
- 1981-01-05 PH PH25051A patent/PH18739A/en unknown
- 1981-01-05 IE IE6/81A patent/IE50657B1/en not_active IP Right Cessation
- 1981-01-05 AU AU65974/81A patent/AU538993B2/en not_active Ceased
- 1981-01-06 PL PL1981229072A patent/PL127050B1/pl unknown
- 1981-01-06 YU YU8/81A patent/YU42995B/xx unknown
- 1981-01-06 DD DD81226847A patent/DD157190A5/de unknown
- 1981-01-07 JP JP54081A patent/JPS56100757A/ja active Granted
-
1982
- 1982-07-07 US US06/395,882 patent/US4443477A/en not_active Expired - Lifetime
-
1987
- 1987-01-15 SG SG23/87A patent/SG2387G/en unknown
- 1987-09-24 HK HK688/87A patent/HK68887A/xx unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01175962A (ja) * | 1987-12-28 | 1989-07-12 | Tanabe Seiyaku Co Ltd | フェニル酢酸誘導体 |
| JPH0296537A (ja) * | 1988-04-11 | 1990-04-09 | E R Squibb & Sons Inc | プロタミンの使用における有害作用の予防または減少用組成物 |
| WO1993013057A1 (en) * | 1991-12-20 | 1993-07-08 | Hokuriku Pharmaceutical Co., Ltd. | Substituted benzenesulfonamide derivative |
| WO1994007848A1 (en) * | 1992-10-01 | 1994-04-14 | Hokuriku Seiyaku Co., Ltd. | Benzenesulfonamide derivative and use thereof |
| US5597848A (en) * | 1992-10-01 | 1997-01-28 | Hokuriku Seiyaku Co., Ltd. | Benzenesulfonamide derivatives and use thereof |
| JP2010525029A (ja) * | 2007-04-27 | 2010-07-22 | テイボテク・フアーマシユーチカルズ・リミテツド | Ｎ−イソブチル−ｎ−（２−ヒドロキシ−３−アミノ−４−フェニルブチル）−ｐ−ニトロベンゼンスルホニルアミド誘導体の製造方法 |
| JP2011527345A (ja) * | 2008-07-07 | 2011-10-27 | ファスジェン， インコーポレイテッド | 新規な化合物、この化合物を含む医薬組成物、この化合物の使用方法、およびこの化合物の調製方法 |
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