JPS55164663A - Nonapeptide and decapeptide derivatives of progesterone release hormone and its manufacture - Google Patents
Nonapeptide and decapeptide derivatives of progesterone release hormone and its manufactureInfo
- Publication number
- JPS55164663A JPS55164663A JP14595879A JP14595879A JPS55164663A JP S55164663 A JPS55164663 A JP S55164663A JP 14595879 A JP14595879 A JP 14595879A JP 14595879 A JP14595879 A JP 14595879A JP S55164663 A JPS55164663 A JP S55164663A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- leucyl
- nonapeptide
- phenylalanyl
- alanyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003146 progesterones Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 biphenylyl Chemical group 0.000 abstract 4
- 101000904177 Clupea pallasii Gonadoliberin-1 Proteins 0.000 abstract 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 2
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 2
- 125000000405 phenylalanyl group Chemical group 0.000 abstract 2
- 150000008574 D-amino acids Chemical group 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 abstract 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000005561 phenanthryl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/047,661 US4234571A (en) | 1979-06-11 | 1979-06-11 | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55164663A true JPS55164663A (en) | 1980-12-22 |
| JPS6356238B2 JPS6356238B2 (show.php) | 1988-11-07 |
Family
ID=21950237
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14595879A Granted JPS55164663A (en) | 1979-06-11 | 1979-11-10 | Nonapeptide and decapeptide derivatives of progesterone release hormone and its manufacture |
| JP63043256A Granted JPS63264498A (ja) | 1979-06-11 | 1988-02-25 | 黄体形成ホルモン放出ホルモンのノナペプチド及びデカペプチド誘導体 |
| JP63145979A Granted JPS6425794A (en) | 1979-06-11 | 1988-06-15 | Production of novel peptide derivative of luteinizing hormone discharge hormone |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63043256A Granted JPS63264498A (ja) | 1979-06-11 | 1988-02-25 | 黄体形成ホルモン放出ホルモンのノナペプチド及びデカペプチド誘導体 |
| JP63145979A Granted JPS6425794A (en) | 1979-06-11 | 1988-06-15 | Production of novel peptide derivative of luteinizing hormone discharge hormone |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4234571A (show.php) |
| JP (3) | JPS55164663A (show.php) |
| KR (1) | KR840001921B1 (show.php) |
| AT (1) | ATE9089T1 (show.php) |
| FR (1) | FR2458538A1 (show.php) |
| HU (1) | HU185379B (show.php) |
| LU (1) | LU88272I2 (show.php) |
| MX (1) | MX9203594A (show.php) |
| NO (1) | NO1994006I1 (show.php) |
| SI (1) | SI8011553A8 (show.php) |
| SU (2) | SU1681733A3 (show.php) |
| ZA (1) | ZA803453B (show.php) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57118512A (en) * | 1980-11-18 | 1982-07-23 | Syntex Inc | Microencapsulation of water-soluble polypeptide |
| JPS57150609A (en) * | 1981-02-16 | 1982-09-17 | Ici Ltd | Pharmaceutical composition, heterogeneous copolymer comprising lactic acid and glycolic acid units and manufacture |
| JPS58125819U (ja) * | 1982-02-19 | 1983-08-26 | 名伸電機株式会社 | 積算電力量計用パツキン |
| JPS59500863A (ja) * | 1982-05-25 | 1984-05-17 | リ−ナル フイノムベジエセルジヤ−ル | ゴナドリベリン誘導体、その製造方法及びその医薬及び獣医薬組成物 |
| JPS617297A (ja) * | 1984-06-18 | 1986-01-13 | ジ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデュケイショナル・ファンド | 治療用ｌｈｒｈ類似体 |
| JPS6299397A (ja) * | 1985-10-22 | 1987-05-08 | リヒタ− ゲデオン ベジエセテイ ジヤ−ル ア−ル．テ−． | 高活性のゴナドリベリン類似体 |
| EP0779072A1 (en) | 1995-12-15 | 1997-06-18 | Takeda Chemical Industries, Ltd. | Production of microspheres |
| EP0781548A2 (en) | 1995-12-15 | 1997-07-02 | Takeda Chemical Industries, Ltd. | Production of sustained-release preparation for injection |
| JP2672677B2 (ja) * | 1989-02-09 | 1997-11-05 | タツプ・フアーマシユーテイカルズ・インコーポレイテツド | Ｌｈｒｈ同族体 |
| WO2003041739A1 (fr) | 2001-11-13 | 2003-05-22 | Takeda Chemical Industries, Ltd. | Agents anticancer |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2465486A1 (fr) * | 1979-09-21 | 1981-03-27 | Roussel Uclaf | Nouvelle application utilisant la lh-rh ou des agonistes |
| US5389613A (en) * | 1979-09-21 | 1995-02-14 | Roussel Uclaf | Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis |
| US4409208A (en) * | 1980-04-15 | 1983-10-11 | The Salk Institute For Biological Studies | GnRH antagonists |
| WO1982000004A1 (en) * | 1980-06-26 | 1982-01-07 | Salk Inst For Biological Studi | Contraceptive treatment of male mammals |
| US4382922A (en) * | 1980-08-29 | 1983-05-10 | The Salk Institute For Biological Studies | Peptides affecting gonadal function |
| US4419347A (en) * | 1980-10-06 | 1983-12-06 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4341767A (en) * | 1980-10-06 | 1982-07-27 | Syntex Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US5366734A (en) * | 1981-02-16 | 1994-11-22 | Zeneca Limited | Continuous release pharmaceutical compositions |
| US4619914A (en) * | 1983-03-10 | 1986-10-28 | The Salk Institute For Biological Studies | GNRH antagonists IIIB |
| CH661206A5 (fr) * | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
| JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4547370A (en) * | 1983-11-29 | 1985-10-15 | The Salk Institute For Biological Studies | GnRH Antagonists |
| US4652550A (en) * | 1984-05-21 | 1987-03-24 | The Salk Institute For Biological Studies | GnRH antagonists VII |
| US4760053A (en) * | 1984-08-02 | 1988-07-26 | Fernand Labrie | Combination therapy for selected sex steroid dependent cancers |
| US4565804A (en) * | 1984-09-07 | 1986-01-21 | The Salk Institute For Biological Studies | GnRH Antagonists VI |
| EP0181110A3 (en) * | 1984-10-22 | 1988-05-11 | Kissei Pharmaceutical Co. Ltd. | Histidine derivatives as renin inhibitors |
| DE3445669A1 (de) * | 1984-12-14 | 1986-06-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| EP0190891A3 (en) * | 1985-01-31 | 1988-04-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
| ATE61935T1 (de) * | 1985-02-07 | 1991-04-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
| US4642332A (en) * | 1985-04-26 | 1987-02-10 | The Board Of Regents, The University Of Texas System | Effective hormonal peptides: D-3-Pal6 -LHRH |
| US4656247A (en) * | 1985-04-26 | 1987-04-07 | Board Of Regents, The University Of Texas System | Effective hormonal peptides: D-3-QA1 6-LHRH |
| EP0206807A3 (en) * | 1985-06-28 | 1988-01-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
| US4853463A (en) * | 1985-09-04 | 1989-08-01 | Kissei Pharmaceutical Co., Ltd. | Amino acid derivatives |
| US4762717A (en) * | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
| JPS6322081A (ja) * | 1986-07-11 | 1988-01-29 | Kissei Pharmaceut Co Ltd | 新規なアミノ酸誘導体 |
| US4761398A (en) * | 1986-08-18 | 1988-08-02 | Embrex, Inc. | Method of inducing birds to molt |
| US5028430A (en) * | 1987-05-08 | 1991-07-02 | Syntex (U.S.A.) Inc. | Delivery systems for the controlled administration of LHRH analogs |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| NZ228285A (en) * | 1988-03-11 | 1991-08-27 | Teikoku Seiyaku Kk | Pharmaceutical composition comprising a polypeptide and adapted for intravaginal administration |
| JPH02235975A (ja) * | 1989-03-09 | 1990-09-18 | Masaya Takinami | 粘着シート |
| US6156731A (en) * | 1989-05-10 | 2000-12-05 | G. D. Searle & Co. | Polypeptide composition for oral administration |
| US5232707A (en) * | 1989-07-10 | 1993-08-03 | Syntex (U.S.A.) Inc. | Solvent extraction process |
| JP2911496B2 (ja) * | 1989-09-11 | 1999-06-23 | 帝國製薬株式会社 | 生理活性ポリペプチド含有高吸収性経膣剤 |
| US5169932A (en) * | 1989-10-30 | 1992-12-08 | The Salk Institute For Biological Studies | Gnrh analogs |
| US5580957A (en) * | 1989-10-30 | 1996-12-03 | The Salk Institute For Biological Studies | GnRH analogs |
| JP2653255B2 (ja) | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
| US5212288A (en) * | 1990-02-20 | 1993-05-18 | Syntex (U.S.A.) Inc. | Temporary minimal protection synthesis of serine-containing polypeptides |
| US6353030B1 (en) | 1990-08-01 | 2002-03-05 | Novartis Ag | Relating to organic compounds |
| JPH05117604A (ja) * | 1990-11-01 | 1993-05-14 | Koopack Kk | 粘着シールによる表示製品 |
| US5744450A (en) | 1991-03-14 | 1998-04-28 | The Salk Institute For Biological Studies | GnRH analogs |
| IL101074A (en) * | 1991-03-14 | 1997-09-30 | Salk Inst For Biological Studi | GnRH ANALOGS AND THEIR PREPARATION |
| DE4117507A1 (de) * | 1991-05-24 | 1992-11-26 | Schering Ag | Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten |
| US5518730A (en) | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
| TW333456B (en) * | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| WO1999007874A1 (en) * | 1996-06-13 | 1999-02-18 | Itoham Foods Inc. | Process for producing lh-rh derivatives |
| US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
| US6458357B1 (en) * | 1997-09-09 | 2002-10-01 | Myelos Corporation | Retro-inverso neurotrophic and analgesic peptides |
| US6242421B1 (en) | 1997-11-06 | 2001-06-05 | Richard Lloyd Bowen | Methods for preventing and treating Alzheimer's disease |
| US6117441A (en) * | 1998-07-02 | 2000-09-12 | The Population Council, Inc. | Silicone core long term androgen delivery implant |
| US7112341B1 (en) | 1999-04-13 | 2006-09-26 | Nektar Therapeutics | Pulmonary administration of dry powder formulations for treating infertility |
| US20040241842A1 (en) * | 1999-04-15 | 2004-12-02 | Monash University | Stimulation of thymus for vaccination development |
| US20070274946A1 (en) * | 1999-04-15 | 2007-11-29 | Norwood Immunoloty, Ltd. | Tolerance to Graft Prior to Thymic Reactivation |
| US20050020524A1 (en) * | 1999-04-15 | 2005-01-27 | Monash University | Hematopoietic stem cell gene therapy |
| AUPR074500A0 (en) * | 2000-10-13 | 2000-11-09 | Monash University | Treatment of t cell disorders |
| US20040265285A1 (en) * | 1999-04-15 | 2004-12-30 | Monash University | Normalization of defective T cell responsiveness through manipulation of thymic regeneration |
| US20040259803A1 (en) * | 1999-04-15 | 2004-12-23 | Monash University | Disease prevention by reactivation of the thymus |
| AR023940A1 (es) | 2000-05-03 | 2002-09-04 | Eriochem Sa | Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua |
| US20060088512A1 (en) * | 2001-10-15 | 2006-04-27 | Monash University | Treatment of T cell disorders |
| US20060287282A1 (en) * | 2001-06-25 | 2006-12-21 | Steiner Mitchell S | Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof |
| US20030144203A1 (en) * | 2001-12-19 | 2003-07-31 | Voyager Pharmaceutical Corporation | Methods for slowing senescence and treating and preventing diseases associated with senescence |
| GB0307777D0 (en) * | 2003-04-04 | 2003-05-07 | Medical Res Council | Conjugate compounds |
| AU2004235744A1 (en) * | 2003-05-01 | 2004-11-18 | Archimedes Development Limited | Nasal administration of the LH-RH analog leuprolide |
| GB0320806D0 (en) | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
| US20080279812A1 (en) * | 2003-12-05 | 2008-11-13 | Norwood Immunology, Ltd. | Disease Prevention and Vaccination Prior to Thymic Reactivation |
| RU2522634C2 (ru) * | 2012-07-31 | 2014-07-20 | Общество с ограниченной ответственностью "Научно-производственное предприятие "ИнБио Текс" | Способ получения трудногорючих полимерных изделий на основе полиэтилентерефталата с биоцидными свойствами |
| WO2021110609A1 (en) * | 2019-12-05 | 2021-06-10 | Bcn Peptides, S.A. | Peptides for the treatment of cancer and/or metastasis |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5059370A (show.php) * | 1973-09-29 | 1975-05-22 | ||
| JPS50121277A (show.php) * | 1974-03-08 | 1975-09-23 | ||
| JPS5231073A (en) * | 1975-06-12 | 1977-03-09 | Andrew Victor Schally | Peptide and intermediate thereof |
| JPS5299230A (en) * | 1976-02-11 | 1977-08-19 | Abbott Lab | Antiitumor agent |
| JPS52136172A (en) * | 1976-05-11 | 1977-11-14 | Ici Ltd | Polypeptide* its preparation and medical and veterinary compositions having rulibeline synergistic effect |
| JPS5382776A (en) * | 1977-10-07 | 1978-07-21 | Takeda Chem Ind Ltd | Preparation of polypeptides |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50142563A (show.php) * | 1974-04-26 | 1975-11-17 | ||
| DE2438350C3 (de) * | 1974-08-09 | 1979-06-13 | Hoechst Ag, 6000 Frankfurt | Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| US4018726A (en) * | 1975-06-12 | 1977-04-19 | Andrew Victor Schally | [D-Phe6 ]-LH-RH and intermediates therefor |
| US4010125A (en) * | 1975-06-12 | 1977-03-01 | Schally Andrew Victor | [D-Trp6 ]-LH-RH and intermediates therefor |
| US4005194A (en) * | 1975-06-23 | 1977-01-25 | Abbott Laboratories | Treatment of prostatic hyperplasia |
| GB1542703A (en) * | 1975-10-29 | 1979-03-21 | Parke Davis & Co | Nonapeptides and methods for their production |
| US3992530A (en) * | 1975-12-08 | 1976-11-16 | American Home Products Corporation | [D-2-(1,4-Cyclohexadienyl)gly]6 -des-gly10 -lrh nonapeptide amides |
| DE2617646C2 (de) * | 1976-04-22 | 1986-07-31 | Hoechst Ag, 6230 Frankfurt | Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| US4089946A (en) * | 1976-06-07 | 1978-05-16 | American Home Products Corporation | Claudogenic-interceptive nonapeptides |
| US4143133A (en) * | 1977-10-03 | 1979-03-06 | American Home Products Corporation | Claudogenic-interceptive nonapeptides |
-
1979
- 1979-06-11 US US06/047,661 patent/US4234571A/en not_active Expired - Lifetime
- 1979-11-09 FR FR7927754A patent/FR2458538A1/fr active Granted
- 1979-11-10 JP JP14595879A patent/JPS55164663A/ja active Granted
-
1980
- 1980-06-10 LU LU88272C patent/LU88272I2/xx unknown
- 1980-06-10 HU HU801458A patent/HU185379B/hu unknown
- 1980-06-10 ZA ZA00803453A patent/ZA803453B/xx unknown
- 1980-06-10 AT AT80103222T patent/ATE9089T1/de active
- 1980-06-10 SU SU802929801A patent/SU1681733A3/ru active
- 1980-06-10 KR KR1019800002276A patent/KR840001921B1/ko not_active Expired
- 1980-06-11 SI SI8011553A patent/SI8011553A8/sl unknown
-
1983
- 1983-05-30 SU SU833597664A patent/SU1428205A3/ru active
-
1988
- 1988-02-25 JP JP63043256A patent/JPS63264498A/ja active Granted
- 1988-06-15 JP JP63145979A patent/JPS6425794A/ja active Granted
-
1992
- 1992-06-26 MX MX9203594A patent/MX9203594A/es unknown
-
1994
- 1994-07-29 NO NO1994006C patent/NO1994006I1/no unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5059370A (show.php) * | 1973-09-29 | 1975-05-22 | ||
| JPS50121277A (show.php) * | 1974-03-08 | 1975-09-23 | ||
| JPS5231073A (en) * | 1975-06-12 | 1977-03-09 | Andrew Victor Schally | Peptide and intermediate thereof |
| JPS5299230A (en) * | 1976-02-11 | 1977-08-19 | Abbott Lab | Antiitumor agent |
| JPS52136172A (en) * | 1976-05-11 | 1977-11-14 | Ici Ltd | Polypeptide* its preparation and medical and veterinary compositions having rulibeline synergistic effect |
| JPS5382776A (en) * | 1977-10-07 | 1978-07-21 | Takeda Chem Ind Ltd | Preparation of polypeptides |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57118512A (en) * | 1980-11-18 | 1982-07-23 | Syntex Inc | Microencapsulation of water-soluble polypeptide |
| JPS57150609A (en) * | 1981-02-16 | 1982-09-17 | Ici Ltd | Pharmaceutical composition, heterogeneous copolymer comprising lactic acid and glycolic acid units and manufacture |
| JPH05221871A (ja) * | 1981-02-16 | 1993-08-31 | Imperial Chem Ind Plc <Ici> | 薬理学上活性で酸に安定なポリペプチドの製剤 |
| JPS58125819U (ja) * | 1982-02-19 | 1983-08-26 | 名伸電機株式会社 | 積算電力量計用パツキン |
| JPS59500863A (ja) * | 1982-05-25 | 1984-05-17 | リ−ナル フイノムベジエセルジヤ−ル | ゴナドリベリン誘導体、その製造方法及びその医薬及び獣医薬組成物 |
| JPS617297A (ja) * | 1984-06-18 | 1986-01-13 | ジ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデュケイショナル・ファンド | 治療用ｌｈｒｈ類似体 |
| JPS6299397A (ja) * | 1985-10-22 | 1987-05-08 | リヒタ− ゲデオン ベジエセテイ ジヤ−ル ア−ル．テ−． | 高活性のゴナドリベリン類似体 |
| JP2672677B2 (ja) * | 1989-02-09 | 1997-11-05 | タツプ・フアーマシユーテイカルズ・インコーポレイテツド | Ｌｈｒｈ同族体 |
| EP0779072A1 (en) | 1995-12-15 | 1997-06-18 | Takeda Chemical Industries, Ltd. | Production of microspheres |
| EP0781548A2 (en) | 1995-12-15 | 1997-07-02 | Takeda Chemical Industries, Ltd. | Production of sustained-release preparation for injection |
| WO2003041739A1 (fr) | 2001-11-13 | 2003-05-22 | Takeda Chemical Industries, Ltd. | Agents anticancer |
Also Published As
| Publication number | Publication date |
|---|---|
| SI8011553A8 (sl) | 1998-02-28 |
| NO1994006I1 (no) | 1994-07-29 |
| KR840001921B1 (ko) | 1984-10-25 |
| FR2458538A1 (fr) | 1981-01-02 |
| MX9203594A (es) | 1992-07-01 |
| LU88272I2 (show.php) | 1994-02-03 |
| SU1681733A3 (ru) | 1991-09-30 |
| JPS6356238B2 (show.php) | 1988-11-07 |
| JPH0371438B2 (show.php) | 1991-11-13 |
| JPS63264498A (ja) | 1988-11-01 |
| US4234571A (en) | 1980-11-18 |
| FR2458538B1 (show.php) | 1984-10-19 |
| SU1428205A3 (ru) | 1988-09-30 |
| ATE9089T1 (de) | 1984-09-15 |
| HU185379B (en) | 1985-01-28 |
| KR830002804A (ko) | 1983-05-30 |
| JPH0371439B2 (show.php) | 1991-11-13 |
| ZA803453B (en) | 1982-01-27 |
| JPS6425794A (en) | 1989-01-27 |
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