JPS55120559A - Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity - Google Patents

Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity

Info

Publication number
JPS55120559A
JPS55120559A JP1671180A JP1671180A JPS55120559A JP S55120559 A JPS55120559 A JP S55120559A JP 1671180 A JP1671180 A JP 1671180A JP 1671180 A JP1671180 A JP 1671180A JP S55120559 A JPS55120559 A JP S55120559A
Authority
JP
Japan
Prior art keywords
radical
radicals
lower alkyl
hydrogen atom
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1671180A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6348864B2 (enExample
Inventor
Gunaaru Furiibe Buarutaa
Mihieru Herumuuto
Haintsu Rosu Kaaru
Buiideman Furitsutsu
Baruchiyu Buorufugangu
Deiitoman Kaaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPS55120559A publication Critical patent/JPS55120559A/ja
Publication of JPS6348864B2 publication Critical patent/JPS6348864B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
JP1671180A 1979-02-16 1980-02-15 Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity Granted JPS55120559A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792905877 DE2905877A1 (de) 1979-02-16 1979-02-16 Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
JPS55120559A true JPS55120559A (en) 1980-09-17
JPS6348864B2 JPS6348864B2 (enExample) 1988-09-30

Family

ID=6063044

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1671180A Granted JPS55120559A (en) 1979-02-16 1980-02-15 Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity

Country Status (17)

Country Link
US (1) US4346093A (enExample)
EP (1) EP0014951B1 (enExample)
JP (1) JPS55120559A (enExample)
AT (1) ATE2190T1 (enExample)
AU (1) AU531282B2 (enExample)
CA (1) CA1134827A (enExample)
CS (1) CS227305B2 (enExample)
DD (1) DD148774A5 (enExample)
DE (2) DE2905877A1 (enExample)
DK (1) DK65380A (enExample)
ES (1) ES488657A1 (enExample)
FI (1) FI66371C (enExample)
HK (1) HK4486A (enExample)
HU (1) HU184719B (enExample)
IL (1) IL59352A (enExample)
SU (1) SU1243622A3 (enExample)
ZA (1) ZA80894B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5826871A (ja) * 1981-08-06 1983-02-17 ベ−リンガ−・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規ヘテロアリールオキシプロパノールアミンおよびその製法
JP2019521964A (ja) * 2016-05-13 2019-08-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー アドレナリン受容体調節化合物およびその使用方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD150456A5 (de) * 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
FR2455587A1 (fr) 1979-05-04 1980-11-28 Continental Pharma Derives de benzimidazole, leur preparation et utilisation dans le traitement des affections cardiovasculaires et compositions les contenant
IE810250L (en) * 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
DE3030047A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3029980A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
DE3310891A1 (de) * 1983-03-25 1984-09-27 Boehringer Mannheim Gmbh, 6800 Mannheim Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
WO1985004580A1 (en) * 1984-04-09 1985-10-24 American Hospital Supply Corporation Pharmaceutical composition and method for treatment or prophylaxis of cardiac disorders
DE3540149A1 (de) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten
DE68917024D1 (de) * 1988-05-24 1994-09-01 Kirin Brewery 4(1H)-Chinolonderivate.
JPH06500551A (ja) * 1990-09-13 1994-01-20 ビーチャム・グループ・パブリック・リミテッド・カンパニー ５ｈｔ受容体アンタゴニストとしてのインドールウレア
WO1995004047A1 (en) * 1993-07-31 1995-02-09 Smithkline Beecham Plc 2-benzoheterocyclyloxy or thiopropanolamine derivatives with adreno receptor agonist activity
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5741789A (en) 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
ATE215369T1 (de) 1996-09-05 2002-04-15 Lilly Co Eli Carbazolanaloge als selektive beta3-adrenergische agonisten
US5808080A (en) * 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
FR2756286A1 (fr) * 1996-11-27 1998-05-29 Pf Medicament Amino alcools aromatiques, leur preparation et leurs applications comme medicaments
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
AU1580101A (en) * 1999-11-15 2001-05-30 Eli Lilly And Company Indazolyloxy propanolamines for improving livestock production
TW593278B (en) * 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
SE0102640D0 (sv) * 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
GB202213163D0 (en) * 2022-09-08 2022-10-26 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2700193A1 (de) * 1976-01-08 1977-07-14 Ciba Geigy Ag Veraetherte hydroxy-benzodiheterocyclen
DE2819458A1 (de) * 1977-05-03 1978-11-16 Hoffmann La Roche Benzimidazol-derivate
DE2830211A1 (de) * 1977-07-21 1979-02-01 Sandoz Ag Substituierte indol-derivate, ihre herstellung und verwendung

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE623749A (enExample) 1961-12-08
CH483423A (de) * 1967-05-29 1969-12-31 Sandoz Ag Verfahren zur Herstellung einer neuen Indolverbindung
CH532040A (de) * 1970-03-24 1972-12-31 Sandoz Ag Verfahren zur Herstellung neuer Indolderivate
US3751429A (en) * 1970-03-24 1973-08-07 Sandoz Ltd 4-(3-amino-2-substituted propoxy)indole derivatives
US3699123A (en) * 1970-03-24 1972-10-17 Sandoz Ltd 4-(3-amino-2-hydroxy-propoxy) indole derivatives
CH536839A (de) * 1970-03-24 1973-05-15 Sandoz Ag Verfahren zur Herstellung einer neuen Indolverbindung
SE379196B (enExample) 1971-06-24 1975-09-29 Sandoz Ag
DE2508251C2 (de) 1975-02-26 1983-12-29 Boehringer Mannheim Gmbh, 6800 Mannheim Derivate des Indols, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
US4189494A (en) * 1975-11-06 1980-02-19 Sandoz Ltd. Reducing free fatty acid of the blood and suppressing appetite
DE2619164C2 (de) 1976-04-30 1985-07-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indazolyl-(4)-oxy-propanolamine, Verfahren zu ihrer Herstellung und deren Verwendung
DE2626890A1 (de) 1976-06-16 1977-12-29 Boehringer Mannheim Gmbh Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2651574A1 (de) 1976-11-12 1978-05-18 Boehringer Mannheim Gmbh Ein neues aminopropanol-derivat und verfahren zu dessen herstellung
US4235919A (en) * 1977-07-21 1980-11-25 Sandoz Ltd. 1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof
DE2801980A1 (de) * 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
EP0003758A1 (de) * 1978-02-09 1979-09-05 Ciba-Geigy Ag Verätherte Hydroxy-benzodiheterocyclen und ihre Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2700193A1 (de) * 1976-01-08 1977-07-14 Ciba Geigy Ag Veraetherte hydroxy-benzodiheterocyclen
DE2819458A1 (de) * 1977-05-03 1978-11-16 Hoffmann La Roche Benzimidazol-derivate
DE2830211A1 (de) * 1977-07-21 1979-02-01 Sandoz Ag Substituierte indol-derivate, ihre herstellung und verwendung

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5826871A (ja) * 1981-08-06 1983-02-17 ベ−リンガ−・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規ヘテロアリールオキシプロパノールアミンおよびその製法
JP2019521964A (ja) * 2016-05-13 2019-08-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー アドレナリン受容体調節化合物およびその使用方法
US11173144B2 (en) 2016-05-13 2021-11-16 The Board Of Trustees Of The Leland Stanford Junior University Adrenergic receptor modulating compounds and methods of using the same

Also Published As

Publication number Publication date
DE2905877A1 (de) 1980-08-28
US4346093A (en) 1982-08-24
FI66371C (fi) 1984-10-10
CS227305B2 (en) 1984-04-16
HU184719B (en) 1984-10-29
IL59352A0 (en) 1980-05-30
AU5541080A (en) 1980-08-21
IL59352A (en) 1985-01-31
EP0014951B1 (de) 1983-01-12
DK65380A (da) 1980-08-17
DD148774A5 (de) 1981-06-10
AU531282B2 (en) 1983-08-18
JPS6348864B2 (enExample) 1988-09-30
EP0014951A2 (de) 1980-09-03
SU1243622A3 (ru) 1986-07-07
ES488657A1 (es) 1980-09-16
ZA80894B (en) 1981-09-30
EP0014951A3 (en) 1981-02-04
HK4486A (en) 1986-01-31
FI800408A7 (fi) 1980-08-17
ATE2190T1 (de) 1983-01-15
CA1134827A (en) 1982-11-02
DE3061555D1 (en) 1983-02-17
FI66371B (fi) 1984-06-29

Similar Documents

Publication Publication Date Title
JPS55120559A (en) Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity
IL107426A (en) 3-HALO-8-ARALKOXY (OR ARALKYLAMINO) IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2416274A1 (en) N-phenyl-2-pyrimidine-amine derivatives
GB1014053A (en) 7-hydroxy-coumarin derivatives and process for their production
ES479931A1 (es) Un procedimiento para la preparacion de derivados de amino- piridina.
GB1369379A (en) Benzodioxole derivatives and processes for preparing them
ATE22891T1 (de) Pyrimidinonderivate und diese enthaltende pharmazeutische zusammensetzungen.
ES8402562A1 (es) Procedimiento para preparar derivados de guanidina.
HUT42480A (en) Process for producing gamma carboline derivatives and pharmaceutical compositions containing them
ES472085A1 (es) Un procedimiento para la preparacion de una composicion te- rapeutica para el tratamiento de enfermedades alergicas.
EP0299076A4 (en) 5-hydroxyindole-3-carboxamide compound and medicinal use thereof
ES8206537A1 (es) Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a) pirimidina
DE3063450D1 (en) Theophylline derivatives, process for their preparation and medicaments containing these compounds
DE3161640D1 (en) Propanol amine, derivatives, process for their preparation and medicines containing these compounds
DK610586D0 (da) 5-aminoalkyl-beta-carbolinderivater, deres fremstilling og deres anvendelse som laegemiddel
PT77574A (en) Indole derivatives
ES445969A1 (es) Un procedimiento de preparacion de la (fluoro-4-trifluorome-tiltio-3-fenil)-1-piperazina.
ZA812349B (en) Thiazole derivates, their preparation and pharmaceutical compostions containing them
DK608586D0 (da) Polysubstituerede pyridin-1-oxider og fysiologisk aktive salte deraf, deres fremstilling og anvendelse som laegemidler
MY105852A (en) New 2-methoxycarbonyl substituted n, n'' -di- (trimethoxybenzoyl) piperazines, process for preparing the same and therapeutical compounds containing them.
CA2149147A1 (en) Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof
ATE121937T1 (de) Verwendung von 2h-1,2,4-benzothiadiazin-3(4h)- thion-1,1-dioxiden als antivirale arzneimittel.
GB1076867A (en) Improvements in or relating to 2,4-diamino-6-substituted pyrimidines
FR2322592A1 (fr) Nouveaux sulfonamides, leur preparation et leur application comme medicaments
ES483301A1 (es) Un procedimiento para la preparacion de derivados de benzo- diacepina