JPS55105699A - 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative - Google Patents

3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative

Info

Publication number
JPS55105699A
JPS55105699A JP1140279A JP1140279A JPS55105699A JP S55105699 A JPS55105699 A JP S55105699A JP 1140279 A JP1140279 A JP 1140279A JP 1140279 A JP1140279 A JP 1140279A JP S55105699 A JPS55105699 A JP S55105699A
Authority
JP
Japan
Prior art keywords
derivative
formula
give
protecting
dideoxykanamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1140279A
Other languages
English (en)
Other versions
JPS633874B2 (ja
Inventor
Hamao Umezawa
Sumio Umezawa
Osamu Tsuchiya
Tomo Naohara
Toshiaki Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP1140279A priority Critical patent/JPS55105699A/ja
Priority to SE7910734A priority patent/SE446005B/sv
Priority to NL8000005A priority patent/NL8000005A/nl
Priority to AU54767/80A priority patent/AU535371B2/en
Priority to BE2/58350A priority patent/BE881251A/fr
Priority to US06/114,779 priority patent/US4298727A/en
Priority to GB8003417A priority patent/GB2043634B/en
Priority to FR8002740A priority patent/FR2447934B1/fr
Priority to IT67167/80A priority patent/IT1147712B/it
Priority to AT0058880A priority patent/AT371479B/de
Priority to ES488285A priority patent/ES8101623A1/es
Priority to DE19803004178 priority patent/DE3004178A1/de
Publication of JPS55105699A publication Critical patent/JPS55105699A/ja
Priority to ES495096A priority patent/ES495096A0/es
Priority to AT118982A priority patent/AT371480B/de
Publication of JPS633874B2 publication Critical patent/JPS633874B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP1140279A 1979-02-05 1979-02-05 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative Granted JPS55105699A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP1140279A JPS55105699A (en) 1979-02-05 1979-02-05 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative
SE7910734A SE446005B (sv) 1979-02-05 1979-12-28 Forfarande for framstellning av 3',4'-dideoxikanamycin
NL8000005A NL8000005A (nl) 1979-02-05 1980-01-02 3',4'-didesoxykanamycine a en een 1-n-((s)-alfa- -hydroxy-omega-aminoalkanoyl) derivaat daarvan.
AU54767/80A AU535371B2 (en) 1979-02-05 1980-01-21 3:,4: - dideoxykanamycin a and derivatives
BE2/58350A BE881251A (fr) 1979-02-05 1980-01-21 3', 4'-dideoxykanamycine a et un de ses derives 1-n- ( (s)-alpha-hydroxy-omega-aminoalcanoyle)
US06/114,779 US4298727A (en) 1979-02-05 1980-01-23 3',4'-Dideoxykanamycin A and 1-N-(S)-α-hydroxy-ω-aminoalkanoyl) derivatives thereof
GB8003417A GB2043634B (en) 1979-02-05 1980-02-01 3'4'-dideoxykanamycin a and 1-n-(s)-hydroxy-aminoalkanoyl) derivatives thereof
FR8002740A FR2447934B1 (fr) 1979-02-05 1980-02-04 3', 4'-didesoxykanamycine a et ses derives a-hydroxy-o-amino-alcanoyl en 1-n, leurs procedes de production et leurs applications comme agents antibacteriens
IT67167/80A IT1147712B (it) 1979-02-05 1980-02-04 3 4 di desossi canamicina a e suoi derivati particolarmente utili come antibatterici e procedimento per la loro preparazione
AT0058880A AT371479B (de) 1979-02-05 1980-02-04 Verfahren zur herstellung eines neuen kanamycin a derivates und dessen saeureadditionssalzen
ES488285A ES8101623A1 (es) 1979-02-05 1980-02-05 Proceso para la produccion de 3'-4'-didesoxikanamicina a.
DE19803004178 DE3004178A1 (de) 1979-02-05 1980-02-05 3',4'-didesoxykanamycin a und dessen 1-n-((s)- alpha -hydroxy- omega -aminoalkanoyl)-derivate sowie salze dieser verbindungen mit saeuren, verfahren zu ihrer herstellung und ihre verwendung als antibakterielle wirkstoffe
ES495096A ES495096A0 (es) 1979-02-05 1980-09-16 Proceso para la produccion de 1-n-(2-hidroxi-3-aminopropio- nil)-3',4'-didesoxikanamicina a o 1-n-(2-hidroxi-4-aminobu- tiril)-3',4'-didesoxikanamicina a
AT118982A AT371480B (de) 1979-02-05 1982-03-26 Verfahren zur herstellung von neuen kanamycin a derivaten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1140279A JPS55105699A (en) 1979-02-05 1979-02-05 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative

Publications (2)

Publication Number Publication Date
JPS55105699A true JPS55105699A (en) 1980-08-13
JPS633874B2 JPS633874B2 (ja) 1988-01-26

Family

ID=11777015

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1140279A Granted JPS55105699A (en) 1979-02-05 1979-02-05 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative

Country Status (12)

Country Link
US (1) US4298727A (ja)
JP (1) JPS55105699A (ja)
AT (1) AT371479B (ja)
AU (1) AU535371B2 (ja)
BE (1) BE881251A (ja)
DE (1) DE3004178A1 (ja)
ES (2) ES8101623A1 (ja)
FR (1) FR2447934B1 (ja)
GB (1) GB2043634B (ja)
IT (1) IT1147712B (ja)
NL (1) NL8000005A (ja)
SE (1) SE446005B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953498A (ja) * 1982-09-20 1984-03-28 Microbial Chem Res Found ５，２′，３′，４′，４″，６″−ヘキサデオキシカナマイシンおよびその１−ｎ−アシル誘導体
JPS6041692A (ja) * 1983-08-15 1985-03-05 Microbial Chem Res Found ２′，３′−ジデオキシカナマイシンａ誘導体
US4656160A (en) * 1984-11-29 1987-04-07 Fujisawa Pharmaceutical Co., Ltd. Aminoglycoside derivatives
JPH01126284U (ja) * 1988-02-19 1989-08-29

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2931798A (en) * 1956-09-05 1960-04-05 Umezawa Hamao Kanamycin and processes for the preparation thereof
USRE28647E (en) 1971-06-02 1975-12-09 Preparation of 3-4 dideoxykanamycin B active against resistant bacteria
US3781268A (en) * 1972-01-27 1973-12-25 Bristol Myers Co Antibiotic derivatives of kanamycin
JPS5220991B2 (ja) * 1972-08-23 1977-06-07
US4001208A (en) * 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
US4107424A (en) * 1972-10-06 1978-08-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl] derivatives of 3',4'-dideoxykanamycin B and 3'-deoxykanamycin B antibiotics
US3904597A (en) * 1973-02-23 1975-09-09 Bristol Myers Co Antibiotic derivatives
US3886139A (en) * 1973-02-23 1975-05-27 Bristol Myers Co Derivatives of kanamycin
US4170642A (en) * 1973-10-01 1979-10-09 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Derivatives of kanamycin A
JPS51127045A (en) * 1975-04-24 1976-11-05 Microbial Chem Res Found A process for preparing 3'- deoxykanamycin a derivatives.
US4147861A (en) * 1975-09-24 1979-04-03 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1N-(α-Hydroxy-ω-aminoalkanoyl)-6'N-methyl-3',4'-dideoxykanamycin B and the production thereof
JPS6029720B2 (ja) * 1975-12-11 1985-07-12 財団法人微生物化学研究会 ３′，４′‐ジデオキシカナマイシンｂの新規な製造法
JPS52153942A (en) * 1976-06-16 1977-12-21 Microbial Chem Res Found Preparation of kanamicin c deoxy derivatives and kanamicine c or its deoxy derivatives
JPS6052719B2 (ja) * 1976-12-16 1985-11-20 財団法人微生物化学研究会 ３′，４′−ジデオキシカナマイシンｂの新規な製造法
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic

Also Published As

Publication number Publication date
GB2043634A (en) 1980-10-08
ES488285A0 (es) 1980-12-16
GB2043634B (en) 1983-10-12
NL8000005A (nl) 1980-08-07
US4298727A (en) 1981-11-03
ES8202832A1 (es) 1982-02-01
ES495096A0 (es) 1982-02-01
DE3004178C2 (ja) 1988-02-18
ATA58880A (de) 1982-11-15
AT371479B (de) 1983-06-27
JPS633874B2 (ja) 1988-01-26
IT1147712B (it) 1986-11-26
FR2447934A1 (fr) 1980-08-29
FR2447934B1 (fr) 1985-06-14
DE3004178A1 (de) 1980-08-07
AU535371B2 (en) 1984-03-15
SE446005B (sv) 1986-08-04
SE7910734L (sv) 1980-08-06
ES8101623A1 (es) 1980-12-16
BE881251A (fr) 1980-05-16
AU5476780A (en) 1980-08-14
IT8067167A0 (it) 1980-02-04

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