FR2447934A1 - 3', 4'-didesoxykanamycine a et ses derives a-hydroxy-o-amino-alcanoyl en 1-n, leurs procedes de production et leurs applications comme agents antibacteriens - Google Patents
3', 4'-didesoxykanamycine a et ses derives a-hydroxy-o-amino-alcanoyl en 1-n, leurs procedes de production et leurs applications comme agents antibacteriensInfo
- Publication number
- FR2447934A1 FR2447934A1 FR8002740A FR8002740A FR2447934A1 FR 2447934 A1 FR2447934 A1 FR 2447934A1 FR 8002740 A FR8002740 A FR 8002740A FR 8002740 A FR8002740 A FR 8002740A FR 2447934 A1 FR2447934 A1 FR 2447934A1
- Authority
- FR
- France
- Prior art keywords
- kanamycin
- didesoxykanamycin
- hydroxy
- protected
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
LES DERIVES 3, 4-DIDESOXY- ET 1-N((S)-A-HYDROXY-O-AMINO-ALCANOYL)-3, 4-DIDESOXY DE KANAMYCINE A, SYNTHETISES A PARTIR DE LA KANAMYCINE A MONTRENT UNE ACTIVITE ANTIBACTERIENNE ELEVEE ET SUPERIEURE A CELLES DE LA KANAMYCINE A. ILS SONT PRODUITS PAR PREPARATION D'UN DERIVE DE KANAMYCINE A PROTEGE DONT LES GROUPES HYDROXYLES EN 3 ET 4 NE SONT PAS PROTEGES ET DONT TOUS OU PRATIQUEMENT TOUS LES AUTRES GROUPES FONCTIONNELS SONT PROTEGES, SULFONYLATION DES GROUPES HYDROXYLES EN 3 ET 4, ELIMINATION DES GROUPES SULFONYLOXY EN 3 ET 4 DE L'ESTER DE L'ACIDE 3, 4-DISULFONIQUE RESULTANT POUR DONNER LE DERIVE 3-ENO-KANAMYCINE A, HYDROGENATION DE CE DERIVE POUR SATURER LA DOUBLE LIAISON EN 3, 4 ET DONNER UNE 3, 4-DIDESOXYKANAMYCINE A PROTEGEE, SUIVIE D'ELIMINATION DES GROUPES PROTECTEURS RESTANT ET, EVENTUELLEMENT SUIVIE A NOUVEAU D'UNE ACYLATION EN 1-N DU GROUPE 1-AMINO DE LA 3, 4-DIDESOXYKANAMYCINE A OBTENUE AVEC UN ACIDE (S)-A-HYDROXY-O-AMINOALCANOIQUE OU SON EQUIVALENT REACTIF.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1140279A JPS55105699A (en) | 1979-02-05 | 1979-02-05 | 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2447934A1 true FR2447934A1 (fr) | 1980-08-29 |
FR2447934B1 FR2447934B1 (fr) | 1985-06-14 |
Family
ID=11777015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8002740A Expired FR2447934B1 (fr) | 1979-02-05 | 1980-02-04 | 3', 4'-didesoxykanamycine a et ses derives a-hydroxy-o-amino-alcanoyl en 1-n, leurs procedes de production et leurs applications comme agents antibacteriens |
Country Status (12)
Country | Link |
---|---|
US (1) | US4298727A (fr) |
JP (1) | JPS55105699A (fr) |
AT (1) | AT371479B (fr) |
AU (1) | AU535371B2 (fr) |
BE (1) | BE881251A (fr) |
DE (1) | DE3004178A1 (fr) |
ES (2) | ES8101623A1 (fr) |
FR (1) | FR2447934B1 (fr) |
GB (1) | GB2043634B (fr) |
IT (1) | IT1147712B (fr) |
NL (1) | NL8000005A (fr) |
SE (1) | SE446005B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5953498A (ja) * | 1982-09-20 | 1984-03-28 | Microbial Chem Res Found | 5,2′,3′,4′,4″,6″−ヘキサデオキシカナマイシンおよびその1−n−アシル誘導体 |
JPS6041692A (ja) * | 1983-08-15 | 1985-03-05 | Microbial Chem Res Found | 2′,3′−ジデオキシカナマイシンa誘導体 |
US4656160A (en) * | 1984-11-29 | 1987-04-07 | Fujisawa Pharmaceutical Co., Ltd. | Aminoglycoside derivatives |
JPH01126284U (fr) * | 1988-02-19 | 1989-08-29 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2931798A (en) * | 1956-09-05 | 1960-04-05 | Umezawa Hamao | Kanamycin and processes for the preparation thereof |
USRE28647E (en) | 1971-06-02 | 1975-12-09 | Preparation of 3-4 dideoxykanamycin B active against resistant bacteria | |
US3781268A (en) * | 1972-01-27 | 1973-12-25 | Bristol Myers Co | Antibiotic derivatives of kanamycin |
JPS5220991B2 (fr) * | 1972-08-23 | 1977-06-07 | ||
US4107424A (en) * | 1972-10-06 | 1978-08-15 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | 1-N-[(S)-α-hydroxy-ω-aminoacyl] derivatives of 3',4'-dideoxykanamycin B and 3'-deoxykanamycin B antibiotics |
US4001208A (en) * | 1972-10-06 | 1977-01-04 | Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai | 1-N-[(S)-α-hydroxy-ω-aminoacyl] |
US3904597A (en) * | 1973-02-23 | 1975-09-09 | Bristol Myers Co | Antibiotic derivatives |
US3886139A (en) * | 1973-02-23 | 1975-05-27 | Bristol Myers Co | Derivatives of kanamycin |
US4170642A (en) * | 1973-10-01 | 1979-10-09 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Derivatives of kanamycin A |
JPS51127045A (en) * | 1975-04-24 | 1976-11-05 | Microbial Chem Res Found | A process for preparing 3'- deoxykanamycin a derivatives. |
US4147861A (en) * | 1975-09-24 | 1979-04-03 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | 1N-(α-Hydroxy-ω-aminoalkanoyl)-6'N-methyl-3',4'-dideoxykanamycin B and the production thereof |
JPS6029720B2 (ja) * | 1975-12-11 | 1985-07-12 | 財団法人微生物化学研究会 | 3′,4′‐ジデオキシカナマイシンbの新規な製造法 |
JPS52153942A (en) * | 1976-06-16 | 1977-12-21 | Microbial Chem Res Found | Preparation of kanamicin c deoxy derivatives and kanamicine c or its deoxy derivatives |
HU177398B (en) * | 1976-12-16 | 1981-12-28 | Microbial Chem Res Found | New process for producing 3:4'-dideoxi-kanamycin b |
IE48972B1 (en) * | 1978-11-11 | 1985-06-26 | Microbial Chem Res Found | The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic |
-
1979
- 1979-02-05 JP JP1140279A patent/JPS55105699A/ja active Granted
- 1979-12-28 SE SE7910734A patent/SE446005B/sv not_active IP Right Cessation
-
1980
- 1980-01-02 NL NL8000005A patent/NL8000005A/nl not_active Application Discontinuation
- 1980-01-21 BE BE2/58350A patent/BE881251A/fr not_active IP Right Cessation
- 1980-01-21 AU AU54767/80A patent/AU535371B2/en not_active Ceased
- 1980-01-23 US US06/114,779 patent/US4298727A/en not_active Expired - Lifetime
- 1980-02-01 GB GB8003417A patent/GB2043634B/en not_active Expired
- 1980-02-04 FR FR8002740A patent/FR2447934B1/fr not_active Expired
- 1980-02-04 IT IT67167/80A patent/IT1147712B/it active
- 1980-02-04 AT AT0058880A patent/AT371479B/de not_active IP Right Cessation
- 1980-02-05 DE DE19803004178 patent/DE3004178A1/de active Granted
- 1980-02-05 ES ES488285A patent/ES8101623A1/es not_active Expired
- 1980-09-16 ES ES495096A patent/ES495096A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
SE446005B (sv) | 1986-08-04 |
ES8202832A1 (es) | 1982-02-01 |
GB2043634B (en) | 1983-10-12 |
SE7910734L (sv) | 1980-08-06 |
BE881251A (fr) | 1980-05-16 |
ES488285A0 (es) | 1980-12-16 |
AT371479B (de) | 1983-06-27 |
US4298727A (en) | 1981-11-03 |
JPS633874B2 (fr) | 1988-01-26 |
ATA58880A (de) | 1982-11-15 |
IT1147712B (it) | 1986-11-26 |
ES495096A0 (es) | 1982-02-01 |
ES8101623A1 (es) | 1980-12-16 |
DE3004178C2 (fr) | 1988-02-18 |
NL8000005A (nl) | 1980-08-07 |
GB2043634A (en) | 1980-10-08 |
IT8067167A0 (it) | 1980-02-04 |
AU535371B2 (en) | 1984-03-15 |
DE3004178A1 (de) | 1980-08-07 |
JPS55105699A (en) | 1980-08-13 |
AU5476780A (en) | 1980-08-14 |
FR2447934B1 (fr) | 1985-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |