JPS55102519A - Stabilization of interferon - Google Patents
Stabilization of interferonInfo
- Publication number
- JPS55102519A JPS55102519A JP993979A JP993979A JPS55102519A JP S55102519 A JPS55102519 A JP S55102519A JP 993979 A JP993979 A JP 993979A JP 993979 A JP993979 A JP 993979A JP S55102519 A JPS55102519 A JP S55102519A
- Authority
- JP
- Japan
- Prior art keywords
- interferon
- freeze
- antibiotic
- drying
- nonionic surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000014150 Interferons Human genes 0.000 title abstract 4
- 108010050904 Interferons Proteins 0.000 title abstract 4
- 229940079322 interferon Drugs 0.000 title abstract 4
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- -1 polyethylene Polymers 0.000 abstract 3
- 239000004698 Polyethylene Substances 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 238000004108 freeze drying Methods 0.000 abstract 2
- 239000002736 nonionic surfactant Substances 0.000 abstract 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 abstract 2
- 229920000573 polyethylene Polymers 0.000 abstract 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 229930027917 kanamycin Natural products 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- 229960002446 octanoic acid Drugs 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP993979A JPS55102519A (en) | 1979-01-31 | 1979-01-31 | Stabilization of interferon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP993979A JPS55102519A (en) | 1979-01-31 | 1979-01-31 | Stabilization of interferon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55102519A true JPS55102519A (en) | 1980-08-05 |
| JPS6326120B2 JPS6326120B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-05-27 |
Family
ID=11733977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP993979A Granted JPS55102519A (en) | 1979-01-31 | 1979-01-31 | Stabilization of interferon |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55102519A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5877824A (ja) * | 1981-10-13 | 1983-05-11 | エクソバ−，インコ−ポレイテイド | インターフェロンを含む組成物 |
| JPS5892621A (ja) * | 1981-11-28 | 1983-06-02 | Sunstar Inc | インタ−フエロンを安定に配合した製剤 |
| JPS58146504A (ja) * | 1981-12-23 | 1983-09-01 | シエリング・コーポレーシヨン | α―インターフェロン製剤およびその製造方法 |
| US4486407A (en) * | 1983-02-28 | 1984-12-04 | Fumiaki Taguchi | Method for enhancing production of interferon |
| US4496537A (en) * | 1981-12-23 | 1985-01-29 | Schering Corporation | Biologically stable alpha-interferon formulations |
| US4507281A (en) * | 1981-10-13 | 1985-03-26 | Exovir, Inc. | Interferon-containing compositions |
| JPS60188328A (ja) * | 1984-02-07 | 1985-09-25 | インターフエロン・サイエンシズ・インコーポレーテツド | インターフエロン投与用ビヒクル |
| WO1986000531A1 (en) * | 1984-07-10 | 1986-01-30 | Takeda Chemical Industries, Ltd. | Gamma-interferon composition |
| EP0080879B1 (en) * | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Pharmaceutical composition containing interferon in stable state |
| JPS61277633A (ja) * | 1985-05-31 | 1986-12-08 | Toray Ind Inc | インタ−フエロン組成物 |
| JPS63146829A (ja) * | 1986-07-18 | 1988-06-18 | Chugai Pharmaceut Co Ltd | 安定な顆粒球コロニ−刺激因子含有製剤 |
| JPS63146826A (ja) * | 1986-07-18 | 1988-06-18 | Chugai Pharmaceut Co Ltd | 安定な顆粒球コロニ−刺激因子含有製剤 |
| JPS63179833A (ja) * | 1986-10-27 | 1988-07-23 | カイロン コーポレイション | 組換えベータ−インターフェロンの医薬組成物及び配合方法 |
| US4855134A (en) * | 1983-10-14 | 1989-08-08 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release preparation |
| US4888416A (en) * | 1987-03-30 | 1989-12-19 | International Minerals & Chemical Corp. | Method for stabilizing somatotropins |
| US4957734A (en) * | 1982-06-14 | 1990-09-18 | Exovir, Inc. | Treatment of certain skin malignancies and pre-malignant skin lesions, herpes zoster and psoriasis |
| US5385738A (en) * | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
| JP2003342193A (ja) * | 2002-05-30 | 2003-12-03 | Otsuka Pharmaceut Co Ltd | 注射用製剤 |
| JP2005511520A (ja) * | 2001-10-05 | 2005-04-28 | ビスカム・アーゲー | 組換え炭水化物結合ポリペプチドの安定型凍結乾燥生薬製剤 |
| JP2009541446A (ja) * | 2006-06-29 | 2009-11-26 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | フェニルアラニンを含む吸入用粉末 |
| US10022319B2 (en) | 2010-01-20 | 2018-07-17 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing liquid formulations |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04200105A (ja) * | 1990-11-29 | 1992-07-21 | Nec Corp | 進行波管電力増幅器 |
-
1979
- 1979-01-31 JP JP993979A patent/JPS55102519A/ja active Granted
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507281A (en) * | 1981-10-13 | 1985-03-26 | Exovir, Inc. | Interferon-containing compositions |
| JPS5877824A (ja) * | 1981-10-13 | 1983-05-11 | エクソバ−，インコ−ポレイテイド | インターフェロンを含む組成物 |
| EP0080879B1 (en) * | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Pharmaceutical composition containing interferon in stable state |
| JPS5892621A (ja) * | 1981-11-28 | 1983-06-02 | Sunstar Inc | インタ−フエロンを安定に配合した製剤 |
| US4496537A (en) * | 1981-12-23 | 1985-01-29 | Schering Corporation | Biologically stable alpha-interferon formulations |
| JPS58146504A (ja) * | 1981-12-23 | 1983-09-01 | シエリング・コーポレーシヨン | α―インターフェロン製剤およびその製造方法 |
| US4957734A (en) * | 1982-06-14 | 1990-09-18 | Exovir, Inc. | Treatment of certain skin malignancies and pre-malignant skin lesions, herpes zoster and psoriasis |
| US4486407A (en) * | 1983-02-28 | 1984-12-04 | Fumiaki Taguchi | Method for enhancing production of interferon |
| US5081156A (en) * | 1983-10-14 | 1992-01-14 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release preparation |
| US5385738A (en) * | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
| US4855134A (en) * | 1983-10-14 | 1989-08-08 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release preparation |
| JPS60188328A (ja) * | 1984-02-07 | 1985-09-25 | インターフエロン・サイエンシズ・インコーポレーテツド | インターフエロン投与用ビヒクル |
| WO1986000531A1 (en) * | 1984-07-10 | 1986-01-30 | Takeda Chemical Industries, Ltd. | Gamma-interferon composition |
| JPS61277633A (ja) * | 1985-05-31 | 1986-12-08 | Toray Ind Inc | インタ−フエロン組成物 |
| JPS63146826A (ja) * | 1986-07-18 | 1988-06-18 | Chugai Pharmaceut Co Ltd | 安定な顆粒球コロニ−刺激因子含有製剤 |
| JPS63146829A (ja) * | 1986-07-18 | 1988-06-18 | Chugai Pharmaceut Co Ltd | 安定な顆粒球コロニ−刺激因子含有製剤 |
| JPS63179833A (ja) * | 1986-10-27 | 1988-07-23 | カイロン コーポレイション | 組換えベータ−インターフェロンの医薬組成物及び配合方法 |
| US4888416A (en) * | 1987-03-30 | 1989-12-19 | International Minerals & Chemical Corp. | Method for stabilizing somatotropins |
| JP2005511520A (ja) * | 2001-10-05 | 2005-04-28 | ビスカム・アーゲー | 組換え炭水化物結合ポリペプチドの安定型凍結乾燥生薬製剤 |
| JP2003342193A (ja) * | 2002-05-30 | 2003-12-03 | Otsuka Pharmaceut Co Ltd | 注射用製剤 |
| JP2009541446A (ja) * | 2006-06-29 | 2009-11-26 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | フェニルアラニンを含む吸入用粉末 |
| US8226982B2 (en) | 2006-06-29 | 2012-07-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalable powders comprising protein, phenylalanine, and other protein stabilizers |
| US10022319B2 (en) | 2010-01-20 | 2018-07-17 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing liquid formulations |
| US11612562B2 (en) | 2010-01-20 | 2023-03-28 | Chugai Seiyaku Kabushiki Kaisha | Solution preparation containing stabilized antibody |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6326120B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-05-27 |
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