JPS5495552A - Prostacyline derivative and its preparation - Google Patents

Prostacyline derivative and its preparation

Info

Publication number
JPS5495552A
JPS5495552A JP46278A JP46278A JPS5495552A JP S5495552 A JPS5495552 A JP S5495552A JP 46278 A JP46278 A JP 46278A JP 46278 A JP46278 A JP 46278A JP S5495552 A JPS5495552 A JP S5495552A
Authority
JP
Japan
Prior art keywords
formula
compound
alkyl
preparation
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP46278A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6121216B2 (US06312121-20011106-C00033.png
Inventor
Koichi Kojima
Kiyoshi Sakai
Shinsaku Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP46278A priority Critical patent/JPS5495552A/ja
Priority to DE19792900352 priority patent/DE2900352A1/de
Priority to DE2954373A priority patent/DE2954373C2/de
Priority to IT67023/79A priority patent/IT1192762B/it
Priority to CH15079A priority patent/CH639359A5/de
Priority to CH4279/83A priority patent/CH651292A5/de
Priority to FR7900343A priority patent/FR2414039A1/fr
Priority to GB79630A priority patent/GB2012265B/en
Publication of JPS5495552A publication Critical patent/JPS5495552A/ja
Priority to US06/153,825 priority patent/US4322435A/en
Priority to JP58015819A priority patent/JPS58192845A/ja
Priority to JP60250186A priority patent/JPS61112039A/ja
Publication of JPS6121216B2 publication Critical patent/JPS6121216B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/613—Unsaturated compounds containing a keto groups being part of a ring polycyclic
    • C07C49/617—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system
    • C07C49/623—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings
    • C07C49/633—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings the condensed ring system containing eight or nine carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP46278A 1978-01-06 1978-01-06 Prostacyline derivative and its preparation Granted JPS5495552A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP46278A JPS5495552A (en) 1978-01-06 1978-01-06 Prostacyline derivative and its preparation
DE19792900352 DE2900352A1 (de) 1978-01-06 1979-01-05 Prostacyclinderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2954373A DE2954373C2 (US06312121-20011106-C00033.png) 1978-01-06 1979-01-05
IT67023/79A IT1192762B (it) 1978-01-06 1979-01-05 Derivati di prostaciclina e procedimento per la loro preparazione
CH4279/83A CH651292A5 (de) 1978-01-06 1979-01-08 Bicyclo(3,3,0)octan-derivate.
CH15079A CH639359A5 (de) 1978-01-06 1979-01-08 Prostacyclinderivate, deren herstellung und diese prostacyclinderivate enthaltende pharmazeutische praeparate.
FR7900343A FR2414039A1 (fr) 1978-01-06 1979-01-08 Derives de prostacycline, leur procede de preparation et leurs applications en therapeutique
GB79630A GB2012265B (en) 1978-01-06 1979-01-08 Prostacyclin derivatives their use and preparation
US06/153,825 US4322435A (en) 1978-01-06 1980-05-27 Prostacyclin compounds
JP58015819A JPS58192845A (ja) 1978-01-06 1983-02-02 ビシクロ〔３．３．０〕オクタン誘導体
JP60250186A JPS61112039A (ja) 1978-01-06 1985-11-08 ビシクロ〔３．３．０〕オクタン化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP46278A JPS5495552A (en) 1978-01-06 1978-01-06 Prostacyline derivative and its preparation

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP58015819A Division JPS58192845A (ja) 1978-01-06 1983-02-02 ビシクロ〔３．３．０〕オクタン誘導体
JP60250186A Division JPS61112039A (ja) 1978-01-06 1985-11-08 ビシクロ〔３．３．０〕オクタン化合物

Publications (2)

Publication Number Publication Date
JPS5495552A true JPS5495552A (en) 1979-07-28
JPS6121216B2 JPS6121216B2 (US06312121-20011106-C00033.png) 1986-05-26

Family

ID=11474452

Family Applications (1)

Application Number Title Priority Date Filing Date
JP46278A Granted JPS5495552A (en) 1978-01-06 1978-01-06 Prostacyline derivative and its preparation

Country Status (7)

Country Link
US (1) US4322435A (US06312121-20011106-C00033.png)
JP (1) JPS5495552A (US06312121-20011106-C00033.png)
CH (2) CH651292A5 (US06312121-20011106-C00033.png)
DE (2) DE2954373C2 (US06312121-20011106-C00033.png)
FR (1) FR2414039A1 (US06312121-20011106-C00033.png)
GB (1) GB2012265B (US06312121-20011106-C00033.png)
IT (1) IT1192762B (US06312121-20011106-C00033.png)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5557559A (en) * 1978-10-19 1980-04-28 Schering Ag Prostane derivative*its manufacture and antihypertensive drug containing it
JPS6216A (ja) * 1985-03-19 1987-01-06 Sankyo Co Ltd カルバサイクリン類及びこれを有効成分とする抗潰瘍剤
WO2011059053A1 (ja) 2009-11-13 2011-05-19 東レ株式会社 糖尿病の治療または予防薬

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2013661B (en) * 1978-01-26 1982-11-10 Erba Farmitalia 9-deoxy-9 -methylene isosteres of pgi2
US4732914A (en) * 1978-02-13 1988-03-22 The Upjohn Company Prostacyclin analogs
JPS54119441A (en) * 1978-03-09 1979-09-17 Sumitomo Chem Co Ltd Novel bicyclooctane derivative
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
US4525586A (en) * 1980-02-28 1985-06-25 The Upjohn Company Composition and process
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3201764A1 (de) * 1982-01-21 1983-09-08 Merck Patent Gmbh, 6100 Darmstadt 13-thia-prostacycline, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4590297A (en) * 1982-02-16 1986-05-20 The Upjohn Company Novel 9-substituted carbacyclin analogs
US4487961A (en) * 1982-02-16 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
US4588823A (en) * 1982-02-16 1986-05-13 The Upjohn Company 9-substituted carbacyclin analogs
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
US4585886A (en) * 1982-03-19 1986-04-29 The Upjohn Company 9-Substituted carbacyclin analogs
US4490555A (en) * 1982-03-19 1984-12-25 The Upjohn Company 9-Substituted carbacyclin analogs
US4487960A (en) * 1982-04-19 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
US4689345A (en) * 1982-05-06 1987-08-25 Cbd Corporation Oxygenated alkyl substituted bicyclo alkanes
US4689349A (en) * 1982-05-06 1987-08-25 Cbd Corporation Anti-tumor halo bicyclo alkanones
ATE38028T1 (de) * 1982-05-06 1988-11-15 Cbd Corp Cycloaliphatische heilmittelzusammensetzungen.
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4552898A (en) * 1982-07-14 1985-11-12 Syntex (U.S.A.) Inc. [3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties
JPS5978179A (ja) * 1982-10-26 1984-05-04 Sankyo Co Ltd エポキシカルバサイクリン誘導体およびその製造法
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
US4561604A (en) * 1983-07-18 1985-12-31 Shimano Industrial Company Limited Spinning reel
EP0162894A4 (en) * 1983-11-08 1987-01-22 Cbd Corp HALO-BICYCLO-ALCANONES.
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
US4668814A (en) * 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
JPH075494B2 (ja) 1985-04-30 1995-01-25 三共株式会社 プロスタグランジン類
JPS61280294A (ja) * 1985-06-04 1986-12-10 Nisshin Flour Milling Co Ltd 光学活性カルバサイクリン中間体の製造方法
ATE80314T1 (de) * 1987-07-14 1992-09-15 Sankyo Co Zusammensetzung zur herstellung von antithrombotischen medizinischen erzeugnissen.
DE3835162A1 (de) * 1988-10-13 1990-04-19 Schering Ag (1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung
EP1245556B1 (de) * 2001-03-29 2004-09-15 DSM Fine Chemicals Austria Nfg GmbH & Co KG Verfahren zur Herstellung von Carbonsäuren durch Oxidation von Aldehyden in Gegenwart von Periodat, Dichromat und Säure in Wasser
ES2745956T3 (es) * 2009-09-23 2020-03-04 Int Flavors & Fragrances Inc Método de oxidación alílica para la preparación de fragancias usando compuestos organometálicos y catalizadores de oro

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4064351A (en) * 1974-09-19 1977-12-20 Sankyo Company Limited 9-OXO-15 ξ-HYDROXY-20-ALKYLIDENEPROST-13(TRANS)-ENOIC ACID DERIVATIVES
GB2017699B (en) 1978-03-31 1983-01-12 Ono Pharmaceutical Co 6,9-methano-pgi2 analogues
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5557559A (en) * 1978-10-19 1980-04-28 Schering Ag Prostane derivative*its manufacture and antihypertensive drug containing it
JPS6312051B2 (US06312121-20011106-C00033.png) * 1978-10-19 1988-03-17 Schering Ag
JPS6216A (ja) * 1985-03-19 1987-01-06 Sankyo Co Ltd カルバサイクリン類及びこれを有効成分とする抗潰瘍剤
JPH0584295B2 (US06312121-20011106-C00033.png) * 1985-03-19 1993-12-01 Sankyo Co
WO2011059053A1 (ja) 2009-11-13 2011-05-19 東レ株式会社 糖尿病の治療または予防薬
US9492422B2 (en) 2009-11-13 2016-11-15 Toray Industries, Inc. Therapeutic or prophylactic agent for diabetes

Also Published As

Publication number Publication date
FR2414039A1 (fr) 1979-08-03
US4322435A (en) 1982-03-30
FR2414039B1 (US06312121-20011106-C00033.png) 1981-11-27
DE2954373A1 (US06312121-20011106-C00033.png) 1985-03-21
IT7967023A0 (it) 1979-01-05
DE2900352A1 (de) 1979-07-19
CH639359A5 (de) 1983-11-15
CH651292A5 (de) 1985-09-13
GB2012265A (en) 1979-07-25
JPS6121216B2 (US06312121-20011106-C00033.png) 1986-05-26
DE2954373C2 (US06312121-20011106-C00033.png) 1989-03-23
IT1192762B (it) 1988-05-04
GB2012265B (en) 1982-07-21
DE2900352C2 (US06312121-20011106-C00033.png) 1987-04-16

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