JPS5473194A - Preparation of antibiotic substance c-15003p-3 - Google Patents

Preparation of antibiotic substance c-15003p-3

Info

Publication number
JPS5473194A
JPS5473194A JP13938577A JP13938577A JPS5473194A JP S5473194 A JPS5473194 A JP S5473194A JP 13938577 A JP13938577 A JP 13938577A JP 13938577 A JP13938577 A JP 13938577A JP S5473194 A JPS5473194 A JP S5473194A
Authority
JP
Japan
Prior art keywords
culturing
antibiotic substance
pref
isobutyryl
nocardia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13938577A
Other languages
English (en)
Other versions
JPS6016236B2 (ja
Inventor
Eiji Higashide
Kazunori Hatano
Mitsuko Asai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP52139385A priority Critical patent/JPS6016236B2/ja
Priority to US05/959,602 priority patent/US4228239A/en
Priority to CH1180078A priority patent/CH640270A5/de
Priority to DE19782849696 priority patent/DE2849696A1/de
Priority to NL7811325A priority patent/NL7811325A/xx
Priority to HU78TA1500A priority patent/HU179600B/hu
Priority to IT7829922A priority patent/IT1206651B/it
Priority to FR7832577A priority patent/FR2409307A1/fr
Priority to ES78475178A priority patent/ES475178A1/es
Priority to DK514378A priority patent/DK144657C/da
Priority to SU782688152A priority patent/SU1036251A3/ru
Priority to PL1978211028A priority patent/PL122463B1/pl
Priority to GB7845285A priority patent/GB2011385B/en
Publication of JPS5473194A publication Critical patent/JPS5473194A/ja
Publication of JPS6016236B2 publication Critical patent/JPS6016236B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP52139385A 1977-11-18 1977-11-18 抗生物質ｃ―１５００３ ｐ―３の製造法 Expired JPS6016236B2 (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP52139385A JPS6016236B2 (ja) 1977-11-18 1977-11-18 抗生物質ｃ―１５００３ ｐ―３の製造法
US05/959,602 US4228239A (en) 1977-11-18 1978-11-13 Method for producing antibiotic C-15003 P-3
CH1180078A CH640270A5 (de) 1977-11-18 1978-11-16 Verfahren zur herstellung des antibiotikums c-15003 p-3.
DE19782849696 DE2849696A1 (de) 1977-11-18 1978-11-16 Verfahren zur herstellung des antibiotikums c-15003 p-3
NL7811325A NL7811325A (nl) 1977-11-18 1978-11-16 Werkwijze ter bereiding van antibioticum c-15003 p-3.
HU78TA1500A HU179600B (en) 1977-11-18 1978-11-17 Process for preparing antibiotic c-15003 p-3
IT7829922A IT1206651B (it) 1977-11-18 1978-11-17 Procedimento per la produzione dell'antibiotico ottenuto coltivando un microorganismo del genere nocardia
FR7832577A FR2409307A1 (fr) 1977-11-18 1978-11-17 Procede de production de l'antibiotique c-15003 p-3 par culture d'un micro-organisme
ES78475178A ES475178A1 (es) 1977-11-18 1978-11-17 Un metodo mejorado para producir antibiotico c-15003 p-3.
DK514378A DK144657C (da) 1977-11-18 1978-11-17 Fremgangsmaade til fremstilling af antibiotikum c-15003 p-3
SU782688152A SU1036251A3 (ru) 1977-11-18 1978-11-17 Способ получени антибиотика @ -15003 @ -3
PL1978211028A PL122463B1 (en) 1977-11-18 1978-11-17 Process for preparing novel c-15003 p-3 antibiotic
GB7845285A GB2011385B (en) 1977-11-18 1978-11-20 Method for producing antibiotic c15003p/3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52139385A JPS6016236B2 (ja) 1977-11-18 1977-11-18 抗生物質ｃ―１５００３ ｐ―３の製造法

Publications (2)

Publication Number Publication Date
JPS5473194A true JPS5473194A (en) 1979-06-12
JPS6016236B2 JPS6016236B2 (ja) 1985-04-24

Family

ID=15244070

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52139385A Expired JPS6016236B2 (ja) 1977-11-18 1977-11-18 抗生物質ｃ―１５００３ ｐ―３の製造法

Country Status (13)

Country Link
US (1) US4228239A (ja)
JP (1) JPS6016236B2 (ja)
CH (1) CH640270A5 (ja)
DE (1) DE2849696A1 (ja)
DK (1) DK144657C (ja)
ES (1) ES475178A1 (ja)
FR (1) FR2409307A1 (ja)
GB (1) GB2011385B (ja)
HU (1) HU179600B (ja)
IT (1) IT1206651B (ja)
NL (1) NL7811325A (ja)
PL (1) PL122463B1 (ja)
SU (1) SU1036251A3 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005519594A (ja) * 2002-01-29 2005-07-07 イムノージェン インコーポレーテッド メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP4832697B2 (ja) * 2000-04-12 2011-12-07 スミスクライン ビーチャム ピー エル シー アンサミトシンの製法
JP2015509970A (ja) * 2012-03-17 2015-04-02 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ コンホメーション制約された全合成されたマクロ環化合物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162940A (en) * 1977-03-31 1979-07-31 Takeda Chemical Industries, Ltd. Method for producing Antibiotic C-15003 by culturing nocardia
JPS55162791A (en) * 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS5645483A (en) * 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
JPS56102793A (en) * 1979-12-28 1981-08-17 Takeda Chem Ind Ltd Preparation of antibiotic c-15003 p-3
US20110313230A1 (en) 2001-05-11 2011-12-22 Terrance Grant Johns Specific binding proteins and uses thereof
US20050261493A1 (en) * 2002-08-08 2005-11-24 Mark Fulston Methods for the isolation and purification of ansamitocins
US7432088B2 (en) 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
US20070135629A1 (en) * 2005-12-08 2007-06-14 Millennium Pharmaceuticals, Inc. Isolation of ansamitocins
US20110076232A1 (en) 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
CN101921817A (zh) * 2010-09-07 2010-12-22 上海交通大学 安莎霉素发酵产量提高方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3902968A (en) * 1974-04-25 1975-09-02 Merck & Co Inc Fermentation process
JPS58876B2 (ja) * 1975-11-19 1983-01-08 藤沢薬品工業株式会社 Ｆｒ −１９２３ ブツシツノ セイゾウホウホウ
JPS6010718B2 (ja) * 1977-03-31 1985-03-19 武田薬品工業株式会社 メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法
US4162940A (en) * 1977-03-31 1979-07-31 Takeda Chemical Industries, Ltd. Method for producing Antibiotic C-15003 by culturing nocardia
FR2385714A1 (fr) * 1977-03-31 1978-10-27 Takeda Chemical Industries Ltd Nouvel antibiotique denomme c-15003, son procede de preparation et son application comme medicament
US4151042A (en) * 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4832697B2 (ja) * 2000-04-12 2011-12-07 スミスクライン ビーチャム ピー エル シー アンサミトシンの製法
JP2005519594A (ja) * 2002-01-29 2005-07-07 イムノージェン インコーポレーテッド メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP2010110328A (ja) * 2002-01-29 2010-05-20 Immunogen Inc メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP2015509970A (ja) * 2012-03-17 2015-04-02 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ コンホメーション制約された全合成されたマクロ環化合物

Also Published As

Publication number Publication date
IT1206651B (it) 1989-04-27
HU179600B (en) 1982-11-29
NL7811325A (nl) 1979-05-22
FR2409307B1 (ja) 1981-03-06
DE2849696A1 (de) 1979-05-23
CH640270A5 (de) 1983-12-30
ES475178A1 (es) 1979-05-16
DK144657B (da) 1982-05-03
FR2409307A1 (fr) 1979-06-15
PL122463B1 (en) 1982-07-31
GB2011385B (en) 1982-05-26
SU1036251A3 (ru) 1983-08-15
US4228239A (en) 1980-10-14
GB2011385A (en) 1979-07-11
IT7829922A0 (it) 1978-11-17
PL211028A1 (pl) 1979-07-16
JPS6016236B2 (ja) 1985-04-24
DK144657C (da) 1982-11-22
DK514378A (da) 1979-05-19

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