JPS5473190A - Preparation of physiologically active substance, forphenicine - Google Patents

Preparation of physiologically active substance, forphenicine

Info

Publication number
JPS5473190A
JPS5473190A JP14077477A JP14077477A JPS5473190A JP S5473190 A JPS5473190 A JP S5473190A JP 14077477 A JP14077477 A JP 14077477A JP 14077477 A JP14077477 A JP 14077477A JP S5473190 A JPS5473190 A JP S5473190A
Authority
JP
Japan
Prior art keywords
forphenicine
cultivation
amino acid
medium
phenylglycine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14077477A
Other languages
Japanese (ja)
Other versions
JPS613479B2 (en
Inventor
Hamao Umezawa
Takaaki Aoyanagi
Tomio Takeuchi
Takuzou Yamamoto
Katsuhisa Ojiri
Eiji Kurosu
Ikuo Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP14077477A priority Critical patent/JPS5473190A/en
Publication of JPS5473190A publication Critical patent/JPS5473190A/en
Publication of JPS613479B2 publication Critical patent/JPS613479B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PURPOSE: To improve the productivity of immune-reactivative forphenicine by culturing forphenicine-producing fungi belonging to Streptomyces genus in a medium containing an amino acid such as phenylglycine, etc.
CONSTITUTION: Forphenicine is prepared by culturing forphenicine-producing micro- bials belonging to Streptomyces genus, e.g. Actinomyces fulvoviridis var. acarbodicus MC 974WA5 strain (FERM-P No.2015), in a medium containing an amino acid selected from phenylglycine, phenylalanine and tyrosine. The amino acid is added to the medium at the relatively early stage of the cultivation, pref. within 48 hours from the start of the cultivation. The cultivation is carried out at 27°C, and the productivity reaches maximum by the agitating culture for 3W5 days, or the agitating and aerating culture for 2W4 days. The amount of forphenycine prepared by this process is 3W20 times the amount by the cultivation in a medium free of amino acid.
COPYRIGHT: (C)1979,JPO&Japio
JP14077477A 1977-11-25 1977-11-25 Preparation of physiologically active substance, forphenicine Granted JPS5473190A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14077477A JPS5473190A (en) 1977-11-25 1977-11-25 Preparation of physiologically active substance, forphenicine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14077477A JPS5473190A (en) 1977-11-25 1977-11-25 Preparation of physiologically active substance, forphenicine

Publications (2)

Publication Number Publication Date
JPS5473190A true JPS5473190A (en) 1979-06-12
JPS613479B2 JPS613479B2 (en) 1986-02-01

Family

ID=15276430

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14077477A Granted JPS5473190A (en) 1977-11-25 1977-11-25 Preparation of physiologically active substance, forphenicine

Country Status (1)

Country Link
JP (1) JPS5473190A (en)

Also Published As

Publication number Publication date
JPS613479B2 (en) 1986-02-01

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