JPS5677296A - Tryptophane derivative and its preparation - Google Patents

Tryptophane derivative and its preparation

Info

Publication number
JPS5677296A
JPS5677296A JP15481779A JP15481779A JPS5677296A JP S5677296 A JPS5677296 A JP S5677296A JP 15481779 A JP15481779 A JP 15481779A JP 15481779 A JP15481779 A JP 15481779A JP S5677296 A JPS5677296 A JP S5677296A
Authority
JP
Japan
Prior art keywords
water
salt
streptomyces
tryptophane
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15481779A
Other languages
Japanese (ja)
Inventor
Sawao Murao
Kenichi Fukuhara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP15481779A priority Critical patent/JPS5677296A/en
Publication of JPS5677296A publication Critical patent/JPS5677296A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NEW MATERIAL:N-(6-Deoxy-L-tolosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophane shown by the formula. Having the following properties. Elementary analysis: C 56.60%, H 8.21%, N 9.31%. Molecular weight (mass spectrometry): 543. Melting point (di-cyclohexylamine salt, C=0.5, water): 153W156°C (decomposition). [α]D21=-25.6° (di-cylcohexylamine salt, C=0.5, water). Positive in Rydon Smith reagent, etc.
USE: A remedy for an infectious disease by Pseudomonas aeruginosa, and an inhibiting substance of a metal protease as a growth regulator for microorganisms.
PROCESS: An actinomycete belonging to the genus Streptomyces, e.g., Streptomyces morzuensis AJ 9406 (FREM-P 4589, NRRL 12054), etc. is subjected to aerated cultivation preferably at pH 5W9 at 15W40°C. Isolation is then carried out by extraction, dialysis, distribution, etc.
COPYRIGHT: (C)1981,JPO&Japio
JP15481779A 1979-11-29 1979-11-29 Tryptophane derivative and its preparation Pending JPS5677296A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15481779A JPS5677296A (en) 1979-11-29 1979-11-29 Tryptophane derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15481779A JPS5677296A (en) 1979-11-29 1979-11-29 Tryptophane derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5677296A true JPS5677296A (en) 1981-06-25

Family

ID=15592516

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15481779A Pending JPS5677296A (en) 1979-11-29 1979-11-29 Tryptophane derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5677296A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5929278A (en) * 1994-10-27 1999-07-27 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US6307101B1 (en) 1994-10-27 2001-10-23 David A. Campbell Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use

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