JPS4874292A - - Google Patents

Info

Publication number
JPS4874292A
JPS4874292A JP48004534A JP453473A JPS4874292A JP S4874292 A JPS4874292 A JP S4874292A JP 48004534 A JP48004534 A JP 48004534A JP 453473 A JP453473 A JP 453473A JP S4874292 A JPS4874292 A JP S4874292A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP48004534A
Other languages
Japanese (ja)
Other versions
JPS5613266B2 (cs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPS4874292A publication Critical patent/JPS4874292A/ja
Publication of JPS5613266B2 publication Critical patent/JPS5613266B2/ja
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1024—Counting particles by non-optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/103—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1406—Control of droplet point
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1477—Multiparameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
JP734534A 1971-12-23 1972-12-23 Expired JPS5613266B2 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21147371A 1971-12-23 1971-12-23

Publications (2)

Publication Number Publication Date
JPS4874292A true JPS4874292A (cs) 1973-10-06
JPS5613266B2 JPS5613266B2 (cs) 1981-03-27

Family

ID=22787055

Family Applications (1)

Application Number Title Priority Date Filing Date
JP734534A Expired JPS5613266B2 (cs) 1971-12-23 1972-12-23

Country Status (11)

Country Link
US (1) US3710933A (cs)
JP (1) JPS5613266B2 (cs)
AU (1) AU468637B2 (cs)
BE (1) BE793185A (cs)
CA (1) CA971913A (cs)
DE (1) DE2261695C2 (cs)
FR (1) FR2164898B1 (cs)
GB (1) GB1380756A (cs)
NL (1) NL7216901A (cs)
NO (1) NO138305C (cs)
SE (1) SE388278B (cs)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5821166A (ja) * 1981-07-30 1983-02-07 Fujitsu Ltd 被測定物質分離方式
JPS5826268A (ja) * 1981-07-22 1983-02-16 インタ−ナシヨナル・リモ−ト・イメ−ジング・システムズ 懸濁液中の粒子と液体との間の反応物質の分布の分析法
JPS5847239A (ja) * 1981-09-14 1983-03-18 Nisshin Denki Seisakusho:Kk 液体クロマトグラフ装置
JPS5960261A (ja) * 1982-08-30 1984-04-06 ベクトン・デイツキンソン・アンド・カンパニ− 細胞の多数の予備増殖を識別する方法
JPS5995440A (ja) * 1982-11-25 1984-06-01 Eisai Co Ltd 光学測定方法と装置
JPS59173759A (ja) * 1983-03-11 1984-10-01 イ−・アイ・デユポン・デ・ニモアス・アンド・カンパニ− 免疫学的検定用の粒子試薬粒径分布測定方法
JPS59174742A (ja) * 1983-03-25 1984-10-03 Agency Of Ind Science & Technol 微小粒子を区分又は選別する方法及びその装置
JPS6080764A (ja) * 1983-10-12 1985-05-08 Agency Of Ind Science & Technol 微小粒子を識別する方法及びその装置
JPH04125244U (ja) * 1991-05-07 1992-11-16 日工株式会社 管体切り出し装置
JP2020510222A (ja) * 2017-04-11 2020-04-02 ソニー株式会社 微粒子分類装置と遅延時間決定方法

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826364A (en) * 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US3819270A (en) * 1972-10-02 1974-06-25 Block Engineering Blood cell analyzer
US3791517A (en) * 1973-03-05 1974-02-12 Bio Physics Systems Inc Digital fluidic amplifier particle sorter
US3827555A (en) * 1973-03-05 1974-08-06 Bio Physics Systems Inc Particle sorter with segregation indicator
US3984307A (en) * 1973-03-05 1976-10-05 Bio/Physics Systems, Inc. Combined particle sorter and segregation indicator
US3907437A (en) * 1973-04-26 1975-09-23 Block Engineering Cell classification system
US3824402A (en) * 1973-06-04 1974-07-16 Energy Commission Dual parameter flow photometric apparatus and method
US4009435A (en) * 1973-10-19 1977-02-22 Coulter Electronics, Inc. Apparatus for preservation and identification of particles analyzed by flow-through apparatus
US3924947A (en) * 1973-10-19 1975-12-09 Coulter Electronics Apparatus for preservation and identification of particles analyzed by flow-through apparatus
US4074939A (en) * 1973-12-19 1978-02-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Apparatus for investigating fast chemical reactions by optical detection
US3910702A (en) * 1974-02-12 1975-10-07 Particle Technology Inc Apparatus for detecting particles employing apertured light emitting device
US3963606A (en) * 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US4071298A (en) * 1974-06-27 1978-01-31 Stanford Research Institute Laser Raman/fluorescent device for analyzing airborne particles
DE2543310C2 (de) * 1975-09-27 1982-04-29 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Einrichtung zum Zählen und Klassifizieren von in einer Flüssigkeit suspendierten Teilchen
FR2328960A1 (fr) * 1975-10-08 1977-05-20 Coulter Electronics Dispositif pour la preservation et l'identification de particules analysees par un dispositif a ecoulement traversant
US4053229A (en) * 1976-01-13 1977-10-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration 2°/90° Laboratory scattering photometer
SE400841B (sv) * 1976-02-05 1978-04-10 Hertz Carl H Sett att alstra en vetskestrale samt anordning for genomforande av settet
US4162282A (en) * 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4101276A (en) * 1976-06-02 1978-07-18 Beckman Instruments, Inc. Method and apparatus for signalling the introduction of chemical reaction components into a chemical analyzing system
US4095898A (en) * 1976-06-10 1978-06-20 Coulter Electronics, Inc. Particle analysis system with photochromic filter
JPS5319891A (en) * 1976-06-10 1978-02-23 Coulter Electronics Method and apparatus for folling drop formation and separation
NL180704C (nl) * 1976-06-14 Coulter Electronics Inrichting voor gelijktijdige optische meting van kenmerken van zich in een suspensie bevindende deeltjes.
DE2632962C3 (de) * 1976-07-22 1980-08-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Partikelseparator
DE2712360A1 (de) * 1977-03-22 1978-09-28 Zoeld Tibor Dr Phys Kanalzaehler zur zaehlung und groessenbestimmung von in einem elektrolyten suspendierten teilchen
DE2742838A1 (de) * 1977-09-23 1979-04-05 Zoeld Tibor Dr Phys Kanalzaehler zur zaehlung und groessenbestimmung von in einem elektrolyten suspendierten teilchen
US4097373A (en) * 1977-03-23 1978-06-27 John Caldwell Allred High speed particle sorter using a field emission electrode
US4203670A (en) * 1977-04-21 1980-05-20 Bromberg Nathan S System and method of fluorescence polarimetry
US4191739A (en) * 1977-10-17 1980-03-04 General Electric Company Antigen-antibody reaction assay employing particle aggregation and resistive pulse analysis
US4343782A (en) * 1978-04-20 1982-08-10 Shapiro Howard M Cytological assay procedure
US4230031A (en) * 1978-04-26 1980-10-28 Coulter Electronics, Inc. Biohazard containment apparatus and method
FR2431694A1 (fr) * 1978-07-18 1980-02-15 Berber Viktor Dispositif pour l'enregistrement granulometrique des particules presentes dans un liquide
US4577964A (en) * 1978-09-06 1986-03-25 Ortho Diagnostics, Inc. Apparatus and method for detecting platelets in whole blood
US4293221A (en) * 1979-04-17 1981-10-06 Research Corporation Multidimensional slit-scan flow system
US4263508A (en) * 1979-04-20 1981-04-21 Research Corporation Pulse edge measurement for determining particle dimensional characteristics
US4347935A (en) * 1979-05-16 1982-09-07 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for electrostatically sorting biological cells
US4279345A (en) * 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
US4318481A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4318480A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4325483A (en) * 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4318482A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
US4317520A (en) * 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4318483A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
NO145176C (no) 1979-11-23 1982-01-27 Norsk Hydros Inst For Kreftfor Anordning ved vaeskestroemsfotometer.
US4298836A (en) * 1979-11-23 1981-11-03 Coulter Electronics, Inc. Particle shape determination
US4284495A (en) * 1979-12-10 1981-08-18 Newton William A Coating apparatus and method
US4284496A (en) * 1979-12-10 1981-08-18 Newton William A Particle guiding apparatus and method
US4329787A (en) * 1980-01-04 1982-05-18 Newton William A Droplet exploding and freezing apparatus and method
US4350892A (en) * 1980-07-31 1982-09-21 Research Corporation X'-, Y'-, Z'- axis multidimensional slit-scan flow system
US4352731A (en) * 1980-11-03 1982-10-05 Occidental Research Corporation Apparatus for selective wetting of particles
US4487320A (en) * 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4691829A (en) * 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4395676A (en) * 1980-11-24 1983-07-26 Coulter Electronics, Inc. Focused aperture module
US4399219A (en) * 1981-01-29 1983-08-16 Massachusetts Institute Of Technology Process for isolating microbiologically active material
US4401755A (en) * 1981-01-29 1983-08-30 Massachusetts Institute Of Technology Process for measuring microbiologically active material
US4818103A (en) * 1981-05-15 1989-04-04 Ratcom Flow cytometry
US4673288A (en) * 1981-05-15 1987-06-16 Ratcom, Inc. Flow cytometry
US4667830A (en) * 1981-06-15 1987-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like
DE3266669D1 (en) * 1981-06-24 1985-11-07 Becton Dickinson Co Analyzer for simultaneously determining volume and light emission characteristics of particles
US4444317A (en) * 1981-08-26 1984-04-24 Georg Wick Observation of immunofluorescene for distinguishing between specific and nonspecific binding of conjugates
US4515274A (en) * 1981-12-02 1985-05-07 Coulter Corporation Particle analyzing and sorting apparatus
US4510438A (en) * 1982-02-16 1985-04-09 Coulter Electronics, Inc. Coincidence correction in particle analysis system
US4498766A (en) * 1982-03-25 1985-02-12 Becton, Dickinson And Company Light beam focal spot elongation in flow cytometry devices
DE3233055C2 (de) * 1982-09-06 1994-07-28 Coulter Electronics Durchflußvorrichtung zur Untersuchung einzelner, in einer Flüssigkeit suspendierter Teilchen
DE3238353A1 (de) * 1982-10-15 1984-04-19 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verfahren zur simultanen quantitativen bestimmung der blutzellen und reagenz hierfuer
CA1206559A (en) * 1983-03-04 1986-06-24 Robert E. Auer Method of and apparatus for detecting change in the breakoff point of a droplet generation system
CH651930A5 (en) * 1983-03-24 1985-10-15 Coulter Corp Apparatus for analysis and sorting of particles
JPS59184841A (ja) * 1983-04-05 1984-10-20 ベクトン・デイツキンソン・アンド・カンパニ− サンプル中の白血球のサブクラスを識別する方法および装置
JPS59167065U (ja) * 1983-04-25 1984-11-08 日産ディーゼル工業株式会社 全油圧式パワ−ステアリング装置
US4564803A (en) * 1983-08-29 1986-01-14 Coulter Corporation Method and apparatus for removing foreign matter from a flow cell of a particle study device
US4538733A (en) * 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
US4735504A (en) * 1983-10-31 1988-04-05 Technicon Instruments Corporation Method and apparatus for determining the volume & index of refraction of particles
JPS6078013U (ja) * 1983-11-02 1985-05-31 三洋電機株式会社 液晶表示器用基板
JPS60100785U (ja) * 1983-12-15 1985-07-09 シャープ株式会社 表示装置
US5188935A (en) * 1984-05-31 1993-02-23 Coulter Electronics, Inc. Reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
US4751179A (en) * 1984-05-31 1988-06-14 Coulter Electronics, Inc. Method and reagents for differential determination of four populations of leukocytes in blood
DE3574617D1 (de) * 1984-09-11 1990-01-11 Partec Ag Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln.
US4661913A (en) * 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
US4916060A (en) * 1985-09-17 1990-04-10 Massachusetts Institute Of Technology Process for chemical measurement in small volume samples by fluorescent indicators
US4760328A (en) * 1986-05-05 1988-07-26 Integrated Ionics, Inc. Particle counter having electrodes and circuitry mounted on the pane of the orifice
DE3786657D1 (de) * 1987-02-17 1993-08-26 Ratcom Inc Durchflusszytometrie.
US4987539A (en) * 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US4988619A (en) * 1987-11-30 1991-01-29 United States Department Of Energy Flow cytometry apparatus
US4837446A (en) * 1988-03-31 1989-06-06 International Paper Company Apparatus and process for testing uniformity of pulp
US4844610A (en) * 1988-04-29 1989-07-04 Becton, Dickinson And Company Backflow isolator and capture system
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
CA1324894C (en) * 1989-03-31 1993-12-07 Maritime Scientific Services Ltd. Method and apparatus for the identification of particles
JPH02289808A (ja) * 1989-04-28 1990-11-29 Olympus Optical Co Ltd 照明光学系
GB2233759B (en) * 1989-06-12 1993-08-25 De Beers Ind Diamond Particulate ore sorting
US5030002A (en) * 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube
US5275787A (en) * 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
EP0422616B1 (en) * 1989-10-11 1996-02-07 Canon Kabushiki Kaisha Apparatus for and method of fractionating particle in particle-suspended liquid in conformity with the properties thereof
FR2653885B1 (fr) * 1989-10-27 1994-01-14 Abx Appareil pour le comptage et la determination d'au moins une sous-population leucocytaire.
US5194909A (en) * 1990-12-04 1993-03-16 Tycko Daniel H Apparatus and method for measuring volume and hemoglobin concentration of red blood cells
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5558998A (en) * 1992-02-25 1996-09-24 The Regents Of The Univ. Of California DNA fragment sizing and sorting by laser-induced fluorescence
US5232828A (en) * 1992-03-09 1993-08-03 Becton, Dickinson And Company Coating agents for cell recovery
US5859705A (en) * 1993-05-26 1999-01-12 The Dow Chemical Company Apparatus and method for using light scattering to determine the size of particles virtually independent of refractive index
US5464581A (en) * 1993-08-02 1995-11-07 The Regents Of The University Of California Flow cytometer
US5540494A (en) * 1994-06-03 1996-07-30 Purvis, Jr.; Norman B. Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry
EP0695941B1 (en) * 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US6121048A (en) * 1994-10-18 2000-09-19 Zaffaroni; Alejandro C. Method of conducting a plurality of reactions
US5641457A (en) * 1995-04-25 1997-06-24 Systemix Sterile flow cytometer and sorter with mechanical isolation between flow chamber and sterile enclosure
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
US6145247A (en) 1996-06-27 2000-11-14 Weyerhaeuser Company Fluid switch
EP0946278A1 (en) 1996-10-21 1999-10-06 Smithkline Beecham Plc Apparatus and method for distributing beads
DE19700648A1 (de) * 1997-01-10 1998-07-23 Basf Ag Verfahren und Vorrichtung zur Bestimmung der Größenverteilung von verschiedenartigen Partikeln in einer Probe
DE69830598T2 (de) 1997-01-31 2006-05-18 The Horticulture And Food Research Institute Of New Zealand Limited Optische vorrichtung und methode
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) * 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6265163B1 (en) 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes
US6211477B1 (en) * 1998-02-26 2001-04-03 Becton Dickinson And Company Electrostatic deceleration system for flow cytometer
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
US6079836A (en) * 1998-07-20 2000-06-27 Coulter International Corp. Flow cytometer droplet break-off location adjustment mechanism
ATE488247T1 (de) 1998-07-30 2010-12-15 Xy Llc Pferdesystem für die künstliche befruchtung ohne chirurgischen eingriff
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US8148110B2 (en) * 1999-03-15 2012-04-03 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by β-lactamase reporter fragment complementation
US7097973B1 (en) * 1999-06-14 2006-08-29 Alpha Mos Method for monitoring molecular species within a medium
US7024316B1 (en) * 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
UA95899C2 (ru) 2000-05-09 2011-09-26 Эксуай, Ллк Популяции сперматозоидов высокой чистоты с x-хромосомами и y-хромосомами
AU2001269795B2 (en) * 2000-06-12 2006-07-20 Xy, Inc. Integrated herd management system utilizing isolated populations of x-chromosome bearing and y-chromosome bearing spermatozoa
US6455007B1 (en) * 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
US20020064809A1 (en) 2000-11-29 2002-05-30 Mutz Mitchell W. Focused acoustic ejection cell sorting system and method
US6849423B2 (en) * 2000-11-29 2005-02-01 Picoliter Inc Focused acoustics for detection and sorting of fluid volumes
AU2002220018A1 (en) 2000-11-29 2002-06-11 Colorado State University System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
EP1352237A4 (en) * 2000-12-15 2009-03-04 Beckman Coulter Inc ELECTROCONDUCTIVE CONTAINMENT SYSTEM
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
WO2002078906A2 (en) * 2001-03-29 2002-10-10 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
ES2405320T3 (es) 2001-05-17 2013-05-30 Beckman Coulter, Inc. Citómetro de flujo con un sistema de alienación óptica automatizado activo
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
AUPR846501A0 (en) * 2001-10-26 2001-11-15 Btf Pty Ltd A cytometer
DE60233708D1 (de) * 2001-11-30 2009-10-29 Sysmex Corp Teilchenanalysator
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
EP2275533B9 (en) * 2002-08-01 2016-10-19 Xy, Llc Method of assessing sperm cells
BRPI0313476B1 (pt) * 2002-08-15 2015-06-23 Xy Llc Citômetro de fluxo de alta resolução
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7201875B2 (en) * 2002-09-27 2007-04-10 Becton Dickinson And Company Fixed mounted sorting cuvette with user replaceable nozzle
EP1544600B1 (en) * 2002-09-27 2010-07-07 Rion Co., Ltd. Flow cell, and particle measurement device using the same
US6941005B2 (en) * 2002-11-01 2005-09-06 Coulter International Corp. Monitoring and control of droplet sorting
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
CN102830053A (zh) 2003-03-28 2012-12-19 英格朗公司 用于分拣颗粒和提供性别分拣的动物精子的设备、方法和程序
CA2566749C (en) 2003-05-15 2017-02-21 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
PL1756547T3 (pl) * 2004-03-01 2014-11-28 Partec Gmbh Urządzenie do pomiaru światła, jakie jest emitowane przez mikroskopowe małe cząstki lub komórki biologiczne
EP2260854A1 (en) 2004-03-29 2010-12-15 Inguran, LLC Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
WO2006012597A2 (en) 2004-07-22 2006-02-02 Monsanto Technology Llc Process for enriching a population of sperm cells
US9134220B2 (en) * 2004-07-27 2015-09-15 Beckman Coulter, Inc. Enhancing flow cytometry discrimination with geometric transformation
CN100595564C (zh) 2004-07-30 2010-03-24 百维吉伦特系统有限公司 病原体和粒子检测器系统和方法
US7392908B2 (en) * 2005-01-12 2008-07-01 Beckman Coulter, Inc. Methods and apparatus for sorting particles hydraulically
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US20060284930A1 (en) * 2005-06-21 2006-12-21 George Mejalli Methods and arrangements for adjusting and aligning fluid dispensing devices and the like such as continuous ink jet printheads
US7738099B2 (en) * 2005-07-15 2010-06-15 Biovigilant Systems, Inc. Pathogen and particle detector system and method
US7618770B2 (en) * 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US20070059370A1 (en) * 2005-09-15 2007-03-15 Industrial Technology Research Institute Method and apparatus for fabricating nanoparticles
US20080187487A1 (en) * 2006-05-03 2008-08-07 Gustavo Larsen Methods for producing multilayered particles, fibers and sprays and methods for administering the same
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
CN101687227B (zh) * 2006-12-04 2013-01-02 昆士兰大学 颗粒分离装置和方法
US9267918B2 (en) 2007-10-16 2016-02-23 Cambridge Enterprise Limited Microfluidic systems
GB0720202D0 (en) 2007-10-16 2007-11-28 Cambridge Entpr Ltd Microfluidic systems
US8628976B2 (en) * 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
FR2933192B1 (fr) * 2008-06-25 2010-09-17 Horiba Abx Sas Dispositif et procede de mesure electro optique destines a la classification et au comptage d'elements microscopiques.
PL2304020T3 (pl) 2008-06-30 2019-06-28 Microbix Biosystems Inc. Sposób i urządzenie do sortowania komórek
JP5382852B2 (ja) 2009-02-06 2014-01-08 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたフローサイトメーター
JP5487638B2 (ja) * 2009-02-17 2014-05-07 ソニー株式会社 微小粒子分取のための装置及びマイクロチップ
US8665439B2 (en) * 2009-06-30 2014-03-04 Microbix Biosystems, Inc. Method and apparatus for limiting effects of refraction in cytometry
AT508806B1 (de) * 2009-10-07 2013-06-15 Onkotec Gmbh Analysegerät und verfahren
US8589851B2 (en) * 2009-12-15 2013-11-19 Memoir Systems, Inc. Intelligent memory system compiler
WO2011077765A1 (ja) * 2009-12-25 2011-06-30 古河電気工業株式会社 検体識別分取装置および検体識別分取方法
CN102753955B (zh) 2010-01-15 2015-02-04 芯片生物技术株式会社 一次性芯片型流动室与利用其的细胞分选仪
WO2012055048A1 (en) * 2010-10-29 2012-05-03 The University Of British Columbia Methods and apparatus for detecting particles entrained in fluids
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
CA2823193C (en) 2010-12-27 2017-06-06 Ibis Biosciences, Inc. Quantitating high titer samples by digital pcr
FR2970334A1 (fr) * 2011-01-07 2012-07-13 Horiba Abx Sas Dispositif d'inspection d'un fluide biologique
FR2971337B1 (fr) * 2011-02-04 2013-03-01 Horiba Abx Sas Dispositif et procede de mesures multiparametriques de microparticules dans un fluide
MX346463B (es) 2011-02-15 2017-03-21 Microbix Biosystems Inc Métodos, sistemas y aparato para realizar citometrías de flujo.
US10723497B2 (en) * 2014-11-03 2020-07-28 Vanrx Pharmasystems Inc. Apparatus and method for monitoring and controlling the filling of a container with a pharmaceutical fluid in an aseptic environment
US9242248B2 (en) * 2011-09-16 2016-01-26 The University Of North Carolina At Charlotte Methods and devices for optical sorting of microspheres based on their resonant optical properties
US9841367B2 (en) 2011-09-16 2017-12-12 The University Of North Carolina At Charlotte Methods and devices for optical sorting of microspheres based on their resonant optical properties
EP2795290B1 (en) * 2011-12-20 2021-03-03 Becton Dickinson and Company Method, system, computer-readable storage medium and cell sorter to improve yield of sorted particles
EP2872523B1 (en) 2011-12-30 2018-01-17 Abbott Molecular Inc. Microorganism nucleic acid purification from host samples
US9087371B2 (en) 2012-03-30 2015-07-21 Sony Corporation Microparticle sorting device and method of optimizing fluid stream therein
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
JP6065527B2 (ja) * 2012-11-08 2017-01-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取方法
JP6304034B2 (ja) 2013-01-28 2018-04-04 ソニー株式会社 微小粒子分取装置、微小粒子分取方法及びプログラム
JP2014174139A (ja) * 2013-03-13 2014-09-22 Sony Corp 流路デバイス、粒子分取装置、粒子流出方法、及び粒子分取方法
US11579072B2 (en) 2013-03-15 2023-02-14 Particles Plus, Inc. Personal air quality monitoring system
US10983040B2 (en) 2013-03-15 2021-04-20 Particles Plus, Inc. Particle counter with integrated bootloader
US10352844B2 (en) 2013-03-15 2019-07-16 Particles Plus, Inc. Multiple particle sensors in a particle counter
US12044611B2 (en) 2013-03-15 2024-07-23 Particles Plus, Inc. Particle counter with integrated bootloader
US9677990B2 (en) 2014-04-30 2017-06-13 Particles Plus, Inc. Particle counter with advanced features
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
CN107576634B (zh) * 2013-07-16 2021-07-23 成都深迈瑞医疗电子技术研究院有限公司 血液细胞分析仪及其细胞的识别方法与系统
EP3035030B1 (en) 2013-10-16 2019-07-10 Sony Corporation Particle fractionation device, particle fractionation method, and program
JP6136843B2 (ja) * 2013-10-17 2017-05-31 ソニー株式会社 粒子分取装置、粒子分取方法及びプログラム
AU2014343391B2 (en) 2013-10-30 2019-01-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
WO2015122071A1 (ja) 2014-02-13 2015-08-20 ソニー株式会社 粒子分取装置、粒子分取方法、プログラム及び粒子分取システム
US8820538B1 (en) 2014-03-17 2014-09-02 Namocell LLC Method and apparatus for particle sorting
FR3022998B1 (fr) * 2014-06-30 2016-07-15 Alain Rousseau Techniques & Innovations Arteion Systeme et ensemble de cytometrie en flux, dispositif d’analyse comprenant un tel ensemble de cytometrie et ensemble comprenant un tel systeme de cytometrie
JP6657625B2 (ja) 2014-09-05 2020-03-04 ソニー株式会社 液滴分取装置、液滴分取方法及びプログラム
EP3943912B1 (en) * 2015-02-12 2025-08-20 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Cell analyzer and particle sorting method and device
EP4137798A1 (en) 2015-02-19 2023-02-22 1087 Systems, Inc. Scanning infrared measurement system
WO2016182034A1 (ja) * 2015-05-12 2016-11-17 株式会社オンチップ・バイオテクノロジーズ 単一粒子解析方法およびその解析のためのシステム
EP3343200B1 (en) 2015-10-19 2021-12-15 Sony Group Corporation Image processing device, microparticle separation device, and image processing method
DE102016115891A1 (de) * 2016-08-26 2018-03-01 Krones Aktiengesellschaft Abfüllanlage zum Befüllen eines Behälters mit einem Füllprodukt
JP7020689B2 (ja) 2016-09-16 2022-02-16 株式会社オンチップ・バイオテクノロジーズ 微粒子分注装置、微粒子解析装置、及び反応検出装置、並びにそれらを用いる方法
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
CN113784618B (zh) 2019-04-18 2023-12-22 艾步思国际有限责任公司 用于连续添加冷冻保护剂的系统和工艺
US11307132B2 (en) 2019-06-26 2022-04-19 Life Technologies Corporation Integrated biocontainment cell sorter
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
WO2021262191A1 (en) * 2020-06-26 2021-12-30 Hewlett-Packard Development Company, L.P. Target particle ejection from recirculating fluid ejection channels
US11988591B2 (en) 2020-07-01 2024-05-21 Particles Plus, Inc. Modular optical particle counter sensor and apparatus
EP4248190A4 (en) 2020-11-23 2024-12-25 ABS Global, Inc. MODULAR FLOW CYTOMETRY SYSTEMS AND METHODS FOR PROCESSING SAMPLES
CN119915706B (zh) * 2025-04-07 2025-06-27 四川大学华西医院 一种应用于流式细胞仪的数据处理方法及系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3380584A (en) * 1965-06-04 1968-04-30 Atomic Energy Commission Usa Particle separator
US3560754A (en) * 1965-11-17 1971-02-02 Ibm Photoelectric particle separator using time delay
US3497690A (en) * 1967-09-21 1970-02-24 Bausch & Lomb Method and apparatus for classifying biological cells by measuring the size and fluorescent response thereof
US3675768A (en) * 1969-03-17 1972-07-11 Gildardo Legorreta Sanchez Method and apparatus for classifying and segregating particles with electrical and optical means

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5826268A (ja) * 1981-07-22 1983-02-16 インタ−ナシヨナル・リモ−ト・イメ−ジング・システムズ 懸濁液中の粒子と液体との間の反応物質の分布の分析法
JPS5821166A (ja) * 1981-07-30 1983-02-07 Fujitsu Ltd 被測定物質分離方式
JPS5847239A (ja) * 1981-09-14 1983-03-18 Nisshin Denki Seisakusho:Kk 液体クロマトグラフ装置
JPS5960261A (ja) * 1982-08-30 1984-04-06 ベクトン・デイツキンソン・アンド・カンパニ− 細胞の多数の予備増殖を識別する方法
JPS5995440A (ja) * 1982-11-25 1984-06-01 Eisai Co Ltd 光学測定方法と装置
JPS59173759A (ja) * 1983-03-11 1984-10-01 イ−・アイ・デユポン・デ・ニモアス・アンド・カンパニ− 免疫学的検定用の粒子試薬粒径分布測定方法
JPS59174742A (ja) * 1983-03-25 1984-10-03 Agency Of Ind Science & Technol 微小粒子を区分又は選別する方法及びその装置
JPS6080764A (ja) * 1983-10-12 1985-05-08 Agency Of Ind Science & Technol 微小粒子を識別する方法及びその装置
JPH04125244U (ja) * 1991-05-07 1992-11-16 日工株式会社 管体切り出し装置
JP2020510222A (ja) * 2017-04-11 2020-04-02 ソニー株式会社 微粒子分類装置と遅延時間決定方法

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DE2261695A1 (de) 1973-06-28
FR2164898B1 (cs) 1974-08-02
FR2164898A1 (cs) 1973-08-03
BE793185A (fr) 1973-04-16
AU468637B2 (en) 1974-06-20
SE388278B (sv) 1976-09-27
NL7216901A (cs) 1973-06-26
AU5020272A (en) 1974-06-20
JPS5613266B2 (cs) 1981-03-27
US3710933A (en) 1973-01-16
CA971913A (en) 1975-07-29
NO138305B (no) 1978-05-02
NO138305C (no) 1978-08-09
GB1380756A (en) 1975-01-15

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