JPS4857993A - - Google Patents
Info
- Publication number
- JPS4857993A JPS4857993A JP47115495A JP11549572A JPS4857993A JP S4857993 A JPS4857993 A JP S4857993A JP 47115495 A JP47115495 A JP 47115495A JP 11549572 A JP11549572 A JP 11549572A JP S4857993 A JPS4857993 A JP S4857993A
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5375071A GB1400999A (en) | 1971-11-19 | 1971-11-19 | Imidazo-triazine compounds and their use in therapeutic compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS4857993A true JPS4857993A (forum.php) | 1973-08-14 |
| JPS563873B2 JPS563873B2 (forum.php) | 1981-01-27 |
Family
ID=10468856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11549572A Expired JPS563873B2 (forum.php) | 1971-11-19 | 1972-11-17 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3840537A (forum.php) |
| JP (1) | JPS563873B2 (forum.php) |
| AT (1) | AT321923B (forum.php) |
| AU (1) | AU472127B2 (forum.php) |
| BE (1) | BE791025A (forum.php) |
| CA (1) | CA990292A (forum.php) |
| CH (1) | CH594671A5 (forum.php) |
| DE (1) | DE2255172A1 (forum.php) |
| DK (1) | DK138691B (forum.php) |
| ES (1) | ES408736A1 (forum.php) |
| FR (1) | FR2160407B1 (forum.php) |
| GB (1) | GB1400999A (forum.php) |
| IE (1) | IE37046B1 (forum.php) |
| IL (1) | IL40686A (forum.php) |
| NL (1) | NL7215646A (forum.php) |
| PH (1) | PH9669A (forum.php) |
| SE (1) | SE402915B (forum.php) |
| ZA (1) | ZA727532B (forum.php) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017204316A1 (ja) * | 2016-05-27 | 2017-11-30 | 塩野義製薬株式会社 | ５－オキソ－１，２，４－トリアジン誘導体およびその医薬組成物 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1457873A (en) * | 1973-01-04 | 1976-12-08 | Allen & Hanburys Ltd | Imidazotriazines |
| DE2314488C3 (de) * | 1973-03-23 | 1979-01-04 | C.H. Boehringer Sohn, 6507 Ingelheim | 8-(2,6-Dichlorphenyl)-7-(4-chlorphenyl)-5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazin, Verfahren zu dessen Herstellung und dieses enthaltene Arzneimittel |
| DE2335193A1 (de) * | 1973-07-11 | 1975-01-30 | Hoechst Ag | Bis-triazinobenzimidazole und ihre herstellung |
| US4107307A (en) * | 1977-02-03 | 1978-08-15 | American Cyanamid Company | Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones |
| USRE30511E (en) * | 1977-02-03 | 1981-02-10 | American Cyanamid Company | Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones |
| US4115572A (en) * | 1977-02-03 | 1978-09-19 | American Cyanamid Company | Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma |
| DK109578A (da) * | 1977-03-25 | 1978-09-26 | Allen & Hanburys Ltd | Fremgangsmaade til fremstilling af heterocycliske forbindelser |
| US4107308A (en) * | 1977-10-18 | 1978-08-15 | American Cyanamid Company | Imidazo[1,5-d]-as-triazines |
| US4308384A (en) * | 1978-09-18 | 1981-12-29 | Glaxo Group Limited | Production of triazinones |
| HU187474B (en) * | 1981-11-18 | 1986-01-28 | Gyogyszerkutato Intezet,Hu | Process for producing new spiro-pyrazole-square bracket-1,5-d-square bracket closed-square bracket-1,2,4-square bracket closed-triazine derivatives |
| US4395547A (en) * | 1982-02-10 | 1983-07-26 | American Cyanamid Co. | Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones |
| AU622330B2 (en) * | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
| US6624181B1 (en) * | 1997-02-28 | 2003-09-23 | Altana Pharma Ag | Synergistic combination |
| CZ301911B6 (cs) | 1997-11-12 | 2010-07-28 | Bayer Schering Pharma Aktiengesellschaft | 2-Fenylsubstituované imidazotriazinony, zpusob jejich výroby, léciva tyto látky obsahující a jejich použití |
| DE19827640A1 (de) * | 1998-06-20 | 1999-12-23 | Bayer Ag | 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone |
| CN1314811A (zh) | 1998-08-26 | 2001-09-26 | 史密丝克莱恩比彻姆公司 | 治疗肺病的方法 |
| HU229439B1 (hu) * | 1999-08-21 | 2013-12-30 | Takeda Gmbh | Roflumilast és salmeterol szinergetikus kombinációja |
| CN1633298A (zh) * | 2001-05-09 | 2005-06-29 | 拜尔健康护理股份公司 | 2－苯基取代的咪唑三嗪酮的新用途 |
| GB0113343D0 (en) * | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel Heterocycles 2 |
| GB0113344D0 (en) | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel heterocycles 3 |
| DE10135815A1 (de) | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
| DE10232113A1 (de) * | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
| JP2006522127A (ja) * | 2003-04-01 | 2006-09-28 | スミスクライン ビーチャム コーポレーション | イミダゾトリアジン化合物 |
| SI1740591T1 (sl) | 2004-04-02 | 2009-12-31 | Osi Pharm Inc | Heterobiciklični inhibitorji protein-kinaze, substituirani s 6,6-bicikličnim obročem |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| DE102005009240A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
| DE102005009241A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit kontrollierter Bioverfügbarkeit |
| AU2006299232A1 (en) * | 2005-09-29 | 2007-04-12 | Bayer Schering Pharma Aktiengesellschaft | PDE inhibitors and combinations thereof for the treatment of urological disorders |
| CN102936250B (zh) | 2005-11-17 | 2014-07-09 | Osi医药有限责任公司 | 稠合双环mTOR抑制剂 |
| CA2689638A1 (en) * | 2007-06-13 | 2008-12-18 | Bayer Schering Pharma Aktiengesellschaft | Pde inhibitors for the treatment of hearing impairment |
| WO2010123792A1 (en) | 2009-04-20 | 2010-10-28 | Osi Pharmaceuticals, Inc. | Preparation of c-pyrazine-methylamines |
| CN103374002B (zh) * | 2012-04-19 | 2015-07-15 | 山东轩竹医药科技有限公司 | 磷酸二酯酶-5抑制剂 |
| JP2018508555A (ja) * | 2015-03-16 | 2018-03-29 | 大日本住友製薬株式会社 | 二環性イミダゾロ誘導体 |
| WO2017000276A1 (en) * | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
-
0
- BE BE791025D patent/BE791025A/xx unknown
-
1971
- 1971-11-19 GB GB5375071A patent/GB1400999A/en not_active Expired
-
1972
- 1972-10-23 IE IE1433/72A patent/IE37046B1/xx unknown
- 1972-10-23 ZA ZA727532A patent/ZA727532B/xx unknown
- 1972-10-23 DK DK525172AA patent/DK138691B/da unknown
- 1972-10-25 US US00300749A patent/US3840537A/en not_active Expired - Lifetime
- 1972-10-26 AU AU48191/72A patent/AU472127B2/en not_active Expired
- 1972-10-27 IL IL40686A patent/IL40686A/xx unknown
- 1972-11-01 CA CA155,720A patent/CA990292A/en not_active Expired
- 1972-11-06 SE SE7214358A patent/SE402915B/xx unknown
- 1972-11-08 FR FR7239498A patent/FR2160407B1/fr not_active Expired
- 1972-11-10 DE DE2255172A patent/DE2255172A1/de not_active Withdrawn
- 1972-11-16 PH PH14090*UA patent/PH9669A/en unknown
- 1972-11-16 CH CH1668372A patent/CH594671A5/xx not_active IP Right Cessation
- 1972-11-17 ES ES408736A patent/ES408736A1/es not_active Expired
- 1972-11-17 NL NL7215646A patent/NL7215646A/xx not_active Application Discontinuation
- 1972-11-17 AT AT982372A patent/AT321923B/de not_active IP Right Cessation
- 1972-11-17 JP JP11549572A patent/JPS563873B2/ja not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017204316A1 (ja) * | 2016-05-27 | 2017-11-30 | 塩野義製薬株式会社 | ５－オキソ－１，２，４－トリアジン誘導体およびその医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| BE791025A (fr) | 1973-05-07 |
| CH594671A5 (forum.php) | 1978-01-13 |
| JPS563873B2 (forum.php) | 1981-01-27 |
| AU472127B2 (en) | 1976-05-20 |
| NL7215646A (forum.php) | 1973-05-22 |
| FR2160407B1 (forum.php) | 1975-10-17 |
| AU4819172A (en) | 1974-05-16 |
| GB1400999A (en) | 1975-07-16 |
| IE37046B1 (en) | 1977-04-27 |
| IL40686A0 (en) | 1972-12-29 |
| ZA727532B (en) | 1973-07-25 |
| SE402915B (sv) | 1978-07-24 |
| DK138691C (forum.php) | 1979-03-26 |
| US3840537A (en) | 1974-10-08 |
| PH9669A (en) | 1976-02-10 |
| IL40686A (en) | 1975-12-31 |
| FR2160407A1 (forum.php) | 1973-06-29 |
| AT321923B (de) | 1975-04-25 |
| DK138691B (da) | 1978-10-16 |
| ES408736A1 (es) | 1976-03-01 |
| CA990292A (en) | 1976-06-01 |
| DE2255172A1 (de) | 1973-05-24 |
| IE37046L (en) | 1973-05-19 |