JPH11508771A5 - - Google Patents
Info
- Publication number
- JPH11508771A5 JPH11508771A5 JP1997504614A JP50461497A JPH11508771A5 JP H11508771 A5 JPH11508771 A5 JP H11508771A5 JP 1997504614 A JP1997504614 A JP 1997504614A JP 50461497 A JP50461497 A JP 50461497A JP H11508771 A5 JPH11508771 A5 JP H11508771A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58995P | 1995-06-28 | 1995-06-28 | |
| US60/000,589 | 1995-06-28 | ||
| PCT/US1996/011178 WO1997001571A1 (en) | 1995-06-28 | 1996-06-28 | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008179448A Division JP2009039101A (ja) | 1995-06-28 | 2008-07-09 | 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11508771A JPH11508771A (ja) | 1999-08-03 |
| JPH11508771A5 true JPH11508771A5 (enExample) | 2004-08-05 |
Family
ID=21692156
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9504614A Withdrawn JPH11508771A (ja) | 1995-06-28 | 1996-06-28 | 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法 |
| JP2008179448A Withdrawn JP2009039101A (ja) | 1995-06-28 | 2008-07-09 | 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法 |
| JP2011220536A Pending JP2012070735A (ja) | 1995-06-28 | 2011-10-04 | 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008179448A Withdrawn JP2009039101A (ja) | 1995-06-28 | 2008-07-09 | 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法 |
| JP2011220536A Pending JP2012070735A (ja) | 1995-06-28 | 2011-10-04 | 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US6262025B1 (enExample) |
| EP (1) | EP0861261B9 (enExample) |
| JP (3) | JPH11508771A (enExample) |
| AT (1) | ATE442373T1 (enExample) |
| AU (1) | AU723939B2 (enExample) |
| CA (1) | CA2226087C (enExample) |
| DE (1) | DE69638023D1 (enExample) |
| DK (1) | DK0861261T3 (enExample) |
| ES (1) | ES2334953T3 (enExample) |
| PT (1) | PT861261E (enExample) |
| WO (1) | WO1997001571A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| WO1997001571A1 (en) | 1995-06-28 | 1997-01-16 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| EP0861894B1 (en) * | 1995-11-17 | 2006-03-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| US6887475B1 (en) | 1996-11-07 | 2005-05-03 | Lorantis Limited | Notch |
| AU6952498A (en) | 1997-04-04 | 1998-10-30 | Millenium Pharmaceuticals, Inc. | Novel human delta3 compositions and therapeutic and diagnostic uses therefor |
| US20060122373A1 (en) | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
| US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
| US6664098B1 (en) | 1997-05-14 | 2003-12-16 | Asahi Kasei Kabushiki Kaisha | Differentiation inhibitory agent |
| NZ501873A (en) * | 1997-06-18 | 2002-02-01 | Zymogenetics Inc | Mammalian neuro-growth factor like protein |
| US6692919B1 (en) | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
| CA2333893A1 (en) * | 1998-07-13 | 2000-01-20 | Yale University | Delta cleavage products and methods based thereon |
| EP1100899A2 (en) * | 1998-07-27 | 2001-05-23 | Amgen Inc. | Delta-related polypeptides |
| EP1114159A1 (en) * | 1998-09-18 | 2001-07-11 | Hyseq, Inc. | Methods and compositions relating to egf-repeat-containing polypeptides |
| EP1518930B1 (en) * | 1998-10-13 | 2007-05-30 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| GB9927328D0 (en) | 1999-11-18 | 2000-01-12 | Lorantis Ltd | Immunotherapy |
| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| US20080194022A1 (en) * | 2000-08-03 | 2008-08-14 | Clarke Michael F | Isolation and use of solid tumor stem cells |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| AU2001288628A1 (en) * | 2000-08-31 | 2002-03-13 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
| WO2003012441A1 (en) * | 2001-07-25 | 2003-02-13 | Lorantis Limited | Method for detecting modulators of notch signalling |
| GB0118155D0 (en) | 2001-07-25 | 2001-09-19 | Lorantis Ltd | Superantigen |
| AU2002339157A1 (en) * | 2001-11-14 | 2003-05-26 | Lorantis Limited | Inhibitors of the notch signalling pathway for use in the treatment of cancer |
| JP2006515177A (ja) * | 2002-09-10 | 2006-05-25 | ロランティス リミテッド | Notchリガンドタンパク質を含む医薬組成物及び医学的処置 |
| GB0300428D0 (en) * | 2003-01-09 | 2003-02-05 | Lorantis Ltd | Medical treatment |
| GB0307472D0 (en) * | 2003-04-01 | 2003-05-07 | Lorantis Ltd | Medical treatment |
| US20060019256A1 (en) * | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US8029984B2 (en) * | 2003-08-08 | 2011-10-04 | Licentia, Ltd. | Materials and methods for colorectal cancer screening, diagnosis and therapy |
| WO2006135886A2 (en) * | 2005-06-13 | 2006-12-21 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US7906116B2 (en) | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
| WO2007028110A2 (en) * | 2005-09-01 | 2007-03-08 | Vasgene Therapeutics, Inc. | Methods for using and identifying modulators of delta-like 4 |
| JP5129149B2 (ja) * | 2005-10-31 | 2013-01-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を処置および診断するための組成物および方法 |
| HUE031122T2 (en) | 2005-10-31 | 2017-07-28 | Oncomed Pharm Inc | Preparations and methods for the treatment of cancer based on human FZD receptors |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| PL2066694T3 (pl) | 2006-09-29 | 2016-04-29 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworu |
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| US8148147B2 (en) | 2007-01-24 | 2012-04-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| TWI506037B (zh) | 2008-09-26 | 2015-11-01 | Oncomed Pharm Inc | 捲曲結合劑類及彼等之用途 |
| EP2488204B1 (en) | 2009-10-16 | 2016-04-06 | Oncomed Pharmaceuticals, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| CA2782299A1 (en) * | 2009-12-01 | 2011-06-09 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancers comprising k-ras mutations |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
| CN102971337B (zh) | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
| US20130095080A1 (en) | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Reserach Center | Compositions and methods for providing hematopoietic function |
| EP3590520B1 (en) | 2010-04-09 | 2021-12-29 | Fred Hutchinson Cancer Research Center | Compositions for providing hematopoietic function without hla matching |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| EA029958B1 (ru) | 2011-09-23 | 2018-06-29 | Онкомед Фармасьютикалс, Инк. | Антитела, связывающие фактор роста эндотелия сосудов (vegf)/дельта-подобный лиганд (dll4), и их применение |
| CA2858069C (en) | 2011-12-08 | 2020-02-11 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| CA2868747A1 (en) * | 2012-03-29 | 2013-10-03 | Robert J. Fleming | Methods and compositions for modulating notch activity |
| HK1212216A1 (en) | 2012-10-23 | 2016-06-10 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| WO2014071018A1 (en) | 2012-10-31 | 2014-05-08 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a dll4 antagonist |
| CA2897499A1 (en) | 2013-01-08 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
| HK1211887A1 (en) | 2013-02-04 | 2016-06-03 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| CA2929087A1 (en) | 2013-10-31 | 2015-05-07 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| DK3212233T3 (da) | 2014-10-31 | 2020-07-27 | Oncomed Pharm Inc | Kombinationsterapi til behandling af sygdom |
| US10350245B2 (en) | 2015-01-21 | 2019-07-16 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| US20180355318A1 (en) | 2015-04-29 | 2018-12-13 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| US11339213B2 (en) | 2015-09-23 | 2022-05-24 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| WO1993012141A1 (en) * | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US6004924A (en) * | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
| US5786158A (en) | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| AU5168393A (en) | 1992-09-30 | 1994-04-26 | Yale University | Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids |
| US5750652A (en) | 1994-01-21 | 1998-05-12 | Yale University | Deltex proteins |
| WO1997001571A1 (en) | 1995-06-28 | 1997-01-16 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| EP0861894B1 (en) * | 1995-11-17 | 2006-03-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| EP0869802A4 (en) | 1995-11-22 | 2001-11-14 | Univ Yale | DELTEX PROTEINS, NUCLEIC ACIDS, AND ANTIBODIES OF VERTEBRATES, AS WELL AS THESE PROCEDURES AND COMPOSITIONS |
| WO1997045143A1 (en) | 1996-05-31 | 1997-12-04 | The National American Red Cross | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
| WO1998017793A1 (en) | 1996-10-21 | 1998-04-30 | Hsc Research And Development Limited Partnership | Fringe proteins and notch signalling |
| ATE299184T1 (de) | 1996-11-07 | 2005-07-15 | Lorantis Ltd | Notch-liganden zur verwendung in der immuntherapie |
| US20020010137A1 (en) * | 1997-09-18 | 2002-01-24 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
| AU6952498A (en) | 1997-04-04 | 1998-10-30 | Millenium Pharmaceuticals, Inc. | Novel human delta3 compositions and therapeutic and diagnostic uses therefor |
| US6664098B1 (en) | 1997-05-14 | 2003-12-16 | Asahi Kasei Kabushiki Kaisha | Differentiation inhibitory agent |
| US6692919B1 (en) * | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
| TW406393B (en) * | 1997-12-01 | 2000-09-21 | United Microelectronics Corp | Method of manufacturing dielectrics and the inner-lining |
| CA2333893A1 (en) | 1998-07-13 | 2000-01-20 | Yale University | Delta cleavage products and methods based thereon |
| US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| WO2002059285A1 (en) | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| US20070003893A1 (en) * | 2005-06-30 | 2007-01-04 | Radek Bures | Combination lighter and breath freshener dispenser |
-
1996
- 1996-06-28 WO PCT/US1996/011178 patent/WO1997001571A1/en not_active Ceased
- 1996-06-28 PT PT96924334T patent/PT861261E/pt unknown
- 1996-06-28 CA CA2226087A patent/CA2226087C/en not_active Expired - Lifetime
- 1996-06-28 DE DE69638023T patent/DE69638023D1/de not_active Expired - Lifetime
- 1996-06-28 US US08/981,392 patent/US6262025B1/en not_active Expired - Lifetime
- 1996-06-28 AU AU64817/96A patent/AU723939B2/en not_active Expired
- 1996-06-28 DK DK96924334T patent/DK0861261T3/da active
- 1996-06-28 ES ES96924334T patent/ES2334953T3/es not_active Expired - Lifetime
- 1996-06-28 EP EP96924334A patent/EP0861261B9/en not_active Expired - Lifetime
- 1996-06-28 JP JP9504614A patent/JPH11508771A/ja not_active Withdrawn
- 1996-06-28 AT AT96924334T patent/ATE442373T1/de active
-
2001
- 2001-02-15 US US09/783,931 patent/US7118890B2/en not_active Expired - Fee Related
- 2001-07-17 US US09/908,322 patent/US6783956B2/en not_active Expired - Fee Related
-
2006
- 2006-07-24 US US11/492,497 patent/US7928071B2/en not_active Expired - Fee Related
- 2006-10-10 US US11/546,583 patent/US8415303B2/en not_active Expired - Fee Related
-
2008
- 2008-07-09 JP JP2008179448A patent/JP2009039101A/ja not_active Withdrawn
-
2011
- 2011-10-04 JP JP2011220536A patent/JP2012070735A/ja active Pending