JPH11508771A5 - - Google Patents

Info

Publication number
JPH11508771A5
JPH11508771A5 JP1997504614A JP50461497A JPH11508771A5 JP H11508771 A5 JPH11508771 A5 JP H11508771A5 JP 1997504614 A JP1997504614 A JP 1997504614A JP 50461497 A JP50461497 A JP 50461497A JP H11508771 A5 JPH11508771 A5 JP H11508771A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1997504614A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11508771A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1996/011178 external-priority patent/WO1997001571A1/en
Publication of JPH11508771A publication Critical patent/JPH11508771A/ja
Publication of JPH11508771A5 publication Critical patent/JPH11508771A5/ja
Withdrawn legal-status Critical Current

Links

JP9504614A 1995-06-28 1996-06-28 脊椎動物のＤｅｌｔａ遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法 Withdrawn JPH11508771A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58995P 1995-06-28 1995-06-28
US60/000,589 1995-06-28
PCT/US1996/011178 WO1997001571A1 (en) 1995-06-28 1996-06-28 Nucleotide and protein sequences of vertebrate delta genes and methods based thereon

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008179448A Division JP2009039101A (ja) 1995-06-28 2008-07-09 脊椎動物のＤｅｌｔａ遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法

Publications (2)

Publication Number Publication Date
JPH11508771A JPH11508771A (ja) 1999-08-03
JPH11508771A5 true JPH11508771A5 (enExample) 2004-08-05

Family

ID=21692156

Family Applications (3)

Application Number Title Priority Date Filing Date
JP9504614A Withdrawn JPH11508771A (ja) 1995-06-28 1996-06-28 脊椎動物のＤｅｌｔａ遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法
JP2008179448A Withdrawn JP2009039101A (ja) 1995-06-28 2008-07-09 脊椎動物のＤｅｌｔａ遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法
JP2011220536A Pending JP2012070735A (ja) 1995-06-28 2011-10-04 脊椎動物のＤｅｌｔａ遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2008179448A Withdrawn JP2009039101A (ja) 1995-06-28 2008-07-09 脊椎動物のＤｅｌｔａ遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法
JP2011220536A Pending JP2012070735A (ja) 1995-06-28 2011-10-04 脊椎動物のＤｅｌｔａ遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法

Country Status (11)

Country Link
US (5) US6262025B1 (enExample)
EP (1) EP0861261B9 (enExample)
JP (3) JPH11508771A (enExample)
AT (1) ATE442373T1 (enExample)
AU (1) AU723939B2 (enExample)
CA (1) CA2226087C (enExample)
DE (1) DE69638023D1 (enExample)
DK (1) DK0861261T3 (enExample)
ES (1) ES2334953T3 (enExample)
PT (1) PT861261E (enExample)
WO (1) WO1997001571A1 (enExample)

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US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US6337387B1 (en) 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
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DK1004669T3 (da) 1997-05-14 2007-08-27 Asahi Chemical Ind Hidtil ukendte differentieringsinhibitor
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US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
CA2333893A1 (en) * 1998-07-13 2000-01-20 Yale University Delta cleavage products and methods based thereon
CA2337492A1 (en) * 1998-07-27 2000-02-10 Amgen Inc. Delta-related polypeptides
JP2002526077A (ja) * 1998-09-18 2002-08-20 ハイセック，インコーポレーテッド Ｅｇｆ反復を含むポリペプチドに関する方法と組成物
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US8084258B2 (en) * 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
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US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US20080194022A1 (en) * 2000-08-03 2008-08-14 Clarke Michael F Isolation and use of solid tumor stem cells
WO2002018544A2 (en) * 2000-08-31 2002-03-07 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
CA2454937A1 (en) * 2001-07-25 2003-02-13 Lorantis Limited Modulators of notch signalling for use in immunotherapy
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
AU2002339157A1 (en) * 2001-11-14 2003-05-26 Lorantis Limited Inhibitors of the notch signalling pathway for use in the treatment of cancer
WO2004024764A1 (en) * 2002-09-10 2004-03-25 Lorantis Limited Pharmaceutical composition and medical treatments comprising notch ligand proteins
GB0300428D0 (en) * 2003-01-09 2003-02-05 Lorantis Ltd Medical treatment
GB0307472D0 (en) * 2003-04-01 2003-05-07 Lorantis Ltd Medical treatment
KR20060031809A (ko) * 2003-06-09 2006-04-13 더 리젠츠 오브 더 유니버시티 오브 미시간 암 치료 및 진단용 조성물 및 방법
US8029984B2 (en) * 2003-08-08 2011-10-04 Licentia, Ltd. Materials and methods for colorectal cancer screening, diagnosis and therapy
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US7906116B2 (en) 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
JP2009507796A (ja) * 2005-09-01 2009-02-26 バスジーン セラピューティクス， インコーポレイテッド デルタ様リガンド４のモジュレーターの利用及び同定方法
ES2547421T3 (es) 2005-10-31 2015-10-06 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para diagnosticar y tratar el cáncer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP1945754B1 (en) 2005-10-31 2014-07-23 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
HUE028379T2 (en) 2006-09-29 2016-12-28 Oncomed Pharm Inc Preparations and procedures for the diagnosis and treatment of cancer
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
US8148147B2 (en) * 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
AU2009296246B2 (en) 2008-09-26 2015-07-30 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
TR201818814T4 (tr) 2009-10-16 2019-01-21 Oncomed Pharm Inc Dll4 antagonist antikorlarının ve anti-hipertansif ajanların terapötik kombinasyonu ve kullanımı.
EP2506875A4 (en) * 2009-12-01 2013-11-27 Oncomed Pharm Inc METHOD FOR THE TREATMENT OF TUMORS WITH K-RAS MUTATIONS
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CN102971337B (zh) 2010-04-01 2016-09-21 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
EP3097916B1 (en) 2010-04-09 2021-07-07 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function
EP3097917B1 (en) 2010-04-09 2019-08-14 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
ES2707580T3 (es) 2011-09-23 2019-04-04 Oncomed Pharm Inc Agentes de unión a VEGF/DLL4 y usos de los mismos
CA2858069C (en) 2011-12-08 2020-02-11 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US20150291681A1 (en) * 2012-03-29 2015-10-15 Robert J. Fleming Methods and compositions for modulating notch activity
CN104768579A (zh) 2012-10-23 2015-07-08 昂科梅德制药有限公司 使用Wnt途径结合剂来治疗神经内分泌肿瘤的方法
WO2014071018A1 (en) 2012-10-31 2014-05-08 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a dll4 antagonist
AU2014205662B2 (en) 2013-01-08 2019-09-05 Fred Hutchinson Cancer Research Center Compositions and methods for expansion of embryonic hematopoietic stem cells
CN105073195A (zh) 2013-02-04 2015-11-18 昂科梅德制药有限公司 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
CN105873952A (zh) 2013-10-31 2016-08-17 弗莱德哈钦森癌症研究中心 经修饰的造血干细胞/祖细胞和非t效应细胞及其用途
WO2016070051A2 (en) 2014-10-31 2016-05-06 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
EP3247808B1 (en) 2015-01-21 2021-05-05 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
EP3288569A4 (en) 2015-04-29 2018-12-19 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
WO2016176652A2 (en) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
JP6967003B2 (ja) 2015-09-23 2021-11-17 メレオ バイオファーマ ５ インコーポレイテッド がんの処置のための方法および組成物

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