JPH11508126A - 多量体タンパク質 - Google Patents
多量体タンパク質Info
- Publication number
- JPH11508126A JPH11508126A JP8535396A JP53539696A JPH11508126A JP H11508126 A JPH11508126 A JP H11508126A JP 8535396 A JP8535396 A JP 8535396A JP 53539696 A JP53539696 A JP 53539696A JP H11508126 A JPH11508126 A JP H11508126A
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- protein
- dna sequence
- human
- sequence according
- multimeric
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95107914 | 1995-05-23 | ||
| DE95107914.4 | 1995-05-23 | ||
| PCT/EP1996/002230 WO1996037621A2 (en) | 1995-05-23 | 1996-05-23 | Multimeric proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11508126A true JPH11508126A (ja) | 1999-07-21 |
| JPH11508126A5 JPH11508126A5 (enExample) | 2004-07-22 |
Family
ID=8219284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8535396A Ceased JPH11508126A (ja) | 1995-05-23 | 1996-05-23 | 多量体タンパク質 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0827544B1 (enExample) |
| JP (1) | JPH11508126A (enExample) |
| AT (1) | ATE274064T1 (enExample) |
| CA (1) | CA2222055A1 (enExample) |
| DE (1) | DE69633175T2 (enExample) |
| WO (1) | WO1996037621A2 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005524385A (ja) * | 2001-07-19 | 2005-08-18 | パーラン セラピューティクス， インコーポレイテッド | Ｉｃａｍ−１に対するヒト化抗体、それらの生成および使用 |
| JP2007528708A (ja) * | 2003-06-30 | 2007-10-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆトラップおよびその治療的使用 |
| JP2011144205A (ja) * | 1998-04-30 | 2011-07-28 | Imperial Innovations Ltd | Ｔ細胞同時刺激シグナル２（ｂ７／ｃｄ２８相互作用）を遮断することによる免疫抑制 |
| JP2016187358A (ja) * | 2011-03-04 | 2016-11-04 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | ポリペプチド組成物用ペプチドリンカーおよびその使用方法 |
| JP2020501508A (ja) * | 2016-09-15 | 2020-01-23 | クアドルセプト バイオ リミテッド | 多量体、四量体および八量体 |
Families Citing this family (166)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0866805A1 (en) | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
| EP0938571B8 (en) * | 1996-10-28 | 2008-07-02 | University of Lausanne | Method for the oligomerisation of peptides |
| US6924123B2 (en) | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
| GB9622500D0 (en) * | 1996-10-29 | 1997-01-08 | Oxford Biomedica Ltd | Therapeutic gene |
| GB2333527B (en) * | 1996-10-29 | 2001-05-02 | Oxford Biomedica Ltd | Therapeutic gene |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| EP0979281B1 (en) | 1997-05-02 | 2005-07-20 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| WO1998056906A1 (en) * | 1997-06-11 | 1998-12-17 | Thoegersen Hans Christian | Trimerising module |
| US6737252B2 (en) | 1997-07-25 | 2004-05-18 | Schering Corporation | 7 transmembrane receptor family member BLRX |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US7083950B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | High affinity fusion proteins and therapeutic and diagnostic methods for use |
| PL199645B1 (pl) * | 1998-12-23 | 2008-10-31 | Regeneron Pharma | Kwas nukleinowy, polipeptyd fuzyjny, kompozycja, wektor, wektor ekspresyjny, układ gospodarz wektor, sposób wytwarzania polipeptydu fuzyjnego, kwas nukleinowy i sposób wytwarzania polipeptydu fuzyjnego |
| WO2000044908A2 (en) * | 1999-02-01 | 2000-08-03 | Beth Israel Deaconess Medical Center | Comp/tsp-1, comp/tsp-2 and other tsp chimeric proteins |
| GB9903408D0 (en) * | 1999-02-15 | 1999-04-07 | Oxford Biomedica Ltd | Peptides |
| US6828106B2 (en) * | 1999-02-26 | 2004-12-07 | Cyclacel Limited | Methods and compositions using coiled binding partners |
| US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
| JP2003502024A (ja) * | 1999-05-14 | 2003-01-21 | メディカル リサーチ カウンシル | タンパク質骨格および単量体ポリペプチドを多量体化するためのその使用 |
| CA2372199A1 (en) * | 1999-05-14 | 2000-11-23 | Medical Research Council | Oligomeric chaperone proteins |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
| CA2440235A1 (en) * | 2001-03-06 | 2002-09-12 | Mustapha Abdelouahed | Carrier chimeric proteins, targeted carrier chimeric proteins and preparation thereof |
| PT1390535E (pt) * | 2001-04-26 | 2010-10-04 | Amgen Mountain View Inc | Bibliotecas combinatórias de domínios monoméricos |
| JP3563366B2 (ja) * | 2001-05-07 | 2004-09-08 | 独立行政法人 科学技術振興機構 | 蛋白質高次構造に対してアンフォールド活性を有する蛋白質多量体 |
| IL159177A0 (en) | 2001-06-20 | 2004-06-01 | Prochon Biotech Ltd | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| AU2002349204A1 (en) * | 2001-11-26 | 2003-06-10 | University Health Network | Self-assembling p53 peptides as gene delivery vehicles |
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| AU2003239777A1 (en) * | 2002-07-05 | 2004-01-23 | Borean Pharma A/S | Multimerised growth hormone fusion proteins |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| FR2856070A1 (fr) * | 2003-06-13 | 2004-12-17 | Bionexis | Molecules pour le ciblage et l'assemblage in situ de proteines therapeutiques et leur utilisation |
| ES2304812B1 (es) * | 2003-12-03 | 2009-10-21 | Instituto Nacional De Investigacion Y Tecnologia Agraria Y Alimentaria (Inia) | Sistema para producir peptidos y proteinas, multimericos, y sus aplicaciones. |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015210A1 (en) * | 1992-01-23 | 1993-08-05 | Merck Patent Gmbh | Monomeric and dimeric antibody-fragment fusion proteins |
| JP3659261B2 (ja) * | 1994-10-20 | 2005-06-15 | モルフォシス・アクチェンゲゼルシャフト | 組換体タンパク質の多機能性複合体への標的化ヘテロ結合 |
-
1996
- 1996-05-23 JP JP8535396A patent/JPH11508126A/ja not_active Ceased
- 1996-05-23 EP EP96916159A patent/EP0827544B1/en not_active Revoked
- 1996-05-23 WO PCT/EP1996/002230 patent/WO1996037621A2/en not_active Ceased
- 1996-05-23 DE DE69633175T patent/DE69633175T2/de not_active Expired - Fee Related
- 1996-05-23 AT AT96916159T patent/ATE274064T1/de not_active IP Right Cessation
- 1996-05-23 CA CA002222055A patent/CA2222055A1/en not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011144205A (ja) * | 1998-04-30 | 2011-07-28 | Imperial Innovations Ltd | Ｔ細胞同時刺激シグナル２（ｂ７／ｃｄ２８相互作用）を遮断することによる免疫抑制 |
| JP2005524385A (ja) * | 2001-07-19 | 2005-08-18 | パーラン セラピューティクス， インコーポレイテッド | Ｉｃａｍ−１に対するヒト化抗体、それらの生成および使用 |
| JP2007528708A (ja) * | 2003-06-30 | 2007-10-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆトラップおよびその治療的使用 |
| JP2016187358A (ja) * | 2011-03-04 | 2016-11-04 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | ポリペプチド組成物用ペプチドリンカーおよびその使用方法 |
| JP2020501508A (ja) * | 2016-09-15 | 2020-01-23 | クアドルセプト バイオ リミテッド | 多量体、四量体および八量体 |
| JP2023015311A (ja) * | 2016-09-15 | 2023-01-31 | クアドルセプト バイオ リミテッド | 多量体、四量体および八量体 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69633175D1 (de) | 2004-09-23 |
| CA2222055A1 (en) | 1996-11-28 |
| ATE274064T1 (de) | 2004-09-15 |
| EP0827544A2 (en) | 1998-03-11 |
| DE69633175T2 (de) | 2005-08-11 |
| WO1996037621A3 (en) | 1997-01-03 |
| EP0827544B1 (en) | 2004-08-18 |
| WO1996037621A2 (en) | 1996-11-28 |
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