CA2222055A1 - Multimeric proteins - Google Patents
Multimeric proteins Download PDFInfo
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- CA2222055A1 CA2222055A1 CA002222055A CA2222055A CA2222055A1 CA 2222055 A1 CA2222055 A1 CA 2222055A1 CA 002222055 A CA002222055 A CA 002222055A CA 2222055 A CA2222055 A CA 2222055A CA 2222055 A1 CA2222055 A1 CA 2222055A1
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- protein
- dna sequence
- human
- multimerization
- sequence according
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95107914 | 1995-05-23 | ||
| EP95107914.4 | 1995-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2222055A1 true CA2222055A1 (en) | 1996-11-28 |
Family
ID=8219284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002222055A Abandoned CA2222055A1 (en) | 1995-05-23 | 1996-05-23 | Multimeric proteins |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0827544B1 (enExample) |
| JP (1) | JPH11508126A (enExample) |
| AT (1) | ATE274064T1 (enExample) |
| CA (1) | CA2222055A1 (enExample) |
| DE (1) | DE69633175T2 (enExample) |
| WO (1) | WO1996037621A2 (enExample) |
Families Citing this family (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0866805A1 (en) | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
| EP0938571B8 (en) * | 1996-10-28 | 2008-07-02 | University of Lausanne | Method for the oligomerisation of peptides |
| US6924123B2 (en) | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
| GB9622500D0 (en) * | 1996-10-29 | 1997-01-08 | Oxford Biomedica Ltd | Therapeutic gene |
| GB2333527B (en) * | 1996-10-29 | 2001-05-02 | Oxford Biomedica Ltd | Therapeutic gene |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| EP0979281B1 (en) | 1997-05-02 | 2005-07-20 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| WO1998056906A1 (en) * | 1997-06-11 | 1998-12-17 | Thoegersen Hans Christian | Trimerising module |
| US6737252B2 (en) | 1997-07-25 | 2004-05-18 | Schering Corporation | 7 transmembrane receptor family member BLRX |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| GB9809280D0 (en) * | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
| US7083950B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | High affinity fusion proteins and therapeutic and diagnostic methods for use |
| US20030035798A1 (en) * | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
| PL199645B1 (pl) * | 1998-12-23 | 2008-10-31 | Regeneron Pharma | Kwas nukleinowy, polipeptyd fuzyjny, kompozycja, wektor, wektor ekspresyjny, układ gospodarz wektor, sposób wytwarzania polipeptydu fuzyjnego, kwas nukleinowy i sposób wytwarzania polipeptydu fuzyjnego |
| WO2000044908A2 (en) * | 1999-02-01 | 2000-08-03 | Beth Israel Deaconess Medical Center | Comp/tsp-1, comp/tsp-2 and other tsp chimeric proteins |
| GB9903408D0 (en) * | 1999-02-15 | 1999-04-07 | Oxford Biomedica Ltd | Peptides |
| US6828106B2 (en) * | 1999-02-26 | 2004-12-07 | Cyclacel Limited | Methods and compositions using coiled binding partners |
| US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
| JP2003502024A (ja) * | 1999-05-14 | 2003-01-21 | メディカル リサーチ カウンシル | タンパク質骨格および単量体ポリペプチドを多量体化するためのその使用 |
| CA2372199A1 (en) * | 1999-05-14 | 2000-11-23 | Medical Research Council | Oligomeric chaperone proteins |
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
| CA2440235A1 (en) * | 2001-03-06 | 2002-09-12 | Mustapha Abdelouahed | Carrier chimeric proteins, targeted carrier chimeric proteins and preparation thereof |
| PT1390535E (pt) * | 2001-04-26 | 2010-10-04 | Amgen Mountain View Inc | Bibliotecas combinatórias de domínios monoméricos |
| JP3563366B2 (ja) * | 2001-05-07 | 2004-09-08 | 独立行政法人 科学技術振興機構 | 蛋白質高次構造に対してアンフォールド活性を有する蛋白質多量体 |
| IL159177A0 (en) | 2001-06-20 | 2004-06-01 | Prochon Biotech Ltd | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| AU2002349204A1 (en) * | 2001-11-26 | 2003-06-10 | University Health Network | Self-assembling p53 peptides as gene delivery vehicles |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| AU2003239777A1 (en) * | 2002-07-05 | 2004-01-23 | Borean Pharma A/S | Multimerised growth hormone fusion proteins |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| FR2856070A1 (fr) * | 2003-06-13 | 2004-12-17 | Bionexis | Molecules pour le ciblage et l'assemblage in situ de proteines therapeutiques et leur utilisation |
| ES2304812B1 (es) * | 2003-12-03 | 2009-10-21 | Instituto Nacional De Investigacion Y Tecnologia Agraria Y Alimentaria (Inia) | Sistema para producir peptidos y proteinas, multimericos, y sus aplicaciones. |
| WO2006021954A2 (en) | 2004-08-23 | 2006-03-02 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Peptide inhibitors for mediating stress responses |
| AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015210A1 (en) * | 1992-01-23 | 1993-08-05 | Merck Patent Gmbh | Monomeric and dimeric antibody-fragment fusion proteins |
| JP3659261B2 (ja) * | 1994-10-20 | 2005-06-15 | モルフォシス・アクチェンゲゼルシャフト | 組換体タンパク質の多機能性複合体への標的化ヘテロ結合 |
-
1996
- 1996-05-23 JP JP8535396A patent/JPH11508126A/ja not_active Ceased
- 1996-05-23 EP EP96916159A patent/EP0827544B1/en not_active Revoked
- 1996-05-23 WO PCT/EP1996/002230 patent/WO1996037621A2/en not_active Ceased
- 1996-05-23 DE DE69633175T patent/DE69633175T2/de not_active Expired - Fee Related
- 1996-05-23 AT AT96916159T patent/ATE274064T1/de not_active IP Right Cessation
- 1996-05-23 CA CA002222055A patent/CA2222055A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69633175D1 (de) | 2004-09-23 |
| JPH11508126A (ja) | 1999-07-21 |
| ATE274064T1 (de) | 2004-09-15 |
| EP0827544A2 (en) | 1998-03-11 |
| DE69633175T2 (de) | 2005-08-11 |
| WO1996037621A3 (en) | 1997-01-03 |
| EP0827544B1 (en) | 2004-08-18 |
| WO1996037621A2 (en) | 1996-11-28 |
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| EEER | Examination request | ||
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