JPH11505540A - カルノシンあるいはその誘導体および分枝アミノ酸を含む抗酸化活性を有する医薬組成物および/まはた栄養組成物 - Google Patents
カルノシンあるいはその誘導体および分枝アミノ酸を含む抗酸化活性を有する医薬組成物および/まはた栄養組成物Info
- Publication number
- JPH11505540A JPH11505540A JP8534555A JP53455596A JPH11505540A JP H11505540 A JPH11505540 A JP H11505540A JP 8534555 A JP8534555 A JP 8534555A JP 53455596 A JP53455596 A JP 53455596A JP H11505540 A JPH11505540 A JP H11505540A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- carnosine
- inorganic
- organic
- branched amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- ZQTHOIGMSJMBLM-BUJSFMDZSA-N pangamic acid Chemical compound CN(C)CC(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O ZQTHOIGMSJMBLM-BUJSFMDZSA-N 0.000 description 1
- 108700024047 pangamic acid Proteins 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000009894 physiological stress Effects 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.a)カルノシンおよび/またはその誘導体、例えばホモカルノシン、アン セリン、オフィジンおよび/または薬理的に適合する無機および有機塩および/ または薬理的に適合する有機酸によるそのアシル誘導体およびその無機塩; b)適当な比率の一つあるいはそれ以上の分枝アミノ酸、例えば:遊離形態およ び無機あるいは有機塩基あるいは酸で塩形成された形態の両方における薬理的に 適合するロイシン、イソロイシンおよびバリン、および/または無機あるいは有 機塩基で塩形成されたそのアシル誘導体、および/または選択的に無機あるいは 有機酸で塩形成された直鎖あるいは分枝アルコールによるそのエステル を含む、医薬組成物および/または栄養組成物。 2.構成成分a)の含量が15〜20重量%の範囲である、請求項1の組成物 。 3.ロイシンが3種のアミノ酸の混合物の少なくとも20%である、請求項1 または2の組成物。 4.構成成分b)の含量が50〜70重量%の範囲である、請求項1、2また は3の組成物。 5.下記の構成成分 c)カルニチン、その誘導体およびクレアチン d)少量要素 e)ビタミン f)ビオフラボノイド の1以上を含有する、請求項1、2、3または4の組成物。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI951021A IT1275434B (it) | 1995-05-19 | 1995-05-19 | Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante |
IT95A001021 | 1995-05-19 | ||
ITMI95A001021 | 1995-05-19 | ||
PCT/EP1996/002079 WO1996036348A1 (en) | 1995-05-19 | 1996-05-15 | Pharmaceutical and/or dietetic compositions with antioxidant activity containing carnosine or derivatives and branched amino acids |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11505540A true JPH11505540A (ja) | 1999-05-21 |
JP4850986B2 JP4850986B2 (ja) | 2012-01-11 |
Family
ID=11371632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53455596A Expired - Fee Related JP4850986B2 (ja) | 1995-05-19 | 1996-05-15 | カルノシンあるいはその誘導体および分枝アミノ酸を含む抗酸化活性を有する医薬組成物および/または栄養組成物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5866537A (ja) |
EP (1) | EP0825871B1 (ja) |
JP (1) | JP4850986B2 (ja) |
AT (1) | ATE204479T1 (ja) |
AU (1) | AU697990B2 (ja) |
CA (1) | CA2221455C (ja) |
DE (1) | DE69614681T2 (ja) |
ES (1) | ES2159737T3 (ja) |
IT (1) | IT1275434B (ja) |
PT (1) | PT825871E (ja) |
WO (1) | WO1996036348A1 (ja) |
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JP2004508407A (ja) * | 2000-09-14 | 2004-03-18 | ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ネブラスカ | クレアチンエステル代替栄養素化合物及び調合物 |
JP2006052186A (ja) * | 2004-08-16 | 2006-02-23 | Toagosei Co Ltd | 新規ジヒドロフェルラ酸縮合物 |
JPWO2004064866A1 (ja) * | 2003-01-20 | 2006-05-18 | イノヴェイティブ ヴィジョン プロダクツ インコーポレーテッド | カルノシナーゼ阻害剤とl−カルノシン類との併用および組成物 |
JP2011037892A (ja) * | 2002-09-30 | 2011-02-24 | Mark A Babizhayev | 治療手段 |
WO2011078204A1 (ja) * | 2009-12-24 | 2011-06-30 | 浜理薬品工業株式会社 | 高脂血症の予防または治療剤、および抗疲労剤 |
JP2014114244A (ja) * | 2012-12-11 | 2014-06-26 | Ito En Ltd | 抗疲労剤組成物 |
JP2016102068A (ja) * | 2014-11-27 | 2016-06-02 | Shiodaライフサイエンス株式会社 | 鯨筋肉抽出物からなる中長期記憶障害予防改善剤 |
JP2016130229A (ja) * | 2015-01-15 | 2016-07-21 | 有限会社アント | アミノ酸溶解物の製造方法および該製造方法により製造したアミノ酸溶解物 |
US10531680B2 (en) | 2000-09-14 | 2020-01-14 | Board Of Regents Of The University Of Nebraska | Creatine ester pronutrient compounds and formulations |
WO2023199930A1 (ja) * | 2022-04-13 | 2023-10-19 | サントリーホールディングス株式会社 | 組成物 |
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WO1996014063A1 (en) * | 1994-11-08 | 1996-05-17 | Avicena Group, Inc. | Use of creatine or creatine analogs for the treatment of diseases of the nervous system |
IT1283967B1 (it) * | 1996-03-29 | 1998-05-07 | Sigma Tau Ind Farmaceuti | Uso di l-carnitina o derivati della l-carnitina ed antiossidanti nella prevenzione e trattamento di patologie derivanti da danni ossidativi |
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US8128955B2 (en) | 1996-05-31 | 2012-03-06 | The Original Creatine Patent Company | Food compositions containing creatine |
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US7150880B2 (en) | 1996-05-31 | 2006-12-19 | The Original Creatine Patent Co. Ltd. | Compositions containing creatine and creatinine and a methyl xanthine |
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---|---|---|---|---|
IT1240336B (it) * | 1990-03-21 | 1993-12-07 | Setra | Composizioni farmaceutiche,dietetiche o veterinarie ad attivita' eumetabolica |
-
1995
- 1995-05-19 IT ITMI951021A patent/IT1275434B/it active IP Right Grant
-
1996
- 1996-05-15 CA CA002221455A patent/CA2221455C/en not_active Expired - Fee Related
- 1996-05-15 PT PT96916082T patent/PT825871E/pt unknown
- 1996-05-15 DE DE69614681T patent/DE69614681T2/de not_active Expired - Lifetime
- 1996-05-15 WO PCT/EP1996/002079 patent/WO1996036348A1/en active IP Right Grant
- 1996-05-15 AT AT96916082T patent/ATE204479T1/de active
- 1996-05-15 JP JP53455596A patent/JP4850986B2/ja not_active Expired - Fee Related
- 1996-05-15 US US08/952,437 patent/US5866537A/en not_active Expired - Lifetime
- 1996-05-15 EP EP96916082A patent/EP0825871B1/en not_active Expired - Lifetime
- 1996-05-15 AU AU58974/96A patent/AU697990B2/en not_active Ceased
- 1996-05-15 ES ES96916082T patent/ES2159737T3/es not_active Expired - Lifetime
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10531680B2 (en) | 2000-09-14 | 2020-01-14 | Board Of Regents Of The University Of Nebraska | Creatine ester pronutrient compounds and formulations |
JP2004508407A (ja) * | 2000-09-14 | 2004-03-18 | ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ネブラスカ | クレアチンエステル代替栄養素化合物及び調合物 |
JP2011037892A (ja) * | 2002-09-30 | 2011-02-24 | Mark A Babizhayev | 治療手段 |
JP2014012735A (ja) * | 2003-01-20 | 2014-01-23 | Innovative Vision Products Inc | カルノシナーゼ阻害剤とl−カルノシン類との併用および組成物 |
JPWO2004064866A1 (ja) * | 2003-01-20 | 2006-05-18 | イノヴェイティブ ヴィジョン プロダクツ インコーポレーテッド | カルノシナーゼ阻害剤とl−カルノシン類との併用および組成物 |
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JP2006052186A (ja) * | 2004-08-16 | 2006-02-23 | Toagosei Co Ltd | 新規ジヒドロフェルラ酸縮合物 |
JPWO2011078204A1 (ja) * | 2009-12-24 | 2013-05-09 | 浜理薬品工業株式会社 | 高脂血症の予防または治療剤、および抗疲労剤 |
WO2011078204A1 (ja) * | 2009-12-24 | 2011-06-30 | 浜理薬品工業株式会社 | 高脂血症の予防または治療剤、および抗疲労剤 |
JP2014114244A (ja) * | 2012-12-11 | 2014-06-26 | Ito En Ltd | 抗疲労剤組成物 |
JP2016102068A (ja) * | 2014-11-27 | 2016-06-02 | Shiodaライフサイエンス株式会社 | 鯨筋肉抽出物からなる中長期記憶障害予防改善剤 |
JP2016130229A (ja) * | 2015-01-15 | 2016-07-21 | 有限会社アント | アミノ酸溶解物の製造方法および該製造方法により製造したアミノ酸溶解物 |
WO2023199930A1 (ja) * | 2022-04-13 | 2023-10-19 | サントリーホールディングス株式会社 | 組成物 |
Also Published As
Publication number | Publication date |
---|---|
US5866537A (en) | 1999-02-02 |
ITMI951021A0 (it) | 1995-05-19 |
DE69614681D1 (de) | 2001-09-27 |
IT1275434B (it) | 1997-08-07 |
PT825871E (pt) | 2001-12-28 |
JP4850986B2 (ja) | 2012-01-11 |
AU697990B2 (en) | 1998-10-22 |
ES2159737T3 (es) | 2001-10-16 |
ITMI951021A1 (it) | 1996-11-19 |
CA2221455C (en) | 2008-07-08 |
WO1996036348A1 (en) | 1996-11-21 |
EP0825871A1 (en) | 1998-03-04 |
CA2221455A1 (en) | 1996-11-21 |
ATE204479T1 (de) | 2001-09-15 |
AU5897496A (en) | 1996-11-29 |
DE69614681T2 (de) | 2002-07-04 |
EP0825871B1 (en) | 2001-08-22 |
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