IT1302863B1 - Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un - Google Patents

Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un

Info

Publication number
IT1302863B1
IT1302863B1 IT1998RM000706A ITRM980706A IT1302863B1 IT 1302863 B1 IT1302863 B1 IT 1302863B1 IT 1998RM000706 A IT1998RM000706 A IT 1998RM000706A IT RM980706 A ITRM980706 A IT RM980706A IT 1302863 B1 IT1302863 B1 IT 1302863B1
Authority
IT
Italy
Prior art keywords
carnitine
thrombotic
antioxidant
composition
preventive activity
Prior art date
Application number
IT1998RM000706A
Other languages
English (en)
Inventor
Claudio Cavazza
Original Assignee
Sigma Tau Healthscience Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Healthscience Spa filed Critical Sigma Tau Healthscience Spa
Publication of ITRM980706A0 publication Critical patent/ITRM980706A0/it
Priority to IT1998RM000706A priority Critical patent/IT1302863B1/it
Priority to ARP990105588A priority patent/AR021089A1/es
Priority to EP99956311A priority patent/EP1128822B1/en
Priority to SK616-2001A priority patent/SK6162001A3/sk
Priority to DK99956311T priority patent/DK1128822T3/da
Priority to TR2001/01344T priority patent/TR200101344T2/xx
Priority to PL348515A priority patent/PL201896B1/pl
Priority to ES99956311T priority patent/ES2249039T3/es
Priority to CZ20011609A priority patent/CZ20011609A3/cs
Priority to HU0104347A priority patent/HU229061B1/hu
Priority to PCT/IT1999/000351 priority patent/WO2000028986A1/en
Priority to CA002350220A priority patent/CA2350220C/en
Priority to IL14300199A priority patent/IL143001A0/xx
Priority to AU12941/00A priority patent/AU766402B2/en
Priority to AT99956311T priority patent/ATE306258T1/de
Priority to DE69927701T priority patent/DE69927701T2/de
Priority to MA25841A priority patent/MA25592A1/fr
Priority to TNTNSN99212A priority patent/TNSN99212A1/fr
Publication of ITRM980706A1 publication Critical patent/ITRM980706A1/it
Application granted granted Critical
Publication of IT1302863B1 publication Critical patent/IT1302863B1/it
Priority to NO20012338A priority patent/NO20012338D0/no
Priority to US10/453,787 priority patent/US20030206895A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
IT1998RM000706A 1998-11-13 1998-11-13 Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un IT1302863B1 (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT1998RM000706A IT1302863B1 (it) 1998-11-13 1998-11-13 Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un
ARP990105588A AR021089A1 (es) 1998-11-13 1999-11-04 Composicion preventiva antioxidante contra anormalidades tromboticas y ateroscleroticas, que comprende una carnitina y un flavonoide
PCT/IT1999/000351 WO2000028986A1 (en) 1998-11-13 1999-11-05 Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis
AU12941/00A AU766402B2 (en) 1998-11-13 1999-11-05 Antioxidant composition comprising propionyl L-carnitine and a flavonoid against thrombosis and atherosclerosis
DK99956311T DK1128822T3 (da) 1998-11-13 1999-11-05 Antioxidantsammensætning, der omfatter propionyl-L-carnitin og et flavonoid mod trombose og aterosklerose
TR2001/01344T TR200101344T2 (tr) 1998-11-13 1999-11-05 Propionil L-karnitinden ve bir flavonoid'den oluşan antioksidan bileşim
PL348515A PL201896B1 (pl) 1998-11-13 1999-11-05 Zastosowanie propionylo-L-karnityny i kwercetyny
ES99956311T ES2249039T3 (es) 1998-11-13 1999-11-05 Composicion antioxidante que comprende propionil l-carnitina y un flavonoide contra la trombosis y la ateroesclerosis.
CZ20011609A CZ20011609A3 (cs) 1998-11-13 1999-11-05 Antioxidační přípravek proti tromboze a ateroskleroze obsahující propionyl- L-karnitin a flavonoid
HU0104347A HU229061B1 (hu) 1998-11-13 1999-11-05 Propionil-L-karnitint és egy flavonoidot tartalmazó antioxidáns készítmény, amely a trombózis és az ateroszklerózis kezelésében alkalmazható
EP99956311A EP1128822B1 (en) 1998-11-13 1999-11-05 Antioxidant compositioncomprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis
CA002350220A CA2350220C (en) 1998-11-13 1999-11-05 Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis
IL14300199A IL143001A0 (en) 1998-11-13 1999-11-05 Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis
SK616-2001A SK6162001A3 (en) 1998-11-13 1999-11-05 Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis
AT99956311T ATE306258T1 (de) 1998-11-13 1999-11-05 Antioxidative zusammensetzung enthaltend propionyl l-carnitin und ein flavonoid gegen thrombose und atherosklerose
DE69927701T DE69927701T2 (de) 1998-11-13 1999-11-05 Antioxidative zusammensetzung enthaltend propionyl l-carnitin und ein flavonoid gegen thrombose und atherosklerose
MA25841A MA25592A1 (fr) 1998-11-13 1999-11-09 Composition antioxydante et preventive contre les anomalies thrombotiques et atherosclerotiques comportant un carnitine et un flavonoide
TNTNSN99212A TNSN99212A1 (fr) 1998-11-13 1999-11-11 Composition antioxydante et preventive contre les anomalies thrombotiques et atherosclerotiques, comportant un carnitine et un flavonoide
NO20012338A NO20012338D0 (no) 1998-11-13 2001-05-11 Antioksydasjonsmiddel-preparat omfattende propionyl L- karnitin og et flavonoid mot trombose og aterosklerose
US10/453,787 US20030206895A1 (en) 1998-11-13 2003-06-04 Antioxidant composition comprising propionyl L-carnitine and a flavonoid against throm-bosis and atherosclerosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998RM000706A IT1302863B1 (it) 1998-11-13 1998-11-13 Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un

Publications (3)

Publication Number Publication Date
ITRM980706A0 ITRM980706A0 (it) 1998-11-13
ITRM980706A1 ITRM980706A1 (it) 2000-05-13
IT1302863B1 true IT1302863B1 (it) 2000-10-10

Family

ID=11406214

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998RM000706A IT1302863B1 (it) 1998-11-13 1998-11-13 Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un

Country Status (19)

Country Link
EP (1) EP1128822B1 (it)
AR (1) AR021089A1 (it)
AT (1) ATE306258T1 (it)
AU (1) AU766402B2 (it)
CA (1) CA2350220C (it)
CZ (1) CZ20011609A3 (it)
DE (1) DE69927701T2 (it)
DK (1) DK1128822T3 (it)
ES (1) ES2249039T3 (it)
HU (1) HU229061B1 (it)
IL (1) IL143001A0 (it)
IT (1) IT1302863B1 (it)
MA (1) MA25592A1 (it)
NO (1) NO20012338D0 (it)
PL (1) PL201896B1 (it)
SK (1) SK6162001A3 (it)
TN (1) TNSN99212A1 (it)
TR (1) TR200101344T2 (it)
WO (1) WO2000028986A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1316998B1 (it) * 2000-03-02 2003-05-26 Sigma Tau Healthscience Spa Composizione per la prevenzione e/o il trattamento degli effetticitotossici indotti dall'uso di agenti immunosoppressori.
IT1317035B1 (it) * 2000-05-30 2003-05-26 Sigma Tau Healthscience Spa Integratore ad attivita' antiossidante comprendente unaalcanoilcarnitina ed una associazione di polifenoli estratti dal
US7338971B2 (en) * 2001-08-30 2008-03-04 El-Naggar Mawaheb M Treatment of inflammatory, cancer, and thrombosis disorders
US6923960B2 (en) 2001-10-03 2005-08-02 Vsl Pharmaceuticals Inc. Antioxidant combination composition and use thereof
GB0819960D0 (en) * 2008-10-31 2008-12-10 Provexis Natural Products Ltd Therapeutic composition
EP2353596A1 (en) * 2010-02-02 2011-08-10 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Combination composition, comprising as active ingredients L-carnitine or propionyl L-carnitine, for the prevention or treatment of chronic venous insufficiency
KR101758949B1 (ko) * 2010-04-09 2017-07-17 시구마-토우인더스트리에파아마슈우티히리유니트에스.피이.에이. 활성 성분으로 ｌ-카르니틴 또는 프로피오닐 ｌ-카르니틴을 포함하는, 만성 정맥 기능부전의 예방 또는 치료용 복합 조성물
US10391096B2 (en) 2011-10-13 2019-08-27 Quercegen Pharmaceuticals Llc Method for treating thrombotic disorders using quercetin-containing compositions
BR112021010500A2 (pt) 2018-11-30 2021-08-24 Beth Israel Deaconess Medical Center, Inc. Método para reduzir a p-selectina solúvel em um paciente com câncer, método para reduzir ou prevenir a formação de um trombo em um paciente com câncer, método para promover a regressão tumoral em um paciente com câncer, método para estabilizar ou reduzir o câncer metastático em um paciente com câncer, composição farmacêutica para reduzir a p-selectina solúvel em um paciente com câncer, composição farmacêutica para reduzir ou prevenir a formação de um trombo em um paciente com câncer, composição farmacêutica para promover a regressão tumoral em um paciente com câncer e composição farmacêutica para estabilizar ou reduzir câncer metastático em um paciente com câncer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1275434B (it) * 1995-05-19 1997-08-07 Farmila Farma Milano Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante
PT755633E (pt) * 1995-07-28 2000-04-28 Hamm Prof Dr Michael Preparacao bifasica
JP2001511153A (ja) * 1997-02-04 2001-08-07 ブイ． コスバブ，ジョン 血管変性性疾患の予防および処置のための組成物および方法
US5976568A (en) * 1997-02-21 1999-11-02 Medical Doctors' Research Institute, Inc. Modular system of dietary supplement compositions for optimizing health benefits and methods
ATE249150T1 (de) * 1997-12-17 2003-09-15 Meta Handelsgesellschaft M B H Trinkflüssigkeit
DE19806890A1 (de) * 1998-02-19 1999-08-26 Beiersdorf Ag Kosmetische und dermatologische Wirkstoffkombinationen aus mindestens einer Substanz gewählt aus der Gruppe, bestehend aus Carnitin und den Acylcarnitinen, und mindestens einem Antioxidans sowie Zubereitungen mit einem Gehalt an solchen Wirkstoffkombinationen
EP0960572A1 (en) * 1998-05-12 1999-12-01 N.V. Nutricia Nutritional composition for the treatment of pressure ulcers
IT1299191B1 (it) * 1998-06-23 2000-02-29 Sigma Tau Healthscience Spa Composizione atta a prevenire e trattare l'osteoporosi e le alterazioni legate alla menopausa

Also Published As

Publication number Publication date
HUP0104347A3 (en) 2003-01-28
NO20012338L (no) 2001-05-11
DE69927701D1 (de) 2006-02-23
ITRM980706A1 (it) 2000-05-13
NO20012338D0 (no) 2001-05-11
ATE306258T1 (de) 2005-10-15
EP1128822B1 (en) 2005-10-12
AU766402B2 (en) 2003-10-16
DK1128822T3 (da) 2006-02-06
EP1128822A1 (en) 2001-09-05
CA2350220C (en) 2008-06-17
TR200101344T2 (tr) 2001-10-22
ITRM980706A0 (it) 1998-11-13
IL143001A0 (en) 2002-04-21
MA25592A1 (fr) 2002-12-31
AR021089A1 (es) 2002-06-12
TNSN99212A1 (fr) 2005-11-10
PL201896B1 (pl) 2009-05-29
CA2350220A1 (en) 2000-05-25
CZ20011609A3 (cs) 2002-01-16
HU229061B1 (hu) 2013-07-29
SK6162001A3 (en) 2001-10-08
WO2000028986A1 (en) 2000-05-25
AU1294100A (en) 2000-06-05
PL348515A1 (en) 2002-06-03
ES2249039T3 (es) 2006-03-16
DE69927701T2 (de) 2006-07-20
HUP0104347A2 (hu) 2002-04-29

Similar Documents

Publication Publication Date Title
AP2001002286A0 (en) Compound and its use
FI982310A (fi) Säteilykovetteisia syaaniakrylaattia sisältäviä koostumuksia
DE69907503D1 (de) Spindeltrieb mit schmiermitteldosierung sowie bremssattel
PL346781A1 (en) Factor viia inhibitors
IT1283637B1 (it) Composti ad attivita' antinfiammatoria ed immunosoppressiva
GB2292831B (en) Semiconductor laser diode and manufacturing method therefor
BR9502407A (pt) Composição lubrificante e concetrado
IT1297664B1 (it) Valvola di sicurezza e di morosita'
PL342319A1 (en) Direct oxidation of cycloalkanes
IT1302863B1 (it) Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un
EP1056455A4 (en) EPIMORPHIN COMPOUND AND USE OF THE SAME
PL349389A1 (en) Combination of cerivastatin and fibrates
DE69836972D1 (de) Lysophophasäure enthaltende zusammensetzungen die die apoptose hemmen und deren verwendung
IT1302125B1 (it) Composizione ad attivita' antiossidante ed antiproliferativacomprendente una carnitina ed un carotenoide
IT1308082B1 (it) Procedimento ed apparecchiatura per l'assemblaggio di una strutturaoffshore galleggiante
IT1299161B1 (it) Composizione comprendente l-carnitina o un'alcanoil l-carnitina e nadh e/o nadph
EE200100046A (et) ACAT ja MMP inhibiitorite koosmanustamine aterosklerootiliste kahjustuste raviks
IT1312261B1 (it) Strumento combinato e corrispondente procedimento di fabbricazione
GB9819102D0 (en) Horseshoe 2
IL131322A0 (en) Serine protease and topical retinoid compositions
PT999910E (pt) Maquina-ferramenta e funcionamento de uma maquina-ferramenta no fabrico de cambotas
IT242807Y1 (it) Ferro di cavallo
DE29803398U1 (de) Verbesserung einer Werkzeugkühlung und deren Dichtung
IT1304888B1 (it) Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
DE9420640U1 (de) Strahlungsaushärtbare Zusammensetzungen mit einem Gehalt an hydroxy-terminierten Polyurethanen und einer Epoxy-Verbindung

Legal Events

Date Code Title Description
0001 Granted