JPH11246363A - Hair grower - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair grower capable of manifesting excellent depilation- preventing activities and hair-fostering activities such as hair-growing activities by formulating a coriander extract of a plant extract in combination with a specific amine oxide. SOLUTION: This hair grower contains (A) a coriander extract and (B) one or more kinds of amine oxide of the formula [R<1> is a 2-24C linear or branched alkyl; R<2> is methyl or 2-hydroxyethyl; (n) is 0-5]. Preferably, the formulated amount of the component A expressed in terms of the dried weight is 0.00001-20.0 wt.%, and the formulated amount of the component B is 0.0001-20.0 wt.%. The component A is obtained by extracting seeds of the coriander with hot water, a lower alcohol such as methanol, a polyhydric alcohol such as propylene glycol, or the like. As the result, the hair tonic having excellent hair-fostering activities compared to a conventional hair grower is expected.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention belongs to the technical field related to hair restoration. More specifically, it belongs to the technical field related to a hair restorer having an excellent hair loss-preventing effect and a hair-growth effect such as a hair-growth effect, and the hair restorer of the present invention is used particularly in the fields of pharmaceuticals, quasi-drugs, and cosmetics.

[0002]

2. Description of the Related Art Hair restoration is a product that promotes or stimulates the growth of hair, and in today's aging society, the demand for hair growth is increasing year by year as social stress increases. In general, the causes of head baldness and hair loss include the activation of androgens in organs such as hair roots and sebaceous glands, decreased blood flow to hair follicles, excessive secretion of sebum, and the production of peroxides in the scalp. Various causes such as abnormalities, malnutrition, and stress are considered. Conventional hair restorations contain a substance having an action of removing or reducing the factors generally considered to be the cause of baldness and hair loss. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as assembly extract and acetylcholine derivative, anti-inflammatory agents such as purple root extract and hinokitiol, female hormones such as estradiol, cepharanthin and the like Are used in the prevention and treatment of baldness and hair loss.

[0003]

However, although many attempts have been made as described above, the hair-growing effects of the conventional hair-growing agents such as the hair-removing preventing effect and the hair-growing effect are not always sufficient. Was. The reason for this is that, as mentioned above, the causes of baldness and hair loss are very diverse, and the mechanism of hair growth itself is also very complicated. It is not sufficient as a hair effect.

[0004]

Means for Solving the Problems In order to solve this problem, the present inventor has made intensive studies to provide a new hair restorer having an excellent hair loss preventing effect and a hair growth effect. As a result, the present inventors have found that a hair restorer prepared by combining a coriander extract, which is a plant extract, and a specific amine oxide has an excellent hair restorer effect, and completed the present invention.

That is, the present invention provides a hair restorer comprising the following components 1) and 2). 1) Coriander extract 2) One or more amine oxides represented by the following formula (I):

Embedded image (Wherein, R ¹ is a linear or branched alkyl group having 2 to 24 carbon atoms, R ² is a methyl group or a 2-hydroxyethyl group, and n represents a number of 0 or more and 5 or less).

[0006]

Embodiments of the present invention will be described below. A. The hair restoration of the present invention is a hair restoration containing a coriander extract.

[0007] The coriander extract formulated in the present invention is
It is usually an extract obtained by extracting from the seeds of coriander (Coriandrum Sativum L.). As a method for extracting the extract from the seeds of coriander, generally known methods can be used. For example, from coriander seeds, hot water, lower alcohols such as methanol and ethanol or hydrates of these lower alcohols, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, or hydrates of these polyhydric alcohols Can be obtained by solvent extraction with the above solvent.

[0008] The amount of the coriander extract in the hair restoration of the present invention should be appropriately changed depending on the specific embodiment of the coriander extract and the hair restoration of the present invention. Although it is not a matter, the dry weight of the coriander extract is preferably 0.00001% by weight or more and 20.0% by weight or less, preferably 0.01% by weight or more and 5.0% by weight or less in the total amount of hair restoration. The following are particularly preferred. 0.00001% by weight of compounding amount
If the amount is less than the above, the intended effect of the present invention tends not to be sufficiently exerted, which is not preferable. If the amount is more than 20.0% by weight, it often causes troubles in the preparation, which is not preferable.

B. The hair restorer of the present invention contains an amine oxide represented by the formula (I). This amine oxide (I)
It can be roughly divided into three modes. That is,
R ² of the amine oxide (I) is a methyl group, and n = 0
A dimethylalkylamine oxide (a), wherein R ² is a 2-hydroxyethyl group, and bis (2-hydroxyethyl) -alkylamine oxide (b) wherein n = 0, or R ² is a methyl group , N ≧ 1 and dimethylalkyl polyoxyethylene amine oxide (c).

Embedded image

R ¹ which is a straight-chain alkyl group or a branched-chain alkyl group having 2 to 24 carbon atoms is an ethyl group,
Propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl , Icosyl group, henicosyl group,
Linear alkyl group such as docosyl group, tricosyl group or tetracosyl group; branched chain alkyl group such as isopropyl group, isobutyl group, sec- butyl group, tert -butyl group, isopentyl group, neopentyl group, tert -pentyl group, isohexyl group And the like.

Also, n, which is the number of oxyethylene groups polymerized,
Is in the range of 1 or more and 5 or less when the amine oxide (I) is dimethylalkyl polyoxyethylene amine oxide (c).

Specifically, dimethylalkylamine oxide (a) includes N, N-dimethylethylamine oxide, N, N-dimethylbutylamine oxide, N, N
-Dimethylhexylamine oxide, N, N-dimethyloctylamine oxide, N, N-dimethyldecylamine oxide, N, N-dimethyldodecylamine oxide, N, N-dimethyltetradecylamine oxide,
N, N-dimethylhexadecylamine oxide, N, N
-Dimethyloctadecylamine oxide, N, N-dimethyleicosylamine oxide, N, N-dimethyltetracosylamine oxide, N, N-dimethyl-2-decyltetradecylamine oxide and the like.

The bis (2-hydroxyethyl) -alkylamine oxide (b) includes N, N-bis (2-hydroxyethyl) -ethylamine oxide,
N, N-bis (2-hydroxyethyl) -butylamine oxide, N, N-bis (2-hydroxyethyl) -hexylamine oxide, N, N-bis (2-hydroxyethyl) hexylamine oxide, N, N- Screw (2-
Hydroxyethyl) -octylamine oxide, N, N
-Bis (2-hydroxyethyl) -2-ethyloctylamine oxide, N, N-bis (2-hydroxyethyl) -decylamine oxide, N, N-bis (2-hydroxyethyl) -dodecylamine oxide, N-bis (2-hydroxyethyl) -tetradecylamine oxide, N, N-bis (hydroxyethyl) -hexadecylamine oxide, N, N-bis (2-hydroxyethyl) -octadecylamine oxide, N, N- Screw (2
-Hydroxyethyl) -icosylamine oxide, N,
Examples thereof include N-bis (2-hydroxyethyl) -2-decyldecylamine oxide and N, N-bis (2-hydroxyethyl) -tetracosylamine oxide.

The dimethylalkyl polyoxyethylene amine oxide (c) includes dimethylethyl polyoxyethylene (1.5 mol) amine oxide, dimethylbutyl polyoxyethylene (3 mol) amine oxide, dimethylhexyl polyoxyethylene (c). 5 mol) amine oxide, dimethyl octyl polyoxyethylene (3 mol) amine oxide, dimethyl decyl polyoxy ethylene (1.5 mol) amine oxide, dimethyl dodecyl polyoxy ethylene (3 mol) amine oxide, dimethyl tetradecyl polyoxy ethylene (5 mol) amine oxide, dimethyl hexadecyl polyoxyethylene (3 mol) amine oxide, dimethyl octadecyl polyoxyethylene (1.5 mol) amine oxide, dimethyl icosyl polyoxy Styrene (1.5 moles) amine oxide, dimethyl tetracosyl polyoxyethylene (1.5 moles) amine oxide can be exemplified.

These amine oxides (I) can be produced by a known method, and the hair restoration of the present invention can contain the amine oxide (I) produced by such a method. These amine oxides (I)
Although it is also possible to independently blend in the hair restoration of the present invention,
It is also possible to mix two or more amine oxides (I) in combination.

The amount of these amine oxides (I) in the hair growth composition of the present invention is appropriately changed depending on the specific compound of the amine oxide (I) and the specific mode of the hair growth composition of the invention. Although should not be particularly limited in what should be, generally 0.0001% by weight or more in the total amount of hair restoration,
It is preferably 20.0% by weight or less, more preferably 0.01% by weight or more and 5.0% by weight or less. If the amount is less than 0.0001% by weight of the total amount of the hair restorer, the intended effect of the present invention tends not to be sufficiently exerted, which is not preferable.
If the amount exceeds 20.0% by weight, the effect corresponding to the increase in the amount is not enhanced, which is not preferable. Thus, by combining the above cilantro extract and the amine oxide (I) in combination, a hair restorer having an extremely excellent hair loss preventing effect and a hair growth effect is provided.

In the hair restoration of the present invention, the desired effect of the present invention is intended for the purpose of exhibiting the general effect of the hair restoration component normally incorporated in the hair restoration. Can be blended as long as is not impaired. For example, other alkoxycarbonyl pyridine N- oxide, Kapuroniumu chloride, assembly extract, vasodilators such as acetylcholine derivatives; serine, amino acids such as methionine, vitamin B _6, vitamin E or a derivative thereof, vitamins such as biotin; pantothenic An acid or a derivative thereof;
Glycyrrhetinic acid or a derivative thereof; nicotinic acid esters such as benzyl nicotinate; skin function enhancers such as cepharanthin; and female hormones such as estradiol can also be incorporated into the hair restorer of the present invention.

Further, plant extracts other than coriander extract, which are usually incorporated in hair restorer, such as Altea extract,
Yotei extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mannequin extract, mannen wax extract, kossaiho extract, enishida extract, gentian extract, tanjin extract, luffa extract , Extract of fennel, extract of pine, extract of pine, extract of touki, extract of peonies, extract of safflower, extract of barberry, extract of areca eucalypt, extract of eucalyptus, extract of maggot, extract of mokutsu, extract of gossip, Psycho extract,
Tea extract, liquorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, sage extract, cashew extract, wolfberry extract, mugwort extract, cuckoo extract, button extract, squid extract Ingredients, saffron extract, rosemary extract, pheasant extract, mallow extract, persimmon extract, peppermint extract, yoquinin extract and the like can also be incorporated into the hair restorer of the present invention.

Also, antibacterial agents such as hinokitiol, hexachlorophen, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanide and bithionol; cooling agents such as menthol; salicylic acid, zinc or derivatives thereof; lactic acid or its alkyl ester Organic acids such as citric acid; protease inhibitors such as tranexamic acid; amino acids such as arginine; oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols;
Polyhydric alcohols such as glycerin and propylene glycol, other surfactants, humectants, thickeners, fragrances, antioxidants, ultraviolet absorbers, dyes, ethanol, water, etc., do not impair the intended effects of the present invention. Can be appropriately blended into the hair restorer of the present invention.

The form of the hair restorer of the present invention is not particularly limited as long as it can be applied to the outer skin such as a liquid, an emulsion, an ointment, and the like. Of the present invention can be prepared. In addition, the hair restoration of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The hair restorer of the present invention can be used for the treatment and prevention of alopecia, for example, the treatment and prevention of androgenetic alopecia, the treatment and prevention of diffuse alopecia common to women, the treatment of alopecia areata, etc. Can be widely used. The names of hair loss diseases shown here are examples, and diseases to which the hair restoration of the present invention can be applied are not limited to these hair loss diseases.

The hair restorer of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin. The dose of the hair restorer of the present invention should be appropriately determined according to individual differences such as age and degree of hair loss, but the dose for general adults is 0.01 to 100 mg / kg body weight. Daily, preferably 0.1 to 10 mg / day, which can be administered once a day or divided into 2 to 4 times a day.

[0023]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to the disclosure of each embodiment, tests for examining the hair-growing effect of these embodiments and the like will be described.

1. Hair growth test Using C3H / HeNCrJ mice in the telogen phase of the hair cycle, the method of Ogawa et al. (Normal and Abnormal)
Epidermal Differentiation (Normal and
Abnormal Epidermal Differentiation, M. Seiji and
A hair growth test was performed according to IABernstein, pp. 159-170, 1982, published by The University of Tokyo. That is, a group of 10 mice, each group of no application, Example and Comparative Example,
The back of the mouse was shaved with a clipper and a shaver, and 0.1 ml of each sample was applied once a day. The hair growth effect of each sample was determined by calculating the average hair growth rate of the shaved area on the back of the mouse (area of hair growth area / area of shaved area × 10) for each group.
0 (%)).

2. Hair Restoration Effect Test In order to further examine the hair restoration effect such as the hair loss prevention effect and the hair growth effect of the hair growth preparation of the present invention, a tricogram test and a hair loss prevention test were performed on healthy individuals. Tricogram test Observe the removed hair with a microscope before and after use of the hair restoration,
Count the number of telogen follicles from the morphology of the follicles (the telogen follicles are the roots of hair that has stopped growing, and those who report hair loss have a higher percentage of this telogen follicle than normal people. Was observed.), And the hair growth effects of the hair growth materials were compared by increasing or decreasing the ratio. Specifically, the hair growth preparation of the present invention was applied to the scalp of 10 male subjects (IX) twice a day, 5 times a day.
Each ml was applied for 6 consecutive months. Immediately before the application and immediately before the end of the application for 6 months, 100 hairs were removed per subject and the number of hair roots in the telogen was counted. Then, the rate of change in the number of hair roots in the rest period (the number of hair roots in the rest period immediately before application / the number of roots in the rest period immediately before application × 100 (%)) was determined, and the determination was made according to the following criteria. <Judgment criteria> Significant effect: The change rate was less than 80% and a remarkable effect was recognized. Effective: The change rate was 80% or more and less than 97%, and a considerable effect was recognized. Invalid: The change rate was 97%. No effect was observed

Hair loss prevention test The change in the number of hair loss before and after use of the hair restorer during hair washing was used as an index of the hair loss preventive effect of the hair restorer. That is, two months before the start of the tricogram test was defined as a sample non-application period, the subject was washed every day for one week before the start of the test and for six months after the start, the hair removed at that time was collected, and the thickness was 50 μm or more. The number of hair was counted. Then, the change rate of the average number of hair removals per day for each subject (the average number of hair removals during the hair application period / the average number of hair removals during the no application period × 100 (%)) was determined, and the determination was made according to the following criteria. <Judgment criteria> Significant effect: The change rate was less than 70%, and a remarkable effect was recognized. Effective: The change rate was 70% or more and less than 90%, and a considerable effect was recognized. Invalid: The change rate was 90%. No effect was observed

Examples 1 to 7 and Comparative Examples 1 to 8 Hair restorations were prepared according to the formulations shown in Table 1 (Tables 1 and 2).

[Table 1]

[0028]

[Table 2]

<Production method> Amine oxide (I), an adduct of hydrogenated castor oil and ethylene oxide (40 mol) and a coriander extract were added to 95% ethanol, dissolved by stirring, and then purified water was added and mixed. To prepare the desired hair restoration.

The results of the hair growth test of the hair growth preparations of Examples shown in Table 1 are shown in Table 2 together with the results of the comparative examples shown in Table 1.

[Table 3]

As described above, the hair restorer of the present invention containing the amine oxide (I) and the coriander extract has a shorter hair cycle than the hair restorer of the comparative example containing only one of these components. It was found that the hair growth effect for transferring to the growing period was excellent.

Next, the hair growth effect test was carried out on the hair growth material of Example 1 shown in Table 1. The results are shown in Table 3.

[Table 4]

As shown in Table 3, by applying the hair restorer of Example 1 to the subject, the ratio of hair roots in the rest period of the hair cycle was reduced, and the number of hair removals was also reduced.
It has been clarified that the present hair restorer has an excellent hair restorer effect. In addition, when the above-mentioned hair-growth effect test was performed also about the other Example shown in Table 1, the excellent hair-growth effect was recognized also about these Examples.

Hereinafter, various formulations of the hair growth preparation of the present invention will be described. Each of the hair growth preparations had excellent hair growth effect and hair growth effect in the hair growth test and the hair growth effect test.
In addition, the hair nourishes which do not particularly describe the manufacturing method were manufactured by a conventional method according to the dosage form.

Example 8 Hair Tonic% by Weight Coriander Extract (1,3-butylene glycol solution) 0.01 (dry weight: 0.0005) N, N-bis (2-hydroxyethyl) -tetracosylamine Oxide 1.0 N, N-dimethyldecylamine oxide 1.0 Hinokitiol 1.0 Vitamin B ₆ 0.2 Vitamin E acetate 0.02 Menthol 0.2 Assembly extract 1.0 Salicylic acid 0.1 Propylene glycol 2.0 Hyaluronic Sodium acid salt 0.01 Polyoxyethylene (10 mol) monostearate 2.0 75% ethanol Residue

Example 9 Hair Tonic Weight% Coriander Extract (Ethanol Extract) 5.0 (Dry Weight: 0.01) N, N-Dimethyldecylamine Oxide 0.05 Dimethyloctylpolyoxyethylene (3 mol) ) Amine oxide 0.05 Hinokitiol 1.0 Vitamin B ₆ 0.2 Vitamin E acetate 0.02 Menthol 0.2 Salicylic acid 0.1 Bracken extract (ethanol extract) 0.5 Propylene glycol 2.0 Sodium hyaluronate 0 .01 polyoxyethylene (10 mol) monostearate 2.0 70% ethanol residue

Example 10 Hair Tonic% by Weight Coriander Extract (Ethanol Extract) 2.5 (Dry Weight: 0.0125) N, N-Dimethyldodecylamine Oxide 2.5 N, N-Dimethyl-2- Decyltetradecylamine oxide 2.5 N, N-bis (2-hydroxyethyl) -hexadecylamine oxide 2.5 N, N-bis (2-hydroxyethyl) -icosylamine oxide 2.5 dimethylhexylpolyoxy Ethylene (5 mol) amine oxide 2.5 Dimethyltetradecyl polyoxyethylene (3 mol) amine oxide 2.5 N, N-dimethyldecylamine oxide 1.0 Senkyu extract (ethanol extract) 0.05 Propylene glycol 2 0.0 65% ethanol residue

Example 11 Hair tonic 95% by weight 95% ethanol 50.0 Monoammonium glycyrrhizinate 0.05 Coriander extract (1,3-butylene glycol solution) 0.05 (dry weight: 0.0001) Extract (ethanol extract) 0.05 Saffron extract (ethanol extract) 0.05 Rosemary extract (ethanol extract) 0.05 Senkyu extract (ethanol extract) 0.05 Touki extract (ethanol extract) ) 0.05 Dioe extract (ethanol extract) 0.05 Bombyx mori extract (ethanol extract) 0.05 Sodium lauryl sulfate 0.1 N, N-dimethyl-2-decyltetradecylamine oxide 0.5 N, N-bis (2-hydroxyethyl) -hexadecylamine oxide 0.5 Methylhexyl polyoxyethylene (5 moles) amine oxide 0.5 Hydrogenated Castor Oil oxide (40 mol) adduct 0.5 Succinic acid q.s. perfume and dye qs Ion exchanged water Balance

[Example 12] O / W emulsion type hair nourisher weight% (A phase) N, N-dimethylhexylamine oxide 1.0 N, N-bis (2-hydroxyethyl) -decylamine oxide 5 hydrogenated castor oil ethylene oxide (60 mol) adduct 2.0 glycerin 10.0 dipropylene glycol 10.0 1,3-butylene glycol 4.0 coriander extract (ethanol extract) 0.01 (dry weight: 0. 00005) Peony extract (ethanol extract) 0.2 Polyethylene glycol 1500 5.0 (B phase) Cetyl isooctanoate 10.0 Squalane 5.0 Vaseline 2.0 Propyl paraben 2.0 (C phase) Carboxyvinyl polymer 1% aqueous solution 30.0 sodium hexametaphosphate 0.03 ion exchanged water 8.3 (D phase) Ion exchanged water 4.5 (E phase) KOH 0.12 Ion-exchange water Balance

<Preparation Method> The phases A and B were each dissolved by heating at 60 ° C., mixed and treated with a homomixer to prepare a gel. Phase D was gradually added to the gel and dispersed with a homomixer. Next, C previously dissolved in this gel dispersion
The phase was added, and the previously dissolved phase E was added and emulsified with a homomixer to produce a desired O / W emulsion type hair restorer.

[Example 13] Creamy hair restorer (% by weight) (A phase) Dimethylhexyl polyoxyethylene (5 mol) amine oxide 2.5 Liquid paraffin 5.0 Cetostearyl alcohol 5.5 Glyceryl monostearate 3.0 Polyoxyethylene (20 mol) -2-octyldodecyl ether 3.0 Propylparaben 0.3 Fragrance 0.1 (Phase B) Yoquinin extract (1,3-butylene glycol solution) 0.03 Coriander extract (Ethanol extraction Liquid) 0.04 (dry weight: 0.002) glycerin 8.0 dipropylene glycol 20.0 polyethylene glycol 4000 5.0 sodium hexametaphosphate 0.005 ion-exchanged water residue

<Production Method> The phases A and B were each dissolved by heating, mixed, and emulsified by a homomixer to obtain a desired creamy hair restorer.

[Example 14] Aerosol hair restoration weight% (stock solution formulation) 95% ethanol 50.0 Glycyrrhetinic acid 0.1 Coriander extract (ethanol extract) 0.025 (dry weight: 0.0005) Arnica extract (Ethanol extract) 0.055 Assembly extract 0.1 Sodium lauryl sulfate 0.1 N, N-dimethyltetradecylamine oxide 0.2 N, N-bis (2-hydroxyethyl) -decylamine oxide 0.3 dimethyl Decyl polyoxyethylene (5 mol) amine oxide 0.1 Hardened castor oil ethylene oxide (40 mol) adduct 0.5 Lactic acid proper amount Sodium lactate proper amount Fragrance and dye proper amount Ion-exchanged water residue (filling formula) stock solution 50. 0 Liquefied petroleum gas 50.0

<Production Method> Each component of the stock solution formulation was mixed and dissolved to prepare a stock solution, which was filled in a can, fitted with a valve, and then filled with liquefied petroleum gas to prepare a desired aerosol hair growth material.

[0045]

Industrial Applicability According to the present invention, there is provided a hair restorer having a hair growth effect such as an excellent hair loss prevention effect and a hair growth effect.

Claims (1)

[Claims] 1. A hair restorer comprising the following components 1) and 2): 1) Coriander extract 2) One or more amine oxides of the formula (I): ## STR1 ## (Wherein, R ¹ is a linear or branched alkyl group having 2 to 24 carbon atoms, R ² is a methyl group or a 2-hydroxyethyl group, and n represents a number of 0 or more and 5 or less).