JPH09328415A - Hair tonic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair tonic, having excellent hair tonic effects such as preventing effects on alopecia or trichogenous effects and useful in the field of medicines, quasi-drugs or cosmetics by combining a specific plant extract with a specified amine oxide. SOLUTION: This hair tonic is prepared by using one or more plant extracts selected from the group of an extract of Mentha piperita L, an extract of Althaea officinalis L. and an extract of Coix lachryma-jobi L. var. ma-yuen Stapf and one or more amine oxides of the formula [R<1> is a 2-24C alkyl; R<2> is methyl or hydroxyethyl; A is monooxyethylene; (n) is >=0 and <=5] in combination. The amount of the blended plant extracts is about 0.005-20wt.% expressed in terms of the dry weight and the amount of the blended amine oxides is preferably about 0.001-20wt.%, especially preferably about 0.1-10wt.%. The daily does thereof for an adult is 0.01-100mg, preferably 0.1-10mg based on 1kg body weight and can be administered once or divided into 2-4 portions.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention belongs to the technical field related to hair restoration. More specifically, it belongs to the technical field related to a hair restorer having an excellent hair loss-preventing effect and a hair-growth effect such as a hair-growth effect, and the hair restorer of the present invention is used particularly in the fields of pharmaceuticals, quasi-drugs, and cosmetics.

[0002]

2. Description of the Related Art Hair restoration is a product that promotes or stimulates the growth of hair, and in today's aging society, the demand for hair growth is increasing year by year as social stress increases. In general, the causes of head baldness and hair loss include the activation of androgens in organs such as hair roots and sebaceous glands, decreased blood flow to hair follicles, excessive secretion of sebum, and the production of peroxides in the scalp. Various causes such as abnormalities, malnutrition, and stress are considered. Conventional hair restorations generally contain a substance having an action of removing or reducing factors considered to be the cause of baldness and hair loss. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as assembly extract and acetylcholine derivative, anti-inflammatory agents such as purple root extract and hinokitiol, female hormones such as estradiol, cepharanthin and the like Are used in the prevention and treatment of baldness and hair loss.

[0003]

However, in spite of many attempts as described above, the hair-growing effects such as the hair-growth-preventing effect and the hair-growth effect of the conventional hair-growing agent are not always sufficient. Was. The reason for this is that, as described above, the causes of baldness and hair loss are extremely diverse, and the mechanism of hair growth itself is also very complicated, so it is not enough to use a hair restoration that focuses only on those causes and one aspect of the mechanism. It is mentioned.

[0004]

Means for Solving the Problems In order to solve this problem, the present inventor has made intensive studies to provide a new hair restorer having an excellent hair loss preventing effect and a hair growth effect. As a result, the present inventors have found that a hair restorer prepared by combining a specific plant extract and a specific amine oxide has an excellent hair restorer effect, and completed the present invention.

That is, the present invention provides a hair restorer comprising the following components: 1 or 2 selected from plant extracts of the group consisting of peppermint extract, Altea extract and Yokuinin extract
One or more kinds of amine oxides represented by the following formula (I)
More than species:

Embedded image (In the formula, R ¹ is a linear or branched alkyl group having 2 to 24 carbon atoms, R ² is a methyl group or a hydroxyethyl group, A is a monooxyethylene group, and n is 0 or more and 5 or less. Represents a number).

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below. A. The hair nourishing agent of the present invention comprises one or more plant extracts selected from the group consisting of peppermint extract, Altea extract and Yokuinin extract.

The peppermint extract blended in the present invention is
Peppermint (Mentha piperita L.)
It is an extract of whole grass. The Altea extract is an extract of seeds of Althea officinalis L. And, Yokuinin extract is Yokuinin (coix lachryma-jobi L. var.ma).
yuen Stapf) seed extract. As a method for extracting these extracts from the above-mentioned raw materials, generally known methods can be used. For example, the above-mentioned raw materials may be prepared from hot water, lower alcohols such as methanol and ethanol, or hydrates of these lower alcohols, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, or hydrates of these polyhydric alcohols. It can be obtained by solvent extraction with a solvent. These plant extracts can be blended alone in the hair nourishing agent of the present invention, but it is also possible to blend a plurality of plant extracts in combination.

The amount of these plant extracts in the hair growth composition of the present invention should be appropriately changed according to the specific combination of the plant extract to be blended and the specific mode of the hair growth composition of the present invention. Although not to be limited, in general, in the total amount of hair restoration, as the dry weight of the plant extract,
It is preferably 0.005% by weight or more and 20% by weight or less.
If the amount is less than the above 0.005% by weight, the intended effect of the present invention tends not to be sufficiently exerted, which is not preferable. If the amount exceeds 20% by weight, it often causes troubles in the preparation, which is not preferable. .

B. The hair restorer of the present invention comprises an amine oxide represented by the formula (I). This amine oxide (I) can be roughly classified into three modes.
That is, dimethylalkylamine oxide (a) in which R ² of amine oxide (I) is a methyl group and n = 0; similarly, R ² is a hydroxyethyl group;
Dihydroxyethylalkylamine oxide (b), which is 0, or dimethylalkylpolyoxyethyleneamine oxide (c), wherein R ² is a methyl group and n> 1.

R ¹ which is a straight-chain alkyl group or a branched-chain alkyl group having 2 to 24 carbon atoms is an ethyl group,
Propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl , Eicosacyl, heneicosacyl, docosacyl, tricosanyl, tetracosanyl, and other linear alkyl groups; isopropyl, isobutyl, sec-butyl, tert-butyl, isopentyl, neopentyl, tert-pentyl, and isohexyl Examples include a branched alkyl group such as a group.

The polymerization number n of the monooxyethylene group A is in the range of 1 to 5 when the amine oxide (I) is dimethylalkylpolyoxyethylene amine oxide.

Specifically, dimethylalkylamine oxide (a) includes N, N-dimethyl-2-ethylamine oxide, N, N-dimethyl-2-butylamine oxide, N, N-dimethyl-2-hexylamine oxide , N, N-dimethyl-2-octylamine oxide,
N, N-dimethyl-2-decylamine oxide, N, N
-Dimethyl-2-dodecylamine oxide, N, N-dimethyl-2-tetradecylamine oxide, N, N-dimethyl-2-hexadecylamine oxide, N, N-dimethyl-2-octadecylamine oxide, N, N -Dimethyl-2-eicosylamine oxide, N, N-dimethyl-2-tetraeicosylamine oxide, N, N-
Dimethyl-2-decyltetradecylamine oxide and the like can be exemplified.

The dihydroxyethylalkylamine oxide (b) includes N, N-dihydroxyethyl-2-ethylamine oxide, N, N-dihydroxyethyl-2-butylamine oxide, N, N-dihydroxyethyl-2-hexyl. Amine oxide, N, N-dihydroxyethyl-2-hexylamine oxide, N, N
-Dihydroxyethyl-2-octylamine oxide,
N, N-dihydroxyethyl-2-ethyloctylamine oxide, N, N-dihydroxyethyl-2-decylamine oxide, N, N-dihydroxyethyl-2-dodecylamine oxide, N, N-dihydroxyethyl-
2-tetradecylamine oxide, N, N-dihydroxyethyl-2-hexadecylamine oxide, N, N-
Dihydroxyethyl-2-octadecylamine oxide, N, N-dihydroxyethyl-2-eicosylamine oxide, N, N-dihydroxyethyl-2-decyldecylamine oxide, N, N-dihydroxyethyl-
Examples include 2-decyldecylamine tetraeicosylamine oxide.

The dimethylalkyl polyoxyethylene amine oxide (c) includes dimethylethyl polyoxyethylene (1.5 mol) amine oxide, dimethylbutyl polyoxyethylene (3 mol) amine oxide, dimethylhexyl polyoxyethylene (c). 5 mol) amine oxide, dimethyl octyl polyoxyethylene (3 mol) amine oxide, dimethyl decyl polyoxy ethylene (1.5 mol) amine oxide, dimethyl dodecyl polyoxy ethylene (3 mol) amine oxide, dimethyl tetradecyl polyoxy ethylene (5 mol) amine oxide, dimethyl hexadecyl polyoxyethylene (3 mol) amine oxide, dimethyl octadecyl polyoxyethylene (1.5 mol) amine oxide, dimethyl eicosyl polio Shiechiren (1.5 mol) amine oxide, dimethyl tetra et eicosyl polyoxyethylene (1.5 moles) amine oxide can be exemplified.

These amine oxides (I) can be used alone in the hair restorer of the present invention, but can also be used in combination with a plurality of amine oxides (I).

The amount of these amine oxides (I) to be blended in the hair nourishing composition of the present invention may be appropriately changed depending on the combination of amine oxides (I) to be specifically blended and the specific embodiment of the hair nourishing composition of the present invention. Although it is not particularly limited, it is preferably 0.001% by weight or more and 20% by weight or less, particularly 0.1% by weight or more and 10% by weight or less in the total amount of the hair nourishing agent. preferable. If the blending amount is less than 0.001% by weight based on the total amount of the hair nourishing agent, the desired effect of the present invention tends not to be sufficiently exhibited, which is not preferable.
Even if the amount is more than 20% by weight, the effect is not enhanced in proportion to the increase in the amount, which is not preferable. In this way,
By combining the plant extract and the amine oxide (I) in combination, a hair nourishing agent having an extremely excellent hair loss prevention effect and hair growth effect is provided.

In the hair restoration of the present invention, the desired effect of the present invention is intended for the purpose of exhibiting the general effect of the hair restoration component normally incorporated in the hair restoration. Can be blended as long as is not impaired. For example, other alkoxycarbonyl pyridine N- oxide, Kapuroniumu chloride, assembly extract, vasodilators such as acetylcholine derivatives; serine, amino acids such as methionine, vitamin B _6, vitamin E or a derivative thereof, vitamins such as biotin; pantothenic An acid or a derivative thereof;
Glycyrrhetinic acid or a derivative thereof; nicotinic acid esters such as benzyl nicotinate; skin function enhancers such as cepharanthin; and female hormones such as estradiol can also be incorporated in the hair restorer of the present invention.

[0018] Further, plant extracts usually contained in hair nourishing agents, for example, Yotei extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, ginseng extract, mannen wax extract, Kossaiho extract, Ganoderma lucidum extract, Gentian extract, Tanjin extract, Loofah extract, Kyokyo extract, Pine extract, Kujin extract, Toki extract, Peony extract, Safflower extract, Barberry extract, Areca extract , Eucalyptus extract, Kagosou extract, Mokutou extract, Gossitsu extract,
Psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract, kashi extract, wolfberry extract, mugwort extract, cucumber extract, button extract , Squid extract, saffron extract, rosemary extract, rhizome extract, mallow extract and the like can be added to the hair nourishing agent of the present invention.

Also, hinokitiol. Hexachlorophen. Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanide and bithionol; cooling agents such as menthol; salicylic acid, zinc or derivatives thereof; drugs such as lactic acid or its alkyl ester; organic acids such as citric acid Protease inhibitors such as tranexamic acid; amino acids such as arginine; oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols;
Polyhydric alcohols such as glycerin and propylene glycol, other surfactants, humectants, thickeners, fragrances, antioxidants, ultraviolet absorbers, pigments, ethanol, water, etc., do not impair the intended effects of the present invention. Can be appropriately blended.

The form of the hair restorer of the present invention is not particularly limited as long as it can be applied to the outer skin such as a liquid, an emulsion, an ointment, and the like. Of the present invention can be prepared. In addition, the hair restoration of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The hair restorer of the present invention can be used for the treatment and prevention of alopecia, for example, the treatment and prevention of androgenetic alopecia, the treatment and prevention of diffuse alopecia common to women, the treatment of alopecia areata, etc. Can be widely used. It should be noted that the names of hair loss diseases shown here are examples, and diseases to which the hair restoration of the present invention can be applied are not limited to these hair loss diseases.

The hair restorer of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin. The dose of the hair restorer of the present invention should be appropriately determined according to individual differences such as age and degree of hair loss, but the dose for general adults is 0.01 to 100 mg / kg body weight. Daily, preferably 0.1 to 10 mg / day, which can be administered once a day or divided into 2 to 4 times a day.

[0023]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to the disclosure of each embodiment, tests for examining the hair-growing effect of these embodiments and the like will be described.

1. Hair growth test Using C3H / HeNCrJ mice in the telogen phase of the hair cycle, the method of Ogawa et al. (Normal and Abnormal)
Epidermal Differentiation (Normal and
Abnormal Epidermal Differentiation, M. Seiji and
A hair growth test is performed according to IABernstein, pp. 159-170, 1982, published by The University of Tokyo. That is, mice are group 1
The number of mice was zero, and the mice were divided into groups of no application, examples and comparative examples. The backs of the mice were shaved with a hair clipper and a shaver, and 0.1 ml of each sample was applied once a day. The hair growth effect of each sample was calculated as the area ratio of the hair growth part on the back of the mouse (the area of the hair growth part / the area of the shaved part × 100 = hair growth rate).
Assess by

2. Hair Restoration Effect Test In order to further examine the hair restoration effect such as the hair loss prevention effect and the hair growth effect of the hair restorer of the present invention, a tricogram test and a hair loss prevention test are performed on healthy individuals. Tricogram test The hair removed before and after use of the hair restoration was observed under a microscope,
Count the number of telogen follicles from the morphology of the follicles (the telogen follicles are the roots of hair that has stopped growing, and those who report hair loss have a higher percentage of this telogen follicle than normal people. Is observed.), And the hair growth effect of the hair growth material is compared by increasing or decreasing the ratio. Specifically, the hair restorer of the present invention was applied to the scalp of 10 male subjects twice a day, 5 ml per time, for 6 consecutive months, and applied to one subject immediately before application and immediately before the end of application for 6 months. One hundred hairs are withdrawn and each hair root is examined as described above.

Hair Loss Prevention Test The change in the number of hair loss before and after use of the hair restorer during hair washing was used as an index of the hair loss preventive effect of the hair restorer. That is, two months before the start of the tricogram test was defined as a sample non-application period, and the subject was washed every day one week before the start of the test and six days after the start, and the hair removed at that time was collected, and the thickness was 50 μm or more. The number of hair was counted. Then, for each subject, the change rate of the average number of hair removals per day (average number of hair removals during hair application period / average number of hair removals during no application period × 100) was calculated (%).

[Examples 1 to 19] Table 1 (Table 1-1)
A hair restorer was prepared according to the formulation shown in 2, 3).

[Table 1]

[0028]

[Table 2]

[0029]

[Table 3]

<Production Method> To 95% ethanol, an amine oxide (I), hydrogenated castor oil ethylene oxide (40 mol) adduct and an extract of peppermint, altea and / or yoquinin were added and dissolved by stirring. Ion-exchanged water was added and mixed to prepare a desired hair restorer.

The results of the hair growth test of the hair growth preparations of the examples shown in Table 1 are shown in Table 2 together with the results of the comparative examples.

[Table 4]

As described above, the hair nourishing agent of the present invention containing the extract liquid of amine oxide (I) and the specific plant extract components peppermint, altea and / or yoquinin is:
It was found that the hair growth effect of shifting the hair cycle from the resting phase to the growing phase was superior to the hair nourishing agent of the comparative example in which only one of these components was blended.

Next, the hair nourishing effect test was carried out on the hair nourishing agent of Example 13 shown in Table 1. The result is the third
Shown in the table.

[Table 5]

As shown in Table 3, by applying the hair nourishing agent of Example 13 to the test subject, the number of hairs removed decreased,
It was also found that the proportion of hair roots in the rest period of the hair cycle was also reduced, and it was revealed that the hair growth preparation of the present invention had an excellent hair growth effect. In view of the blended components of the other examples shown in Table 1 and the results of the hair growth test in each of the examples shown in Table 2, the excellent hair nourishing found in the hair nourishment of this Example 13 was observed. It is clear that the effect is also observed in the hair nourishing agents in other examples.

Hereinafter, the formulations of the hair growth preparation of the present invention having various formulations are described. Each hair growth preparation had excellent hair growth and hair growth effects in the hair growth test and the hair growth effect test.
In addition, these hair nourishes which do not particularly describe the production method were produced by a conventional method according to the dosage form.

[Example 20] Palemint extract (1,3-butylene glycol extract) by weight percent of heartonic 0.1 N, N-diethyloxymethyl-2-tetraeicosylamine oxydide 1.0 N, N-dimethyl -2-Desylamine Oxide 1.0 Hinokitiol 1.0 Vitamin B6 0.2 Vitamin E Acetate 0.02 Menthol 0.2 Assembly extract 1.0 Salicylic acid 0.1 Mica extract (ethanol extract) 0.5 Propylene glycol 2.0 Sodium hyaluronate 0.01 Polyoxyethylene (10 mol) Monostearate 2.0 75% Ethanol Residual

[Example 21] Hairnic% by weight Altea extract (ethanol extract) 1.5 Yokuinin extract (ethanol extract) 1.5 N, N-Dimethyl-2-decylamine oxydide 0.05 Dimethyloctyl Polyoxyethylene (3 mol) amine oxydide 0.05 Hinokitiol 1.0 Vitamin B6 0.2 Vitamin E acetate 0.02 Menthol 0.2 Salicylic acid 0.1 Kacon extract (ethanol extract) 0.5 Propylene glycol 2. 0 Sodium hyaluronate 0.01 Polyoxyethylene (10 mol) Monostearate 2.0 70% Ethanol Residual

[Example 22] Hair artic weight% Altea extract (ethanol extract) 3.3 Yokuinin extract (1,3-butylene glycol extract) 3.3 Peppermint extract (ethanol extract) 3.4 N, N-Dimethyl-2-dedecylamine oxydide 2.5 N, N-Dimethyl-2-decyltetradecylamine oxydide 2.5 N, N-Human doxymethyl-2-hexadecylamine oxydide 2.5 N, N- Human Ethoxymethyl-2-eicosylamine oxydide 2.5 Dimethylhexyl polyoxyethylene (5 mol) Amine oxydide 2.5 Dimethyl tetradecyl polyoxyethylene (3 mol) Amine oxydide 2.5 N, N-Dimethyl-2-decyl Amine Oxide 1.0 Senkyu extract (ethanol extract) 0.05 Propylene Glycol Lumpur 2.0 65% Ethanol Balance

Example 23 Hairnic% wt.% 95% Ethanol 50.0 Glycyrrhizin monoammonium 0.05 Altea extract (ethanol extract) 0.05 Yokuinin extract (1,3-butylene glycol extract) 0 .05 peppermint extract (ethanol extract) 0.05 saffron extract (ethanol extract) 0.05 rosemary extract (ethanol extract) 0.05 senkyu extract (ethanol extract) 0.05 touki extract (Ethanol extract) 0.05 Zyou extract (Ethanol extract) 0.05 Mica extract (Ethanol extract) 0.05 Sodium lauryl sulfate 0.1 N, N-Dimethyl-2-decyltetradecylamine oxide 0 .5 N, N-Diethyloxymethyl-2-hexadecylami N-oxydone 0.5 Dimethylhexyl polyoxyethylene (5 moles) Amine oxydide 0.5 Hardened castor oil Ethylene oxydide (40 moles) Adduct 0.5 Succinic acid Appropriate amount Fragrance and dye Appropriate amount Ion-exchanged water Residual

[Example 24] O / W emulsion type hair nourishing agent wt% (Phase A) N, N-dimethyl-2-hexylamine oxydide 1.0 N, N-dimethytoxymethyl-2-decylamine oxydide 2. 5 Polyoxyethylene (60 mol) Addition hydrogenated castor oil 2.0 Glycerin 10.0 Dipropylene glycol 10.0 1,3-butylene glycol 4.0 Peppermint extract (1,3-ethylene glycol extract) 0.05 Yokuinin extract (ethanol extract) 0.1 Altea extract (ethanol extract) 0.1 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanoate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2 0.0 (C phase) Carboxyvinyl polymer 1% aqueous solution 30.0 Sodium hexametaphosphate 0.03 Ion-exchanged water 8.35 (D phase) Ion-exchanged water 4.5 (E-phase) KOH 0.12 Ion-exchanged water Residual

<Preparation Method> The phases A and B were each dissolved by heating at 60 ° C., mixed, and treated with a homomixer to prepare a gel. Phase D was gradually added to this gel and dispersed with a homomixer. Next, C previously dissolved in this gel dispersion
The phase was added, and the previously dissolved phase E was added and emulsified with a homomixer to produce a desired O / W emulsion type hair restorer.

[Example 25] Creamy hair nourishing agent wt% (Phase A) Dimethylhexyl polyoxyethylene (5 moles) Amine oxide 2.5 Liquid paraffin 5.0 Cetostearyl alcohol 5.5 Glyceryl monostearate 3.0 EO (20 mol) -2-octyl decyl ether 3.0 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) Altea extract (ethanol extract) 0.03 Yokuinin extract (1,3-butylene glycol extract) ) 0.03 peppermint extract (ethanol extract) 0.04 glycerin 8.0 dipropylene glycol 20.0 polyethylene glycol 4000 5.0 sodium hexametaphosphate 0.005 ion-exchanged water residual

<Production Method> The phases A and B were each dissolved by heating, mixed, and emulsified with a homomixer to obtain a desired creamy hair restorer.

[Example 26] Aerosol hair restorer wt% (stock solution formulation) 95% ethanol 50.0 glycyrrhetinic acid 0.1 Altea extract (ethanol extract) 0.05 peppermint extract (ethanol extract) 0.05 Peony extract (1,3-butylene glycol extract) 0.05 Peppermint extract (1,3-butylene glycol extract) 0.05 Sembri extract 0.1 Sodium lauryl sulfate 0.1 N, N-Dimethyl-2 -Tetradecylamine oxydide 0.2 N, N-diethyloxymethyl-2-decylamine oxydide 0.3 Dimethyldecyl polyoxyethylene (5 mol) Amine oxyde 0.1 Hardened castor oil Ethylene oxyde (40 mol) adduct 0.5 Lactic acid Appropriate amount Sodium lactate Appropriate amount Perfume and pigment Appropriate amount Ion-exchanged water Residual (filling prescription) Undiluted solution 50.0 Liquefied petroleum gas 50.0

<Manufacturing Method> A stock solution was prepared by dissolving the stock solution formulation, and the stock solution was filled in a can and fitted with a valve and then filled with gas to prepare a desired aerosol hair nourishing agent.

[0046]

Industrial Applicability According to the present invention, there is provided a hair restorer having a hair growth effect such as an excellent hair loss prevention effect and a hair growth effect.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Shunsuke Takeda, 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Inside Shiseido Research Center 1 (72) Inventor Yosuke Nakazawa 1050, Niiga-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Co., Ltd. Research Center No. 1 (72) Inventor Masaaki Uemura 1050 Shinba-cho, Kohoku Ward, Yokohama City, Kanagawa Prefecture Shiseido Co., Ltd. Research Center No. 1 (72) Inventor Masahiro Tajima Shinba-cho, Kohoku Ward, Yokohama City, Kanagawa Prefecture No. 1050 Stock company Shiseido Research Center No. 1

Claims (1)

[Claims] 1. A hair nourishing agent comprising the following ingredients and one or two selected from plant extracts of the group consisting of peppermint extract, Altea extract and Yokuinin extract.
One or more kinds of amine oxides represented by the following formula (I)
Species or more: (In the formula, R ¹ is a linear or branched alkyl group having 2 to 24 carbon atoms, R ² is a methyl group or a hydroxyethyl group, A is a monooxyethylene group, and n is 0 or more and 5 or less. Represents a number).