JPH10511402A - 凍結保存溶液 - Google Patents
凍結保存溶液Info
- Publication number
- JPH10511402A JPH10511402A JP8527053A JP52705396A JPH10511402A JP H10511402 A JPH10511402 A JP H10511402A JP 8527053 A JP8527053 A JP 8527053A JP 52705396 A JP52705396 A JP 52705396A JP H10511402 A JPH10511402 A JP H10511402A
- Authority
- JP
- Japan
- Prior art keywords
- cells
- target cells
- cryopreservation
- solution
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Reproductive Health (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catching Or Destruction (AREA)
- Peptides Or Proteins (AREA)
- Luminescent Compositions (AREA)
- Led Device Packages (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.実質的に、(a)グリセリン: (b)細胞生存度を高めるのに十分な量のアルカリ金属塩化物; (c)環境条件下で細胞維持を支持するのに有効な量の生理学的に代謝し得る単 糖類; 及び (d)プラズマ膜(plasma membrane)構造完全性を維持するた めに有効な量の血漿アルブミン からなる濃厚凍結保存溶液。 2.更に希釈剤を含有している請求項1記載の凍結保存溶液。 3.溶液のpHが約7と7.5の間である請求項1記載の凍結保存溶液。 4.濃厚液が実質的に(a)約60ないし80重量%のグリセリン、(b)約5ない し約10重量%のアルカリ金属塩化物、(c)約0.2ないし約1重量%の単糖類 ;及び(d)約20ないし30重量%の血漿アルブミンからなる請求項1記載の凍 結保存溶液。 5.溶液が実質的に(a)約20ないし40重量%のグリセリン、(b)約1.5な いし約5重量%のアルカリ金属塩化物、(c)約0.1ないし約0.5重量%の単 糖類;(d)約6ないし15重量%の血漿アルブミン及び(e)残部希釈剤(bala nce diluent)からなる請求項2記載の凍結保存溶液。 6.アルカリ金属塩化物が塩化ナトリウムである請求項1記載の濃厚凍結保存 溶液。 7.アルカリ金属塩化物が塩化ナトリウムである請求項2記載の凍結保存溶液 。 8.単糖類がグルコースである請求項1記載の濃厚凍結保存溶液。 9.単糖類がグルコースである請求項2記載の凍結保存溶液。 10.血漿アルブミンがヒト血漿アルブミンである請求項1記載の濃厚凍結保 存溶液。 11.血漿アルブミンがヒト血漿アルブミンである請求項2記載の凍結保存溶 液。 12.実質的に、 (a)約60ないし80重量%のグリセリン; (b)約5ないし約10重量%のアルカリ金属塩化物; (c)約0.2ないし約1重量%のグルコース;及び (d)約20ないし30重量%の血漿アルブミン からなる濃厚凍結保存溶液。 13.実質的に、 (a)約20ないし40重量%のグリセリン; (b)約1.5ないし約5重量%のアルカリ金属塩化物; (c)約0.1ないし約0.5重量%のグルコース; (d)約6ないし15重量%の血漿アルブミン;及び (e)残部の希釈剤(balance of diluent) からなる凍結保存溶液。 14.(i)請求項2に記載の凍結保存溶液に標的細胞を導入し、そして (ii)保護された標的細胞を凍結保存することからなる細胞を凍結保存する方 法。 15.標的細胞を含む溶液の、凍結保存溶液に対する体積比が約1:1ないし 約1:10でありそして標的細胞の、凍結保存溶液に対する比率が約1×105 細胞/mlないし約1×109細胞/mlである請求項14記載の方法。 16.標的細胞が造血幹細胞又は前駆細胞である請求項14記載の方法。 17.標的細胞が血液の血小板である請求項14記載の方法。 18.標的細胞がCD34+ 細胞であると同定されている細胞である請求項14 記載の方法。 19.標的細胞が臍帯の血液から採取される請求項14記載の方法。 20.(i)請求項13に記載の凍結保存溶液に標的細胞を導入し、そして (ii)保護された標的細胞を凍結保存することからなる細胞を凍結保存する方 法。 21.標的細胞を含む溶液の、凍結保存溶液に対する体積比が約1:1ないし 約1:10でありそして標的細胞の、凍結保存溶液に対する比率が約1×105 細胞/ mlないし約1×109細胞/mlである請求項20記載の方法。 22.保護された標的細胞が分当り1−2℃の速度で約−70と約−196℃ の間の温度まで冷却される請求項20記載の方法。 23.(i)請求項2記載の凍結保存溶液に標的細胞を導入し、(ii)保護さ れた標的細胞を凍結保存し、そして(iii)保護された標的細胞を解凍すること からなる生存細胞を凍結保存しそして回収するための方法。 24.標的細胞を含む溶液の、凍結保存溶液に対する体積比が約1:1ないし 1:10の間であり標的細胞に対する凍結保存溶液の比が約1×105細胞/m lないし約1×109細胞/mlの間にある請求項23記載の方法。 25.標的細胞が造血幹細胞又は前駆細胞である請求項23記載の方法。 26.(i)標的細胞を請求項2記載の凍結保存溶液に導入し、(ii)保護さ れた標的細胞を凍結保存し、 (iii)保護された標的細胞を解凍し、そして(iv)解凍した保護された標的細 胞を、標的細胞と凍結保存溶液の分離をしないで、その標的細胞を必要としてい る対象に導入することからなる細胞の凍結保存、回収と医療的使用のための方法 。 27.標的細胞を含む溶液の、凍結保存溶液に対する体積比が約1:1ないし 1:10の間であり標的細胞に 対する凍結保存溶液の比が約1×105細胞/mlないし約1×109細胞/ml の間にある請求項26記載の方法。 28.標的細胞が造血幹細胞又は前駆細胞である請求項26記載の方法。 29.標的細胞が血液の血小板である請求項26記載の方法。 30.標的細胞がCD34+ 細胞であると同定されている細胞である請求項26 記載の方法。 31.標的細胞が臍帯の血液から得られる請求項26記載の方法。 32.対象がヒトである請求項26記載の方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US399,077 | 1995-03-08 | ||
US08/399,077 US5580714A (en) | 1995-03-08 | 1995-03-08 | Cryopreservation solution |
US08/399,077 | 1995-03-08 | ||
PCT/US1996/003153 WO1996027287A1 (en) | 1995-03-08 | 1996-03-07 | Cryopreservation solution |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10511402A true JPH10511402A (ja) | 1998-11-04 |
JP3165863B2 JP3165863B2 (ja) | 2001-05-14 |
Family
ID=23578046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52705396A Expired - Fee Related JP3165863B2 (ja) | 1995-03-08 | 1996-03-07 | 凍結保存溶液 |
Country Status (13)
Country | Link |
---|---|
US (2) | US5580714A (ja) |
EP (1) | EP0813361B1 (ja) |
JP (1) | JP3165863B2 (ja) |
AT (1) | ATE253818T1 (ja) |
AU (1) | AU693339B2 (ja) |
BR (1) | BR9607147A (ja) |
CA (1) | CA2214280C (ja) |
DE (1) | DE69630679T2 (ja) |
ES (1) | ES2210352T3 (ja) |
NO (1) | NO974108L (ja) |
NZ (1) | NZ304628A (ja) |
RU (1) | RU2146088C1 (ja) |
WO (1) | WO1996027287A1 (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011030557A (ja) * | 2009-08-04 | 2011-02-17 | Bio Verde:Kk | 医療用細胞凍害防御液 |
JP2012116823A (ja) * | 2010-12-03 | 2012-06-21 | Kyoto Univ | 生体組織保存溶液及びそれを用いる方法 |
JPWO2011021618A1 (ja) * | 2009-08-19 | 2013-01-24 | タカラバイオ株式会社 | 細胞の保存方法 |
JP2014504510A (ja) * | 2011-02-07 | 2014-02-24 | アドバンスド プリザベイションズ テクノロジーズ リミテッド ライアビリティー カンパニー | 細胞の保存及び細胞培養のための方法 |
US9603355B2 (en) | 2008-06-27 | 2017-03-28 | Bio Verde Inc. | Composition for cryopreservation of cells and tissues |
WO2019059235A1 (ja) * | 2017-09-19 | 2019-03-28 | 株式会社メガカリオン | 精製血小板の製造方法、血小板製剤の製造方法、血液製剤の製造方法、血小板保存液、血小板保存剤および血小板の保存方法 |
KR20190112746A (ko) | 2017-01-31 | 2019-10-07 | 사라야 컴퍼니 리미티드 | 세포의 동결 보존 조성물 및 동결 보존 방법 |
JP2020502284A (ja) * | 2016-12-23 | 2020-01-23 | セルラー バイオメディスン グループ (シャンハイ) エルティーディー. | 臨床使用可能な細胞凍結保存液 |
KR20210069983A (ko) | 2019-12-04 | 2021-06-14 | 고려대학교 산학협력단 | 황산화 히알루론산을 포함하는 세포 동결보존용 조성물 |
KR20210075406A (ko) | 2019-12-13 | 2021-06-23 | 고려대학교 산학협력단 | 올리고펩티드 자기조립 나노 구조체를 포함하는 결빙 제어용 조성물 |
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US6541028B1 (en) | 1997-01-17 | 2003-04-01 | Celadon Science, Llc | Methods for promoting healing of corneal resurfacing wounds |
US6713084B1 (en) | 1997-01-17 | 2004-03-30 | Celadon Science, Llc | Methods for promoting healing of skin resurfacing wounds |
EP1028622A1 (en) | 1997-09-22 | 2000-08-23 | University Of Guelph | Reduction of sperm sensitivity to chilling |
US5955257A (en) * | 1997-10-21 | 1999-09-21 | Regents Of The University Of Minnesota | Infusible grade short-term cell storage medium for mononuclear cells |
US5972592A (en) * | 1997-12-29 | 1999-10-26 | Cornell Research Foundation, Inc. | Increasing reproductive efficiency of bull semen using fucose or a compound with a fucose moiety |
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US6248585B1 (en) * | 1998-11-19 | 2001-06-19 | Thomas Jefferson University | Compositions for preserving haptenized tumor cells for use in vaccines |
US6267925B1 (en) | 1998-12-07 | 2001-07-31 | Haemonetics Corporation | Method for cryopreservation and recovery of red blood cells |
US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
US6358739B1 (en) | 1999-04-12 | 2002-03-19 | Modex Therapeutiques, S.A. | Transiently immortalized cells |
US6878543B1 (en) | 1999-10-25 | 2005-04-12 | Nsgene Sa | Cultures of GFAP+ nestin+ cells that differentiate to neurons |
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DE10041515A1 (de) * | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
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- 1996-03-07 NZ NZ304628A patent/NZ304628A/en unknown
- 1996-03-07 CA CA002214280A patent/CA2214280C/en not_active Expired - Fee Related
- 1996-03-07 BR BR9607147A patent/BR9607147A/pt not_active Application Discontinuation
- 1996-03-07 WO PCT/US1996/003153 patent/WO1996027287A1/en active IP Right Grant
- 1996-03-07 AU AU51869/96A patent/AU693339B2/en not_active Ceased
- 1996-03-07 JP JP52705396A patent/JP3165863B2/ja not_active Expired - Fee Related
- 1996-03-07 RU RU97116829A patent/RU2146088C1/ru not_active IP Right Cessation
- 1996-03-07 AT AT96908717T patent/ATE253818T1/de not_active IP Right Cessation
- 1996-03-07 DE DE69630679T patent/DE69630679T2/de not_active Expired - Fee Related
- 1996-03-07 EP EP96908717A patent/EP0813361B1/en not_active Expired - Lifetime
- 1996-05-31 US US08/658,666 patent/US5759764A/en not_active Expired - Lifetime
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JP2011030557A (ja) * | 2009-08-04 | 2011-02-17 | Bio Verde:Kk | 医療用細胞凍害防御液 |
JPWO2011021618A1 (ja) * | 2009-08-19 | 2013-01-24 | タカラバイオ株式会社 | 細胞の保存方法 |
JP2012116823A (ja) * | 2010-12-03 | 2012-06-21 | Kyoto Univ | 生体組織保存溶液及びそれを用いる方法 |
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US11773374B2 (en) | 2017-09-19 | 2023-10-03 | Megakaryon Corporation | Method for producing purified platelets, method for producing platelet product, method for producing blood product, platelet preserving solution, platelet preserving agent, and method for preserving platelets |
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KR20210075406A (ko) | 2019-12-13 | 2021-06-23 | 고려대학교 산학협력단 | 올리고펩티드 자기조립 나노 구조체를 포함하는 결빙 제어용 조성물 |
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---|---|
US5580714A (en) | 1996-12-03 |
EP0813361A4 (en) | 2000-01-05 |
AU5186996A (en) | 1996-09-23 |
NO974108L (no) | 1997-11-06 |
NO974108D0 (no) | 1997-09-05 |
ES2210352T3 (es) | 2004-07-01 |
CA2214280C (en) | 2001-01-02 |
AU693339B2 (en) | 1998-06-25 |
RU2146088C1 (ru) | 2000-03-10 |
MX9706843A (es) | 1998-06-30 |
BR9607147A (pt) | 1997-11-25 |
EP0813361A1 (en) | 1997-12-29 |
NZ304628A (en) | 1998-09-24 |
DE69630679D1 (de) | 2003-12-18 |
EP0813361B1 (en) | 2003-11-12 |
CA2214280A1 (en) | 1996-09-12 |
US5759764A (en) | 1998-06-02 |
ATE253818T1 (de) | 2003-11-15 |
DE69630679T2 (de) | 2004-10-21 |
WO1996027287A1 (en) | 1996-09-12 |
JP3165863B2 (ja) | 2001-05-14 |
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