JPH10508866A - オンダンセトロンを含有する経口組成物 - Google Patents
オンダンセトロンを含有する経口組成物Info
- Publication number
- JPH10508866A JPH10508866A JP8516719A JP51671996A JPH10508866A JP H10508866 A JPH10508866 A JP H10508866A JP 8516719 A JP8516719 A JP 8516719A JP 51671996 A JP51671996 A JP 51671996A JP H10508866 A JPH10508866 A JP H10508866A
- Authority
- JP
- Japan
- Prior art keywords
- ondansetron
- composition
- composition according
- range
- expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 甘味剤が1または2以上の多価アルコールを含んでなり、そして液状組 成物のpHが2.0〜5.0の範囲内であることを特徴とする、オンダンセトロ ンまたはその薬学上許容される誘導体と、甘味剤と、1または2以上の薬学上許 容される賦形剤とを含んでなる経口投与用液状組成物。 2. 塩酸塩の形態のオンダンセトロンを含んでなる請求項1に記載の組成物 。 3. 塩酸塩二水和物の形態のオンダンセトロンを含んでなる、請求項1に記 載の組成物。 4. 甘味剤がソルビトールを含んでなる、請求項1〜3のいずれか一項に記 載の組成物。 5. オンダンセトロン塩酸塩二水和物と、甘味剤としてソルビトールとを含 んでなる、請求項4に記載の組成物。 6. 組成物中のオンダンセトロンの濃度が、遊離塩基として表して、 0.005〜1%w/vの範囲内である、請求項1〜5のいずれか一項に記載の 組成物。 7. 組成物の合計の多価アルコールの含量が、多価アルコールの固体として 表して、20〜85%w/vである、請求項1〜6のいずれか一項に記載の組成 物。 8. pHが2.5〜4.5の範囲内である、請求項1〜7のいずれか一項に 記載の組成物。 9. 組成物中のオンダンセトロンの濃度が、遊離塩基として表して、0.0 05〜1%w/vの範囲内であり、組成物中の多価アルコールの含量が、多価ア ルコールの固体として表して、20〜85%w/vであり、そしてpHが2.5 〜4.5の範囲内である、請求項1〜8のいずれか一項に記載の組成物。 10. 1〜100cpsの範囲内の粘度を有する、請求項1〜9のいずれか 一項に記載の組成物。 11. フルクトースまたはフルクトース含有サッカリドを実質的に含まない 、請求項1〜10のいずれか一項に記載の組成物。 12. 請求項1〜11のいずれか一項に記載の組成物を投与することを含ん でなる、5HT3レセプターにおける5HTの作用を介して伝達される症状に患 った人間を含む哺乳動物を治療する方法。 13. 嘔吐を治療する請求項12に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9423588A GB9423588D0 (en) | 1994-11-22 | 1994-11-22 | Compositions |
GB9423588.4 | 1994-11-22 | ||
PCT/IB1995/001152 WO1996015786A2 (en) | 1994-11-22 | 1995-11-20 | Oral compositions containing ondansetron |
Publications (2)
Publication Number | Publication Date |
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JPH10508866A true JPH10508866A (ja) | 1998-09-02 |
JP2965704B2 JP2965704B2 (ja) | 1999-10-18 |
Family
ID=10764811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8516719A Expired - Lifetime JP2965704B2 (ja) | 1994-11-22 | 1995-11-20 | オンダンセトロンを含有する経口組成物 |
Country Status (33)
Country | Link |
---|---|
US (1) | US5854270A (ja) |
EP (1) | EP0792149B1 (ja) |
JP (1) | JP2965704B2 (ja) |
KR (1) | KR100292124B1 (ja) |
CN (1) | CN1108153C (ja) |
AT (1) | ATE196084T1 (ja) |
AU (1) | AU703932B2 (ja) |
BE (1) | BE1009458A5 (ja) |
BR (1) | BR9509807A (ja) |
CA (1) | CA2205546C (ja) |
CY (1) | CY2171B1 (ja) |
CZ (1) | CZ285187B6 (ja) |
DE (1) | DE69518767T2 (ja) |
DK (1) | DK0792149T3 (ja) |
ES (1) | ES2151083T3 (ja) |
FI (1) | FI119356B (ja) |
FR (1) | FR2727015B1 (ja) |
GB (2) | GB9423588D0 (ja) |
GR (1) | GR3034684T3 (ja) |
HK (1) | HK1009590A1 (ja) |
HU (1) | HU226947B1 (ja) |
IE (1) | IE950884A1 (ja) |
IL (1) | IL116083A (ja) |
IT (1) | IT1282353B1 (ja) |
NO (1) | NO306892B1 (ja) |
NZ (1) | NZ297879A (ja) |
PL (1) | PL181522B1 (ja) |
PT (1) | PT792149E (ja) |
RU (1) | RU2145853C1 (ja) |
SI (1) | SI0792149T1 (ja) |
TW (1) | TW413634B (ja) |
WO (1) | WO1996015786A2 (ja) |
ZA (1) | ZA959820B (ja) |
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WO2006006595A1 (ja) * | 2004-07-12 | 2006-01-19 | Teikokumedix Co., Ltd. | 経口医薬組成物 |
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ES2162561B1 (es) * | 1999-06-28 | 2002-07-16 | Boehringer Ingelheim Espana | Composicion farmaceutica de metamizol oral, liquida, transparente, estable y de sabor aceptable. |
US6473876B1 (en) | 1999-06-29 | 2002-10-29 | Sony Corporation | Method and apparatus for encoding of bitstreams using rotation |
AU6934400A (en) * | 1999-08-25 | 2001-03-19 | Barrett R. Cooper | Compositions and methods for treating opiate intolerance |
MXPA03003761A (es) * | 2000-10-30 | 2003-07-28 | Teva Pharma | Formas de cristales y solvatos de clorhidrato de ondansetron y procesos para su preparacion. |
US20020115707A1 (en) * | 2001-01-11 | 2002-08-22 | Rami Lidor-Hadas | Process for preparing pure ondansetron hydrochloride dihydrate |
CN100553625C (zh) | 2002-04-09 | 2009-10-28 | 弗拉梅技术公司 | 活性成分微囊的口服混悬液 |
JP2005529142A (ja) * | 2002-04-29 | 2005-09-29 | テバ ジョジセルジャール レースベニュタールシャシャーグ | 1,2,3,9−テトラヒドロ−9−メチル−3−[(2−メチル−1h−イミダゾル−1−イル)メチル]−4h−カルバゾル−4−オンの製造方法 |
US20050131045A1 (en) * | 2002-04-30 | 2005-06-16 | Judith Aronhime | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them |
AU2003223763A1 (en) * | 2002-04-30 | 2003-11-17 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them |
WO2004045615A1 (en) * | 2002-11-15 | 2004-06-03 | Helsinn Healthcare Sa | Palonosetron for the treatment of chemotherapy-induced emesis |
US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
TWI355936B (en) * | 2003-02-18 | 2012-01-11 | Helsinn Healthcare Sa | Uses of palonosetron hydrochloride |
US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
US20060167072A1 (en) * | 2004-01-30 | 2006-07-27 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
CN100423779C (zh) * | 2006-09-27 | 2008-10-08 | 中国药科大学 | 一种以5-羟色胺3受体拮抗剂和h2受体拮抗剂为活性成分的药用组合物及其制药用途 |
PL2124556T3 (pl) | 2006-10-09 | 2015-02-27 | Charleston Laboratories Inc | Kompozycje farmaceutyczne |
WO2009089494A2 (en) | 2008-01-09 | 2009-07-16 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
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EP2451274B1 (en) | 2009-07-08 | 2017-10-04 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
US20110288115A1 (en) * | 2010-05-24 | 2011-11-24 | Avmedis Llc | Treatment of vagally-mediated spectrum disorders |
US20120302616A1 (en) * | 2010-12-03 | 2012-11-29 | Nikhilesh Singh | Method of treatment of obsessive compulsive disorder with ondansetron |
KR101058749B1 (ko) * | 2010-12-29 | 2011-08-24 | 에스씨바이오팜 주식회사 | 네오헤스피리딘 디하이드로찰콘을 감미료로 사용하는 온단세트론 염산염 이수화물 함유 액상 조성물 |
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1994
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1995
- 1995-11-20 DK DK95941825T patent/DK0792149T3/da active
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- 1995-11-20 US US08/817,831 patent/US5854270A/en not_active Expired - Lifetime
- 1995-11-20 NZ NZ297879A patent/NZ297879A/xx not_active IP Right Cessation
- 1995-11-20 ZA ZA959820A patent/ZA959820B/xx unknown
- 1995-11-20 WO PCT/IB1995/001152 patent/WO1996015786A2/en active IP Right Grant
- 1995-11-20 CA CA002205546A patent/CA2205546C/en not_active Expired - Lifetime
- 1995-11-20 SI SI9530444T patent/SI0792149T1/xx unknown
- 1995-11-20 CZ CZ971548A patent/CZ285187B6/cs not_active IP Right Cessation
- 1995-11-20 GB GB9523666A patent/GB2295317B/en not_active Expired - Lifetime
- 1995-11-20 RU RU97110066A patent/RU2145853C1/ru active
- 1995-11-20 KR KR1019970703400A patent/KR100292124B1/ko not_active IP Right Cessation
- 1995-11-20 AT AT95941825T patent/ATE196084T1/de active
- 1995-11-20 JP JP8516719A patent/JP2965704B2/ja not_active Expired - Lifetime
- 1995-11-20 BR BR9509807A patent/BR9509807A/pt not_active Application Discontinuation
- 1995-11-20 FR FR9513722A patent/FR2727015B1/fr not_active Expired - Lifetime
- 1995-11-20 IT IT95RM000763A patent/IT1282353B1/it active IP Right Grant
- 1995-11-20 CN CN95197225A patent/CN1108153C/zh not_active Expired - Lifetime
- 1995-11-20 PT PT95941825T patent/PT792149E/pt unknown
- 1995-11-20 IE IE950884A patent/IE950884A1/en not_active IP Right Cessation
- 1995-11-20 DE DE69518767T patent/DE69518767T2/de not_active Expired - Lifetime
- 1995-11-20 AU AU43135/96A patent/AU703932B2/en not_active Expired
- 1995-11-20 EP EP95941825A patent/EP0792149B1/en not_active Expired - Lifetime
- 1995-11-20 HU HU9800736A patent/HU226947B1/hu unknown
- 1995-11-20 PL PL95320288A patent/PL181522B1/pl unknown
- 1995-11-21 IL IL11608395A patent/IL116083A/xx not_active IP Right Cessation
- 1995-11-21 BE BE9500956A patent/BE1009458A5/fr active
- 1995-12-13 TW TW084113264A patent/TW413634B/zh not_active IP Right Cessation
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1997
- 1997-05-21 FI FI972168A patent/FI119356B/fi not_active IP Right Cessation
- 1997-05-21 NO NO972324A patent/NO306892B1/no not_active IP Right Cessation
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1998
- 1998-09-04 HK HK98110451A patent/HK1009590A1/xx not_active IP Right Cessation
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2000
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006006595A1 (ja) * | 2004-07-12 | 2006-01-19 | Teikokumedix Co., Ltd. | 経口医薬組成物 |
JP2006028028A (ja) * | 2004-07-12 | 2006-02-02 | Teikoku Medix Kk | 経口医薬組成物 |
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