JPH10502702A - 分析および/またはリファレンシング用の発電化学発光標識 - Google Patents
分析および/またはリファレンシング用の発電化学発光標識Info
- Publication number
- JPH10502702A JPH10502702A JP8524293A JP52429396A JPH10502702A JP H10502702 A JPH10502702 A JP H10502702A JP 8524293 A JP8524293 A JP 8524293A JP 52429396 A JP52429396 A JP 52429396A JP H10502702 A JPH10502702 A JP H10502702A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Dental Preparations (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 発電化学発光組成物において、所望によりNおよびSから選択される少 なくとも1個のヘテロ原子で置換された環炭素およびRu(bpy)3 2+の発光 波長から区別される発光波長を有する置換多環化合物、および電気化学エネルギ ーの存在下では発電化学発光を生じる共反応物を含んでなる組成物。 2. 共反応物が存在し、トリ−n−プロピルアミン(TPrA)またはペル オキシジスルフェート(S2O8 2-)を含む、請求の範囲1に記載の組成物。 3. 前記多環化合物が芳香族性の発光化合物である、請求の範囲1に記載の 組成物。 4. 前記芳香族化合物が、少なくとも1個のヘテロ原子で置換した環炭素を 有する、請求の範囲3に記載の組成物。 5. 前記ヘテロ原子がNおよびSから選択される、請求の範囲3に記載の組 成物。 6. 前記芳香族化合物が、9,10−ジフェニルアントラセン−2−スルホ ン酸ナトリウム(DPAS)、1−および2−チアントレンカルボン酸(1−T HCOOHおよび2−THCOOH)、およびクロルプロマジンからなる群から 選択される、請求の範囲3に記載の組成物。 7. a)所望により少なくとも1個のNまたはSヘテロ原子で置換された環 炭素を有する置換多環芳香族標識を有するバイオ分子を提供し、 b)共反応物を提供し、 c)標識したバイオ分子および共反応物を電気化学エネルギーに暴露し、生成 するルミネッセンスを測定する ことを含んでなる、分析物の検出法。 8. 前記標識がRu(bpy)3 2+の発光波長から区別される発光波長を有 する、請求の範囲7に記載の方法。 9. 複数の分析物を検出する方法において、 a)Ru(bpy)3 2+の発光波長から区別される発光波長を有する発光標識を 有する少なくとも1個の第一のバイオ分子の分析物を提供し、 b)ルテニウムまたはオスミウムを含む標識を有する第二のバイオ分子分析物 を提供し、 c)少なくとも1個の共反応物を加え、 d)標識したバイオ分子分析物および共反応物を電気化学エネルギーに暴露し 、生成するルミネッセンスを測定して、含まれている各種のバイオ分子分析物を 検出する ことを含んでなる、方法。 10. Ru(bpy)3 2+・の発光波長から区別される発光波長を有する前記 標識が、所望により少なくとも1個のNまたはSヘテロ原子で置換された環炭素 を有する置換多環芳香族標識である、請求の範囲9に記載の方法。 11. Ru(bpy)3 2+・の発光波長から区別される発光波長を有する前記 標識が、9,10−ジフェニルアントラセン−2−スルホン酸ナトリウム(DP AS)、1−および2−チアントレンカルボン酸(1−THCOOHおよび2− THCOOH)、クロルプロマジンから選択される、請求の範囲9に記載の方法 。 12. 前記の発電化学発光が、前記標識および前記共反応物または同等な環 置換体の反応から生じる、請求の範囲7に記載の方法。 13. トリプロピルアミン共反応物が存在する、請求の範囲7に記載の方法 。 14. 前記バイオ分子が、抗体、抗原、またはDNAプローブである、請求 の範囲7に記載の方法。 15. 前記の発電化学発光が、前記標識および前記共反応物の反応から生じ る、請求の範囲9に記載の方法。 16. トリプロピルアミン共反応物が存在する、請求の範囲9に記載の方法 。 17. 前記バイオ分子が、抗体、抗原、またはDNAプローブである、請求 の範囲9に記載の方法。 18. 前記標識がクロルプロマジンである、請求の範囲7または9に記載の 方法。 19. 前記の共反応物が前記多環化合物上で置換した残基である、請求の範 囲1に記載の組成物。 20. 前記共反応物が前記多環化合物上で置換した残基である、請求の範囲 7または9に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/385,864 | 1995-02-09 | ||
US08/385,864 US5786141A (en) | 1994-08-26 | 1995-02-09 | Electrogenerated chemiluminescence labels for analysis and/or referencing |
PCT/US1996/001113 WO1996024690A1 (en) | 1995-02-09 | 1996-02-09 | Electrogenerated chemiluminescence labels for analysis and/or referencing |
Publications (2)
Publication Number | Publication Date |
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JPH10502702A true JPH10502702A (ja) | 1998-03-10 |
JP3989019B2 JP3989019B2 (ja) | 2007-10-10 |
Family
ID=23523173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP52429396A Expired - Lifetime JP3989019B2 (ja) | 1995-02-09 | 1996-02-09 | 分析および/またはリファレンシング用の発電化学発光標識 |
Country Status (11)
Country | Link |
---|---|
US (2) | US5786141A (ja) |
EP (1) | EP0755458B1 (ja) |
JP (1) | JP3989019B2 (ja) |
AT (1) | ATE274601T1 (ja) |
AU (1) | AU709592B2 (ja) |
CA (1) | CA2186503C (ja) |
DE (1) | DE69633212T2 (ja) |
DK (1) | DK0755458T3 (ja) |
ES (1) | ES2227580T3 (ja) |
PT (1) | PT755458E (ja) |
WO (1) | WO1996024690A1 (ja) |
Cited By (1)
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US5221605A (en) * | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
US5310687A (en) * | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
JPH01305069A (ja) * | 1988-05-31 | 1989-12-08 | Shionogi & Co Ltd | ベンゾトリアゾール誘導体およびそれを含有する発螢光試薬 |
US5324457A (en) * | 1989-10-02 | 1994-06-28 | Board Of Regents, The University Of Tx System | Devices and methods for generating electrogenerated chemiluminescence |
US5340714A (en) * | 1992-05-08 | 1994-08-23 | Monitor Diagnostics, Inc. | Use of nonmetallic tetrapyrrole molecules and novel signal solutions in chemiluminescent reactions and assays |
CA2198489A1 (en) * | 1994-08-26 | 1996-03-07 | Igen International, Inc. | Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface |
-
1995
- 1995-02-09 US US08/385,864 patent/US5786141A/en not_active Expired - Lifetime
-
1996
- 1996-02-09 AT AT96903716T patent/ATE274601T1/de active
- 1996-02-09 DE DE69633212T patent/DE69633212T2/de not_active Expired - Lifetime
- 1996-02-09 ES ES96903716T patent/ES2227580T3/es not_active Expired - Lifetime
- 1996-02-09 WO PCT/US1996/001113 patent/WO1996024690A1/en active IP Right Grant
- 1996-02-09 EP EP96903716A patent/EP0755458B1/en not_active Expired - Lifetime
- 1996-02-09 JP JP52429396A patent/JP3989019B2/ja not_active Expired - Lifetime
- 1996-02-09 PT PT96903716T patent/PT755458E/pt unknown
- 1996-02-09 AU AU47708/96A patent/AU709592B2/en not_active Expired
- 1996-02-09 DK DK96903716T patent/DK0755458T3/da active
- 1996-02-09 CA CA002186503A patent/CA2186503C/en not_active Expired - Lifetime
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1998
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015522801A (ja) * | 2012-05-15 | 2015-08-06 | ウェルスタット ダイアグノスティクス,エルエルシー | 臨床診断システム |
Also Published As
Publication number | Publication date |
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EP0755458A4 (en) | 2000-07-26 |
US6479233B1 (en) | 2002-11-12 |
US5786141A (en) | 1998-07-28 |
DE69633212D1 (de) | 2004-09-30 |
EP0755458B1 (en) | 2004-08-25 |
CA2186503A1 (en) | 1996-08-15 |
EP0755458A1 (en) | 1997-01-29 |
PT755458E (pt) | 2005-01-31 |
AU4770896A (en) | 1996-08-27 |
JP3989019B2 (ja) | 2007-10-10 |
ES2227580T3 (es) | 2005-04-01 |
WO1996024690A1 (en) | 1996-08-15 |
DK0755458T3 (da) | 2004-11-29 |
AU709592B2 (en) | 1999-09-02 |
ATE274601T1 (de) | 2004-09-15 |
CA2186503C (en) | 2007-01-23 |
DE69633212T2 (de) | 2005-09-22 |
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