JPH09508706A - 液相分析のための新規支持メディアにおける小型化平坦カラム - Google Patents
液相分析のための新規支持メディアにおける小型化平坦カラムInfo
- Publication number
- JPH09508706A JPH09508706A JP8514016A JP51401696A JPH09508706A JP H09508706 A JPH09508706 A JP H09508706A JP 8514016 A JP8514016 A JP 8514016A JP 51401696 A JP51401696 A JP 51401696A JP H09508706 A JPH09508706 A JP H09508706A
- Authority
- JP
- Japan
- Prior art keywords
- support
- miniaturized column
- laser
- miniaturized
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44708—Cooling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
- B01L3/5055—Hinged, e.g. opposable surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
- B29C66/549—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles said hollow-preforms being interconnected during their moulding process, e.g. by a hinge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/756—Microarticles, nanoarticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
- G01N2030/3007—Control of physical parameters of the fluid carrier of temperature same temperature for whole column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
- G01N2030/3015—Control of physical parameters of the fluid carrier of temperature temperature gradients along column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
- G01N2030/303—Control of physical parameters of the fluid carrier of temperature using peltier elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6047—Construction of the column with supporting means; Holders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
- G01N30/606—Construction of the column body with fluid access or exit ports
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
- Y10T156/1062—Prior to assembly
- Y10T156/1064—Partial cutting [e.g., grooving or incising]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Electrochemistry (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Hematology (AREA)
- Optical Measuring Cells (AREA)
- Micromachines (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.第1及び第2の実質的に平坦な対向表面を有する基板であって、前記基板が シリコン又は二酸化ケイ素以外の材料から成り、かつ第1の平坦表面にレーザ切 削されたマイクロチャネルを有する基板と; 第1の平坦表面の上方に配置され、細長い分離区画を定めるマイクロチャネル との組み合わされるカバー板と; 分離区画を通して外部ソースからの流体の通過を可能にする、分離区画と連絡 する少なくとも1つの入口ポート及び少なくとも1つの出口ポートと; を含んで成る小型化カラムデバイス。 2.さらに、該基板にレーザ切削した第1の検出手段を包含し、かつ前記第1の 検出手段が分離区画と連絡して該分離区画を通過する試料の検出を可能にする請 求項1記載の小型化カラム。 3.該基板が高分子材料、セラミック材料、及びその組合せから成る群から選択 される請求項2記載の小型化カラム。 4.さらに、カバー板にレーザ切削された第2の検出手段を包含し、前記第2の 検出手段は分離区画と連絡しておりかつ第1の検出手段と対向して配置される請 求項3記載の小型化カラム。 5.第1及び第2の検出手段が基板の平坦表面に直交する軸を有するアパチャー を包含し、前記アパチャーは組合されて検出経路を形成する請求項4記載の小型 化カラム。 6.さらに、第1及び第2の透明シートを包含し、かつ基板が前記第1の透明シ ートと第1の平坦表面との間に挿入され、前記第2の透明シートが第2の平坦表 面上方に置かれており、前記の両透明シートが第1及び第2の検出手段との組合 せで光学的検出経路を形成することを特徴とする請求項5記載の小型化カラム。 7.基板の第1の平坦表面にレーザ切削され、かつ分離区画と検出経路とに連絡 するさらに別の検出手段を包含する請求項5記載の小型化カラム。 8.さらに、それぞれ、第1及び第2の検出手段にインタフェースされ、かつ分 離区画に連絡している第1及び第2の導光手段を包含する請求項5記載の小型化 カラム。 9.別の検出手段が、基板の第1の平坦表面にレーザ切削された溝を包含するこ とを特徴とする請求項7記載の小型化カラム。 10.さらに、別の検出手段内部に配置され、かつ分離区画と検出経路とに連絡 する第3の導光手段を包含する請求項9記載の小型化カラム。 11.検出手段がさらに基板の第1の平坦表面にレーザ切削された第1及び第2 の溝を包含し、前記第1及び第2の溝は分離区画に関して互いに対向して配置さ れて第2の検出経路を形成することを特徴とする請求項7記載の小型化カラム。 12.さらに、それぞれ、第1及び第2の検出手段にインタフェースされ、かつ 分離区画に連絡している第1及び第2の導光手段と、それぞれ、第1及び第2の 溝内部に配置されて、分離区画及び検出経路に連絡している第3及び第4の導光 手段とを包含する請求項11記載の小型化カラム。 13.さらに、第1及び第2の平坦表面にそれぞれレーザ切削された第1及び第 2のマイクロチャネルと; 第1及び第2の平坦表面上方にそれぞれ配置され、第1及び第2の細長い分離 区画を定める、第1及び第2のマイクロチャネルと組み合わされる第1及び第2 のカバー板と; 第1の分離区画と連絡する少なくとも1つの入口ポート、及び第2の分離区画 と連絡する少なくとも1つの出口ポートと; 第1及び第2の分離区画を互いに連絡させて単一の連続的分離区画を形成する コンジット手段であって、前記コンジット手段は平坦表面に直交する軸を有する 基板にレーザ切削されたアパチャーを含むことを特徴とするコンジット手段と; を含んで成る請求項3記載の小型化カラム。 14.さらに、第1及び第2のカバー板にそれぞれレーザ切削され、かつコンジ ット手段と同軸的に連絡して配置されたアパチャーを含む第1及び第2の検出手 段を包含する請求項13記載の小型化カラム。 15.さらに、第1及び第2の透明シートを包含し、かつ第1のカバー板が前記 第1の透明シートと第1の平坦表面との間に挿入され、前記第2のカバー板が前 記第2の透明シートと第2の平坦表面との間に挿入されることを特徴とする請求 項14記載の小型化カラム。 16.コンジット手段が、透明シートとの組合せで、基板の幅に実質的に等しい 経路長を有する光学的検出経路を形成する請求項15記載の小型化カラム。 17.さらに、それぞれ、第1及び第2の検出手段にインタフェースされかつコ ンジット手段に連絡している第1及び第2の導光手段を包含する請求項14記載 の小型化カラム。 18.基板の第1の平坦表面にレーザ切削された溝によって形成され、かつコン ジット手段と連絡しているさらに別の検出手段を包含する請求項14、16又は 17の何れかに記載の小型化カラム。 19.さらに、別の検出手段内に配置されかつコンジット手段と連絡している導 光手段を包含する請求項14記載の小型化カラム。 20.小型化カラムデバイスにおいて、 シリコン又は二酸化ケイ素以外の材料から構成された基板から形成される支持体 であって、実質的に平坦な内表面をそれぞれ有する第1及び第2の構成要素半分 を有する支持体と; 第1の支持体の半分の内表面にレーザ切削された第1のマイクロチャネルと、 第2の支持体の半分の内表面にレーザ切削された第2のマイクロチャネルとであ って、前記の各支持体が相手の鏡像を与えるよう配置された各マイクロチャネル と; 両支持体半分の両内表面を互いに突合せ対向させてアライニングすることによ り形成され、マイクロチャネル群によって定められる細長い穴から成る分離区画 と; 分離区画を通して外部ソースからの流体の通過を可能にする、分離区画と連絡 する少なくとも1つの入口ポート及び少なくとも1つの出口ポートと; を含んで成る小型化デバイス。 21.さらに、支持体にレーザ切削されかつ分離区画と連絡していて、それによ り分離区画を通過する試料の検出を可能にする検出手段を包含する請求項20記 載の小型化カラム。 22.基板が高分子材料、セラミック材料、及びその組合せから成る群から選択 される請求項21記載の小型化カラム。 23.支持体がさらに、該支持体に折曲げ部を作るための折曲げ手段を包含し、 それによって基板が折り曲げられて第1及び第2の構成要素半分を互いに正確に 軸一致状態にすることができる請求項22記載の小型化カラム。 24.第1及び第2の支持体半分がさらに、該支持体半分にレーザ切削された複 数の穴から成るマイクロアライメント手段を包含し、かつ該穴群は、第1及び第 2の支持体半分における対応する穴の同軸アライメントによって該支持体半分の 正確なアライメントができるよう配置されて正確に細長い孔を定めることを特徴 とする請求項23記載の小型化カラム。 25.第1及び第2の支持体半分がさらに、該支持体半分に作られた対応する構 造体から成るマイクロアライメント手段を包含し、前記構造体が第1の支持体半 分の上に配置された複数の凹部と第2の支持体半分に配置された複数の突起から 成り、対応する構造体のアライメントによって両支持体半分の正確なアライメン トが可能となって正確に細長い孔を定めることができるよう前記突起が凹部とか み合うよう形造られることを特徴とする請求項23記載の小型化カラム。 26.さらに、第1及び第2の構成要素半分を通してそれぞれレーザ切削されて いて、分離区画と連絡しかつ支持体の面に直交する軸を有する第1及び第2のア パチャーを包含し、かつ該アパチャーは、両支持体半分の内表面が互いに突合せ 対向状態でアライメントされるときに同軸検出経路を形成するよう配置される請 求項22記載の小型化カラム。 27.さらに、支持体外面の上部に配置されかつ第1及び第2のアパチャーを覆 っている第1及び第2の透明シートを包含し、これにより、分光光度の諸検出手 段を前記透明シートを介して試料にインタフェースさせることによって分離区画 を通過している試料を分析できることを特徴とする請求項26記載の小型化カラ ム。 28.さらに、それぞれ、第1及び第2のアパチャーにインタフェースされかつ 分離区画に連絡している第1及び第2の導光手段を包含する請求項26記載の小 型化カラム。 29.支持体の内表面にレーザ切削され、かつ分離区画に連絡している別の検出 手段を包含する請求項26、27又は28の何れかに記載の小型化カラム。 30.その別の検出手段が、第1の支持体半分の内表面にレーザ切削された溝を 含む請求項29記載の小型化カラム。 31.さらに、その別の検出手段内部に配置されかつ分離区画に連絡している導 光手段を包含する請求項30記載の小型化カラム。 32.その別の検出手段が、第1及び第2の支持体半分の内表面にレーザ切削さ れた一組の相補的溝を包含し、前記溝は分離区画と連絡しかつ各溝が相手の鏡像 を与えるよう配置され、これにより、前記溝は、両支持体半分の内表面が互いに 突合せ対向状態でアライメントされるときにさらに別の検出経路を形成すること を特徴とする請求項29記載の小型化カラム。 33.その別の検出手段が、第1及び第2の支持体半分の内表面にレーザ切削さ れた相補的溝の第1及び第2の組を包含し、前記溝は分離区画と連絡しかつ各そ れぞれ相補的な一組の溝が他の溝の鏡像を与えるよう配置され、これにより、前 記溝の組は、両支持体半分の内表面が互いに突合せ対向状態でアライメントされ るときにさらに別の検出経路を形成することを特徴とする請求項29記載の小型 化カラム。 34.相補的溝の第1及び第2の組が、さらに互いに対向して配置されて連続的 検出経路を形成する請求項33記載の小型化カラム。 35.それぞれ、第1及び第2のアパチャーにインタフェースされかつ分離区画 に連絡している第1及び第2の導光手段と、別の検出手段内に配置されかつ分離 区画に連絡している第3の導光手段をさらに包含する請求項32記載の小型化カ ラム。 36.それぞれ、第1及び第2のアパチャーにインタフェースされかつ分離区画 に連絡している第1及び第2の導光手段と、別の検出手段内に配置されかつ分離 区画に連絡している第3及び第4の導光手段をさらに包含する請求項34記載の 小型化カラム。 37.レーザ切削されたマイクロチャネルは、分離区画が形成される以前に表面 処理にかけられ、かつ該表面処理が、レーザ切削されたマイクロチャネルの内表 面に対する選択種の化学結合もしくは吸着、又はその上への選択された材料の薄 膜堆積から成ることを特徴とする請求項1記載の小型化カラム。 38.レーザ切削されたマイクロチャネル群は、分離区画群が形成される以前に 表面処理にかけられ、かつ該表面処理が、レーザ切削されたマイクロチャネル群 の内表面に対する選択種の化学結合もしくは吸着又はその上への選択された材料 の薄膜堆積から成ることを特徴とする請求項13記載の小型化カラム。 39.レーザ切削されたマイクロチャネル群は、分離区画が形成される以前に表 面処理にかけられ、かつ該表面処理が、レーザ切削されたマイクロチャネル群の 内表面に対する選択種の化学結合もしくは吸着又はその上への選択された材料の 薄膜堆積から成ることを特徴とする請求項20記載の小型化カラム。 40.第1及び第2の実質的に平坦な対向表面を有し、第1の平坦表面にレーザ 切削されたマイクロチャネルを有する支持体と; 第1の平坦表面の上方に配置され、細長い分離区画を定めるマイクロチャネル との組み合わされるカバー板と; 分離区画を通して外部源からの流体の通過を可能にする、分離区画と連絡する 少なくとも1つの入口ポート及び少なくとも1つの出口ポートと; 分離区画に隣接して配置され、分離区画を通過する試料の電気特性の変化の検 出を可能にする複数の連絡経路と; を含んで成る小型化カラムデバイス。 41.第1及び第2の連絡経路を含んで成り、かつ第1の連絡経路が分離区画の 第1の側面に隣接して配置され、第2の連絡経路が分離区画の第2の側面に隣接 して配置されかつ第1の連絡経路に対向して位置決めされることを特徴とする請 求項40記載の小型化カラムデバイス。 42.複数の連絡経路が、分離区画の第1の側面に沿う長手方向に互いに間隔を 置いた関係で配置された少なくとも第1及び第2の連絡経路から成る請求項40 記載の小型化カラムデバイス。 43.複数の連絡経路が、分離区画の周りに同軸関係で配置された第1のコイル と、分離区画の周りに同軸関係でかつ第1のコイルと間隔を置いた関係で配置さ れた第2のコイルとを包含する請求項40記載の小型化カラムデバイス。 44.第1の連絡経路が分離区画の第1の側面に隣接して配置され、第2の連絡 経路が分離区画の第2の側面に隣接して配置されかつ第1の連絡経路に対向して 位置決めされる、第1及び第2の連絡経路をさらに包含する請求項5、14又は 26の何れかに記載の小型化カラム。 45.分離区画の第1の側面に沿う長手方向に互いに間隔を置いた関係で配置さ れた第1及び第2の連絡経路をさらに包含する請求項5、14又は26の何れか に記載の小型化カラム。 46.分離区画の周りに同軸関係で配置された第1のコイルと、分離区画の周り に同軸関係でかつ第1のコイルと間隔を置いた関係で配置された第2のコイルと をさらに包含する請求項5、14又は26の何れかに記載の小型化カラムデバイ ス。 47.第1及び第2の連絡経路が光学的検出経路に隣接して配置される請求項4 4記載の小型化カラム。 48.第1及び第2の連絡経路がコンジット手段に隣接して配置される請求項4 5記載の小型化カラム。 49.第1及び第2のコイルが第1の検出手段に隣接して配置される請求項46 記載の小型化カラム。 50.(a)第1及び第2の構成要素半分を有しかつ実質的に平坦な内表面を有 する支持体を設け; (b)(i)第1の支持体半分の内表面に第1のマイクロチャネルをレーザ切削 し;(ii)第2の支持体半分の内表面に第2のマイクロチャネルをレーザ切削 し、かつ第2のマイクロチャネルを第1のマイクロチャネルの鏡像を与えるよう 配置して、その後で互いに突合せ対向する状態で支持体の両半分の内表面をアラ イメントすることにより細長い孔が定められるようにして、支持体に区画を形成 し; (c)支持体の少なくとも1つの外表面から伸びて少なくとも1つのマイクロチ ャネルと連絡し、これにより、その中を通る液体の通過を可能にする複数のアパ チャーをレーザ切削することにより、該区画と外部の関連した流体収容装置との 間で流体の連絡を可能にする複数のポートを支持体に作り込み; (d)第1及び第2の構成要素半分を通した別のアパチャー群をレーザ切削する ことにより支持体に検出手段を形成して、アパチャー群が該区画と連絡するよう にし; (e)互いに突合せ対向状態で支持体の両半分をアライニングして、小型化カラ ムデバイスを与えるようマイクロチャネル群、ポート群及び検出手段をアライニ ングする; 各ステップを含んで成る小型化カラムデバイスを形成する方法。 51.ヒンジを定めるため支持体に一列の間隔を置いたミシン目をレーザ切削し て、これにより、支持体を前記ヒンジの回りで折り曲げ互いの軸を正確に一致さ せて第1及び第2の構成要素半分を設定できるように、支持体に折曲げ手段を設 けるステップをさらに包含する請求項50記載の方法。 52.支持体に穴群をレーザ切削することにより、前記穴群は同軸アライメント によって支持体半分の正確なアライメントが可能となって細長い孔を正確に定め ることができるよう配置されることで第1及び第2の支持体にマイクロアライメ ント手段を形成するステップをさらに包含する請求項51記載の方法。 53.支持体半分に対応する構造体を形成して、該構造体が第1の支持体半分の 上に配置された複数の凹部と第2の支持体半分に配置された複数の突起から成り 、対応する構造体のアライメントによって両支持体半分の正確なアライメントが 可能となって正確に細長い孔を定めることができるよう、前記突起が凹部とかみ 合うように支持体半分にマイクロアライメント手段を設けるステップをさらに包 含する請求項51記載の方法。 54.マイクロチャネル群が支持体半分の表面にレーザ切削された後及び分離区 画が形成される以前に、第1及び第2のマイクロチャネル群を、レーザ切削した マイクロチャネル群の内表面に対する選択した種の化学結合もしくは吸着又はそ の上への選択された材料の薄膜堆積から成る表面処理にかけるステップをさらに 包含する請求項50記載の方法。 55.熱接着性ポリイミドの第2の薄層と共押出しされたポリイミドの第1の層 から作られたラミネートから成る支持体を設け; 熱積層を用いて第1及び第2の支持体半分を熱シールして、実質的に支持体と同 一の物理的、化学的特性を有する接合が形成されるようにする; ステップをさらに包含する請求項50記載の方法。 56.(a)実質的に平坦な内表面を有する親支持体を用意し; (b)(i)マスター支持体の内表面にマイクロチャネルを形成し;そして(i i)マスター支持体にマイクロチャネルと流体連絡する複数のアパチャーを形成 することにより、小型化カラムデバイスのマスターコピーを形成し; (c)(i)マスターコピーの内表面を第1の金属の層でコーティングし;(i i)第2の金属の層をその上に堆積して内表面に形成されたマイクロチャネルと アパチャー群に充填し;そして(iii)型挿入物が提供されるようマスター支 持体から型挿入物を分離することにより、型挿入物を作り; (d)適当な高分子又はセラミック基板で型挿入物からマスターコピーの多重複 製を射出成形する; 各ステップを含んで成る小型化カラムデバイスの多重複製を作る方法。 57.小型化カラムデバイスのマスターコピーがレーザ切削法を使って作られる 請求項56記載の方法。 58.小型化カラムデバイスのマスターコピーがLIGAプロセスを使って作ら れる請求項56記載の方法。 59.(a)実質的に平坦な内表面をもった第1及び第2の半分部分を有するマ スター支持体を用意し; (b)(i)マスター支持体の第1の半分の内表面に第1のマイクロチャネルを 形成し;(ii)マスター支持体の第2の半分の内表面に第2のマイクロチャネ ルを形成し、ここで第2のマイクロチャネルが第1のマイクロチャネルの鏡像を 与えるよう配置し;そして(iii)マイクロチャネルと流体連絡する複数のア パチャーを形成することにより、小型化カラムデバイスのマスターコピーを形成 し; (c)(i)マスターコピーの内表面を第1の金属の層でコーティングし;(i i)第2の金属の層をその上に堆積して内表面に形成されたマイクロチャネルと アパチャー群に充填し;そして(iii)型挿入物が提供されるようマスター支 持体から型挿入物を分離することによって、型挿入物を作り; (d)適当な高分子又はセラミック基板で型挿入物からマスターコピーの多重複 製を射出成形する; 各ステップを含んで成る小型化カラムデバイスの多重複製を作る方法。 60.小型化カラムデバイスのマスターコピーがレーザ切削法を使って作られる 請求項59記載の方法。 61.小型化カラムデバイスのマスターコピーがLIGAプロセスを使って作ら れる請求項59記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/326,111 US5500071A (en) | 1994-10-19 | 1994-10-19 | Miniaturized planar columns in novel support media for liquid phase analysis |
US08/482,245 | 1995-06-07 | ||
US08/482,245 US5658413A (en) | 1994-10-19 | 1995-06-07 | Miniaturized planar columns in novel support media for liquid phase analysis |
US08/326,111 | 1995-06-07 | ||
PCT/US1995/013258 WO1996012545A1 (en) | 1994-10-19 | 1995-10-19 | Miniaturized planar columns in novel support media for liquid phase analysis |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09508706A true JPH09508706A (ja) | 1997-09-02 |
JP3631758B2 JP3631758B2 (ja) | 2005-03-23 |
Family
ID=26985246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51401696A Expired - Fee Related JP3631758B2 (ja) | 1994-10-19 | 1995-10-19 | 液相分析のための新規支持メディアにおける小型化平坦カラム |
Country Status (5)
Country | Link |
---|---|
US (6) | US5658413A (ja) |
EP (2) | EP0734282B1 (ja) |
JP (1) | JP3631758B2 (ja) |
DE (2) | DE69535176T2 (ja) |
WO (2) | WO1996012546A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08240576A (ja) * | 1995-01-23 | 1996-09-17 | Hewlett Packard Co <Hp> | プレーナ・マニホルド組立体及び分析機器 |
JP2000289166A (ja) * | 1999-04-09 | 2000-10-17 | E I Du Pont De Nemours & Co | 封入された構造を含む一体式ポリイミド積層体および該積層体の製造方法 |
JP2005517959A (ja) * | 2002-02-21 | 2005-06-16 | コミツサリア タ レネルジー アトミーク | 生物又は生化学分析マイクロシステム用のコンポーネント |
JP2010517208A (ja) * | 2006-10-31 | 2010-05-20 | コーニング インコーポレイテッド | マイクロ加工された電解質シート、これを利用する燃料電池デバイス、および燃料電池デバイスを作製するマイクロ加工方法 |
JP2011045981A (ja) * | 2009-08-28 | 2011-03-10 | Ritsumeikan | Mems、及びその製造方法 |
WO2016063950A1 (ja) * | 2014-10-24 | 2016-04-28 | 京都府公立大学法人 | 検体用ホルダ |
Families Citing this family (228)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770029A (en) * | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
US5935401A (en) * | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
US6613560B1 (en) * | 1994-10-19 | 2003-09-02 | Agilent Technologies, Inc. | PCR microreactor for amplifying DNA using microquantities of sample fluid |
US5658413A (en) * | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US5800784A (en) * | 1996-07-09 | 1998-09-01 | Horn; Marcus J. | Chemical sample treatment system and cassette, and methods for effecting multistep treatment process |
US6074827A (en) * | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
US5997708A (en) * | 1997-04-30 | 1999-12-07 | Hewlett-Packard Company | Multilayer integrated assembly having specialized intermediary substrate |
US6375871B1 (en) | 1998-06-18 | 2002-04-23 | 3M Innovative Properties Company | Methods of manufacturing microfluidic articles |
US6431695B1 (en) | 1998-06-18 | 2002-08-13 | 3M Innovative Properties Company | Microstructure liquid dispenser |
US6290685B1 (en) | 1998-06-18 | 2001-09-18 | 3M Innovative Properties Company | Microchanneled active fluid transport devices |
US6068684A (en) * | 1997-09-11 | 2000-05-30 | Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College | Microstructure chromatograph with rectangular column |
CA2306126A1 (en) | 1997-10-15 | 1999-04-22 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
DE19746581A1 (de) * | 1997-10-22 | 1999-04-29 | Merck Patent Gmbh | Mikromischer |
JP2001523001A (ja) * | 1997-11-12 | 2001-11-20 | ピーイー コーポレイション (エヌワイ) | 自己修正ベンドをもつ蛇行電気泳動チャネル |
US6224830B1 (en) | 1998-01-30 | 2001-05-01 | The Governors Of The University Of Alberta | Absorbance cell for microfluid devices |
WO1999060397A1 (en) * | 1998-05-18 | 1999-11-25 | University Of Washington | Liquid analysis cartridge |
US6830729B1 (en) | 1998-05-18 | 2004-12-14 | University Of Washington | Sample analysis instrument |
US6706161B1 (en) | 1998-06-10 | 2004-03-16 | Agilent Technologies, Inc. | Methods and compositions for modifying the surface of a polymeric substrate |
US6459080B1 (en) * | 1998-06-12 | 2002-10-01 | Agilent Technologies, Inc. | Miniaturized device for separating the constituents of a sample and delivering the constituents of the separated sample to a mass spectrometer |
US6194900B1 (en) * | 1998-06-19 | 2001-02-27 | Agilent Technologies, Inc. | Integrated miniaturized device for processing and NMR detection of liquid phase samples |
US7799521B2 (en) * | 1998-06-24 | 2010-09-21 | Chen & Chen, Llc | Thermal cycling |
US6780617B2 (en) * | 2000-12-29 | 2004-08-24 | Chen & Chen, Llc | Sample processing device and method |
US6375901B1 (en) | 1998-06-29 | 2002-04-23 | Agilent Technologies, Inc. | Chemico-mechanical microvalve and devices comprising the same |
DE59914676D1 (de) * | 1998-08-20 | 2008-04-17 | Siemens Ag | Trennsäulen-einheit für einen gaschromatograph und verfahren zu ihrer herstellung |
US6919162B1 (en) * | 1998-08-28 | 2005-07-19 | Agilent Technologies, Inc. | Method for producing high-structure area texturing of a substrate, substrates prepared thereby and masks for use therein |
US6759013B2 (en) | 1998-09-17 | 2004-07-06 | Agilent Technologies, Inc. | Modular apparatus for chemical microanalysis |
CN1312473C (zh) | 1998-09-17 | 2007-04-25 | 阿德文生物科学公司 | 液相色谱系统 |
US6158712A (en) * | 1998-10-16 | 2000-12-12 | Agilent Technologies, Inc. | Multilayer integrated assembly having an integral microminiature valve |
US6240790B1 (en) | 1998-11-09 | 2001-06-05 | Agilent Technologies, Inc. | Device for high throughout sample processing, analysis and collection, and methods of use thereof |
US6320295B1 (en) * | 1998-11-18 | 2001-11-20 | Mcgill Robert Andrew | Diamond or diamond like carbon coated chemical sensors and a method of making same |
US20020006359A1 (en) * | 1998-11-25 | 2002-01-17 | Affymetrix, Inc. | Microplate sample and reagent loading system |
US6913679B1 (en) * | 1999-02-11 | 2005-07-05 | The Regents Of The University Of California | Apparatus and methods for high resolution separation of sample components on microfabricated channel devices |
US6633031B1 (en) * | 1999-03-02 | 2003-10-14 | Advion Biosciences, Inc. | Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method |
US6749814B1 (en) | 1999-03-03 | 2004-06-15 | Symyx Technologies, Inc. | Chemical processing microsystems comprising parallel flow microreactors and methods for using same |
US6367847B1 (en) * | 1999-03-05 | 2002-04-09 | Waters Investments Limited | Coupler for placing two or more fluid streams in communication |
US6703120B1 (en) | 1999-05-05 | 2004-03-09 | 3M Innovative Properties Company | Silicone adhesives, articles, and methods |
DE19919608A1 (de) * | 1999-05-27 | 2000-11-30 | Roche Diagnostics Gmbh | Probenträger für die IR-Spetktroskopie von Probenflüssigkeiten |
DE19927533B4 (de) * | 1999-06-16 | 2004-03-04 | Merck Patent Gmbh | Miniaturisiertes Analysensystem |
US6369384B1 (en) | 1999-06-23 | 2002-04-09 | Agilent Technologies, Inc. | Time-of-flight mass spectrometer with post-deflector filter assembly |
US7223364B1 (en) | 1999-07-07 | 2007-05-29 | 3M Innovative Properties Company | Detection article having fluid control film |
US6489774B1 (en) | 1999-07-08 | 2002-12-03 | Agilent Technologies, Inc. | Miniaturized device for ion analysis, and methods of use thereof |
US6959618B1 (en) | 1999-08-06 | 2005-11-01 | Chempaq A/S | Particle characterization apparatus |
US6495104B1 (en) * | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems |
US6258263B1 (en) * | 1999-09-17 | 2001-07-10 | The University Of Cincinnati | Liquid chromatograph on a chip |
DE19947495C2 (de) * | 1999-10-01 | 2003-05-28 | Agilent Technologies Inc | Mikrofluidischer Mikrochip |
US7157284B2 (en) * | 1999-10-29 | 2007-01-02 | The United States Of America As Represented By The Environmental Protection Agency | Vacuum distillation automatic sampler |
EP1269518B1 (en) | 1999-12-30 | 2011-12-21 | Advion BioSystems, Inc. | Multiple electrospray device, systems and methods |
US6596988B2 (en) * | 2000-01-18 | 2003-07-22 | Advion Biosciences, Inc. | Separation media, multiple electrospray nozzle system and method |
US7485454B1 (en) * | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
US6561208B1 (en) | 2000-04-14 | 2003-05-13 | Nanostream, Inc. | Fluidic impedances in microfluidic system |
US6632400B1 (en) | 2000-06-22 | 2003-10-14 | Agilent Technologies, Inc. | Integrated microfluidic and electronic components |
IL137625A0 (en) * | 2000-08-01 | 2001-10-31 | Sensis Ltd | Detector for an electrophoresis apparatus |
US20020037130A1 (en) * | 2000-08-02 | 2002-03-28 | Sarnoff Corporation | Microfluidic optical switch |
AU2001281076A1 (en) * | 2000-08-07 | 2002-02-18 | Nanostream, Inc. | Fluidic mixer in microfluidic system |
US6890093B2 (en) | 2000-08-07 | 2005-05-10 | Nanostream, Inc. | Multi-stream microfludic mixers |
AU2001286511A1 (en) * | 2000-08-15 | 2002-02-25 | Nanostream, Inc. | Optical devices with fluidic systems |
US7097809B2 (en) * | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
US6508988B1 (en) * | 2000-10-03 | 2003-01-21 | California Institute Of Technology | Combinatorial synthesis system |
DE60126975T2 (de) * | 2000-11-06 | 2007-11-15 | The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services | Probenzuführsystem mit laminarmischung zur biodetektion von mikrovolumen |
US20020079220A1 (en) * | 2000-11-09 | 2002-06-27 | Pawliszyn Janusz B. | Micromachining using printing technology |
US6783992B2 (en) | 2001-01-03 | 2004-08-31 | Agilent Technologies, Inc. | Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples |
US6887429B1 (en) * | 2001-01-26 | 2005-05-03 | Global Fia | Apparatus and method for automated medical diagnostic tests |
CA2450676C (en) * | 2001-03-09 | 2010-03-30 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
US6610978B2 (en) | 2001-03-27 | 2003-08-26 | Agilent Technologies, Inc. | Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry |
JP2002292275A (ja) * | 2001-03-29 | 2002-10-08 | Kanagawa Acad Of Sci & Technol | マイクロチップパイルアップ型化学反応システム |
JP4362987B2 (ja) * | 2001-04-09 | 2009-11-11 | 株式会社島津製作所 | マイクロチップ電気泳動におけるサンプル導入方法 |
CA2440785A1 (en) * | 2001-04-10 | 2002-10-24 | Bioprocessors Corporation | Microfermentor device and cell based screening method |
US20030040119A1 (en) * | 2001-04-11 | 2003-02-27 | The Regents Of The University Of Michigan | Separation devices and methods for separating particles |
US6814938B2 (en) * | 2001-05-23 | 2004-11-09 | Nanostream, Inc. | Non-planar microfluidic devices and methods for their manufacture |
DE60118533T2 (de) * | 2001-06-07 | 2006-08-24 | Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto | Analytischer Mikrochip mit Eingabe- und Ausgabeleitungen zwischen Wanne und Behälter |
US20020186263A1 (en) * | 2001-06-07 | 2002-12-12 | Nanostream, Inc. | Microfluidic fraction collectors |
US6919046B2 (en) * | 2001-06-07 | 2005-07-19 | Nanostream, Inc. | Microfluidic analytical devices and methods |
GB2376644A (en) * | 2001-06-18 | 2002-12-24 | Univ Hull | Micro-reactor with separable electrodes on support members |
US7128876B2 (en) * | 2001-07-17 | 2006-10-31 | Agilent Technologies, Inc. | Microdevice and method for component separation in a fluid |
CN1262351C (zh) | 2001-09-11 | 2006-07-05 | 伊库姆有限公司 | 试样容器 |
SE0103110D0 (sv) * | 2001-09-18 | 2001-09-18 | Aamic Ab | Microscale fluid handling system |
US6803568B2 (en) | 2001-09-19 | 2004-10-12 | Predicant Biosciences, Inc. | Multi-channel microfluidic chip for electrospray ionization |
US6966880B2 (en) * | 2001-10-16 | 2005-11-22 | Agilent Technologies, Inc. | Universal diagnostic platform |
US7275562B2 (en) * | 2001-10-17 | 2007-10-02 | Agilent Technologies, Inc. | Extensible spiral for flex circuit |
US6627076B2 (en) * | 2001-10-19 | 2003-09-30 | Sandia National Laboratories | Compact microchannel system |
CA2463420A1 (en) * | 2001-10-24 | 2003-05-01 | Singulex, Inc. | Methods for detecting genetic haplotypes by interaction with probes |
US6939032B2 (en) * | 2001-10-25 | 2005-09-06 | Erie Scientific Company | Cover slip mixing apparatus |
US20040028559A1 (en) * | 2001-11-06 | 2004-02-12 | Peter Schuck | Sample delivery system with laminar mixing for microvolume biosensing |
GB0128350D0 (en) * | 2001-11-27 | 2002-01-16 | Lab901 Ltd | Non-rigid apparatus for microfluidic applications |
JP3852327B2 (ja) * | 2001-11-30 | 2006-11-29 | 株式会社島津製作所 | 電気泳動部材用リザーバ部材及び電気泳動部材 |
US7105810B2 (en) * | 2001-12-21 | 2006-09-12 | Cornell Research Foundation, Inc. | Electrospray emitter for microfluidic channel |
US7452725B2 (en) * | 2002-01-10 | 2008-11-18 | Board Of Regents, The University Of Texas System | Flow sorting system and methods regarding same |
US6877892B2 (en) * | 2002-01-11 | 2005-04-12 | Nanostream, Inc. | Multi-stream microfluidic aperture mixers |
US6538207B1 (en) | 2002-01-18 | 2003-03-25 | Agilent Technologies, Inc. | Strain relief structures for lead connections |
US6666907B1 (en) * | 2002-01-31 | 2003-12-23 | Sandia Corporation | Temperature programmable microfabricated gas chromatography column |
JP3740528B2 (ja) * | 2002-02-05 | 2006-02-01 | 独立行政法人産業技術総合研究所 | 微細粒子製造方法 |
US20030148291A1 (en) * | 2002-02-05 | 2003-08-07 | Karla Robotti | Method of immobilizing biologically active molecules for assay purposes in a microfluidic format |
US7261812B1 (en) | 2002-02-13 | 2007-08-28 | Nanostream, Inc. | Multi-column separation devices and methods |
CN100528363C (zh) * | 2002-02-13 | 2009-08-19 | 安捷伦科技有限公司 | 微流体分离柱装置及其制备方法 |
US20050211555A1 (en) * | 2002-02-14 | 2005-09-29 | Solus Biosystems, Inc. | Method for multiple sample screening using IR spectroscopy |
US7033542B2 (en) * | 2002-02-14 | 2006-04-25 | Archibald William B | High throughput screening with parallel vibrational spectroscopy |
US6958119B2 (en) | 2002-02-26 | 2005-10-25 | Agilent Technologies, Inc. | Mobile phase gradient generation microfluidic device |
GB0208766D0 (en) * | 2002-04-02 | 2002-05-29 | Univ Surrey | Liquid-liquid separation |
US20040017078A1 (en) * | 2002-04-02 | 2004-01-29 | Karp Christoph D. | Connectors for microfluidic devices |
US6621076B1 (en) | 2002-04-30 | 2003-09-16 | Agilent Technologies, Inc. | Flexible assembly for transporting sample fluids into a mass spectrometer |
US20030224531A1 (en) * | 2002-05-29 | 2003-12-04 | Brennen Reid A. | Microplate with an integrated microfluidic system for parallel processing minute volumes of fluids |
US6859050B2 (en) | 2002-05-31 | 2005-02-22 | Agilent Technologies, Inc. | High frequency contactless heating with temperature and/or conductivity monitoring |
WO2003104771A1 (en) * | 2002-06-01 | 2003-12-18 | Chempaq A/S | Lysing reagent, cartridge and automatic electronic cell counter for simultaneous enumeration of different types of white blood cells |
US7867193B2 (en) * | 2004-01-29 | 2011-01-11 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US20050238506A1 (en) * | 2002-06-21 | 2005-10-27 | The Charles Stark Draper Laboratory, Inc. | Electromagnetically-actuated microfluidic flow regulators and related applications |
AU2003281588A1 (en) * | 2002-07-18 | 2004-02-09 | Canon Kabushiki Kaisha | Process for producing mass transfer device and apparatus for production thereof |
US7470533B2 (en) | 2002-12-20 | 2008-12-30 | Acea Biosciences | Impedance based devices and methods for use in assays |
US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
WO2005047482A2 (en) | 2003-11-12 | 2005-05-26 | Xiao Xu | Real time electronic cell sensing systems and applications for cell-based assays |
US7560269B2 (en) | 2002-12-20 | 2009-07-14 | Acea Biosciences, Inc. | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
US7214320B1 (en) | 2002-08-08 | 2007-05-08 | Nanostream, Inc. | Systems and methods for high throughput sample analysis |
US6812458B2 (en) * | 2002-08-08 | 2004-11-02 | Nanostream, Inc. | Systems and methods for high-throughput microfluidic sample analysis |
AU2003304163A1 (en) * | 2002-08-21 | 2005-01-21 | Shell Oil Company | Method for measuring fluid chemistry in drilling and production operations |
JP3824160B2 (ja) * | 2002-08-28 | 2006-09-20 | 株式会社島津製作所 | 高速液体クロマトグラフ用混合装置 |
US6900133B2 (en) * | 2002-09-18 | 2005-05-31 | Applied Materials, Inc | Method of etching variable depth features in a crystalline substrate |
JP3725109B2 (ja) * | 2002-09-19 | 2005-12-07 | 財団法人生産技術研究奨励会 | マイクロ流体デバイス |
US6774337B2 (en) * | 2002-10-21 | 2004-08-10 | Lockheed Martin Corporation | Method for protecting the diaphragm and extending the life of SiC and/or Si MEMS microvalves |
US6976384B2 (en) * | 2002-10-31 | 2005-12-20 | Nanostream, Inc. | Parallel detection chromatography systems |
US6936167B2 (en) * | 2002-10-31 | 2005-08-30 | Nanostream, Inc. | System and method for performing multiple parallel chromatographic separations |
US20050048669A1 (en) * | 2003-08-26 | 2005-03-03 | Nanostream, Inc. | Gasketless microfluidic device interface |
US7010964B2 (en) * | 2002-10-31 | 2006-03-14 | Nanostream, Inc. | Pressurized microfluidic devices with optical detection regions |
JP2006507504A (ja) * | 2002-11-22 | 2006-03-02 | ソルス バイオシステムズ インコーポレーテッド | 並列振動分光法による高スループットのスクリーニング |
CN1217188C (zh) * | 2002-12-05 | 2005-08-31 | 清华大学 | 微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法 |
WO2004052541A1 (en) * | 2002-12-11 | 2004-06-24 | Inverness Medical Switzerland Gmbh | Micro-fluidic structure, method and apparatus for its production, and use thereof |
US6987263B2 (en) * | 2002-12-13 | 2006-01-17 | Nanostream, Inc. | High throughput systems and methods for parallel sample analysis |
US7147695B2 (en) * | 2002-12-13 | 2006-12-12 | New Jersey Institute Of Technology | Microfabricated microconcentrator for sensors and gas chromatography |
US20060076482A1 (en) * | 2002-12-13 | 2006-04-13 | Hobbs Steven E | High throughput systems and methods for parallel sample analysis |
US6706091B1 (en) * | 2002-12-17 | 2004-03-16 | Sandia Corporation | Sub-to super-ambient temperature programmable microfabricated gas chromatography column |
US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
US9709548B2 (en) | 2008-05-05 | 2017-07-18 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
WO2004080597A2 (en) * | 2003-02-05 | 2004-09-23 | Iquum, Inc. | Sample processing tubule |
SE0300454D0 (sv) * | 2003-02-19 | 2003-02-19 | Aamic Ab | Nozzles for electrospray ionization and methods of fabricating them |
US7007710B2 (en) * | 2003-04-21 | 2006-03-07 | Predicant Biosciences, Inc. | Microfluidic devices and methods |
US7074327B2 (en) * | 2003-05-08 | 2006-07-11 | Nanostream, Inc. | Sample preparation for parallel chromatography |
US7632675B2 (en) | 2003-06-05 | 2009-12-15 | Bioprocessors Corp. | Apparatus and method for manipulating substrates |
JP2005007529A (ja) * | 2003-06-19 | 2005-01-13 | Dainippon Screen Mfg Co Ltd | マイクロ流体デバイスおよびマイクロ流体デバイスの製造方法 |
US20090088982A1 (en) * | 2003-07-31 | 2009-04-02 | Fukushima Noelle H | Co-detection of single polypeptide and polynucleotide molecules |
WO2005015162A2 (en) | 2003-08-06 | 2005-02-17 | Waters Investment Limited | Fluidic terminal |
US7028536B2 (en) * | 2004-06-29 | 2006-04-18 | Nanostream, Inc. | Sealing interface for microfluidic device |
US20050032238A1 (en) * | 2003-08-07 | 2005-02-10 | Nanostream, Inc. | Vented microfluidic separation devices and methods |
DE10336849A1 (de) * | 2003-08-11 | 2005-03-10 | Thinxxs Gmbh | Flusszelle |
GB2439233B (en) * | 2003-09-22 | 2008-04-23 | Shimadzu Corp | An electrophoretic separation method |
JP2007506092A (ja) * | 2003-09-22 | 2007-03-15 | 株式会社島津製作所 | 電気泳動装置及び方法、並びに電気泳動部材及び試料分注プローブ |
US7537807B2 (en) | 2003-09-26 | 2009-05-26 | Cornell University | Scanned source oriented nanofiber formation |
US20080021674A1 (en) * | 2003-09-30 | 2008-01-24 | Robert Puskas | Methods for Enhancing the Analysis of Particle Detection |
KR20050062897A (ko) * | 2003-12-19 | 2005-06-28 | 한국기계연구원 | 계면 교차방향 초음파 방사형 마이크로믹서 및 이를이용한 혼합시료 제조방법 |
US7867194B2 (en) | 2004-01-29 | 2011-01-11 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US7422905B2 (en) * | 2004-02-27 | 2008-09-09 | Medtronic, Inc. | Blood coagulation test cartridge, system, and method |
US7439069B2 (en) * | 2004-02-27 | 2008-10-21 | Nippoldt Douglas D | Blood coagulation test cartridge, system, and method |
US7399637B2 (en) * | 2004-04-19 | 2008-07-15 | Medtronic, Inc. | Blood coagulation test cartridge, system, and method |
JP3952036B2 (ja) * | 2004-05-13 | 2007-08-01 | コニカミノルタセンシング株式会社 | マイクロ流体デバイス並びに試液の試験方法および試験システム |
WO2005116614A1 (en) * | 2004-05-24 | 2005-12-08 | Nanostream, Inc. | Capillary multi-channel optical flow cell |
DE102004030619A1 (de) * | 2004-06-24 | 2006-01-12 | Forschungszentrum Karlsruhe Gmbh | Verfahren zum Verbinden von Werkstücken aus Kunststoff |
US20060011547A1 (en) * | 2004-07-13 | 2006-01-19 | Bell Stephen A | Methods of separating components in treatment fluids |
US20060015039A1 (en) * | 2004-07-19 | 2006-01-19 | Cassidy Kenneth T | Guidewire bearing markings simplifying catheter selection |
US20060022130A1 (en) * | 2004-07-29 | 2006-02-02 | Predicant Biosciences, Inc., A Delaware Corporation | Microfluidic devices and methods with integrated electrical contact |
US20060060769A1 (en) * | 2004-09-21 | 2006-03-23 | Predicant Biosciences, Inc. | Electrospray apparatus with an integrated electrode |
US7591883B2 (en) * | 2004-09-27 | 2009-09-22 | Cornell Research Foundation, Inc. | Microfiber supported nanofiber membrane |
US8685711B2 (en) | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
US9040305B2 (en) * | 2004-09-28 | 2015-05-26 | Singulex, Inc. | Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry |
US7572640B2 (en) * | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
JP2008514955A (ja) * | 2004-09-28 | 2008-05-08 | シンギュレックス・インコーポレイテッド | サンプル分析システムおよび方法 |
KR20060058830A (ko) | 2004-11-26 | 2006-06-01 | 한국표준과학연구원 | 개별시료 주입구가 없는 다중채널 전기영동장치에 의한분리방법 |
JP2008527375A (ja) * | 2005-01-18 | 2008-07-24 | ソルス バイオシステムズ インコーポレイテッド | 赤外線透過基板、半導体基板、珪素基板、流体サンプル分析装置、流体サンプル分析方法、及び計算機読み取り可能な記録媒体 |
US8028566B2 (en) * | 2005-02-10 | 2011-10-04 | Chempaq A/S | Dual sample cartridge and method for characterizing particles in liquid |
EP1891413B1 (en) | 2005-02-10 | 2018-01-24 | Koninklijke Philips N.V. | Dual sample cartridge and method for characterizing particle in liquid |
US8178046B2 (en) * | 2005-02-23 | 2012-05-15 | Sierra Sensors Gmbh | Microfluidic devices with SPR sensing capabilities |
US20060219637A1 (en) * | 2005-03-29 | 2006-10-05 | Killeen Kevin P | Devices, systems and methods for liquid chromatography |
US20060231494A1 (en) * | 2005-04-15 | 2006-10-19 | Lu Jennifer Q | Carbon nanotube stationary phases for chromatography |
US7462280B2 (en) * | 2005-07-22 | 2008-12-09 | Agilent Technologies, Inc. | Liquid chromatography chip with flexible interface |
US7968052B2 (en) * | 2005-09-22 | 2011-06-28 | Chempaq A/S | Detection and subsequent removal of an aperture blockage |
WO2007063719A1 (ja) * | 2005-11-29 | 2007-06-07 | Nec Corporation | 電気泳動チップ、電気泳動装置、および試料分析方法 |
US20070140918A1 (en) * | 2005-12-19 | 2007-06-21 | Hongfeng Yin | Fluidic separation devices and methods with reduced sample broadening |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US20070218454A1 (en) * | 2006-03-16 | 2007-09-20 | Brennen Reid A | Optical detection cell for micro-fluidics |
US8647590B2 (en) | 2006-03-16 | 2014-02-11 | Agilent Technologies, Inc. | Optical detection cell with micro-fluidic chip |
EP3156799B1 (en) | 2006-04-04 | 2024-01-24 | Novilux, LLC | Analyzer and method for highly sensitive detection of analytes |
CN101438146B (zh) * | 2006-04-04 | 2014-12-10 | 神谷来克斯公司 | 高灵敏标志物分析和分子检测的方法和组合物 |
US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
US20070246106A1 (en) * | 2006-04-25 | 2007-10-25 | Velocys Inc. | Flow Distribution Channels To Control Flow in Process Channels |
AU2007257337A1 (en) * | 2006-06-07 | 2007-12-13 | Mycrolab Diagnostics Pty Ltd | Production of microfluidic devices using laser-induced shockwaves |
JPWO2008053720A1 (ja) * | 2006-10-31 | 2010-02-25 | コニカミノルタオプト株式会社 | マスター及びマイクロ反応器 |
US20100038825A1 (en) * | 2006-12-21 | 2010-02-18 | Mcdonald Joel P | Methods of forming microchannels by ultrafast pulsed laser direct-write processing |
GB2445738A (en) * | 2007-01-16 | 2008-07-23 | Lab901 Ltd | Microfluidic device |
GB2445739A (en) * | 2007-01-16 | 2008-07-23 | Lab901 Ltd | Polymeric laminates containing heat seals |
WO2008094672A2 (en) | 2007-01-31 | 2008-08-07 | Charles Stark Draper Laboratory, Inc. | Membrane-based fluid control in microfluidic devices |
US20080318334A1 (en) | 2007-06-20 | 2008-12-25 | Robotti Karla M | Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material |
US8206025B2 (en) | 2007-08-07 | 2012-06-26 | International Business Machines Corporation | Microfluid mixer, methods of use and methods of manufacture thereof |
US20090087860A1 (en) * | 2007-08-24 | 2009-04-02 | Todd John A | Highly sensitive system and methods for analysis of prostate specific antigen (psa) |
JP2009128229A (ja) * | 2007-11-26 | 2009-06-11 | Rohm Co Ltd | マイクロチップ |
CA2709217C (en) | 2007-12-19 | 2021-01-05 | Singulex, Inc. | Scanning analyzer for single molecule detection and methods of use |
CN102016552A (zh) * | 2008-03-05 | 2011-04-13 | 神谷来克斯公司 | 用于分子的高灵敏性检测的方法和组合物 |
US20090250347A1 (en) * | 2008-04-03 | 2009-10-08 | Protea Biosciences, Inc. | Microfluidic devices & processes for electrokinetic transport |
US20090250345A1 (en) * | 2008-04-03 | 2009-10-08 | Protea Biosciences, Inc. | Microfluidic electroelution devices & processes |
US8715590B2 (en) * | 2008-08-15 | 2014-05-06 | Prognosys LLC | Multiplexed lateral flow assay arrays |
KR20110046475A (ko) * | 2008-08-20 | 2011-05-04 | 코니카 미놀타 옵토 인코포레이티드 | 미세 유로 칩의 제조 방법, 미세 유로 칩 성형용 금형 및 미세 유로 칩 |
GB2464183A (en) * | 2008-09-19 | 2010-04-14 | Singulex Inc | Sandwich assay |
US8377643B2 (en) * | 2009-03-16 | 2013-02-19 | Abaxis, Inc. | Split flow device for analyses of specific-binding partners |
US8815178B2 (en) * | 2009-03-26 | 2014-08-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Integrated device for surface-contact sampling, extraction and electrochemical measurements |
WO2010144358A1 (en) * | 2009-06-08 | 2010-12-16 | Singulex, Inc. | Highly sensitive biomarker panels |
DE102009025072A1 (de) * | 2009-06-16 | 2010-12-30 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zum Erzeugen eines Bereiches mit erhöhtem Brechungsindex und ein Substrat mit örtlich variablem Brechungsindex |
US20110301053A1 (en) | 2010-05-06 | 2011-12-08 | Singulex, Inc. | Methods for Diagnosing, Staging, Predicting Risk for Developing and Identifying Treatment Responders for Rheumatoid Arthritis |
WO2011146531A1 (en) | 2010-05-18 | 2011-11-24 | Acea Biosciences, Inc | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments |
EP2576066A4 (en) * | 2010-05-27 | 2015-01-07 | 3M Innovative Properties Co | INTEGRATED SYSTEM AND ASSEMBLIES FOR PROCESSING SAMPLES |
DE102010042824A1 (de) * | 2010-10-22 | 2012-04-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Mikrofluidikmodul und Verfahren zur Herstellung desselben |
CN106423312A (zh) * | 2010-12-03 | 2017-02-22 | 美艾利尔技术公司 | 通过激光照射把材料转换成光学调制状态 |
DE102010053749B4 (de) * | 2010-12-08 | 2015-02-19 | Airbus Defence and Space GmbH | Vorrichtung zum Identifizieren biotischer Partikel |
EP2670456B1 (en) | 2011-02-02 | 2019-12-18 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US8502162B2 (en) | 2011-06-20 | 2013-08-06 | Agilent Technologies, Inc. | Atmospheric pressure ionization apparatus and method |
DE202011102073U1 (de) | 2011-06-20 | 2011-10-10 | Agilent Technologies, Inc. - A Delaware Corporation - | Atmosphärendruck-Ionisationsvorrichtung |
EP2748600A4 (en) | 2011-08-22 | 2015-06-10 | Waters Technologies Corp | ANALYSIS OF DRIED BLOOD TASTING SAMPLE IN A MICROFLUID SYSTEM WITH DILUTION OF EXTRACTED SAMPLES |
DE102011054659A1 (de) * | 2011-10-20 | 2013-04-25 | AeroMegt GmbH | Verfahren und Vorrichtung zum Messen von Aerosolen in einem großen Volumenstrom |
US20130188296A1 (en) | 2012-01-19 | 2013-07-25 | Ford Global Technologies, Llc | Material And Coating For Interconnector Busbars |
WO2013159816A1 (en) * | 2012-04-25 | 2013-10-31 | Agilent Technologies, Inc. | Prevention of phase separation upon proportioning and mixing fluids |
CA2878509C (en) * | 2012-07-16 | 2020-04-28 | Genefluidics, Inc. | Sample dependent selection of parameters for use in electrokinetic treatment of the sample |
US8952326B1 (en) | 2013-11-04 | 2015-02-10 | Agilent Technologies, Inc. | Atmospheric pressure interface with improved ion transfer for spectrometry, and related systems and methods |
JP6310327B2 (ja) * | 2014-05-27 | 2018-04-11 | 株式会社エンプラス | 流体取扱装置 |
US11746328B2 (en) | 2017-03-03 | 2023-09-05 | Agilent Technologies, Inc. | Methods and systems for functional maturation of iPSC and ESC derived cardiomyocytes |
DE102017108120A1 (de) * | 2017-04-13 | 2018-10-18 | Laser-Laboratorium Göttingen e.V. | Analysevorrichtung |
EP4090464A1 (en) | 2020-01-17 | 2022-11-23 | F. Hoffmann-La Roche AG | Microfluidic device and method for automated split-pool synthesis |
CN115003415A (zh) | 2020-01-22 | 2022-09-02 | 豪夫迈·罗氏有限公司 | 用于下一代测序库制备的微流控珠粒捕获装置和方法 |
USD941488S1 (en) | 2020-02-07 | 2022-01-18 | Agilent Technologies, Inc. | Instrument for analyzing biological cells |
CN116710571A (zh) | 2020-10-15 | 2023-09-05 | 卡帕生物系统公司 | 用于下一代测序文库制备的电泳装置和方法 |
JP2022159961A (ja) * | 2021-04-05 | 2022-10-18 | Ckd株式会社 | 配管溶接構造 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3770529A (en) * | 1970-08-25 | 1973-11-06 | Ibm | Method of fabricating multilayer circuits |
US3953056A (en) * | 1972-06-09 | 1976-04-27 | Bookwrights, Inc. | Bookbinding with plastic covers |
US3919768A (en) * | 1973-01-02 | 1975-11-18 | Northrop Corp | Method of tunnel containing structures |
US3925166A (en) * | 1974-09-06 | 1975-12-09 | Us Health | Automated system for the determination of bacterial antibiotic susceptibilities |
US4059009A (en) * | 1976-09-10 | 1977-11-22 | Micromeritics Instrument Corporation | Liquid chromatography system |
JPS5385498A (en) * | 1977-01-05 | 1978-07-27 | Hitachi Ltd | Coulumn for chromatography and production of the same |
US4285901A (en) * | 1978-07-06 | 1981-08-25 | Akira Yotsutsuji | Method of making an insulated metal mold |
DE3011919A1 (de) * | 1979-03-27 | 1980-10-09 | Canon Kk | Verfahren zur herstellung eines aufzeichnungskopfes |
DK429682A (da) * | 1982-09-28 | 1984-03-29 | Inflow Aps | Integrerede mikroroersystemer til kontinuerlig gennemstroemningsanalyse |
JPS60230058A (ja) * | 1984-04-27 | 1985-11-15 | Sord Comput Corp | ポータブルキャピラリーガスクロマトグラフ装置用シリコンウエハ |
JPS60230056A (ja) * | 1984-04-27 | 1985-11-15 | Sord Comput Corp | キヤピラリ−クロマトグラフ装置のカラム用基板及びその製法 |
JPH0726948B2 (ja) * | 1985-02-20 | 1995-03-29 | 株式会社東芝 | クロマトグラフイ用カラム及びその製造方法 |
US4668607A (en) * | 1985-03-26 | 1987-05-26 | E. I. Du Pont De Nemours And Company | Multilevel imaging of photopolymer relief layer for the preparation of casting molds |
JPS6287858A (ja) * | 1985-10-14 | 1987-04-22 | Fujikura Ltd | キヤピラリ−カラム基板 |
US4865729A (en) * | 1985-11-04 | 1989-09-12 | Sepragen Corporation | Radial thin layer chromatography |
GB2191110B (en) * | 1986-06-06 | 1989-12-06 | Plessey Co Plc | Chromatographic separation device |
US4713963A (en) * | 1986-06-26 | 1987-12-22 | Daryl Sharp | Method and device for vacuum chromatography |
JPS63271159A (ja) * | 1987-04-28 | 1988-11-09 | Seiko Instr & Electronics Ltd | 高速液体クロマトグラフに用いるエンプテイカラム |
US4908112A (en) * | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
US5037544A (en) * | 1988-06-17 | 1991-08-06 | Snyder Thomas A | Keyed column chromatography apparatus |
US5132012A (en) * | 1988-06-24 | 1992-07-21 | Hitachi, Ltd. | Liquid chromatograph |
JPH0652913B2 (ja) * | 1988-09-26 | 1994-07-06 | 株式会社テイ・アイ・シイ・シチズン | 二線式表示装置 |
JP2722667B2 (ja) * | 1989-05-26 | 1998-03-04 | 横河電機株式会社 | クロマトグラフィ用カラム |
US5126022A (en) * | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
GB2244135B (en) * | 1990-05-04 | 1994-07-13 | Gen Electric Co Plc | Sensor devices |
SE470347B (sv) * | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
US5291226A (en) * | 1990-08-16 | 1994-03-01 | Hewlett-Packard Company | Nozzle member including ink flow channels |
US5305015A (en) * | 1990-08-16 | 1994-04-19 | Hewlett-Packard Company | Laser ablated nozzle member for inkjet printhead |
DE4112528C2 (de) * | 1991-04-17 | 1995-04-06 | Kernforschungsz Karlsruhe | Spektralfotometer |
SE501380C2 (sv) * | 1993-06-15 | 1995-01-30 | Pharmacia Lkb Biotech | Sätt att tillverka mikrokanal/mikrokavitetsstrukturer |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5688355A (en) * | 1994-10-03 | 1997-11-18 | Xerox Corporation | Process for fabricating flexible belts using laser ablation |
US5658413A (en) * | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
US5500071A (en) * | 1994-10-19 | 1996-03-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
US5641400A (en) * | 1994-10-19 | 1997-06-24 | Hewlett-Packard Company | Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems |
US5645702A (en) * | 1995-06-07 | 1997-07-08 | Hewlett-Packard Company | Low voltage miniaturized column analytical apparatus and method |
US5571410A (en) * | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
US5669997A (en) * | 1995-07-13 | 1997-09-23 | Hughes Danbury Optical Systems, Inc. | Method of bonding optical members together |
-
1995
- 1995-06-07 US US08/482,245 patent/US5658413A/en not_active Expired - Lifetime
- 1995-10-16 EP EP95937504A patent/EP0734282B1/en not_active Expired - Lifetime
- 1995-10-16 US US08/656,281 patent/US6033628A/en not_active Expired - Lifetime
- 1995-10-16 WO PCT/US1995/013365 patent/WO1996012546A1/en active IP Right Grant
- 1995-10-16 DE DE69535176T patent/DE69535176T2/de not_active Expired - Lifetime
- 1995-10-19 DE DE69535259T patent/DE69535259T2/de not_active Expired - Lifetime
- 1995-10-19 EP EP95937465A patent/EP0734281B1/en not_active Expired - Lifetime
- 1995-10-19 WO PCT/US1995/013258 patent/WO1996012545A1/en active IP Right Grant
- 1995-10-19 JP JP51401696A patent/JP3631758B2/ja not_active Expired - Fee Related
-
1997
- 1997-03-27 US US08/824,620 patent/US5882571A/en not_active Expired - Lifetime
- 1997-08-18 US US08/914,297 patent/US5804022A/en not_active Expired - Lifetime
-
1999
- 1999-02-11 US US09/249,531 patent/US6093362A/en not_active Expired - Lifetime
-
2000
- 2000-01-11 US US09/480,922 patent/US6264892B1/en not_active Expired - Lifetime
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08240576A (ja) * | 1995-01-23 | 1996-09-17 | Hewlett Packard Co <Hp> | プレーナ・マニホルド組立体及び分析機器 |
JP2000289166A (ja) * | 1999-04-09 | 2000-10-17 | E I Du Pont De Nemours & Co | 封入された構造を含む一体式ポリイミド積層体および該積層体の製造方法 |
JP2005517959A (ja) * | 2002-02-21 | 2005-06-16 | コミツサリア タ レネルジー アトミーク | 生物又は生化学分析マイクロシステム用のコンポーネント |
JP4727148B2 (ja) * | 2002-02-21 | 2011-07-20 | コミッサリア ア レネルジー アトミーク エ オ ゼネルジ ザルタナテイヴ | 生物又は生化学分析マイクロシステム用のコンポーネント |
JP2010517208A (ja) * | 2006-10-31 | 2010-05-20 | コーニング インコーポレイテッド | マイクロ加工された電解質シート、これを利用する燃料電池デバイス、および燃料電池デバイスを作製するマイクロ加工方法 |
JP2011045981A (ja) * | 2009-08-28 | 2011-03-10 | Ritsumeikan | Mems、及びその製造方法 |
WO2016063950A1 (ja) * | 2014-10-24 | 2016-04-28 | 京都府公立大学法人 | 検体用ホルダ |
JP2016085108A (ja) * | 2014-10-24 | 2016-05-19 | 京都府公立大学法人 | 検体用ホルダ |
Also Published As
Publication number | Publication date |
---|---|
WO1996012545A1 (en) | 1996-05-02 |
US5804022A (en) | 1998-09-08 |
US6093362A (en) | 2000-07-25 |
US6033628A (en) | 2000-03-07 |
DE69535259T2 (de) | 2007-01-25 |
EP0734282B1 (en) | 2006-08-16 |
US6264892B1 (en) | 2001-07-24 |
EP0734281A1 (en) | 1996-10-02 |
DE69535259D1 (de) | 2006-11-23 |
DE69535176D1 (de) | 2006-09-28 |
EP0734282A4 (en) | 1996-11-20 |
JP3631758B2 (ja) | 2005-03-23 |
WO1996012546A1 (en) | 1996-05-02 |
US5658413A (en) | 1997-08-19 |
EP0734282A1 (en) | 1996-10-02 |
EP0734281B1 (en) | 2006-10-11 |
DE69535176T2 (de) | 2007-08-23 |
US5882571A (en) | 1999-03-16 |
EP0734281A4 (en) | 1996-11-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3631758B2 (ja) | 液相分析のための新規支持メディアにおける小型化平坦カラム | |
JP3930889B2 (ja) | 小型化カラムデバイス | |
US5571410A (en) | Fully integrated miniaturized planar liquid sample handling and analysis device | |
US5500071A (en) | Miniaturized planar columns in novel support media for liquid phase analysis | |
US5641400A (en) | Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems | |
US6635226B1 (en) | Microanalytical device and use thereof for conducting chemical processes | |
US5645702A (en) | Low voltage miniaturized column analytical apparatus and method | |
US6459080B1 (en) | Miniaturized device for separating the constituents of a sample and delivering the constituents of the separated sample to a mass spectrometer | |
US8076152B2 (en) | Microfluidic devices comprising fluid flow paths having monolithic chromatographic material | |
US6194900B1 (en) | Integrated miniaturized device for processing and NMR detection of liquid phase samples | |
US6450047B2 (en) | Device for high throughput sample processing, analysis and collection, and methods of use thereof | |
EP0775306B1 (en) | Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis | |
US6489774B1 (en) | Miniaturized device for ion analysis, and methods of use thereof | |
EP0708330B1 (en) | Low voltage miniaturized column analytical apparatus and method | |
Sant et al. | Flexible fabrication, packaging, and detection approach for microscale chromatography systems | |
Shih | Temperature-controlled microchip liquid chromatography system | |
Dorairaj | Dual capillary electrophoresis device with electrochemical detection on a single platform |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040115 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20040413 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20040713 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20040830 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041013 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20041207 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20041220 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20081224 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20091224 Year of fee payment: 5 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101224 Year of fee payment: 6 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101224 Year of fee payment: 6 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111224 Year of fee payment: 7 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111224 Year of fee payment: 7 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121224 Year of fee payment: 8 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121224 Year of fee payment: 8 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131224 Year of fee payment: 9 |
|
LAPS | Cancellation because of no payment of annual fees |