CN1217188C - 微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法 - Google Patents
微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法 Download PDFInfo
- Publication number
- CN1217188C CN1217188C CN021538514A CN02153851A CN1217188C CN 1217188 C CN1217188 C CN 1217188C CN 021538514 A CN021538514 A CN 021538514A CN 02153851 A CN02153851 A CN 02153851A CN 1217188 C CN1217188 C CN 1217188C
- Authority
- CN
- China
- Prior art keywords
- gas
- chromatographic column
- gas chromatographic
- sample
- gas circuit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 51
- 239000000203 mixture Substances 0.000 title claims description 5
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000007789 gas Substances 0.000 claims description 144
- 239000011435 rock Substances 0.000 claims description 43
- 238000004817 gas chromatography Methods 0.000 claims description 34
- 230000005526 G1 to G0 transition Effects 0.000 claims description 28
- 239000012159 carrier gas Substances 0.000 claims description 18
- 238000004458 analytical method Methods 0.000 claims description 9
- 230000008016 vaporization Effects 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- 238000009834 vaporization Methods 0.000 claims description 5
- 238000005530 etching Methods 0.000 claims description 4
- 230000003068 static effect Effects 0.000 claims description 4
- 238000001312 dry etching Methods 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 238000009434 installation Methods 0.000 claims description 3
- 238000000608 laser ablation Methods 0.000 claims description 3
- 239000010453 quartz Substances 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000005476 soldering Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- -1 pottery Substances 0.000 claims description 2
- 238000004062 sedimentation Methods 0.000 claims description 2
- 238000001039 wet etching Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 9
- 238000012545 processing Methods 0.000 description 24
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000001030 gas--liquid chromatography Methods 0.000 description 2
- 238000000574 gas--solid chromatography Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000001020 plasma etching Methods 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 241000282817 Bovidae Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000002359 drug metabolite Substances 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/025—Gas chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6034—Construction of the column joining multiple columns
- G01N30/6039—Construction of the column joining multiple columns in series
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
Description
Claims (26)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN021538514A CN1217188C (zh) | 2002-12-05 | 2002-12-05 | 微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法 |
US10/537,533 US20060144237A1 (en) | 2002-12-05 | 2002-12-31 | Microminiature gas chromatograph column |
CA002507884A CA2507884A1 (en) | 2002-12-05 | 2002-12-31 | Microminiature gas chromatograph column |
EP02808192A EP1576365A4 (en) | 2002-12-05 | 2002-12-31 | GAS CHROMATOGRAPHIC COLUMN MICROMINIATURE |
PCT/CN2002/000941 WO2004051258A1 (en) | 2002-12-05 | 2002-12-31 | Microminiature gas chromatograph column |
JP2004555954A JP2006509191A (ja) | 2002-12-05 | 2002-12-31 | 微細小型ガスクロマトグラフカラム |
AU2002357422A AU2002357422B2 (en) | 2002-12-05 | 2002-12-31 | Microminiature gas chromatograph column |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN021538514A CN1217188C (zh) | 2002-12-05 | 2002-12-05 | 微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1419123A CN1419123A (zh) | 2003-05-21 |
CN1217188C true CN1217188C (zh) | 2005-08-31 |
Family
ID=4752379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN021538514A Expired - Fee Related CN1217188C (zh) | 2002-12-05 | 2002-12-05 | 微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20060144237A1 (zh) |
EP (1) | EP1576365A4 (zh) |
JP (1) | JP2006509191A (zh) |
CN (1) | CN1217188C (zh) |
AU (1) | AU2002357422B2 (zh) |
CA (1) | CA2507884A1 (zh) |
WO (1) | WO2004051258A1 (zh) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060171855A1 (en) * | 2005-02-03 | 2006-08-03 | Hongfeng Yin | Devices,systems and methods for multi-dimensional separation |
US7273517B1 (en) * | 2005-02-25 | 2007-09-25 | Sandia Corporation | Non-planar microfabricated gas chromatography column |
US20070274867A1 (en) * | 2005-02-28 | 2007-11-29 | Honeywell International Inc. | Stationary phase for a micro fluid analyzer |
US8628055B2 (en) | 2005-07-27 | 2014-01-14 | The Board Of Trustees Of The University Of Illinois | Bi-direction rapid action electrostatically actuated microvalve |
US20070204749A1 (en) * | 2006-03-01 | 2007-09-06 | Douglas Adkins | Gas chromatograph column and method of making the same |
US8778059B2 (en) * | 2007-12-03 | 2014-07-15 | Schlumberger Technology Corporation | Differential acceleration chromatography |
US8123841B2 (en) * | 2008-01-16 | 2012-02-28 | The Board Of Trustees Of The University Of Illinois | Column design for micro gas chromatograph |
US8269029B2 (en) | 2008-04-08 | 2012-09-18 | The Board Of Trustees Of The University Of Illinois | Water repellent metal-organic frameworks, process for making and uses regarding same |
WO2009135115A1 (en) * | 2008-05-01 | 2009-11-05 | The Govt. Of The U.S.A. As Represented By The Secretary Of The Navy Naval Research Laboratory | Microfabricated gas chromatograph |
US8999245B2 (en) * | 2009-07-07 | 2015-04-07 | Tricorn Tech Corporation | Cascaded gas chromatographs (CGCs) with individual temperature control and gas analysis systems using same |
US8707760B2 (en) | 2009-07-31 | 2014-04-29 | Tricorntech Corporation | Gas collection and analysis system with front-end and back-end pre-concentrators and moisture removal |
JP5397906B2 (ja) * | 2010-02-05 | 2014-01-22 | シャープ株式会社 | 呼気分析装置 |
US8978444B2 (en) | 2010-04-23 | 2015-03-17 | Tricorn Tech Corporation | Gas analyte spectrum sharpening and separation with multi-dimensional micro-GC for gas chromatography analysis |
CN103069272B (zh) * | 2010-06-07 | 2015-07-01 | 法国原子能及替代能源委员会 | 包括至少一个色谱柱的用于分析气体混合物的系统 |
KR101301256B1 (ko) * | 2011-11-28 | 2013-08-28 | 한국기초과학지원연구원 | 다층의 기체 크로마토그래피용 칩 및 이의 제조방법 |
EP2706352B1 (en) * | 2012-09-05 | 2014-11-05 | Siemens Aktiengesellschaft | Comprehensive two-dimensional gas chromatograph and modulator for such a chromatograph |
CN103776940A (zh) * | 2012-10-19 | 2014-05-07 | 中国科学院电子学研究所 | 一种超大接触面积的阵列化微型气相色谱柱芯片 |
KR101404041B1 (ko) * | 2012-12-07 | 2014-06-10 | 한국기초과학지원연구원 | 가스 크로마토그래피 칩 적층체 |
KR101401342B1 (ko) * | 2012-12-13 | 2014-05-29 | 한국기초과학지원연구원 | 다중 에칭을 통한 가스 크로마토그래피 칩 적층체의 제조 방법 |
CN103063788A (zh) * | 2012-12-27 | 2013-04-24 | 上海集成电路研发中心有限公司 | 气相色谱柱及其形成方法、以及气相色谱仪 |
US9664598B2 (en) * | 2013-10-18 | 2017-05-30 | Agilent Technologies, Inc. | Microfluidic contaminant trap for trapping contaminants in gas chromatography |
WO2015076731A1 (en) | 2013-11-22 | 2015-05-28 | Flatfrog Laboratories Ab | A touch sensitive apparatus with improved spatial resolution |
KR101536164B1 (ko) * | 2013-12-18 | 2015-07-13 | 한국기초과학지원연구원 | 유도체화 반응 기체 크로마토그래피 칩 |
EP2944954A1 (en) * | 2014-05-13 | 2015-11-18 | Thermo Finnigan Llc | Gas chromatograph system employing hydrogen carrier gas |
CN105126387B (zh) * | 2015-09-11 | 2017-01-25 | 电子科技大学 | 波浪形微型气相色谱柱及其制备方法 |
ITUB20155975A1 (it) * | 2015-11-27 | 2017-05-27 | Alifax Srl | Procedimento per la rilevazione di attivita' batterica in un campione biologico e relativa unita' di rilevazione |
CN105510490A (zh) * | 2015-12-05 | 2016-04-20 | 浙江大学 | 一种微型气相色谱柱芯片及其制备方法 |
US11543393B2 (en) * | 2017-03-20 | 2023-01-03 | Koninklijke Philips N.V. | Gas chromatography column with polybutadiene coating |
TWI742274B (zh) * | 2018-05-04 | 2021-10-11 | 研能科技股份有限公司 | 氣相層析設備 |
JP2023503965A (ja) * | 2019-11-25 | 2023-02-01 | ザ レジェンツ オブ ザ ユニバーシティ オブ ミシガン | 固定相の厚さ勾配を有するクロマトグラフィカラム |
WO2021162602A1 (en) | 2020-02-10 | 2021-08-19 | Flatfrog Laboratories Ab | Improved touch-sensing apparatus |
CN112198240A (zh) * | 2020-08-26 | 2021-01-08 | 浙江中环瑞蓝科技发展有限公司 | 一种微型气相色谱柱箱 |
CN112255358A (zh) * | 2020-09-20 | 2021-01-22 | 杭州谱育科技发展有限公司 | 基于单柱的多成分检测系统 |
CN113281424A (zh) * | 2021-03-31 | 2021-08-20 | 天津大学 | 微型色谱柱及其涂覆方法和微型气相色谱仪 |
CN114669338B (zh) * | 2022-04-15 | 2023-05-12 | 扬州大学 | 一种基于尿液检测疾病的微流控芯片 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3149941A (en) * | 1957-12-30 | 1964-09-22 | Cons Electrodynamics Corp | Chromatography apparatus |
JPS61288154A (ja) * | 1985-06-14 | 1986-12-18 | Yokogawa Electric Corp | ガスクロマトグラフイ |
US4935040A (en) * | 1989-03-29 | 1990-06-19 | The Perkin-Elmer Corporation | Miniature devices useful for gas chromatography |
US5658413A (en) * | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
WO1996020401A1 (fr) * | 1994-12-26 | 1996-07-04 | Kabushiki Kaisya Advance | Dispositif de chromatographie a canal poreux |
US6068780A (en) * | 1995-06-05 | 2000-05-30 | The Regents Of The University Of California | Micro-miniature gas chromatograph column disposed in silicon wafers |
JP3839524B2 (ja) * | 1995-06-07 | 2006-11-01 | アジレント・テクノロジーズ・インク | 小型化全分析システム |
US5583281A (en) * | 1995-07-07 | 1996-12-10 | The Regents Of The University Of California | Microminiature gas chromatograph |
US5792943A (en) * | 1997-04-30 | 1998-08-11 | Hewlett-Packard Company | Planar separation column for use in sample analysis system |
US6153076A (en) * | 1998-01-12 | 2000-11-28 | The Regents Of The University Of California | Extended length microchannels for high density high throughput electrophoresis systems |
US6240790B1 (en) * | 1998-11-09 | 2001-06-05 | Agilent Technologies, Inc. | Device for high throughout sample processing, analysis and collection, and methods of use thereof |
AU2082701A (en) * | 1999-12-09 | 2001-06-18 | Motorola, Inc. | Multilayered microfluidic devices for analyte reactions |
US6497138B1 (en) * | 2000-10-18 | 2002-12-24 | Agilent Technologies, Inc., | Multilayered gas chromatograph |
US6666907B1 (en) * | 2002-01-31 | 2003-12-23 | Sandia Corporation | Temperature programmable microfabricated gas chromatography column |
-
2002
- 2002-12-05 CN CN021538514A patent/CN1217188C/zh not_active Expired - Fee Related
- 2002-12-31 EP EP02808192A patent/EP1576365A4/en not_active Ceased
- 2002-12-31 CA CA002507884A patent/CA2507884A1/en not_active Abandoned
- 2002-12-31 US US10/537,533 patent/US20060144237A1/en not_active Abandoned
- 2002-12-31 JP JP2004555954A patent/JP2006509191A/ja active Pending
- 2002-12-31 WO PCT/CN2002/000941 patent/WO2004051258A1/en active Application Filing
- 2002-12-31 AU AU2002357422A patent/AU2002357422B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CN1419123A (zh) | 2003-05-21 |
US20060144237A1 (en) | 2006-07-06 |
AU2002357422A1 (en) | 2004-06-23 |
EP1576365A1 (en) | 2005-09-21 |
JP2006509191A (ja) | 2006-03-16 |
AU2002357422B2 (en) | 2008-04-24 |
WO2004051258A1 (en) | 2004-06-17 |
CA2507884A1 (en) | 2004-06-17 |
EP1576365A4 (en) | 2010-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1217188C (zh) | 微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法 | |
Hawks | Analytical methodology | |
Bugey et al. | Rapid analysis of benzodiazepines in whole blood by high-performance liquid chromatography: use of a monolithic column | |
Streel et al. | Enantiomeric determination of amlodipine in human plasma by liquid chromatography coupled to tandem mass spectrometry | |
KR101004749B1 (ko) | 기체크로마토그래피를 이용한 소변 중 60종 이상 마약성분의 다성분 동시분석법 | |
Wu et al. | Determination of stimulants in human urine and hair samples by polypyrrole coated capillary in-tube solid phase microextraction coupled with liquid chromatography-electrospray mass spectrometry | |
Akramipour et al. | Combination of counter current salting-out homogenous liquid–liquid extraction and dispersive liquid–liquid microextraction as a novel microextraction of drugs in urine samples | |
Thirukumaran et al. | Solid-phase microextraction-probe electrospray ionization devices for screening and quantitating drugs of abuse in small amounts of biofluids | |
EP1962097A1 (en) | Mass spectrometric quantitative detection of methyl malonic acid and succinic acid using hilic on a zwitterionic stationary phase | |
JP2007529001A (ja) | 複合試料処理及び試料保持装置を使用する試料分析のための装置及び方法 | |
Nie et al. | Rapid screening and determination of 11 new psychoactive substances by direct analysis in real time mass spectrometry and liquid chromatography/quadrupole time‐of‐flight mass spectrometry | |
Meng et al. | Small volume liquid extraction of amphetamines in saliva | |
US4988628A (en) | Method of drug detection | |
Pocci et al. | Solid-phase extraction and GC/MS confirmation of barbiturates from human urine | |
Scanferla et al. | Drugs of abuse: A narrative review of recent trends in biological sample preparation and chromatographic techniques | |
Xia et al. | Automated online dual-column extraction coupled with teicoplanin stationary phase for simultaneous determination of (R)-and (S)-propranolol in rat plasma using liquid chromatography–tandem mass spectrometry | |
Projean et al. | Rapid and simple method to determine morphine and its metabolites in rat plasma by liquid chromatography–mass spectrometry | |
Baugh et al. | Simultaneous gas chromatography/mass spectrometry assay of methadone and 2-ethyl-1, 5-dimethyl-3, 3-diphenylpyrrolidine (EDDP) in urine | |
Fraser et al. | The use of capillary high performance liquid chromatography with electrospray mass spectrometry for the analysis of small volume blood samples from serially bled mice to determine the pharmacokinetics of early discovery compounds | |
Messiha | Determination of carbamazepine by HPLC electrochemical detection and application for estimation of imipramine desipramine, doxepin and nordoxepin | |
González et al. | Cardiovascular drug determination in bioanalysis: an update | |
Mile | Chemistry in court | |
Truong et al. | Streamlining regular liquid chromatography with MALDI-TOF MS and NMR spectroscopy using automatic full-contact splitless spotting interface and flash-tap fractioning collection | |
Griffeuille et al. | Driving under the influence of drugs: PESI for the measurement of illicit drugs in saliva | |
Lee et al. | Targeted MRM Screening for Forensic Toxicology in Negative Electrospray Ionization Mode Using the Xevo TQD or Xevo TQ-S micro |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: QINGHUA UNIVERSITY; BOAO BIOLOGICAL CO., LTD. Free format text: FORMER NAME OR ADDRESS: QINGHUA UNIVERSITY; CAPITALBIO CORPORATION |
|
CP03 | Change of name, title or address |
Address after: 100084 Tsinghua University, Beijing, Haidian District Co-patentee after: Capitalbio Corporation Patentee after: Tsinghua University Address before: 100084 Tsinghua University, Beijing, Haidian District Co-patentee before: Boao Biochip Co., Ltd., Beijing Patentee before: Tsinghua University |
|
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: 100084 Haidian District Tsinghua University Beijing Patentee after: Tsinghua University Patentee after: CAPITALBIO CORPORATION Address before: 100084 Haidian District Tsinghua University Beijing Patentee before: Tsinghua University Patentee before: Capitalbio Corporation |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050831 Termination date: 20201205 |
|
CF01 | Termination of patent right due to non-payment of annual fee |