JPH09503782A - ピコサルフェート剤形 - Google Patents
ピコサルフェート剤形Info
- Publication number
- JPH09503782A JPH09503782A JP7511864A JP51186495A JPH09503782A JP H09503782 A JPH09503782 A JP H09503782A JP 7511864 A JP7511864 A JP 7511864A JP 51186495 A JP51186495 A JP 51186495A JP H09503782 A JPH09503782 A JP H09503782A
- Authority
- JP
- Japan
- Prior art keywords
- picosulfate
- matrix
- colon
- dosage form
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. (a)急速溶解性マトリックス中にある安全有効量のピコサルフェート マトリックス;及び (b)被治療体の実質的に小腸及び結腸間の結合部近くか又は結腸内で上記ピ コサルフェートの放出を行う近位結腸デリバリーキャリア; を含んでなる、ヒト又は他の動物被治療体へのピコサルフェートの経口投与用の 単位剤形をした医薬緩下組成物。 2. ピコサルフェートマトリックスが0.1〜25mg、好ましくは0.5 〜15mgのピコサルフェートを含んでいる、請求項1に記載の組成物。 3. ピコサルフェートが37℃で液体である水混和性の製薬上許容される溶 媒中に存在している、請求項1又は2に記載の組成物。 4. 単位剤形が圧縮錠剤の形をしている、請求項1〜3のいずれか一項に記 載の組成物。 5. 単位剤形が固体物充填硬質ゼラチンカプセルの形をしている、請求項1 〜3のいずれか一項に記載の組成物。 6. ピコサルフェートマトリックスが軟質ゼラチンカプセルに封入されてい る、請求項1〜3のいずれか一項に記載の組成物。 7. 近位結腸デリバリーキャリアがパルスカプセルからなる、請求項1〜3 のいずれか一項に記載の組成物。 8. 近位結腸デリバリーキャリアが6.5〜7のpH、好ましくは7のpH で溶解するpH感受性腸溶物質からなる、請求項1〜6のいずれか一項に記載の 組成物。 9. 請求項1〜8のいずれか一項に記載の組成物の経口投与により緩下の必 要なヒト及び動物で緩下させるための方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13936493A | 1993-10-19 | 1993-10-19 | |
US08/139,364 | 1993-10-19 | ||
PCT/US1994/011063 WO1995011024A1 (en) | 1993-10-19 | 1994-09-29 | Picosulphate dosage form |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09503782A true JPH09503782A (ja) | 1997-04-15 |
JP3725542B2 JP3725542B2 (ja) | 2005-12-14 |
Family
ID=22486268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51186495A Expired - Fee Related JP3725542B2 (ja) | 1993-10-19 | 1994-09-29 | ピコサルフェート剤形 |
Country Status (5)
Country | Link |
---|---|
US (1) | US5631022A (ja) |
EP (1) | EP0724441A1 (ja) |
JP (1) | JP3725542B2 (ja) |
AU (1) | AU7961094A (ja) |
WO (1) | WO1995011024A1 (ja) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6028190A (en) | 1994-02-01 | 2000-02-22 | The Regents Of The University Of California | Probes labeled with energy transfer coupled dyes |
GB9412394D0 (en) | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
US6166024A (en) | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
AUPN634595A0 (en) * | 1995-11-03 | 1995-11-30 | Borody, Thomas Julius | Improved method for colonic evacuation |
AU771576B2 (en) * | 1995-11-03 | 2004-03-25 | Red Hill Biopharma Ltd. | Improved preparation for colonic evacuation |
US6103268A (en) * | 1995-11-03 | 2000-08-15 | Borody; Thomas Julius | Administering osmotic colonic evacuant containing a picosulfate |
US6231888B1 (en) | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
IT1282576B1 (it) * | 1996-02-06 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica atta a cedere la sostanza attiva in tempi successivi e predeterminabili |
AR017512A1 (es) * | 1997-08-22 | 2001-09-12 | Smithkline Beecham Corp | Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas |
US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
SE0000773D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
EP2260837A1 (en) * | 2001-06-01 | 2010-12-15 | Pozen, Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
GB0124953D0 (en) * | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
US7282217B1 (en) | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
US8481083B2 (en) * | 2007-10-12 | 2013-07-09 | Ferring International Center S.A. | Granular compositions of magnesium oxide and citric acid and uses thereof |
EA201100313A1 (ru) | 2008-09-09 | 2011-10-31 | Астразенека Аб | Способ доставки фармацевтической композиции пациенту, нуждающемуся в этом |
JP2012531430A (ja) * | 2009-06-25 | 2012-12-10 | ポーゼン インコーポレイテッド | アスピリン療法を必要とする患者を治療するための方法 |
CA2764963C (en) | 2009-06-25 | 2016-11-01 | Astrazeneca Ab | Method for treating a patient at risk for developing an nsaid-associated ulcer |
PL2651415T3 (pl) | 2010-12-13 | 2021-04-19 | Rite-Prep Pty Ltd. | Formulacje dożołądkowe i dookrężnicze oraz sposoby ich wytwarzania i zastosowania |
WO2013101897A2 (en) | 2011-12-28 | 2013-07-04 | Pozen Inc. | Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
US8313774B1 (en) | 2012-06-26 | 2012-11-20 | Magnifica Inc. | Oral solid composition |
JP6454640B2 (ja) | 2012-07-27 | 2019-01-16 | レッド ヒル バイオファーマ リミテッドRedHill Biopharma Ltd. | 結腸排出促進における使用のための製剤および製剤製造方法 |
IN2013MU02911A (ja) * | 2013-09-10 | 2015-07-03 | Cadila Healthcare Ltd | |
US20210346319A1 (en) * | 2018-10-04 | 2021-11-11 | Emory University | Pharmaceutical Compositions of R-(+)-Propranolol in Enantiomeric Excess and Therapeutic Uses Related Thereto |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870061A (en) * | 1956-11-08 | 1959-01-20 | Mead Johnson & Co | Concentrates of dialkyl sulfosuccinates |
US3080286A (en) * | 1961-04-05 | 1963-03-05 | White Lab Inc | Constipation correctives |
JPS5731864A (en) * | 1980-08-04 | 1982-02-20 | Teijin Ltd | Oral activated carbon microcapsule |
US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
JPS5953410A (ja) * | 1982-09-20 | 1984-03-28 | Fujisawa Pharmaceut Co Ltd | 新型ソフトカプセル剤 |
JPS649932A (en) * | 1987-07-01 | 1989-01-13 | Toyo Capsel Kk | Soft capsule preparation using newly combined component as the base |
US5068110A (en) * | 1987-09-29 | 1991-11-26 | Warner-Lambert Company | Stabilization of enteric coated dosage form |
JPH01254626A (ja) * | 1988-04-01 | 1989-10-11 | Taiyo Yakuhin Kogyo Kk | ピコスルフアートナトリウム固型製剤 |
JP2764581B2 (ja) * | 1988-04-05 | 1998-06-11 | 東洋カプセル株式会社 | 腸内拡散の速い新規ピコスルファートナトリウム製剤 |
JPH01283222A (ja) * | 1988-05-10 | 1989-11-14 | Tokai Kapuseru Kk | ピコスルフアートナトリウム軟カプセル剤 |
DE3818022C2 (de) * | 1988-05-24 | 1994-04-28 | Guenter Stephan | Weichgelatinekapsel |
US5194464A (en) * | 1988-09-27 | 1993-03-16 | Takeda Chemical Industries, Ltd. | Enteric film and preparatoin thereof |
JPH0830010B2 (ja) * | 1989-01-13 | 1996-03-27 | 高田製薬株式会社 | ピコスルフアートナトリウム液充填硬カプセル剤 |
GB8903564D0 (en) * | 1989-02-16 | 1989-04-05 | Rashid Abdul | Drug dispensing device |
RU2104084C1 (ru) * | 1989-02-16 | 1998-02-10 | Бритиш Технолоджи Груп Лимитед | Капсула дозируемого выброса |
GB9004702D0 (en) * | 1990-03-02 | 1990-04-25 | Polysystems Limited | Dispensing device |
JP2932086B2 (ja) * | 1990-07-05 | 1999-08-09 | 高田製薬株式会社 | 新規なピコスルファートナトリウム液充填硬カプセル剤 |
-
1994
- 1994-09-29 EP EP94930520A patent/EP0724441A1/en not_active Withdrawn
- 1994-09-29 WO PCT/US1994/011063 patent/WO1995011024A1/en not_active Application Discontinuation
- 1994-09-29 JP JP51186495A patent/JP3725542B2/ja not_active Expired - Fee Related
- 1994-09-29 AU AU79610/94A patent/AU7961094A/en not_active Abandoned
-
1995
- 1995-07-06 US US08/498,612 patent/US5631022A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP3725542B2 (ja) | 2005-12-14 |
AU7961094A (en) | 1995-05-08 |
EP0724441A1 (en) | 1996-08-07 |
US5631022A (en) | 1997-05-20 |
WO1995011024A1 (en) | 1995-04-27 |
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