JPH09500087A - カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法 - Google Patents

カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法

Info

Publication number
JPH09500087A
JPH09500087A JP6502621A JP50262194A JPH09500087A JP H09500087 A JPH09500087 A JP H09500087A JP 6502621 A JP6502621 A JP 6502621A JP 50262194 A JP50262194 A JP 50262194A JP H09500087 A JPH09500087 A JP H09500087A
Authority
JP
Japan
Prior art keywords
leu
group
mammal
alkyl
administering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6502621A
Other languages
English (en)
Japanese (ja)
Inventor
エベレス，デイビッド，ディー．，ジュニア
リンチ，ゲリー
シー． パワーズ，ジャームズ
ティー． バータス，レイモンド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia Tech Research Corp
Original Assignee
Georgia Tech Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Research Corp filed Critical Georgia Tech Research Corp
Publication of JPH09500087A publication Critical patent/JPH09500087A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP6502621A 1992-06-24 1993-06-24 カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法 Pending JPH09500087A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US90380092A 1992-06-24 1992-06-24
US07/903,800 1992-06-24
US3499693A 1993-03-16 1993-03-16
US08/034,996 1993-03-16
US7260993A 1993-06-01 1993-06-01
US08/072,609 1993-06-01
PCT/US1993/006143 WO1994000095A2 (en) 1992-06-24 1993-06-24 Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity

Publications (1)

Publication Number Publication Date
JPH09500087A true JPH09500087A (ja) 1997-01-07

Family

ID=27364781

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6502621A Pending JPH09500087A (ja) 1992-06-24 1993-06-24 カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法

Country Status (5)

Country Link
EP (1) EP0650368A1 (de)
JP (1) JPH09500087A (de)
AU (1) AU4544993A (de)
CA (1) CA2138124A1 (de)
WO (1) WO1994000095A2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008538212A (ja) * 2005-03-21 2008-10-16 アプレラ コーポレイション システインプロテアーゼ阻害剤としてのアルファケトアミド化合物
JP2016210716A (ja) * 2015-05-07 2016-12-15 国立大学法人山口大学 ＳＰＣ／Ｆｙｎ／Ｒｈｏキナーゼシグナル伝達経路の阻害剤

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541290A (en) * 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds
US6660268B1 (en) * 1994-03-18 2003-12-09 The President And Fellows Of Harvard College Proteasome regulation of NF-KB activity
WO1996016079A2 (en) * 1994-11-24 1996-05-30 Takeda Chemical Industries, Ltd Alpha-ketoamide derivatives as cathepsin l inhibitor
US5872101A (en) * 1995-01-06 1999-02-16 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5827877A (en) * 1995-09-14 1998-10-27 Cephalon, Inc. Ketomethylene group-containing cysteine and serine protease inhibitors
US5723580A (en) * 1995-09-14 1998-03-03 Cephalon, Inc. Ketomethylene group-containing aldehyde cysteine and serine protease inhibitors
TR199800767T2 (xx) 1995-10-30 1998-07-21 Smithkline Beecham Corporation Proteaz engelleyicileri.
US6586466B2 (en) 1995-10-30 2003-07-01 Smithkline Beecham Corporation Carbohydrazide-protease inhibitors
ES2293651T3 (es) * 1995-11-28 2008-03-16 Cephalon, Inc. Inhibidores de cisteina y serina proteasas derivados de aminoacidos d.
US5834503A (en) * 1996-06-14 1998-11-10 Qlt Phototherapeutics, Inc. Methods to treat arterial plaque
DE19642591A1 (de) * 1996-10-15 1998-04-16 Basf Ag Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
AU4489397A (en) 1996-10-31 1998-05-22 Alcon Laboratories, Inc. The use of calpain inhibitors to treat ocular neural pathology
DE19650975A1 (de) 1996-12-09 1998-06-10 Basf Ag Neue heterocyclisch substituierte Benzamide und deren Anwendung
TR199901305T2 (xx) * 1996-12-11 1999-08-23 Basf Aktiengesellschaft Calpain-�nleyicileri olarak ketonbenzamidler
JP2002161051A (ja) * 1996-12-24 2002-06-04 Fujisawa Pharmaceut Co Ltd 脳虚血性疾患等の治療剤
DE19817459A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue heterozyklische substituierte Amide, Herstellung und Anwendung
DE19818614A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue substituierte Amide, deren Herstellung und Anwendung
AU3819099A (en) 1998-04-20 1999-11-08 Basf Aktiengesellschaft Heterocyclically substituted amides used as calpain inhibitors
ES2220061T3 (es) 1998-04-20 2004-12-01 ABBOTT GMBH & CO. KG Nuevas amidas substituidas, su obtencion y aplicacion.
US6841538B1 (en) 1998-04-22 2005-01-11 Inex Pharmaceuticals Corporation Combination therapy using nucleic acids and radio therapy
WO1999054445A2 (en) * 1998-04-22 1999-10-28 Inex Pharmaceuticals Corporation Combination therapy using nucleic acids and conventional drugs
US6841537B1 (en) 1998-04-22 2005-01-11 Protiva Biotherapeutics Inc. Combination therapy using nucleic acids and conventional drugs
EP1080074B1 (de) * 1998-05-25 2006-11-08 Abbott GmbH & Co. KG Heterocyclische substituierte Amide, deren Herstellung und Verwendung
DE19847422C1 (de) * 1998-10-14 2000-01-13 Forschungszentrum Juelich Gmbh Chinese-Hamster-Ovary-Zellen zur Produktion von Proteinen
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
EP1232155A4 (de) 1999-11-10 2002-11-20 Smithkline Beecham Corp Protease inhibitoren
EP1232154A4 (de) 1999-11-10 2004-06-23 Smithkline Beecham Corp Protease inhibitoren
US6534498B1 (en) 1999-11-10 2003-03-18 Smithkline Beecham Corporation Protease inhibitors
EA005893B1 (ru) 2000-03-21 2005-06-30 Смитклайн Бичам Корпорейшн Ингибиторы протеаз
PL206255B1 (pl) 2000-07-21 2010-07-30 Dendreon Corporationdendreon Corporation Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
EP1303487A4 (de) 2000-07-21 2005-11-23 Schering Corp Neue peptide als ns3-serin protease inhibitoren des hepatitis c virus
GB0106051D0 (en) * 2001-03-12 2001-05-02 Isis Innovation Diagnostic screens for alzheimer's disease
GB0117645D0 (en) * 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
US6610874B2 (en) 2001-09-28 2003-08-26 Pcbu Services, Inc. Processes and compositions for the production of chiral amino-nitriles
JP2005515254A (ja) 2002-01-17 2005-05-26 スミスクライン ビーチャム コーポレーション カテプシンｋ阻害剤として有用なシクロアルキルケトアミド誘導体
DE602004023873D1 (de) 2003-12-12 2009-12-10 Senju Pharma Co Verwendung davon
GB2467562A (en) * 2009-02-06 2010-08-11 Summit Corp Plc Dual calpain-ROS inhibitors
WO2013067415A1 (en) * 2011-11-02 2013-05-10 Tufts University Identification and use of protease inhibitors to treat or prevent sickle cell disease
CN102988336A (zh) * 2012-05-17 2013-03-27 中国人民解放军第二军医大学 Tpck用于制备抗晶状体混浊产品的用途
EA031266B1 (ru) * 2014-09-08 2018-12-28 Ландштейнер Хенмед, С.Л. Дипептидилкетоамидные соединения и их применение для лечения и/или предотвращения накопления жира
EP3426674A4 (de) * 2016-03-09 2019-08-14 Blade Therapeutics, Inc. Cyclische keto-amid-verbindungen als calpain-modulatoren sowie verfahren zur herstellung und verwendung davon
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
WO2018064119A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
JP2021519312A (ja) * 2018-03-28 2021-08-10 ブレード・セラピューティクス・インコーポレイテッド カルパインモジュレーター及びその治療的使用
RU2020130012A (ru) * 2018-03-28 2022-04-29 Блэйд Терапьютикс, Инк. Способ лечения фиброзного заболевания
WO2023165334A1 (zh) * 2022-03-01 2023-09-07 成都威斯克生物医药有限公司 酮酰胺类衍生物及其制药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845242A (en) * 1987-04-28 1989-07-04 Georgia Tech Research Corporation Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
US4771123A (en) * 1986-03-11 1988-09-13 Enzyme Systems Products, Inc. Peptide thioneamides as selective substrates for cysteine proteases
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
JP2701932B2 (ja) * 1989-04-10 1998-01-21 サントリー株式会社 タンパク質分解酵素阻害剤
US5189144A (en) * 1989-04-28 1993-02-23 Takara Shuzo Co., Ltd. Human calpastatin-like polypeptide

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008538212A (ja) * 2005-03-21 2008-10-16 アプレラ コーポレイション システインプロテアーゼ阻害剤としてのアルファケトアミド化合物
JP2012254985A (ja) * 2005-03-21 2012-12-27 Virobay Inc システインプロテアーゼ阻害剤としてのアルファケトアミド化合物
KR101447897B1 (ko) * 2005-03-21 2014-10-07 비로베이, 인코포레이티드 시스테인 단백질분해효소 억제제로서의 알파 케토아미드화합물
JP2016210716A (ja) * 2015-05-07 2016-12-15 国立大学法人山口大学 ＳＰＣ／Ｆｙｎ／Ｒｈｏキナーゼシグナル伝達経路の阻害剤

Also Published As

Publication number Publication date
WO1994000095A3 (en) 1994-03-17
AU4544993A (en) 1994-01-24
WO1994000095A2 (en) 1994-01-06
CA2138124A1 (en) 1994-01-06
EP0650368A1 (de) 1995-05-03

Similar Documents

Publication Publication Date Title
JPH09500087A (ja) カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法
AU667463B2 (en) Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
US5444042A (en) Method of treatment of neurodegeneration with calpain inhibitors
US5610297A (en) Peptides ketoamides
JP4439111B2 (ja) ジペプチドのアポトーシスインヒビターおよびそれらの使用
US5763576A (en) Tetrapeptide α-ketoamides
JP2004531466A (ja) 血管新生を調節するための治療薬およびその使用方法
EP0564561A1 (de) Peptid-ketoamide, -ketosäuren und ketoester
JPS63253061A (ja) チオールプロテアーゼ阻害剤としてのアリールオキシおよびアリールアシルオキシメチルケトン
DE10143840A1 (de) Neue Inhibitoren der Dipeptidylpeptidase I
EP0586537A1 (de) Substituierte n-carboxylalkylpeptidylderivate als antidegenerativ-aktive agentien
JPH08503475A (ja) 抗変性活性剤としてのカルボキシ−ペプチジル誘導体
US6235929B1 (en) Tripeptide α-ketoamides
CZ277998A3 (cs) Inhibitory serinproteázy a farmaceutický prostředek
US5679700A (en) Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents
AU2005214388A1 (en) Propenoyl hydrazides
JPH02256657A (ja) Ｎ―置換アミド
US5846755A (en) Method for determining the therapeutic activity of metalloproteinase inhibitor compounds
WO2004005270A1 (en) Aza-peptide epoxides
US6090785A (en) Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents
JP2003502442A (ja) セリンエラスターゼの活性を阻害する方法及び化合物
JP6326232B2 (ja) 関節症の処置のためのアミノスタチン誘導体
US6593300B1 (en) (3R)-3-amino-4-carboxybutyraldehyde derivatives inhibiting the release of interleukin-1/beta
JP2003342265A (ja) トリアゾリジン誘導体およびその医薬用途
EP0372410A2 (de) Verwendung heterozyklischer Amide zur Verhinderung der Tumormetastasierung