JPH08511236A - 生物学的に活性な因子の毒性を低減させる組成物および方法 - Google Patents
生物学的に活性な因子の毒性を低減させる組成物および方法Info
- Publication number
- JPH08511236A JPH08511236A JP6521360A JP52136094A JPH08511236A JP H08511236 A JPH08511236 A JP H08511236A JP 6521360 A JP6521360 A JP 6521360A JP 52136094 A JP52136094 A JP 52136094A JP H08511236 A JPH08511236 A JP H08511236A
- Authority
- JP
- Japan
- Prior art keywords
- factor
- composition
- biologically active
- csf
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 73
- 239000013543 active substance Substances 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 26
- 231100000419 toxicity Toxicity 0.000 title description 19
- 230000001988 toxicity Effects 0.000 title description 19
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 58
- 241001465754 Metazoa Species 0.000 claims abstract description 47
- 229910052751 metal Inorganic materials 0.000 claims abstract description 36
- 239000002184 metal Substances 0.000 claims abstract description 36
- 231100000331 toxic Toxicity 0.000 claims abstract description 33
- 230000002588 toxic effect Effects 0.000 claims abstract description 33
- 230000000694 effects Effects 0.000 claims abstract description 23
- 241000282414 Homo sapiens Species 0.000 claims abstract description 17
- 241000282412 Homo Species 0.000 claims abstract description 15
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 5
- 201000010099 disease Diseases 0.000 claims abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 4
- 108010002350 Interleukin-2 Proteins 0.000 claims description 34
- 102000000588 Interleukin-2 Human genes 0.000 claims description 34
- 108090001005 Interleukin-6 Proteins 0.000 claims description 23
- 102000004889 Interleukin-6 Human genes 0.000 claims description 23
- 239000002158 endotoxin Substances 0.000 claims description 20
- 150000002739 metals Chemical class 0.000 claims description 20
- 108010002352 Interleukin-1 Proteins 0.000 claims description 15
- 102000000589 Interleukin-1 Human genes 0.000 claims description 15
- 238000011282 treatment Methods 0.000 claims description 15
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims description 13
- 102000004127 Cytokines Human genes 0.000 claims description 11
- 108090000695 Cytokines Proteins 0.000 claims description 11
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 102000009618 Transforming Growth Factors Human genes 0.000 claims description 11
- 108010009583 Transforming Growth Factors Proteins 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 11
- 239000000427 antigen Substances 0.000 claims description 10
- 108091007433 antigens Proteins 0.000 claims description 10
- 102000036639 antigens Human genes 0.000 claims description 10
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 229920006008 lipopolysaccharide Polymers 0.000 claims description 9
- 201000011510 cancer Diseases 0.000 claims description 8
- 239000003102 growth factor Substances 0.000 claims description 8
- 230000028993 immune response Effects 0.000 claims description 7
- 102000003814 Interleukin-10 Human genes 0.000 claims description 6
- 108090000174 Interleukin-10 Proteins 0.000 claims description 6
- 102000013462 Interleukin-12 Human genes 0.000 claims description 6
- 108010065805 Interleukin-12 Proteins 0.000 claims description 6
- 102000003816 Interleukin-13 Human genes 0.000 claims description 6
- 108090000176 Interleukin-13 Proteins 0.000 claims description 6
- 108010002386 Interleukin-3 Proteins 0.000 claims description 6
- 108090000978 Interleukin-4 Proteins 0.000 claims description 6
- 102000004388 Interleukin-4 Human genes 0.000 claims description 6
- 108010002616 Interleukin-5 Proteins 0.000 claims description 6
- 102100037611 Lysophospholipase Human genes 0.000 claims description 6
- 108010058864 Phospholipases A2 Proteins 0.000 claims description 6
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims description 6
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims description 6
- -1 Type II interfero Proteins 0.000 claims description 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 6
- 210000003714 granulocyte Anatomy 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 230000005012 migration Effects 0.000 claims description 6
- 238000013508 migration Methods 0.000 claims description 6
- 102100022987 Angiogenin Human genes 0.000 claims description 5
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 5
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 5
- 102000002227 Interferon Type I Human genes 0.000 claims description 5
- 108010014726 Interferon Type I Proteins 0.000 claims description 5
- 102000008070 Interferon-gamma Human genes 0.000 claims description 5
- 108010074328 Interferon-gamma Proteins 0.000 claims description 5
- 102000003815 Interleukin-11 Human genes 0.000 claims description 5
- 108090000177 Interleukin-11 Proteins 0.000 claims description 5
- 108010002586 Interleukin-7 Proteins 0.000 claims description 5
- 102000000704 Interleukin-7 Human genes 0.000 claims description 5
- 108090001007 Interleukin-8 Proteins 0.000 claims description 5
- 102000004890 Interleukin-8 Human genes 0.000 claims description 5
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 5
- 108010072788 angiogenin Proteins 0.000 claims description 5
- 208000026278 immune system disease Diseases 0.000 claims description 5
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 5
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 4
- 230000002792 vascular Effects 0.000 claims description 4
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 3
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 3
- 102000004083 Lymphotoxin-alpha Human genes 0.000 claims description 3
- 108090000542 Lymphotoxin-alpha Proteins 0.000 claims description 3
- 231100000655 enterotoxin Toxicity 0.000 claims description 3
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 101800003838 Epidermal growth factor Proteins 0.000 claims description 2
- 229940037003 alum Drugs 0.000 claims description 2
- 230000034994 death Effects 0.000 claims description 2
- 229940116977 epidermal growth factor Drugs 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims description 2
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 2
- 238000002255 vaccination Methods 0.000 claims description 2
- 125000000837 carbohydrate group Chemical group 0.000 claims 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
- 230000008472 epithelial growth Effects 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000011574 phosphorus Substances 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
- 102000012570 Fibroblast growth factor 16 Human genes 0.000 claims 1
- 108050002072 Fibroblast growth factor 16 Proteins 0.000 claims 1
- 102000012558 Fibroblast growth factor 20 Human genes 0.000 claims 1
- 108050002085 Fibroblast growth factor 20 Proteins 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 108060003552 hemocyanin Proteins 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000003127 knee Anatomy 0.000 claims 1
- 108700007621 mifamurtide Proteins 0.000 claims 1
- JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 claims 1
- 229960005225 mifamurtide Drugs 0.000 claims 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 claims 1
- 230000008470 skin growth Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 238000002156 mixing Methods 0.000 abstract description 3
- 239000010931 gold Substances 0.000 description 30
- 229910052737 gold Inorganic materials 0.000 description 29
- 241000699670 Mus sp. Species 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- 229960005486 vaccine Drugs 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 241001529936 Murinae Species 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 231100000956 nontoxicity Toxicity 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 238000002965 ELISA Methods 0.000 description 6
- 230000005875 antibody response Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 230000003053 immunization Effects 0.000 description 6
- 210000001744 T-lymphocyte Anatomy 0.000 description 5
- 210000003719 b-lymphocyte Anatomy 0.000 description 5
- 238000002649 immunization Methods 0.000 description 5
- 231100000614 poison Toxicity 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 239000003440 toxic substance Substances 0.000 description 5
- 239000003053 toxin Substances 0.000 description 5
- 231100000765 toxin Toxicity 0.000 description 5
- 108700012359 toxins Proteins 0.000 description 5
- 206010006187 Breast cancer Diseases 0.000 description 4
- 208000026310 Breast neoplasm Diseases 0.000 description 4
- 239000000084 colloidal system Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 229940011871 estrogen Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- 206010006895 Cachexia Diseases 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 150000001720 carbohydrates Chemical group 0.000 description 2
- 230000003915 cell function Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000011461 current therapy Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 229910052738 indium Inorganic materials 0.000 description 2
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229910052707 ruthenium Inorganic materials 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 description 1
- 101150056293 AJUBA gene Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108010071023 Bacterial Outer Membrane Proteins Proteins 0.000 description 1
- 206010048962 Brain oedema Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 241000272194 Ciconiiformes Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 102400001368 Epidermal growth factor Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 101100306202 Escherichia coli (strain K12) rpoB gene Proteins 0.000 description 1
- 229910052688 Gadolinium Inorganic materials 0.000 description 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 description 1
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000019223 Interleukin-1 receptor Human genes 0.000 description 1
- 108050006617 Interleukin-1 receptor Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 108090000143 Mouse Proteins Proteins 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 101100306001 Mus musculus Mst1r gene Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010061921 Psychotic disorder due to a general medical condition Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 206010049771 Shock haemorrhagic Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002253 Tannate Polymers 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 231100000776 exotoxin Toxicity 0.000 description 1
- 239000002095 exotoxin Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
- 229910052733 gallium Inorganic materials 0.000 description 1
- FDWREHZXQUYJFJ-UHFFFAOYSA-M gold monochloride Chemical compound [Cl-].[Au+] FDWREHZXQUYJFJ-UHFFFAOYSA-M 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910052758 niobium Inorganic materials 0.000 description 1
- 239000010955 niobium Substances 0.000 description 1
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- OIPZNTLJVJGRCI-UHFFFAOYSA-M octadecanoyloxyaluminum;dihydrate Chemical compound O.O.CCCCCCCCCCCCCCCCCC(=O)O[Al] OIPZNTLJVJGRCI-UHFFFAOYSA-M 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000010399 physical interaction Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/242—Gold; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.コロイド状金属と免疫学的に毒性のある生物学的に活性な因子との混合物 を含む組成物。 2.コロイド状金属が、コロイド状の金およびコロイド状の銀よりなる群から 選択される請求項1記載の組成物。 3.生物学的に活性な因子が、サイトカイン、成長因子、および感染性生物由 来の糖蛋白質よりなる群から選択される請求項1記載の組成物。 4.免疫学的に毒性のある生物学的に活性な因子が、インターロイキン−2( 「IL−2」)、リピッドA、ホスホリパーゼA2、エンドトキシン、ブドウ球 菌エンテロトキシンB、タイプIインターフェロン、タイプIIインターフェロ ン、腫瘍壊死因子、IL−1、IL−6、IL−8、IL−4、形質転換成長因 子B、リンホトキシン、IL−5、遊走阻止因子、IL−3、顆粒球−マクロフ ァージコロニー刺激因子(「CSF」)、単球−マクロフアージCSF、顆粒球 CSF、IL−7、IL−10、IL−11、IL−12、IL−13、血管上 皮成長因子(「VEGF」)、アンギオゲニン、形質転換成長因子(「TGFα 」)、熱ショック蛋白質、血液型の炭水化物部分、Rh因子、および繊維芽細胞 成長因子よりなる群から選択される請求項1記載の組成物。 5.賦形剤、緩衝剤、抗原安定剤、および安定化したキャリヤーよりなる群か ら選択される薬学的に許容し得る成分を更に含む請求項1記載の組成物。 6.薬学的に許容し得るアジュバントを更に含む請求項1記載の組成物。 7.アジュバントが、フロインド完全アジュバント、リポ多糖、モノホスホリ ルリピッドA、ムラミルジペプチド、リピッドAを含有するリポソーム、ミョウ バン、ムラミルトリペプチドホスファチジルエタノールアミン、キーホールリン ペットヘモシアニン、およびフロインド不完全アジュバントよりなる群から選択 される請求項6記載の組成物。 8.毒性のある生物学的に活性な因子をヒトまたは動物に投与する方法であっ て、コロイド状金属と毒性のある生物学的に活性な因子との混合物を含む有効量 の組成物をヒトまたは動物に投与する工程を含み、これにより生物学的に活性な 因子に起因する有毒な副作用を低減させながら、組成物によって生物学的に活性 な因子に対する免疫学的応答を誘発させる方法。 9.毒性のある生物学的に活性な因子が、インターロイキン−2(「IL−2 」)、リピッドA、ホスホリパーゼA2、エンドトキシン、ブドウ球菌エンテロ トキシンB、タイプIインターフェロン、タイプIIインターフェロン、腫瘍壊 死因子、IL−1、IL−6、IL−8、IL−4、形質転換成長因子B、リン ホトキシン、IL−5、遊走阻止因子、IL−3、顆粒球−マクロファージコロ ニー剌激因子(「CSF」)、単球−マクロファージCSF、顆粒球CSF、I L−7、IL−10、IL−11、IL−12、IL−13、血管上皮成長因子 (「VEGF」)、アンギオゲニン、形質転換成長因子(「TGFα」)、熱シ ョック蛋白質、血液型の炭水化物部分、Rh因子、および繊維芽細胞成長因子よ りなる群から選択される請求項8記載の方法。 10.組成物を静脈内投与する請求項8記載の方法。 11.組成物を筋肉内投与する請求項8記載の方法。 12.組成物を皮下投与する請求項8記載の方法。 13.組成物を1回の投薬で投与する請求項8記載の方法。 14.組成物を多数回の投薬で投与する請求項8記載の方法。 15.コロイド状金属と毒性のある生物学的に活性な因子との免疫学的に有効 な量の混合物を含む組成物を、ヒトまたは動物に投与する工程を含む、疾患に対 してヒトまたは動物にワクチン接種する方法。 16.毒性のある生物学的に活性な因子が、インターロイキン−2(「IL− 2」)、リピッドA、ホスホリパーゼA2、エンドトキシン、ブドウ球菌エンテ ロトキシンB、タイプIインターフェロン、タイプIIインターフェロン、腫瘍 壊死因子、IL−1、IL−6、IL−8、IL−4、形質転換成長因子B、リ ンホトキシン、IL−5、遊走阻止因子、IL−3、顆粒球−マクロファージコ ロニー刺激因子(「CSF」)、単球−マクロファージCSF、顆粒球CSF、 IL−7、IL−10、IL−11、IL−12、IL−13、血管上皮成長因 子(「VEGF」)、アンギオゲニン、形質転換成長因子(「TGFα」)、熱 ショック蛋白質、血液型の炭水化物部分、Rh因子、および繊維芽細胞成長因子 よりなる群から選択される請求項15記載の方法。 17.組成物を1回の投薬で投与する請求項15記載の方法。 18.組成物を多数回の投薬で投与する請求項15記載の方法。 19.コロイド状金属と毒性のある生物学的に活性な因子との混合物を含む治 療的に有効な量の組成物を、ガンまたは免疫疾患のヒトまたは動物に投与する工 程を含む、ガンまたは免疫疾患のヒトまたは動物を処置する方法。 20.毒性のある生物学的に活性な因子が、インターロイキン−2(「IL− 2」)、リピッドA、ホスホリパーゼA2、エンドトキシン、ブドウ球菌エンテ ロトキシンB、タイプIインターフェロン、タイプIIインターフェロン、腫瘍 壊死因子、IL−1、IL−6、IL−8、IL−4、形質転換成長因子B、リ ンホトキシン、IL−5、遊走阻止因子、IL−3、顆粒球−マクロファージコ ロニー刺激因子(「CSF」)、単球−マクロファージCSF、顆粒球CSF、 IL−7、IL−10、IL−11、IL−12、IL−13、血管上皮成長因 子(「VEGF」)、アンギオゲニン、形質転換成長因子(「TGFα」)、熱 ショック蛋白質、血液型の炭水化物部分、Rh因子、および繊維芽細胞成長因子 よりなる群から選択される請求項19記載の方法。 21.組成物を1回の投薬で投与する請求項19記載の方法。 22.組成物を多数回の投薬で投与する請求項19記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3338593A | 1993-03-18 | 1993-03-18 | |
US08/033,385 | 1993-03-18 | ||
PCT/US1994/003177 WO1994021288A1 (en) | 1993-03-18 | 1994-03-18 | Composition and method for reducing toxicity of biologically-active factors |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08511236A true JPH08511236A (ja) | 1996-11-26 |
JP3880063B2 JP3880063B2 (ja) | 2007-02-14 |
Family
ID=21870121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52136094A Expired - Fee Related JP3880063B2 (ja) | 1993-03-18 | 1994-03-18 | 生物学的に活性な因子の毒性を低減させる組成物および方法 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0690722B1 (ja) |
JP (1) | JP3880063B2 (ja) |
AT (1) | ATE270111T1 (ja) |
AU (1) | AU6414994A (ja) |
CA (1) | CA2158475C (ja) |
DE (1) | DE69433870T2 (ja) |
WO (1) | WO1994021288A1 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001522818A (ja) * | 1997-11-10 | 2001-11-20 | サイティミューン サイエンシーズ, インコーポレイテッド | 生物学的に活性な因子の標的化された送達のための組成物および方法 |
JP2002502802A (ja) * | 1997-12-02 | 2002-01-29 | ニューララブ リミテッド | アミロイド形成疾患の予防および処置 |
WO2006013650A1 (ja) * | 2004-08-06 | 2006-02-09 | Tissue Targeting Japan Inc. | 金属コロイド粒子を含有する脳神経細胞内移行用キャリア |
JP2009215319A (ja) * | 2001-04-30 | 2009-09-24 | Cytimmune Sciences Inc | コロイド状金属組成物および方法 |
US7927811B2 (en) | 2003-08-08 | 2011-04-19 | Proteus Sciences Co., Ltd. | Polypeptides having brain-localizing activity and uses thereof |
JP2015517471A (ja) * | 2012-05-10 | 2015-06-22 | マリー ゴールバーン シーオー−オペレイティブ シーオー.リミテッドMurray Goulburn Co−Operative Co.Limited | 癌治療方法 |
US9789168B2 (en) | 2008-05-14 | 2017-10-17 | Agriculture Victoria Services Pty Ltd | Use of angiogenin or angiogenin agonists for treating diseases and disorders |
JP2018530523A (ja) * | 2015-08-13 | 2018-10-18 | ノースイースタン ユニヴァーシティ | がんの放射線療法と免疫療法の組合せのための生体材料 |
JP2020019739A (ja) * | 2018-07-31 | 2020-02-06 | 株式会社東洋厚生製薬所 | ナチュラルキラー細胞活性化剤 |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
AU2003231660B2 (en) * | 1997-11-10 | 2006-05-18 | Cytimmune Sciences, Inc. | Compositions and methods for targeted delivery of factors |
DE69833455T2 (de) * | 1997-11-10 | 2006-10-19 | Cytimmune Sciences, Inc. | Verfahren und zusammensetzungen zur verstärkung der immunantwort und zur in-vitro herstellung von monoklonalen antikörpern (mabs) |
US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
US6407218B1 (en) | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
CA2361377C (en) | 1999-02-05 | 2009-02-03 | Alk-Abello A/S | Novel mucosal delivery system |
FR2792639B1 (fr) | 1999-04-26 | 2003-06-06 | Neovacs | Nouveaux immunogenes anti-vih (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida |
DK2116257T3 (da) | 2000-08-09 | 2013-02-04 | Alk Abello As | Parenterale vaccineformuleringer og anvendelser deraf |
PT1395268E (pt) | 2001-05-25 | 2005-05-31 | Gorm Danscher | Metodo para implantes de metais pesados tais como metais nobres, por exemplo, ouro e metal para uso em implantacao |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
DE10235602B4 (de) * | 2002-08-02 | 2010-01-14 | Universität Duisburg-Essen | Metallcluster-Nanoverbindungen zur Behandlung von Tumorerkrankungen |
EP1635850B1 (en) * | 2003-06-20 | 2008-08-13 | Johnson & Johnson Medical Ltd. | Antimicrobial silver comprising silver |
JP2008504216A (ja) | 2003-12-02 | 2008-02-14 | サイトイミューン サイエンシズ インコーポレイテッド | モノクローナル抗体の生成のための方法および組成物 |
US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
GB0500898D0 (en) * | 2005-01-18 | 2005-02-23 | Smith & Nephew | Gold-protein coagulation |
EP2001482B1 (en) | 2006-03-20 | 2016-08-24 | CASI Pharmaceuticals, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
PL2182983T3 (pl) | 2007-07-27 | 2014-10-31 | Janssen Alzheimer Immunotherap | Leczenie chorób amyloidowych z wykorzystaniem humanizowanych przeciwciał specyficznych względem Abeta |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
EP2219458B1 (en) | 2007-11-08 | 2015-07-15 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3269912A (en) * | 1963-04-08 | 1966-08-30 | Boehringer & Soehne Gmbh | Aluminum oxide depot vaccines |
FR2334366A2 (fr) * | 1975-12-10 | 1977-07-08 | Anvar | Application a titre d'agents antiviraux de composes d'heteropolyanions contenant du tungstene combine a de l'antimoine |
JPS62162963A (ja) * | 1986-01-10 | 1987-07-18 | Sadao Shiosaka | 金属コロイド粒子を担体とする低分子物質に対する特異抗体の作成法 |
EP0269408A3 (en) * | 1986-11-26 | 1989-08-30 | Genentech, Inc. | Tgf-beta in the treatment of inflammatory disorders |
EP0486526B2 (en) * | 1989-08-07 | 2001-03-07 | Peptech Limited | Tumour necrosis factor binding ligands |
-
1994
- 1994-03-18 AU AU64149/94A patent/AU6414994A/en not_active Abandoned
- 1994-03-18 JP JP52136094A patent/JP3880063B2/ja not_active Expired - Fee Related
- 1994-03-18 DE DE69433870T patent/DE69433870T2/de not_active Expired - Lifetime
- 1994-03-18 CA CA002158475A patent/CA2158475C/en not_active Expired - Fee Related
- 1994-03-18 AT AT94911691T patent/ATE270111T1/de active
- 1994-03-18 WO PCT/US1994/003177 patent/WO1994021288A1/en active IP Right Grant
- 1994-03-18 EP EP94911691A patent/EP0690722B1/en not_active Expired - Lifetime
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001522818A (ja) * | 1997-11-10 | 2001-11-20 | サイティミューン サイエンシーズ, インコーポレイテッド | 生物学的に活性な因子の標的化された送達のための組成物および方法 |
JP4677333B2 (ja) * | 1997-12-02 | 2011-04-27 | ヤンセン アルツハイマー イミュノセラピー | アミロイド形成疾患の予防および治療剤 |
JP2006131639A (ja) * | 1997-12-02 | 2006-05-25 | Neuralab Ltd | アミロイド形成疾患の予防および治療剤 |
JP2002502802A (ja) * | 1997-12-02 | 2002-01-29 | ニューララブ リミテッド | アミロイド形成疾患の予防および処置 |
JP2009215319A (ja) * | 2001-04-30 | 2009-09-24 | Cytimmune Sciences Inc | コロイド状金属組成物および方法 |
US7927811B2 (en) | 2003-08-08 | 2011-04-19 | Proteus Sciences Co., Ltd. | Polypeptides having brain-localizing activity and uses thereof |
WO2006013650A1 (ja) * | 2004-08-06 | 2006-02-09 | Tissue Targeting Japan Inc. | 金属コロイド粒子を含有する脳神経細胞内移行用キャリア |
US9789168B2 (en) | 2008-05-14 | 2017-10-17 | Agriculture Victoria Services Pty Ltd | Use of angiogenin or angiogenin agonists for treating diseases and disorders |
US10456453B2 (en) | 2008-05-14 | 2019-10-29 | Agriculture Victoria Services Pty Ltd | Use of angiogenin or angiogenin agonists for treating diseases and disorders |
JP2015517471A (ja) * | 2012-05-10 | 2015-06-22 | マリー ゴールバーン シーオー−オペレイティブ シーオー.リミテッドMurray Goulburn Co−Operative Co.Limited | 癌治療方法 |
US9839676B2 (en) | 2012-05-10 | 2017-12-12 | Murray Goulburn Co-Operative Co., Limited | Methods of treating cancer using angiogenin or an angiogenin agonist |
JP2018100288A (ja) * | 2012-05-10 | 2018-06-28 | マリー ゴールバーン シーオー−オペレイティブ シーオー.リミテッドMurray Goulburn Co−Operative Co.Limited | 癌治療方法 |
JP2018530523A (ja) * | 2015-08-13 | 2018-10-18 | ノースイースタン ユニヴァーシティ | がんの放射線療法と免疫療法の組合せのための生体材料 |
JP2020019739A (ja) * | 2018-07-31 | 2020-02-06 | 株式会社東洋厚生製薬所 | ナチュラルキラー細胞活性化剤 |
Also Published As
Publication number | Publication date |
---|---|
EP0690722A1 (en) | 1996-01-10 |
WO1994021288A1 (en) | 1994-09-29 |
EP0690722A4 (en) | 1997-08-06 |
CA2158475A1 (en) | 1994-09-29 |
DE69433870D1 (de) | 2004-08-05 |
AU6414994A (en) | 1994-10-11 |
ATE270111T1 (de) | 2004-07-15 |
EP0690722B1 (en) | 2004-06-30 |
DE69433870T2 (de) | 2005-06-30 |
JP3880063B2 (ja) | 2007-02-14 |
CA2158475C (en) | 2009-06-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH08511236A (ja) | 生物学的に活性な因子の毒性を低減させる組成物および方法 | |
US6274552B1 (en) | Composition and method for delivery of biologically-active factors | |
DE69518919T2 (de) | Autoantikörper enthaltende zusammensetzung für tumorbehandlung und -vorbeugung | |
Chused et al. | Enhanced antibody response of mice to polyinosinic polycytidylic acid by antithymocyte serum and its age-dependent loss in NZB/W mice | |
Jurin et al. | Antitumorous and immunomodulatory effects of the Viscum album L. preparation Isorel | |
HRP950052A2 (en) | Use of anti-tnf antibodies as drugs in treating diseases involving elevated interleukin-6 serum levels | |
US20090035265A1 (en) | Compositions and Methods for Targeted Delivery of Factors | |
TW576838B (en) | Glutathione derivatives and application form thereof | |
US8137989B2 (en) | Method for delivering a cytokine using a colloidal metal | |
JP2001511121A (ja) | コポリマー1の摂取又は吸入を通じての多発性硬化症の治療 | |
JPS5920229A (ja) | 強化されたオプソニン活性を有する組成物 | |
JP2002500638A (ja) | ワクチンアジュバントとしての神経成長因子 | |
JP6073239B2 (ja) | 抗原隠蔽剤としての使用のための、ヒトラクトフェリン誘導ペプチド | |
Chan et al. | Inhibition of gallium-67 uptake in melanoma by an anti-human transferrin receptor monoclonal antibody | |
Feldmesser et al. | Effect of antibody to capsular polysaccharide on eosinophilic pneumonia in murine infection with Cryptococcus neoformans | |
JP5175020B2 (ja) | コロイド状金属組成物および方法 | |
DE69833455T2 (de) | Verfahren und zusammensetzungen zur verstärkung der immunantwort und zur in-vitro herstellung von monoklonalen antikörpern (mabs) | |
EP0214265A1 (en) | Antigens, antibodies and their uses | |
KR102373965B1 (ko) | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질을 포함하는 방사선 치료 증진용 약학적 조성물 | |
WO2021095599A1 (ja) | Pd-1シグナル阻害剤の併用療法 | |
DE69622140T2 (de) | Verfahren zur Steigerung und Modifizierung von Immunantworten | |
Doran et al. | Natural and artificial lipoproteins modulate lipopolysaccharide-induced tumour necrosis factor production in vitro and in vivo | |
Wimer | PHA for aplastic anemias: the alpha but not the omega of mitogen therapies | |
Wilson et al. | Immunosuppressive properties of antilymphocyte antibody isolated from a specific immunoadsorbent | |
RU2531049C2 (ru) | Лекарственное средство для лечения заболеваний предстательной железы и способ лечения заболеваний предстательной железы |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050906 |
|
A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20051206 |
|
A072 | Dismissal of procedure [no reply to invitation to correct request for examination] |
Free format text: JAPANESE INTERMEDIATE CODE: A072 Effective date: 20060711 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060725 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060823 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20061010 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20061107 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20091117 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101117 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111117 Year of fee payment: 5 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121117 Year of fee payment: 6 |
|
LAPS | Cancellation because of no payment of annual fees |