JPH08507921A - 癌ワクチンの調製方法 - Google Patents
癌ワクチンの調製方法Info
- Publication number
- JPH08507921A JPH08507921A JP6520658A JP52065894A JPH08507921A JP H08507921 A JPH08507921 A JP H08507921A JP 6520658 A JP6520658 A JP 6520658A JP 52065894 A JP52065894 A JP 52065894A JP H08507921 A JPH08507921 A JP H08507921A
- Authority
- JP
- Japan
- Prior art keywords
- dna
- cells
- adenovirus
- complex
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10361—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0055693A AT399656B (de) | 1993-03-19 | 1993-03-19 | Verfahren zur herstellung von krebsvakzinen |
| DE4326821.8 | 1993-08-10 | ||
| DE556/93 | 1993-08-10 | ||
| DE4326821A DE4326821A1 (de) | 1993-08-10 | 1993-08-10 | Verfahren zur Herstellung von Krebsvakzinen |
| PCT/EP1994/000859 WO1994021808A1 (de) | 1993-03-19 | 1994-03-18 | Verfahren zur herstellung von krebsvakzinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH08507921A true JPH08507921A (ja) | 1996-08-27 |
Family
ID=25593140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6520658A Pending JPH08507921A (ja) | 1993-03-19 | 1994-03-18 | 癌ワクチンの調製方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0689604A1 (fi) |
| JP (1) | JPH08507921A (fi) |
| KR (1) | KR960701211A (fi) |
| CN (1) | CN1119459A (fi) |
| AU (1) | AU6427994A (fi) |
| CA (1) | CA2158655A1 (fi) |
| CZ (1) | CZ241795A3 (fi) |
| FI (1) | FI954383A0 (fi) |
| HU (1) | HUT73383A (fi) |
| NO (1) | NO953684L (fi) |
| NZ (1) | NZ263550A (fi) |
| PL (1) | PL311036A1 (fi) |
| WO (1) | WO1994021808A1 (fi) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515052A (ja) * | 1997-08-13 | 2001-09-18 | ザ ユーエイビー リサーチ ファンデーション | 遺伝子ベクターの局所施用によるワクチン接種 |
| JP2006514653A (ja) * | 2002-12-20 | 2006-05-11 | セル ジェネシス，インコーポレーテッド | 細胞製品の凍結保護の改善をもたらす直接注射可能な製剤 |
| JP2011001378A (ja) * | 1998-02-20 | 2011-01-06 | Univ Of Miami | 改変型熱ショックタンパク質−抗原性ペプチド複合体 |
| JP2021507718A (ja) * | 2017-12-29 | 2021-02-25 | ジーンメディスン・カンパニー・リミテッド | 遺伝子伝達用細胞シート |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093700A (en) | 1995-05-11 | 2000-07-25 | Thomas Jefferson University | Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF |
| DE69535288T2 (de) * | 1994-05-13 | 2007-04-05 | Thomas Jefferson University | Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren |
| DE4426429A1 (de) * | 1994-07-26 | 1996-02-01 | Boehringer Ingelheim Int | Verfahren zum Einführen von DNA in höhere eukaryotische Zellen |
| DE19510344C1 (de) * | 1995-03-22 | 1996-11-07 | Boehringer Ingelheim Int | Verwendung einer Tumorvakzine |
| AU6282896A (en) * | 1995-06-19 | 1997-01-15 | University Of Medicine And Dentistry Of New Jersey | Gene therapy of solid tumors with interferons alone or with other immuno-effector proteins |
| US7001765B2 (en) | 1996-03-06 | 2006-02-21 | Medigene Ag | Adeno-associated virus vector for boosting immunogenicity of cells |
| DE19608753C1 (de) * | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
| DE19608751B4 (de) | 1996-03-06 | 2006-05-18 | Medigene Ag | Verwendung eines Adeno-assoziierten Virus-Vektors zur Steigerung der Immunogenität von Zellen |
| DE19631357A1 (de) * | 1996-08-02 | 1998-02-05 | Deutsches Krebsforsch | Vektor zur Aktivierung des Immunsystems gegen mit Papillomviren bzw. Sequenzen davon assoziierten Zellen |
| CA2299429C (en) | 1997-08-13 | 2010-04-20 | Biontex Laboratories Gmbh | New lipopolyamines,their preparation and the use thereof |
| US7348015B2 (en) | 1998-01-14 | 2008-03-25 | Morphogenesis, Inc. | Antigen modified cancer cell vaccines for cancer therapy |
| US7795020B2 (en) | 1998-01-14 | 2010-09-14 | Morphogenesis, Inc. | Tumor cell vaccines |
| WO1999036433A2 (en) | 1998-01-14 | 1999-07-22 | Morphogenesis, Inc. | Materials and methods for treating oncological disease |
| CN100425287C (zh) * | 1999-02-09 | 2008-10-15 | 理化学研究所 | 肿瘤疫苗 |
| BR0001029A (pt) * | 2000-04-10 | 2001-11-20 | Fk Biotecnologia Ltda | Processo de transformação de células tumorais |
| AUPQ755300A0 (en) | 2000-05-17 | 2000-06-08 | Monash University | Immune potentiating compositions |
| DE10131148A1 (de) * | 2001-06-28 | 2003-01-16 | I P L Internat Pharmaceutics L | Xenogene Oligo- oder/und Polyribonukleotide als Mittel zur Behandlung von malignen Tumoren |
| AU2009223838B2 (en) | 2008-03-03 | 2012-07-26 | The University Of Miami | Allogeneic cancer cell-based immunotherapy |
| CA2718884C (en) | 2008-03-20 | 2016-11-22 | University Of Miami | Heat shock protein gp96 vaccination and methods of using same |
| NZ611361A (en) * | 2010-12-02 | 2014-10-31 | Oncotherapy Science Inc | Tomm34 peptides and vaccines including the same |
| AU2016215175B2 (en) | 2015-02-06 | 2021-09-16 | Heat Biologics, Inc. | Vector co-expressing vaccine and costimulatory molecules |
| US11273170B2 (en) * | 2016-07-25 | 2022-03-15 | Ascend Biopharmaceuticals Ltd | Methods of treating cancer |
| US11666649B2 (en) | 2016-10-11 | 2023-06-06 | University Of Miami | Vectors and vaccine cells for immunity against Zika virus |
| CA3058938A1 (en) | 2017-04-04 | 2018-10-11 | Heat Biologics, Inc. | Intratumoral vaccination |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
-
1994
- 1994-03-18 EP EP94911921A patent/EP0689604A1/de not_active Withdrawn
- 1994-03-18 CZ CZ952417A patent/CZ241795A3/cs unknown
- 1994-03-18 PL PL94311036A patent/PL311036A1/xx unknown
- 1994-03-18 WO PCT/EP1994/000859 patent/WO1994021808A1/de not_active Application Discontinuation
- 1994-03-18 NZ NZ263550A patent/NZ263550A/en unknown
- 1994-03-18 HU HU9502720A patent/HUT73383A/hu unknown
- 1994-03-18 AU AU64279/94A patent/AU6427994A/en not_active Abandoned
- 1994-03-18 JP JP6520658A patent/JPH08507921A/ja active Pending
- 1994-03-18 CA CA002158655A patent/CA2158655A1/en not_active Abandoned
- 1994-03-18 CN CN94191520A patent/CN1119459A/zh active Pending
-
1995
- 1995-08-28 KR KR1019950703645A patent/KR960701211A/ko not_active Application Discontinuation
- 1995-09-18 NO NO953684A patent/NO953684L/no unknown
- 1995-09-18 FI FI954383A patent/FI954383A0/fi unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515052A (ja) * | 1997-08-13 | 2001-09-18 | ザ ユーエイビー リサーチ ファンデーション | 遺伝子ベクターの局所施用によるワクチン接種 |
| JP2011001378A (ja) * | 1998-02-20 | 2011-01-06 | Univ Of Miami | 改変型熱ショックタンパク質−抗原性ペプチド複合体 |
| JP2006514653A (ja) * | 2002-12-20 | 2006-05-11 | セル ジェネシス，インコーポレーテッド | 細胞製品の凍結保護の改善をもたらす直接注射可能な製剤 |
| US9433204B2 (en) | 2002-12-20 | 2016-09-06 | Aduro Gvax Inc. | Directly injectable formulations which provide enhanced cryoprotection of cell products |
| US9848598B2 (en) | 2002-12-20 | 2017-12-26 | Aduro Gvax Inc. | Cryoprotected, frozen recombinant cancer cells |
| JP2021507718A (ja) * | 2017-12-29 | 2021-02-25 | ジーンメディスン・カンパニー・リミテッド | 遺伝子伝達用細胞シート |
| JP2022095954A (ja) * | 2017-12-29 | 2022-06-28 | ジーンメディスン・カンパニー・リミテッド | 遺伝子伝達用細胞シート |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0689604A1 (de) | 1996-01-03 |
| NZ263550A (en) | 1996-12-20 |
| NO953684D0 (no) | 1995-09-18 |
| HUT73383A (en) | 1996-07-29 |
| CN1119459A (zh) | 1996-03-27 |
| FI954383A (fi) | 1995-09-18 |
| PL311036A1 (en) | 1996-01-22 |
| NO953684L (no) | 1995-09-18 |
| HU9502720D0 (en) | 1995-11-28 |
| CA2158655A1 (en) | 1994-09-29 |
| CZ241795A3 (en) | 1996-04-17 |
| WO1994021808A1 (de) | 1994-09-29 |
| AU6427994A (en) | 1994-10-11 |
| FI954383A0 (fi) | 1995-09-18 |
| KR960701211A (ko) | 1996-02-24 |
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