JPH08507773A - 病的に高い眼圧の処置のための置換硝酸アルキルの使用 - Google Patents

病的に高い眼圧の処置のための置換硝酸アルキルの使用

Info

Publication number
JPH08507773A
JPH08507773A JP6520615A JP52061594A JPH08507773A JP H08507773 A JPH08507773 A JP H08507773A JP 6520615 A JP6520615 A JP 6520615A JP 52061594 A JP52061594 A JP 52061594A JP H08507773 A JPH08507773 A JP H08507773A
Authority
JP
Japan
Prior art keywords
group
nitrate
substituted
dinitrate
ethanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6520615A
Other languages
English (en)
Japanese (ja)
Inventor
ヤン ブロン，
ゲールト ヤン シュテルク，
ヘンドリック ティンマーマン，
デア ヴェルフ， ヤン フェッツェ ファン
Original Assignee
ビイク ネダーラント ベスローテン フェンノートシャップ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ビイク ネダーラント ベスローテン フェンノートシャップ filed Critical ビイク ネダーラント ベスローテン フェンノートシャップ
Publication of JPH08507773A publication Critical patent/JPH08507773A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/41—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/16—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP6520615A 1993-03-15 1994-03-12 病的に高い眼圧の処置のための置換硝酸アルキルの使用 Pending JPH08507773A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH76693 1993-03-15
CH766/93-9 1993-03-15
PCT/EP1994/000773 WO1994021248A1 (de) 1993-03-15 1994-03-12 Verwendung von substituierten alkylnitraten zur behandlung des krankhaft erhöhten augeninnendruckes

Publications (1)

Publication Number Publication Date
JPH08507773A true JPH08507773A (ja) 1996-08-20

Family

ID=4194683

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6520615A Pending JPH08507773A (ja) 1993-03-15 1994-03-12 病的に高い眼圧の処置のための置換硝酸アルキルの使用

Country Status (9)

Country Link
EP (1) EP0689435A1 (no)
JP (1) JPH08507773A (no)
KR (1) KR960700702A (no)
AU (1) AU6376894A (no)
CA (1) CA2158368A1 (no)
FI (1) FI954367A (no)
HU (1) HUT72416A (no)
NO (1) NO953620L (no)
WO (1) WO1994021248A1 (no)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001520670A (ja) * 1997-03-26 2001-10-30 イッサム・リサーチ・アンド・ディベロープメント・カンパニー・リミテッド・オブ・ザ・ヘブルー・ユニヴァーシティ・オブ・エルサレム 芳香族及び複素環の硝酸誘導体
JP2011500519A (ja) * 2007-10-12 2011-01-06 ロンザ リミテッド 有機ニトラートの調製のための方法
JP2015536310A (ja) * 2012-10-23 2015-12-21 ニコックス サイエンス アイルランド 眼科用のキノン系一酸化窒素供与化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US6056966A (en) * 1998-05-18 2000-05-02 Baker Norton Pharmaceuticals, Inc. Method and compositions for treating impotence
CA2611140C (en) * 2005-06-09 2013-11-19 University Of Manitoba Compositions and methods for enhancing nitric oxide delivery
CA2692805A1 (en) 2007-07-09 2009-01-15 Nicox S.A. Use of nitric oxide releasing compounds in the treatment of chronic pain

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5481222A (en) * 1977-12-09 1979-06-28 Chugai Pharmaceut Co Ltd Aminoethanol nitrate ester derivative
JPS60149521A (ja) * 1984-01-18 1985-08-07 Eisai Co Ltd 高眼圧・緑内障治療・予防用点眼剤
JPS6115847A (ja) * 1984-07-03 1986-01-23 Kowa Co 硝酸エステル化方法
AU3693789A (en) * 1988-05-10 1989-11-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) New ophthalmic preparation for treating glaucoma
NL8802276A (nl) * 1988-09-15 1990-04-02 Cedona Pharm Bv Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat.
JPH02167279A (ja) * 1988-09-30 1990-06-27 Taisho Pharmaceut Co Ltd アポビンカミン酸誘導体
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
US5298516A (en) * 1991-03-27 1994-03-29 Sankyo Company, Limited Thiazolidone compounds and method of using the same as a vasodilator

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001520670A (ja) * 1997-03-26 2001-10-30 イッサム・リサーチ・アンド・ディベロープメント・カンパニー・リミテッド・オブ・ザ・ヘブルー・ユニヴァーシティ・オブ・エルサレム 芳香族及び複素環の硝酸誘導体
JP2011500519A (ja) * 2007-10-12 2011-01-06 ロンザ リミテッド 有機ニトラートの調製のための方法
JP2015536310A (ja) * 2012-10-23 2015-12-21 ニコックス サイエンス アイルランド 眼科用のキノン系一酸化窒素供与化合物

Also Published As

Publication number Publication date
WO1994021248A1 (de) 1994-09-29
NO953620D0 (no) 1995-09-14
HUT72416A (en) 1996-04-29
CA2158368A1 (en) 1994-09-29
EP0689435A1 (de) 1996-01-03
NO953620L (no) 1995-09-14
FI954367A0 (fi) 1995-09-15
FI954367A (fi) 1995-11-03
HU9502623D0 (en) 1995-11-28
AU6376894A (en) 1994-10-11
KR960700702A (ko) 1996-02-24

Similar Documents

Publication Publication Date Title
JPS6284054A (ja) 新規のスルホニル―フェニルアルキルアミン、及びこれを含有する、高められた血小板凝集又は腎臓機能の病理学的変化に基づく疾病の治療剤
CS240998B2 (en) Production method of 1,4-dihydropiridines
CA2437113A1 (en) N-phenpropylcyclopentyl-substituted glutaramide derivatives as nep inhibitors for fsad
JPH09501670A (ja) フィブリノーゲンを下げる作用を有する医薬剤としてのフェノール及びフェノール誘導体の使用
CA2157412A1 (en) Balanoids
JP2018529690A (ja) アルキニルピリジンプロリルヒドロキシラーゼ阻害剤、及びその製造法及び医薬用途
JPH08507773A (ja) 病的に高い眼圧の処置のための置換硝酸アルキルの使用
JPH02134316A (ja) 活性物質としてナイトレートエステルを含有し弛緩活性を有する医薬組成物
JPH05509094A (ja) 新規１，４―ジヒドロピリジン誘導体
TWI303628B (en) 5-amidino-2-hydroxybenienesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation
AU725042B2 (en) 3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives
JPS58154538A (ja) アルキルアミノアルコ−ル誘導体、その製造法、並びに該誘導体を有効成分とする新規薬剤
DE68907095T2 (de) Verbindungen zur Verhinderung der Biosynthese von der Lipoxygenase abgeleiteten Metaboliten der Arachidonsäure.
KR0150634B1 (ko) 5-치환된 오르니틴 유도체 및 이를 함유하는 약제학적 조성물
US4870091A (en) 1,4-dihydropyridine compounds
AU768217B2 (en) 2-methylpropionic acid derivatives and medicinal compositions containing the same
JP7380555B2 (ja) 重合性化合物の製造方法
Zhao et al. Facile syntheses of (2R, 3R)-(−)-and (2S, 3S)-(+)-chicoric acids
US5804603A (en) Synthesized β-adrenergic blockers derivatives of guaiacol
JPS62286949A (ja) フエニルメチルベンゾキノン誘導体
US4333930A (en) Orthoarylideneaminophenethylamines and pharmaceutical compositions
JPH0225441A (ja) 弗素化ビスアリールオキシ置換アルケン及びその製造法
JP2009519206A (ja) Ｎ−（３，５−ジクロロピリジン−４−イル）−４−ジフルオロメトキシ−８−メタンスルホンアミド−ジベンゾ［ｂ，ｄ］フラン−１−カルボキサミドの製造法
RU2060252C1 (ru) ПРОИЗВОДНЫЕ N-(2,4- ИЛИ 2,5-ДИЗАМЕЩЕННОГО ТЕТРАГИДРОФУРИЛАЛКИЛ)-N-(ФЕНИЛЭТИЛ- β -ОЛ)АМИНА В РАЦЕМИЧЕСКОЙ ИЛИ ЭНАНТИОМЕРНОЙ ФОРМЕ, ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМАЯ СОЛЬ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
CA1136146A (en) Chlorobenzyl phenoxy alkoxylic compounds