NO953620L - Anvendelse av substituerte alkylnitrater ved behandling av sykelig öket trykk i det indre öye - Google Patents
Anvendelse av substituerte alkylnitrater ved behandling av sykelig öket trykk i det indre öyeInfo
- Publication number
- NO953620L NO953620L NO953620A NO953620A NO953620L NO 953620 L NO953620 L NO 953620L NO 953620 A NO953620 A NO 953620A NO 953620 A NO953620 A NO 953620A NO 953620 L NO953620 L NO 953620L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- alkyl
- residue
- halo
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/41—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/16—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anvendelse av forbindelser med formel (R1R2)CHON02/ hvor RI er H, l-4C-alkyl, -CH2-R8 eller -CH2OCH2R8, eller sammen med R2 samt CH-gruppen, som er bundet til RI og R2, en med en OH-gruppe eller en nitryloksygruppe substituert cykloheksyl- eller bicyklo[4.4.0]decylrest eller en i 8-stilling med resten R3-0- substituert 2,6- dioksabicyklo-[3.3.0]okt-4-yl-rest; R2 er rettkjedet eller forgrenet l-12C-alkyl substituert NH2/ R3, R3-0, R4, R4-0, R4-S, R4-NH, R4-CO-0, R4-CO-NH, R5 eller R6, eller er substituert med R3 og R5, eller med R4-0 og R5, eller R4.og R5, eller R2 er 2-7C-alkyl som ev. er substituert med R3, eller betyr R3 eller 3-7C-cykloalk- yl som ev. er substituert med R4 og R5, eller betyr en dibenzo-5-7C-cykloalkanylrest, eller sammen med RI samt CH-gruppen, er bundet til RI og R2, en med en nitryl- oksygruppe substituert cykloheksyl- eller bicyklo[4.4.- 0]decylrest eller en i B-stilling med resten R3-0- substituert 2,6-dioksabicyklo[3.3.0]okt-4-yl-rest; R3 er en med R7 og R8 substituert metylrest [CH(R7)R8]; R4 er fenyl, l-4C-alkyl, 3-7C-cykloalkyl, fenyl substi- tuert med en, to eller tre like eller forskjellige substituenter fra gruppen l-4C-alkyl, l-4C-alkoksy, nitro, halo, nitryloksy-l-4C-alkyl, hydroksy og karb- oksy, naftyl eller tienyl som ev. er substituert med halo; R5 betyr nitryloksy-l-4C-alkyl, hydroksy-l-4C- alkyl eller nitryloksy; R6 betyr nitryloksy-l-4C-alkyl- tetrametylfenyl, dibenzo-5-7C-cykloalkanyl, dibenzo- cykloheptenyl, ev. med halo substituert tioxantenyl ev. i benzodelen med nitro substituert benzo-5-7C-cyklo- alkanyl eller benzyloksy; R7 betyr fenyl, fenyl substi- tuert med en eller to l-4C-alkyl, l-4C-alkoksy, nitro og halo, pyridyl eller tienyl ev. substituert med halo; og R8 er fenyl ev. substituert med l-4C-alkyl, 1-4C- alkoksy, nitro eller halo, og deres farmakologisk akseptable salter for fremstilling av legemidler for behandling av sykelig øket trykk i det indre øye.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH76693 | 1993-03-15 | ||
PCT/EP1994/000773 WO1994021248A1 (de) | 1993-03-15 | 1994-03-12 | Verwendung von substituierten alkylnitraten zur behandlung des krankhaft erhöhten augeninnendruckes |
Publications (2)
Publication Number | Publication Date |
---|---|
NO953620L true NO953620L (no) | 1995-09-14 |
NO953620D0 NO953620D0 (no) | 1995-09-14 |
Family
ID=4194683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO953620A NO953620D0 (no) | 1993-03-15 | 1995-09-14 | Anvendelse av substituerte alkylnitrater ved behandling av sykelig öket trykk i det indre öye |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0689435A1 (no) |
JP (1) | JPH08507773A (no) |
KR (1) | KR960700702A (no) |
AU (1) | AU6376894A (no) |
CA (1) | CA2158368A1 (no) |
FI (1) | FI954367A (no) |
HU (1) | HUT72416A (no) |
NO (1) | NO953620D0 (no) |
WO (1) | WO1994021248A1 (no) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807847A (en) * | 1996-06-04 | 1998-09-15 | Queen's University At Kingston | Nitrate esters |
US6310052B1 (en) | 1996-06-04 | 2001-10-30 | Queen's University At Kingston | Nitrate esters and their use for neurological conditions |
IL120531A (en) * | 1997-03-26 | 2006-12-31 | Yissum Res Dev Co | Nitric oxide donors and pharmaceutical compositions containing them |
US6056966A (en) * | 1998-05-18 | 2000-05-02 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for treating impotence |
CA2611140C (en) * | 2005-06-09 | 2013-11-19 | University Of Manitoba | Compositions and methods for enhancing nitric oxide delivery |
WO2009007230A1 (en) | 2007-07-09 | 2009-01-15 | Nicox S.A. | Use of nitric oxide releasing compounds in the treatment of chronic pain |
EP2048129A1 (en) * | 2007-10-12 | 2009-04-15 | Lonza Ag | Method for the preparation of organic nitrates |
CN104994845B (zh) * | 2012-10-23 | 2017-11-17 | 尼科斯科学爱尔兰公司 | 用于眼科应用的醌基一氧化氮供体化合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5481222A (en) * | 1977-12-09 | 1979-06-28 | Chugai Pharmaceut Co Ltd | Aminoethanol nitrate ester derivative |
JPS60149521A (ja) * | 1984-01-18 | 1985-08-07 | Eisai Co Ltd | 高眼圧・緑内障治療・予防用点眼剤 |
JPS6115847A (ja) * | 1984-07-03 | 1986-01-23 | Kowa Co | 硝酸エステル化方法 |
WO1989010757A1 (en) * | 1988-05-10 | 1989-11-16 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis | New ophthalmic preparation for treating glaucoma |
NL8802276A (nl) * | 1988-09-15 | 1990-04-02 | Cedona Pharm Bv | Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat. |
JPH02167279A (ja) * | 1988-09-30 | 1990-06-27 | Taisho Pharmaceut Co Ltd | アポビンカミン酸誘導体 |
NL9001955A (nl) * | 1990-09-05 | 1992-04-01 | Cedona Pharm Bv | Nieuwe thiazolidinederivaten. |
AU647599B2 (en) * | 1991-03-27 | 1994-03-24 | Sankyo Company Limited | New thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators |
-
1994
- 1994-03-12 CA CA002158368A patent/CA2158368A1/en not_active Abandoned
- 1994-03-12 KR KR1019950703890A patent/KR960700702A/ko not_active Application Discontinuation
- 1994-03-12 AU AU63768/94A patent/AU6376894A/en not_active Abandoned
- 1994-03-12 HU HU9502623A patent/HUT72416A/hu unknown
- 1994-03-12 JP JP6520615A patent/JPH08507773A/ja active Pending
- 1994-03-12 EP EP94911162A patent/EP0689435A1/de not_active Withdrawn
- 1994-03-12 WO PCT/EP1994/000773 patent/WO1994021248A1/de not_active Application Discontinuation
-
1995
- 1995-09-14 NO NO953620A patent/NO953620D0/no unknown
- 1995-09-15 FI FI954367A patent/FI954367A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1994021248A1 (de) | 1994-09-29 |
AU6376894A (en) | 1994-10-11 |
CA2158368A1 (en) | 1994-09-29 |
KR960700702A (ko) | 1996-02-24 |
FI954367A0 (fi) | 1995-09-15 |
JPH08507773A (ja) | 1996-08-20 |
HU9502623D0 (en) | 1995-11-28 |
FI954367A (fi) | 1995-11-03 |
NO953620D0 (no) | 1995-09-14 |
HUT72416A (en) | 1996-04-29 |
EP0689435A1 (de) | 1996-01-03 |
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