JPH08505861A - 局所用ケトコナゾール組成物 - Google Patents
局所用ケトコナゾール組成物Info
- Publication number
- JPH08505861A JPH08505861A JP6516627A JP51662794A JPH08505861A JP H08505861 A JPH08505861 A JP H08505861A JP 6516627 A JP6516627 A JP 6516627A JP 51662794 A JP51662794 A JP 51662794A JP H08505861 A JPH08505861 A JP H08505861A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- ketoconazole
- amount
- desonide
- acetonide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.有効成分ケトコナゾール、アセトニド型グルココルチコステロイドおよび皮 膚科学的に許容できるキャリアーを含んで成り、pHが2.5より高く、かつ6未 満であることを特徴とする局所用医薬組成物。 2.グルココルチコステロイドがデソニドである請求の範囲第1項記載の組成物 。 3.pHが3から5の間である請求の範囲第1項記載の組成物。 4.水−中−油型乳剤の状態にある請求の範囲第1項記載の組成物。 5.ケトコナゾール対デソニドの量比が5:1−500:1の範囲である請求の範囲第1 項記載の組成物。 6.皮膚科学的キャリアーが水、皮膚科学的に許容できる油および組成物のpH を2.5より高く、かつ6未満に維持するための緩衝液を含んで成る請求の範囲第 1項記載の組成物。 7.皮膚科学的キャリアーが増粘剤、乳化剤、抗−酸化剤および湿潤剤を含んで 成る請求の範囲第1項記載の組成物。 8.約(a)0.5−5%ケトコナゾール、 (b)0.01−0.1%デソニド、 (c)0.5−20%増粘剤、 (d)0.5−10%乳化剤、 (e)0.001−0.1%抗−酸化剤、 (f)0.05−0.5%湿潤剤、 (g)組成物のpHを2.5より高く、かつ6未満に維持する緩衝液、 (h)組成物の劣化を防止するための皮膚科学的に許容できる十分な保存剤、 (i)0.5−50%の皮膚科学的に許容できる油、および (j)水、 を含んで成る請求の範囲第1項記載の組成物。 9.ケトコナゾールの量が1−3%であり、 デソニドの量が0.04−0.06%、 増粘剤の量が5−10%であり、 乳化剤の量が1−5%であり、 抗−酸化剤の量が0.002−0.01%であり、そして 湿潤剤の量が0.05−0.2%である、 請求の範囲第8項記載の組成物。 10.約(a)2%ケトコナゾール、 (b)0.05%デソニド、 (c)4% 1-オクタデカノールおよび4% 1-ヘキサデカノール、 (d)2% Spsn 60(商標)および1.5% Tween 60(商標) (e)0.005%ブチルヒドロキシアニソール、 (f)0.1% Tween 80(商標)、 (g)2.4%クエン酸および2.5%リン酸水素二ナトリウム、 (h)0.2%安息香酸および10% 1,2-プロパンジオール、 (i)1%のパラフィン油、 (j)水、そして (k)0.00005% Allura Red AC を含んで成る請求の範囲第1項記載の組成物。 11.治療に有効量のケトコナゾールおよびアセトニドグルココルチコステロイ ドを皮膚科学的に許容できるキャリアーと親密に混合すること を特徴とする請求の範囲第1ないし第10項のいずれか1項記載の組成物の調製 法。 12.(1)保存剤を水性相の画分と温度50℃から100℃の間、好ましくは70℃ から90℃の間の温度で加熱混合し、 (2)増粘剤、乳化剤、抗−酸化剤および油相を65℃から90℃の間、好ましくは 75℃から80℃の間の温度で加熱混合し、 (3)工程(1)および(2)で調製した相を均質化し、そして50℃未満、好ま しくは40℃未満の温度に冷却し、 (4)湿潤剤、緩衝物質および場合によっては着色剤を残りの水相相に溶解し、 次に有効成分を撹拌しながらそこに懸濁し、 (5)工程(3)および(4)で調製した相を均質化し、そして周辺温度に冷却 する、 ことを特徴とする請求の範囲第11項記載の調製法。 13.請求の範囲第11または12項記載の方法により得ることができる生成物 。 14.アセトニドグルココルチコステロイドの抗−炎症作用を増強させるための 、医薬品製造用ケトコナゾールの使用。 15.ケトコナゾールおよびアセトニドグルココルチコステロイドを抗−炎症お よび/または抗−真菌治療に同時、別個または連続的に使用するための調製物と して含有する生成物。 16.ケトコナゾールを含有する組成物を含む容器およびアセトニドグルココル チコステロイドを含有する組成物を含む別の容器を含んで成るキットから成る請 求の範囲第15項記載の生成物。 17.医薬品として使用する請求の範囲第1ないし10項のいずれか1 項記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93200145.6 | 1993-01-21 | ||
EP93200145 | 1993-01-21 | ||
PCT/EP1994/000092 WO1994016710A1 (en) | 1993-01-21 | 1994-01-12 | Topical ketoconazole compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08505861A true JPH08505861A (ja) | 1996-06-25 |
JP3918119B2 JP3918119B2 (ja) | 2007-05-23 |
Family
ID=8213579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51662794A Expired - Lifetime JP3918119B2 (ja) | 1993-01-21 | 1994-01-12 | 局所用ケトコナゾール組成物 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5654293A (ja) |
EP (1) | EP0680328B1 (ja) |
JP (1) | JP3918119B2 (ja) |
KR (1) | KR100300525B1 (ja) |
CN (1) | CN1096860C (ja) |
AT (1) | ATE146965T1 (ja) |
AU (1) | AU683865B2 (ja) |
CA (1) | CA2153681C (ja) |
CY (1) | CY2106B1 (ja) |
DE (1) | DE69401336T2 (ja) |
DK (1) | DK0680328T3 (ja) |
ES (1) | ES2098921T3 (ja) |
FI (1) | FI114009B (ja) |
GR (1) | GR3022212T3 (ja) |
HK (1) | HK1005999A1 (ja) |
HU (1) | HU221319B1 (ja) |
NZ (1) | NZ259866A (ja) |
RU (1) | RU2126256C1 (ja) |
WO (1) | WO1994016710A1 (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2721212B1 (fr) * | 1994-06-17 | 1996-09-13 | Pf Medicament | Composition et procédé d'obtention d'une émulsion de désonide. |
DE4446891A1 (de) * | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stabile wäßrige Budesonid-Lösung |
FR2747568B1 (fr) * | 1996-04-17 | 1999-09-17 | Oreal | Utilisation d'au moins un inhibiteur de lipoxygenase et d'au moins un inhibiteur de cyclo-oxygenase pour modifier la pousse des poils et/ou des cheveux |
EP0872229A1 (en) | 1997-04-14 | 1998-10-21 | Janssen Pharmaceutica N.V. | Compositions containing an antifungal and a phospholipid |
PT1024814E (pt) | 1997-10-22 | 2007-11-29 | Mayo Foundation | Utilização de agentes antifúngicos para o tratamento tópico de mucosite induzida por fungo |
US7179475B1 (en) | 1998-12-04 | 2007-02-20 | Johnson & Johnson Consumer Companies, Inc. | Anhydrous topical skin preparations |
US6238683B1 (en) | 1998-12-04 | 2001-05-29 | Johnson & Johnson Consumer Companies, Inc. | Anhydrous topical skin preparations |
GB9915625D0 (en) | 1999-07-02 | 1999-09-01 | Cortendo Ab | Method |
SE9902675D0 (sv) * | 1999-07-12 | 1999-07-12 | Astra Ab | Pharmaceutical formulations, doses & regimens |
GB2365770B (en) * | 2000-08-18 | 2002-07-31 | Diomed Dev Ltd | Antifungal ketoconazole composition for topical use |
AU2003301516A1 (en) * | 2002-10-24 | 2004-05-13 | Goldstein, Jay A | Antifungal formulations |
DE102004014617A1 (de) * | 2004-03-22 | 2005-10-13 | Beiersdorf Ag | Kosmetisches Produkt, umfassend eine thixotropiearme Öl-in-Wasser-Emulsion und einen transparenten Behälter |
AU2005244734A1 (en) * | 2004-05-13 | 2005-12-01 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
DE102004032837A1 (de) * | 2004-07-02 | 2006-02-09 | Beiersdorf Ag | Verwendung von Wirkstoffkombinationen aus einem oder mehreren Biochinonen und einem oder mehreren Isoflavonen zur Verbesserung der Hautkonturen |
CN100418530C (zh) * | 2005-04-06 | 2008-09-17 | 河南省眼科研究所 | 一种酮康唑滴眼液及其制造方法 |
FR2915097B1 (fr) * | 2007-04-18 | 2012-09-28 | Fabre Pierre Dermo Cosmetique | Mousse antifongique a base de ciclopiroxolamine et de pyrithione de zinc et ses applications medicales et cosmetiques. |
CN103857440B (zh) | 2011-06-22 | 2018-09-25 | 维奥姆生物科学有限公司 | 基于缀合物的抗真菌和抗细菌前药 |
US9029342B2 (en) | 2012-09-17 | 2015-05-12 | Board Of Regents Of The University Of Texas System | Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof |
EP3003031A1 (en) | 2013-06-04 | 2016-04-13 | Vyome Biosciences Pvt Ltd | Coated particles and compositions comprising same |
BE1022727B1 (nl) * | 2015-04-20 | 2016-08-24 | Stasisport Pharma Nv | Fusidinezuur crème en methode voor het maken hiervan |
CN107260656B (zh) * | 2016-04-08 | 2021-02-09 | 湖北人福成田药业有限公司 | 地奈德乳膏及其制备方法 |
WO2018144841A1 (en) * | 2017-02-03 | 2018-08-09 | Board Of Regents, The University Of Texas System | Topical voriconazole for the treatment of pain |
EP3641725A1 (en) | 2017-06-23 | 2020-04-29 | The Procter and Gamble Company | Composition and method for improving the appearance of skin |
WO2020010036A1 (en) | 2018-07-03 | 2020-01-09 | The Procter & Gamble Company | Method of treating a skin condition |
US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
WO2021247496A1 (en) | 2020-06-01 | 2021-12-09 | The Procter & Gamble Company | Method of improving penetration of a vitamin b3 compound into skin |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4883792A (en) * | 1989-01-17 | 1989-11-28 | Peter Timmins | Steroid cream formulation |
AU1779192A (en) * | 1991-04-11 | 1992-11-17 | Drore Eisen | Method of treatment using steroid mouthwash |
-
1994
- 1994-01-12 WO PCT/EP1994/000092 patent/WO1994016710A1/en active IP Right Grant
- 1994-01-12 DK DK94905058.7T patent/DK0680328T3/da active
- 1994-01-12 EP EP94905058A patent/EP0680328B1/en not_active Expired - Lifetime
- 1994-01-12 HU HU9501959A patent/HU221319B1/hu unknown
- 1994-01-12 US US08/448,527 patent/US5654293A/en not_active Expired - Lifetime
- 1994-01-12 JP JP51662794A patent/JP3918119B2/ja not_active Expired - Lifetime
- 1994-01-12 AU AU58833/94A patent/AU683865B2/en not_active Expired
- 1994-01-12 NZ NZ259866A patent/NZ259866A/xx not_active IP Right Cessation
- 1994-01-12 ES ES94905058T patent/ES2098921T3/es not_active Expired - Lifetime
- 1994-01-12 CN CN94190982A patent/CN1096860C/zh not_active Expired - Lifetime
- 1994-01-12 AT AT94905058T patent/ATE146965T1/de active
- 1994-01-12 RU RU95117236A patent/RU2126256C1/ru active
- 1994-01-12 CA CA002153681A patent/CA2153681C/en not_active Expired - Lifetime
- 1994-01-12 DE DE69401336T patent/DE69401336T2/de not_active Expired - Lifetime
- 1994-01-12 KR KR1019950702398A patent/KR100300525B1/ko not_active IP Right Cessation
-
1995
- 1995-07-20 FI FI953505A patent/FI114009B/fi not_active IP Right Cessation
-
1997
- 1997-01-03 GR GR960403564T patent/GR3022212T3/el unknown
-
1998
- 1998-06-11 HK HK98105165A patent/HK1005999A1/xx not_active IP Right Cessation
- 1998-06-16 CY CY9800008A patent/CY2106B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR100300525B1 (ko) | 2001-10-22 |
DE69401336D1 (de) | 1997-02-13 |
WO1994016710A1 (en) | 1994-08-04 |
CN1116824A (zh) | 1996-02-14 |
CA2153681C (en) | 2004-05-25 |
DE69401336T2 (de) | 1997-04-24 |
FI114009B (fi) | 2004-07-30 |
FI953505A0 (fi) | 1995-07-20 |
AU683865B2 (en) | 1997-11-27 |
CA2153681A1 (en) | 1994-08-04 |
US5654293A (en) | 1997-08-05 |
CN1096860C (zh) | 2002-12-25 |
HU221319B1 (en) | 2002-09-28 |
NZ259866A (en) | 1999-07-29 |
GR3022212T3 (en) | 1997-04-30 |
DK0680328T3 (da) | 1997-01-20 |
ATE146965T1 (de) | 1997-01-15 |
FI953505A (fi) | 1995-07-20 |
AU5883394A (en) | 1994-08-15 |
ES2098921T3 (es) | 1997-05-01 |
EP0680328B1 (en) | 1997-01-02 |
EP0680328A1 (en) | 1995-11-08 |
HU9501959D0 (en) | 1995-09-28 |
HK1005999A1 (en) | 1999-02-05 |
JP3918119B2 (ja) | 2007-05-23 |
CY2106B1 (en) | 2002-04-26 |
HUT73233A (en) | 1996-07-29 |
RU2126256C1 (ru) | 1999-02-20 |
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