JPH0774235B2 - 血小板のコラーゲンとの付着を阻止するためのタンパク質 - Google Patents

血小板のコラーゲンとの付着を阻止するためのタンパク質

Info

Publication number
JPH0774235B2
JPH0774235B2 JP4327811A JP32781192A JPH0774235B2 JP H0774235 B2 JPH0774235 B2 JP H0774235B2 JP 4327811 A JP4327811 A JP 4327811A JP 32781192 A JP32781192 A JP 32781192A JP H0774235 B2 JPH0774235 B2 JP H0774235B2
Authority
JP
Japan
Prior art keywords
protein
collagen
dna
amino acid
platelet adhesion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP4327811A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05331197A (ja
Inventor
トーマス・エム・コノリイ
マイケル・ニーパー
ロイド・ワツクスマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPH05331197A publication Critical patent/JPH05331197A/ja
Publication of JPH0774235B2 publication Critical patent/JPH0774235B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43527—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from ticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/858—Proteins from animals other than mammals or birds insects; venom

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP4327811A 1991-12-10 1992-12-08 血小板のコラーゲンとの付着を阻止するためのタンパク質 Expired - Lifetime JPH0774235B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US807022 1991-12-10
US07/807,022 US5321010A (en) 1991-12-10 1991-12-10 Proteins for inhibiting adhesion of platelets to collagen

Publications (2)

Publication Number Publication Date
JPH05331197A JPH05331197A (ja) 1993-12-14
JPH0774235B2 true JPH0774235B2 (ja) 1995-08-09

Family

ID=25195390

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4327811A Expired - Lifetime JPH0774235B2 (ja) 1991-12-10 1992-12-08 血小板のコラーゲンとの付着を阻止するためのタンパク質

Country Status (4)

Country Link
US (1) US5321010A (enExample)
EP (1) EP0546813A2 (enExample)
JP (1) JPH0774235B2 (enExample)
CA (1) CA2084834A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005304A1 (en) * 1994-08-09 1996-02-22 Athena Neurosciences, Inc. Integrin blocking molecules
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
EP1931733A4 (en) * 2005-09-28 2009-11-25 Biovascular Inc METHOD AND COMPOSITIONS FOR BLOCKING THROMBOZYTE AND CELL ADHESION, CELL MIGRATION AND IGNITION
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
WO2008092656A1 (en) * 2007-01-31 2008-08-07 Anders Jeppsson Use of fibrinogen as a prophylactic treatment to prevent bleeding during and after surgery and as a biomarker to identify patient with an increased risk for excessive bleeding and blood transfusion
JP2013526273A (ja) * 2010-05-14 2013-06-24 ストールハンシェ，ペール キットおよび方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
CA2024697A1 (en) * 1989-09-07 1991-03-08 George P. Vlasuk Protein having anticoagulant properties
DE3931839A1 (de) * 1989-09-23 1991-04-04 Basf Ag Neue proteine und ihre herstellung
US5179082A (en) * 1990-11-13 1993-01-12 Merck & Co., Inc. Method for blocking platelet adhesion to collagen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J CELL BIOL=1991 *

Also Published As

Publication number Publication date
CA2084834A1 (en) 1993-06-11
JPH05331197A (ja) 1993-12-14
EP0546813A2 (en) 1993-06-16
EP0546813A3 (enExample) 1994-01-05
US5321010A (en) 1994-06-14

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